FLT3: ITDoes matter in leukemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-09

AUTHORS

M Levis, D Small

ABSTRACT

FMS-like tyrosine kinase-3 (FLT3), a receptor tyrosine kinase, is important for the development of the hematopoietic and immune systems. Activating mutations of FLT3 are now recognized as the most common molecular abnormality in acute myeloid leukemia, and FLT3 mutations may play a role in other hematologic malignancies as well. The poor prognosis of patients harboring these mutations renders FLT3 an obvious target of therapy. This review summarizes the data on the molecular biology and clinical impact of FLT3 mutations, as well as the therapeutic potential of several small-molecule FLT3 inhibitors currently in development. More... »

PAGES

2403099

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.leu.2403099

    DOI

    http://dx.doi.org/10.1038/sj.leu.2403099

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029950764

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12970773


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