Chronic myelogenous leukemia as a paradigm of early cancer and possible curative strategies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-07

AUTHORS

B Clarkson, A Strife, D Wisniewski, C L Lambek, C Liu

ABSTRACT

The chronological history of the important discoveries leading to our present understanding of the essential clinical, biological, biochemical, and molecular features of chronic myelogenous leukemia (CML) are first reviewed, focusing in particular on abnormalities that are responsible for the massive myeloid expansion. CML is an excellent target for the development of selective treatment because of its highly consistent genetic abnormality and qualitatively different fusion gene product, p210(bcr-abl). It is likely that the multiple signaling pathways dysregulated by p210(bcr-abl) are sufficient to explain all the initial manifestations of the chronic phase of the disease, although understanding of the circuitry is still very incomplete. Evidence is presented that the signaling pathways that are constitutively activated in CML stem cells and primitive progenitors cooperate with cytokines to increase the proportion of stem cells that are activated and thereby increase recruitment into the committed progenitor cell pool, and that this increased activation is probably the primary cause of the massive myeloid expansion in CML. The cooperative interactions between Bcr-Abl and cytokine-activated pathways interfere with the synergistic interactions between multiple cytokines that are normally required for the activation of stem cells, while at the same time causing numerous subtle biochemical and functional abnormalities in the later progenitors and precursor cells. The committed CML progenitors have discordant maturation and reduced proliferative capacity compared to normal committed progenitors, and like them, are destined to die after a limited number of divisions. Thus, the primary goal of any curative strategy must be to eliminate all Philadelphia positive (Ph+) primitive cells that are capable of symmetric division and thereby able to expand the Ph+ stem cell pool and recreate the disease. Several highly potent and moderately selective inhibitors of Bcr-Abl kinase have recently been discovered that are capable of killing the majority of actively proliferating early CML progenitors with minimal effects on normal progenitors. However, like their normal counterparts, most of the CML primitive stem cells are quiescent at any given time and are relatively invulnerable to the Bcr-Abl kinase inhibitors as well as other drugs. We propose that survival of dormant Ph+ stem cells may be the most important reason for the inability to cure the disease during initial treatment, while resistance to the inhibitors and other drugs becomes increasingly important later. An outline of a possible curative strategy is presented that attempts to take advantage of the subtle differences in the proliferative behavior of normal and Ph+ stem cells and the newly discovered selective inhibitors of Bcr-Abl. Leukemia (2003) 17, 1211-1262. doi:10.1038/sj.leu.2402912 More... »

PAGES

2402912

References to SciGraph publications

  • 1997-10. Long-term results after allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic phase: a report from the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation in BONE MARROW TRANSPLANTATION
  • 1998-03. Herbimycin A accelerates the induction of apoptosis following etoposide treatment or γ-irradiation of bcr/abl-positive leukaemia cells in ONCOGENE
  • 1998-05. Bcl-2 mRNA-targeted ribozymes: effects on programmed cell death in chronic myelogenous leukemia cell lines in ANNALS OF HEMATOLOGY
  • 1975-10. Cancer and ageing in mice and men in BRITISH JOURNAL OF CANCER
  • 2001-12. Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase in ONCOGENE
  • 2002-04. Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia in LEUKEMIA
  • 1997-06. Signalling through the lipid products of phosphoinositide-3-OH kinase in NATURE
  • 2000-10. Somatic control over the germline stem cell lineage during Drosophila spermatogenesis in NATURE
  • 1999-04. Cell biology of CML cells in LEUKEMIA
  • 1990. Importance of Long-Term Follow-up in Evaluating Treatment Regimens for Adults with Acute Lymphoblastic Leukemia in ACUTE LEUKEMIAS II
  • 1987-07. Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia in NATURE
  • 1974. Clinical Applications of Cell Cycle Kinetics in ANTINEOPLASTIC AND IMMUNOSUPPRESSIVE AGENTS PART I
  • 1999-04. Does long-term culture favor normal clonogenic cells from interferon-treated patients with chronic myelogenous leukemia? in LEUKEMIA
  • 1999-12. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration in NATURE
  • 1987. Persistence of CML Despite Deletion of Rearranged bcr/c-abl Sequences in MODERN TRENDS IN HUMAN LEUKEMIA VII
  • 1993. The molecular pathogenesis of the philadelphia-positive leukemias: Implications for diagnosis and therapy in LEUKEMIA: ADVANCES IN RESEARCH AND TREATMENT
  • 1983-11. Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia in NATURE
  • 1973-06. A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining in NATURE
  • 1954-03. The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis in BRITISH JOURNAL OF CANCER
  • 2001-02. Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR–ABL tyrosine kinase in NATURE MEDICINE
  • 2002-07. Pluripotency of mesenchymal stem cells derived from adult marrow in NATURE
  • 2001-03. Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells in LEUKEMIA
  • 1997-03. The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins in LEUKEMIA
  • 1969-06. Chromosome Pattern of Bone Marrow Fibroblasts in Patients with Chronic Granulocytic Leukaemia in NATURE
  • 1985-06. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia in NATURE
  • 1998-05. Multilineage involvement of Philadelphia chromosome positive acute lymphoblastic leukemia in LEUKEMIA
  • 1971. Consideration of the Cell Cycle in Chemotherapy of Acute Leukemia in CURRENT CONCEPTS IN THE MANAGEMENT OF LYMPHOMA AND LEUKEMIA
  • 2001-05. Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Bcr-Abl-positive acute leukemia cells in LEUKEMIA
  • 1995-02. Protein modules and signalling networks in NATURE
  • 1987-08. Plasma membrane proteins from human normal and chronic myeloid leukemic granulocytes: Identification and partial characterization of the concanavalin A-binding and detergent resistant proteins in ANNALS OF HEMATOLOGY
  • 1997-12. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species in NATURE MEDICINE
  • 1972-08. Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics in BRITISH JOURNAL OF CANCER
  • 1996-05. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells in NATURE MEDICINE
  • 1987-08. Differential endocytosis of fluorescein iso-thiocyanate-concanavalin A by normal and chronic myeloid leukemic granulocytes in ANNALS OF HEMATOLOGY
  • 2002-04. Results of a phase II trial of a combination of oral cytarabine ocfosfate (YNK01) and interferon α-2b for the treatment of chronic myelogenous leukemia patients in chronic phase in LEUKEMIA
  • 1975. Variations of the Proliferative Activity of Leukemic Myeloblasts Related to the Stage of the Disease in UNCLASSIFIABLE LEUKEMIAS
  • 1998-03. Bcl-2-independent Bcr–Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL in ONCOGENE
  • 1965-12. Return of Leucocytes to the Bone Marrow in Chronic Myelogenous Leukaemia in NATURE
  • 1990-03. Acute leukaemia in bcr/abl transgenic mice in NATURE
  • 1986-12. Lineage infidelity in chronic myeloid leukemia in VIRCHOWS ARCHIV B CELL PATHOLOGY
  • 2002-05. Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease in ONCOGENE
  • 1999-09. Philadelphia chromosome-positive cells are equally distributed in AC133+ and AC133− fractions of CD34+ peripheral blood progenitor cells from patients with CML in LEUKEMIA
  • 1998-08. Pten is essential for embryonic development and tumour suppression in NATURE GENETICS
  • 2000-10. The Effect of Bcr-Abl Protein Tyrosine Kinase on Maturation and Proliferation of Primitive Haematopoietic Cells in MOLECULAR MEDICINE
  • 1988. Stem Cell Proliferation and Differentiation, A Multitype Branching Process Model in NONE
  • 1986-03. Genomic diversity correlates with clinical variation in Ph′-negative chronic myeloid leukaemia in NATURE
  • 1998-08. Peptide containing the BCR oligomerization domain (AA 1-160) reverses the transformed phenotype of p210bcr–abl positive 32D myeloid leukemia cells in ONCOGENE
  • 2002-05. BCR–ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor in ONCOGENE
  • 1997-04. Expression of CD95(Fas) by gene transfer does not sensitize K562 to Fas-killing in ANNALS OF HEMATOLOGY
  • 2002-05. JAKs, STATs and Src kinases in hematopoiesis in ONCOGENE
  • 1999-08. Bcr: a negative regulator of the Bcr-Abl oncoprotein in ONCOGENE
  • 1992. Adoptive Immunotherapy in Human and Canine Chimeras in ACUTE LEUKEMIAS
  • 1966-08. Deoxyribonucleic Acid Synthesis Time of Erythropoietic and Granulopoietic Cells in Human Beings in NATURE
  • 1970. Long-Term Survivors in Acute Leukemia in ADVANCES IN THE TREATMENT OF ACUTE (BLASTIC) LEUKEMIAS
  • 1857-07. Ein neuer Fall von Leukämie in VIRCHOWS ARCHIV
  • 1985-10. Megakaryoblastic micromegakaryocytic crisis in chronic myeloid leukemia in ANNALS OF HEMATOLOGY
  • 2000-11. Stem cell repopulation efficiency but not pool size is governed by p27kip1 in NATURE MEDICINE
  • 1991-05. Bcr encodes a GTPase-activating protein for p21rac in NATURE
  • 1969. Discussion Magnitude of Proliferating Fraction and Rate of Proliferation of Populations of Leukemic Cells in Man in NORMAL AND MALIGNANT CELL GROWTH
  • 1997-09. New understanding of the pathogenesis of CML: a prototype of early neoplasia in LEUKEMIA
  • 2000-11. Regulation of cell death by the Abl tyrosine kinase in ONCOGENE
  • 2002-11. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr–Abl signal transduction and oncogenesis in ONCOGENE
  • 1997-11. The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors in ONCOGENE
  • 1982-12. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia in NATURE
  • 1982-10. Chromosomal localization of human cellular homologues of two viral oncogenes in NATURE
  • 1997-02. Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement in NATURE
  • 1997-02. Three-dimensional structure of the tyrosine kinase c-Src in NATURE
  • 1960-12. A Possible Specific Chromosome Abnormality in Human Chronic Myeloid Leukæmia in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.leu.2402912

    DOI

    http://dx.doi.org/10.1038/sj.leu.2402912

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003631832

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12835715


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    664 schema:description The chronological history of the important discoveries leading to our present understanding of the essential clinical, biological, biochemical, and molecular features of chronic myelogenous leukemia (CML) are first reviewed, focusing in particular on abnormalities that are responsible for the massive myeloid expansion. CML is an excellent target for the development of selective treatment because of its highly consistent genetic abnormality and qualitatively different fusion gene product, p210(bcr-abl). It is likely that the multiple signaling pathways dysregulated by p210(bcr-abl) are sufficient to explain all the initial manifestations of the chronic phase of the disease, although understanding of the circuitry is still very incomplete. Evidence is presented that the signaling pathways that are constitutively activated in CML stem cells and primitive progenitors cooperate with cytokines to increase the proportion of stem cells that are activated and thereby increase recruitment into the committed progenitor cell pool, and that this increased activation is probably the primary cause of the massive myeloid expansion in CML. The cooperative interactions between Bcr-Abl and cytokine-activated pathways interfere with the synergistic interactions between multiple cytokines that are normally required for the activation of stem cells, while at the same time causing numerous subtle biochemical and functional abnormalities in the later progenitors and precursor cells. The committed CML progenitors have discordant maturation and reduced proliferative capacity compared to normal committed progenitors, and like them, are destined to die after a limited number of divisions. Thus, the primary goal of any curative strategy must be to eliminate all Philadelphia positive (Ph+) primitive cells that are capable of symmetric division and thereby able to expand the Ph+ stem cell pool and recreate the disease. Several highly potent and moderately selective inhibitors of Bcr-Abl kinase have recently been discovered that are capable of killing the majority of actively proliferating early CML progenitors with minimal effects on normal progenitors. However, like their normal counterparts, most of the CML primitive stem cells are quiescent at any given time and are relatively invulnerable to the Bcr-Abl kinase inhibitors as well as other drugs. We propose that survival of dormant Ph+ stem cells may be the most important reason for the inability to cure the disease during initial treatment, while resistance to the inhibitors and other drugs becomes increasingly important later. An outline of a possible curative strategy is presented that attempts to take advantage of the subtle differences in the proliferative behavior of normal and Ph+ stem cells and the newly discovered selective inhibitors of Bcr-Abl. Leukemia (2003) 17, 1211-1262. doi:10.1038/sj.leu.2402912
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