Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-01

AUTHORS

W J C Rombouts, R E Ploemacher

ABSTRACT

Recent studies describe beneficial effects of bone marrow-derived mesenchymal stem cell infusion in animal models as well as in patients. However, data on the homing abilities of primary and culture-expanded MSC are lacking. In order to systematically investigate MSC homing we compared the fate of both primary and cultured MSC in a syngeneic mouse model. Twenty-four hours after transplantation of uncultured EGFP-transgenic MSC into sublethally irradiated mice, as many as 55-65% of injected CFU-F were recovered from the BM and 3.5-7% from the spleen. In the subsequent 4 weeks these donor CFU-F expanded 100-fold, which resulted in a normalization of femoral and splenic CFU-F numbers. This highly efficient homing of primary CFU-F contrasted with the defective homing of MSC following culture. Following their infusion immortalized multipotent syngeneic stromal cells were undetectable in BM, spleen, lymph nodes or thymus. Remarkably, following transplantation of primary MSC that had been cultured for only 24 h the seeding fraction in the BM was reduced to 10%, while after transplantation of 48 h cultured primary MSC no CFU-F were detected in the lymphohematopoietic organs. These data suggest that in vitro propagation of BM-derived MSC dramatically decreases their homing to BM and spleen. More... »

PAGES

2402763

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2402763

DOI

http://dx.doi.org/10.1038/sj.leu.2402763

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008752494

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12529674


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colony-Forming Units Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescent Dyes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graft Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Green Fluorescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Luminescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Nodes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesoderm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spleen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymus Gland", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Homologous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Whole-Body Irradiation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Erasmus University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5645.2", 
          "name": [
            "Dept of Haematology, Erasmus Medical Center, Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rombouts", 
        "givenName": "W J C", 
        "id": "sg:person.01224422532.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224422532.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Erasmus University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5645.2", 
          "name": [
            "Dept of Haematology, Erasmus Medical Center, Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ploemacher", 
        "givenName": "R E", 
        "id": "sg:person.014316077474.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014316077474.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1006/bbrc.1997.6648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000512369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jor.1100160403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004854834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/81395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006236652", 
          "https://doi.org/10.1038/81395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/81395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006236652", 
          "https://doi.org/10.1038/81395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2001.03084.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007831246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.11.4857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008119461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002239900121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011807123", 
          "https://doi.org/10.1007/s002239900121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-472x(99)00090-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012220077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.1999.14.5.700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012309145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00062752-200011000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013565184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00062752-200011000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013565184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00062752-200011000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013565184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jor.1100090504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013920393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.13.7294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014150838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0047-6374(83)90003-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014362226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0047-6374(83)90003-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014362226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/298280a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014932344", 
          "https://doi.org/10.1038/298280a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1980.tb01200.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015883187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4652(199910)181:1<67::aid-jcp7>3.0.co;2-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016570875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.5.1227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017153300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4644(19990315)72:4<570::aid-jcb12>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017222061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v99.5.1585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018135274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4652(200007)184:1<58::aid-jcp6>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018376893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1983.tb02097.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019465994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198508000-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020621887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198508000-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020621887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198508000-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020621887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-472x(01)00734-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020791196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1999.1620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022158684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1991.tb08041.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025288128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.3.1142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026269780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000047856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027744286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.7.3908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030900025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200102013440516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036384897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-197802000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039009084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-197802000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039009084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2001.tb03569.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039852549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/6529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040720175", 
          "https://doi.org/10.1038/6529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/6529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040720175", 
          "https://doi.org/10.1038/6529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-472x(01)00777-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040791143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/8756-3282(92)90364-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041520893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1997.3858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042288249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1994.tb04764.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042446866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.7.3213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042755493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35070587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046093021", 
          "https://doi.org/10.1038/35070587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35070587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046093021", 
          "https://doi.org/10.1038/35070587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-472x(99)00101-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049023965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2184.1970.tb00343.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049176200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/8756-3282(92)90363-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051939641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/328429a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056438812", 
          "https://doi.org/10.1038/328429a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/152581600319388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059213047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1997.8.2-137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059271985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.276.5309.71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062556263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/3576958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070379676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074254071", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074645522", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074726025", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074737885", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076185256", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079061645", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079679130", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079790256", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080357976", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081698472", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082403639", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082916718", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083173876", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083326175", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-01", 
    "datePublishedReg": "2003-01-01", 
    "description": "Recent studies describe beneficial effects of bone marrow-derived mesenchymal stem cell infusion in animal models as well as in patients. However, data on the homing abilities of primary and culture-expanded MSC are lacking. In order to systematically investigate MSC homing we compared the fate of both primary and cultured MSC in a syngeneic mouse model. Twenty-four hours after transplantation of uncultured EGFP-transgenic MSC into sublethally irradiated mice, as many as 55-65% of injected CFU-F were recovered from the BM and 3.5-7% from the spleen. In the subsequent 4 weeks these donor CFU-F expanded 100-fold, which resulted in a normalization of femoral and splenic CFU-F numbers. This highly efficient homing of primary CFU-F contrasted with the defective homing of MSC following culture. Following their infusion immortalized multipotent syngeneic stromal cells were undetectable in BM, spleen, lymph nodes or thymus. Remarkably, following transplantation of primary MSC that had been cultured for only 24 h the seeding fraction in the BM was reduced to 10%, while after transplantation of 48 h cultured primary MSC no CFU-F were detected in the lymphohematopoietic organs. These data suggest that in vitro propagation of BM-derived MSC dramatically decreases their homing to BM and spleen.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.leu.2402763", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture", 
    "pagination": "2402763", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "29b30f7062f27d98609d748262bfa4f47fa9e5120749ecfe5f5162c91f538ad6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12529674"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.leu.2402763"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008752494"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.leu.2402763", 
      "https://app.dimensions.ai/details/publication/pub.1008752494"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118342_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/2402763"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2402763'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2402763'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2402763'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2402763'


 

This table displays all metadata directly associated to this object as RDF triples.

345 TRIPLES      21 PREDICATES      113 URIs      46 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.leu.2402763 schema:about N16f7ec84d13b46d8b67bab17e14a678b
2 N47f40055597c41cfa40ff6c4f70dfc21
3 N484ef6fd78264656b5e48aaadfe8a3a6
4 N4b91886bc0414a6f88894bdedad30f1d
5 N5709e51df9a1469eae9c427956907087
6 N619f21a2aaaf49748cb0ff5f7f8347c3
7 N653a7bd4eb264842b47c3134b8d9d8a0
8 N6769bf96eedf42bca3c8485ea2f59ea7
9 N6faaf31c0ef841f6aa46b4a54bd5f42e
10 N77aace8ccc59405c8b8a585bdc724811
11 N7fcc79b9d0bf4d94bd1883007752023f
12 N824929f990e44a01ab5f89e129de175e
13 N8c3894d039054e8f869adeeb770bf7c9
14 N8f92dbf1f370496eb43787783ff5341f
15 N95d5a81ffc4c435fa6bf8bf603ff2dde
16 N9dcacf026e744ed6ab860bcbd3df052c
17 N9e31e6d8c3f2458e9732db697433d35a
18 Na8fc25bcc7bb435d86119a8485d53f1a
19 Nb5bd70ab09dc45149e5ff2375552a081
20 Nb9dbb9ce9ab14b1abd0a459cc0303eec
21 Nc986b840f10441dcbe78781b52af98f5
22 Ncfa68136fb7a4ef79b57cd9ab4283c84
23 Ne5f1577da6a4406b8f90fb3eb3da3e5b
24 Ne8964ba119f64ba1a02c8c92f286daf4
25 Nf5166ec08c4f49a290b6f1ccde71c9f8
26 anzsrc-for:11
27 anzsrc-for:1103
28 schema:author Nf4a4eb99efac4485910ed87520816d70
29 schema:citation sg:pub.10.1007/s002239900121
30 sg:pub.10.1038/298280a0
31 sg:pub.10.1038/328429a0
32 sg:pub.10.1038/35070587
33 sg:pub.10.1038/6529
34 sg:pub.10.1038/81395
35 https://app.dimensions.ai/details/publication/pub.1074254071
36 https://app.dimensions.ai/details/publication/pub.1074645522
37 https://app.dimensions.ai/details/publication/pub.1074726025
38 https://app.dimensions.ai/details/publication/pub.1074737885
39 https://app.dimensions.ai/details/publication/pub.1076185256
40 https://app.dimensions.ai/details/publication/pub.1079061645
41 https://app.dimensions.ai/details/publication/pub.1079679130
42 https://app.dimensions.ai/details/publication/pub.1079790256
43 https://app.dimensions.ai/details/publication/pub.1080357976
44 https://app.dimensions.ai/details/publication/pub.1081698472
45 https://app.dimensions.ai/details/publication/pub.1082403639
46 https://app.dimensions.ai/details/publication/pub.1082916718
47 https://app.dimensions.ai/details/publication/pub.1083173876
48 https://app.dimensions.ai/details/publication/pub.1083326175
49 https://doi.org/10.1002/(sici)1097-4644(19990315)72:4<570::aid-jcb12>3.0.co;2-w
50 https://doi.org/10.1002/(sici)1097-4652(199910)181:1<67::aid-jcp7>3.0.co;2-c
51 https://doi.org/10.1002/(sici)1097-4652(200007)184:1<58::aid-jcp6>3.0.co;2-b
52 https://doi.org/10.1002/jor.1100090504
53 https://doi.org/10.1002/jor.1100160403
54 https://doi.org/10.1006/bbrc.1997.6648
55 https://doi.org/10.1006/bbrc.1999.1620
56 https://doi.org/10.1006/excr.1997.3858
57 https://doi.org/10.1016/0047-6374(83)90003-9
58 https://doi.org/10.1016/8756-3282(92)90363-2
59 https://doi.org/10.1016/8756-3282(92)90364-3
60 https://doi.org/10.1016/s0301-472x(01)00734-2
61 https://doi.org/10.1016/s0301-472x(01)00777-9
62 https://doi.org/10.1016/s0301-472x(99)00090-9
63 https://doi.org/10.1016/s0301-472x(99)00101-0
64 https://doi.org/10.1046/j.1365-2141.2001.03084.x
65 https://doi.org/10.1056/nejm200102013440516
66 https://doi.org/10.1073/pnas.92.11.4857
67 https://doi.org/10.1073/pnas.95.3.1142
68 https://doi.org/10.1073/pnas.95.7.3908
69 https://doi.org/10.1073/pnas.96.13.7294
70 https://doi.org/10.1073/pnas.97.7.3213
71 https://doi.org/10.1089/152581600319388
72 https://doi.org/10.1089/hum.1997.8.2-137
73 https://doi.org/10.1097/00007890-197802000-00010
74 https://doi.org/10.1097/00007890-198508000-00018
75 https://doi.org/10.1097/00062752-200011000-00007
76 https://doi.org/10.1111/j.1365-2141.1980.tb01200.x
77 https://doi.org/10.1111/j.1365-2141.1983.tb02097.x
78 https://doi.org/10.1111/j.1365-2141.1991.tb08041.x
79 https://doi.org/10.1111/j.1365-2141.1994.tb04764.x
80 https://doi.org/10.1111/j.1365-2184.1970.tb00343.x
81 https://doi.org/10.1111/j.1749-6632.2001.tb03569.x
82 https://doi.org/10.1126/science.276.5309.71
83 https://doi.org/10.1159/000047856
84 https://doi.org/10.1182/blood.v97.5.1227
85 https://doi.org/10.1182/blood.v99.5.1585
86 https://doi.org/10.1359/jbmr.1999.14.5.700
87 https://doi.org/10.2307/3576958
88 schema:datePublished 2003-01
89 schema:datePublishedReg 2003-01-01
90 schema:description Recent studies describe beneficial effects of bone marrow-derived mesenchymal stem cell infusion in animal models as well as in patients. However, data on the homing abilities of primary and culture-expanded MSC are lacking. In order to systematically investigate MSC homing we compared the fate of both primary and cultured MSC in a syngeneic mouse model. Twenty-four hours after transplantation of uncultured EGFP-transgenic MSC into sublethally irradiated mice, as many as 55-65% of injected CFU-F were recovered from the BM and 3.5-7% from the spleen. In the subsequent 4 weeks these donor CFU-F expanded 100-fold, which resulted in a normalization of femoral and splenic CFU-F numbers. This highly efficient homing of primary CFU-F contrasted with the defective homing of MSC following culture. Following their infusion immortalized multipotent syngeneic stromal cells were undetectable in BM, spleen, lymph nodes or thymus. Remarkably, following transplantation of primary MSC that had been cultured for only 24 h the seeding fraction in the BM was reduced to 10%, while after transplantation of 48 h cultured primary MSC no CFU-F were detected in the lymphohematopoietic organs. These data suggest that in vitro propagation of BM-derived MSC dramatically decreases their homing to BM and spleen.
91 schema:genre research_article
92 schema:inLanguage en
93 schema:isAccessibleForFree true
94 schema:isPartOf N44dd0851eadb41ef9920d7c781d1e260
95 Nd1491526e38242a7a3787f4bbd15ac4e
96 sg:journal.1097065
97 schema:name Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture
98 schema:pagination 2402763
99 schema:productId N4fd5822db5e14fedb410afeabef8bb7f
100 N5007e4b73180499fb5618075ae13dd73
101 N9179c057c038443a89696e7301967e9a
102 Na29fb8fee9724fe4b8322eeda0ac243f
103 Nde422574135441f4814563ed44d2900c
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008752494
105 https://doi.org/10.1038/sj.leu.2402763
106 schema:sdDatePublished 2019-04-11T12:06
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher N9f1c745f1605415ea86d0068c8ea1f86
109 schema:url http://www.nature.com/articles/2402763
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N16f7ec84d13b46d8b67bab17e14a678b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Green Fluorescent Proteins
115 rdf:type schema:DefinedTerm
116 N198bd7206d09487ea74804bcc6b866a6 rdf:first sg:person.014316077474.52
117 rdf:rest rdf:nil
118 N44dd0851eadb41ef9920d7c781d1e260 schema:issueNumber 1
119 rdf:type schema:PublicationIssue
120 N47f40055597c41cfa40ff6c4f70dfc21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Spleen
122 rdf:type schema:DefinedTerm
123 N484ef6fd78264656b5e48aaadfe8a3a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Mesoderm
125 rdf:type schema:DefinedTerm
126 N4b91886bc0414a6f88894bdedad30f1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Graft Survival
128 rdf:type schema:DefinedTerm
129 N4fd5822db5e14fedb410afeabef8bb7f schema:name pubmed_id
130 schema:value 12529674
131 rdf:type schema:PropertyValue
132 N5007e4b73180499fb5618075ae13dd73 schema:name nlm_unique_id
133 schema:value 8704895
134 rdf:type schema:PropertyValue
135 N5709e51df9a1469eae9c427956907087 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Mice, Transgenic
137 rdf:type schema:DefinedTerm
138 N619f21a2aaaf49748cb0ff5f7f8347c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Cells, Cultured
140 rdf:type schema:DefinedTerm
141 N653a7bd4eb264842b47c3134b8d9d8a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Whole-Body Irradiation
143 rdf:type schema:DefinedTerm
144 N6769bf96eedf42bca3c8485ea2f59ea7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Lymph Nodes
146 rdf:type schema:DefinedTerm
147 N6faaf31c0ef841f6aa46b4a54bd5f42e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Thymus Gland
149 rdf:type schema:DefinedTerm
150 N77aace8ccc59405c8b8a585bdc724811 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Luminescent Proteins
152 rdf:type schema:DefinedTerm
153 N7fcc79b9d0bf4d94bd1883007752023f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Stem Cells
155 rdf:type schema:DefinedTerm
156 N824929f990e44a01ab5f89e129de175e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Humans
158 rdf:type schema:DefinedTerm
159 N8c3894d039054e8f869adeeb770bf7c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Antigens, CD
161 rdf:type schema:DefinedTerm
162 N8f92dbf1f370496eb43787783ff5341f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Animals
164 rdf:type schema:DefinedTerm
165 N9179c057c038443a89696e7301967e9a schema:name doi
166 schema:value 10.1038/sj.leu.2402763
167 rdf:type schema:PropertyValue
168 N95d5a81ffc4c435fa6bf8bf603ff2dde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Bone Marrow Cells
170 rdf:type schema:DefinedTerm
171 N9dcacf026e744ed6ab860bcbd3df052c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Cell Movement
173 rdf:type schema:DefinedTerm
174 N9e31e6d8c3f2458e9732db697433d35a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Mice, Inbred C57BL
176 rdf:type schema:DefinedTerm
177 N9f1c745f1605415ea86d0068c8ea1f86 schema:name Springer Nature - SN SciGraph project
178 rdf:type schema:Organization
179 Na29fb8fee9724fe4b8322eeda0ac243f schema:name readcube_id
180 schema:value 29b30f7062f27d98609d748262bfa4f47fa9e5120749ecfe5f5162c91f538ad6
181 rdf:type schema:PropertyValue
182 Na8fc25bcc7bb435d86119a8485d53f1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Bone Marrow
184 rdf:type schema:DefinedTerm
185 Nb5bd70ab09dc45149e5ff2375552a081 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Stem Cell Transplantation
187 rdf:type schema:DefinedTerm
188 Nb9dbb9ce9ab14b1abd0a459cc0303eec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Receptors, Growth Factor
190 rdf:type schema:DefinedTerm
191 Nc986b840f10441dcbe78781b52af98f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Transplantation, Homologous
193 rdf:type schema:DefinedTerm
194 Ncfa68136fb7a4ef79b57cd9ab4283c84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Mice
196 rdf:type schema:DefinedTerm
197 Nd1491526e38242a7a3787f4bbd15ac4e schema:volumeNumber 17
198 rdf:type schema:PublicationVolume
199 Nde422574135441f4814563ed44d2900c schema:name dimensions_id
200 schema:value pub.1008752494
201 rdf:type schema:PropertyValue
202 Ne5f1577da6a4406b8f90fb3eb3da3e5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name In Vitro Techniques
204 rdf:type schema:DefinedTerm
205 Ne8964ba119f64ba1a02c8c92f286daf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Colony-Forming Units Assay
207 rdf:type schema:DefinedTerm
208 Nf4a4eb99efac4485910ed87520816d70 rdf:first sg:person.01224422532.32
209 rdf:rest N198bd7206d09487ea74804bcc6b866a6
210 Nf5166ec08c4f49a290b6f1ccde71c9f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Fluorescent Dyes
212 rdf:type schema:DefinedTerm
213 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
214 schema:name Medical and Health Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
217 schema:name Clinical Sciences
218 rdf:type schema:DefinedTerm
219 sg:journal.1097065 schema:issn 0887-6924
220 1476-5551
221 schema:name Leukemia
222 rdf:type schema:Periodical
223 sg:person.01224422532.32 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
224 schema:familyName Rombouts
225 schema:givenName W J C
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224422532.32
227 rdf:type schema:Person
228 sg:person.014316077474.52 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
229 schema:familyName Ploemacher
230 schema:givenName R E
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014316077474.52
232 rdf:type schema:Person
233 sg:pub.10.1007/s002239900121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011807123
234 https://doi.org/10.1007/s002239900121
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/298280a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014932344
237 https://doi.org/10.1038/298280a0
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/328429a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056438812
240 https://doi.org/10.1038/328429a0
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/35070587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046093021
243 https://doi.org/10.1038/35070587
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/6529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040720175
246 https://doi.org/10.1038/6529
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/81395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006236652
249 https://doi.org/10.1038/81395
250 rdf:type schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1074254071 schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1074645522 schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1074726025 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1074737885 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1076185256 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1079061645 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1079679130 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1079790256 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1080357976 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1081698472 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1082403639 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1082916718 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1083173876 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1083326175 schema:CreativeWork
265 https://doi.org/10.1002/(sici)1097-4644(19990315)72:4<570::aid-jcb12>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1017222061
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/(sici)1097-4652(199910)181:1<67::aid-jcp7>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1016570875
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/(sici)1097-4652(200007)184:1<58::aid-jcp6>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1018376893
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/jor.1100090504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013920393
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/jor.1100160403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004854834
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1006/bbrc.1997.6648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000512369
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1006/bbrc.1999.1620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022158684
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1006/excr.1997.3858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042288249
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/0047-6374(83)90003-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014362226
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/8756-3282(92)90363-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051939641
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/8756-3282(92)90364-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041520893
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s0301-472x(01)00734-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020791196
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s0301-472x(01)00777-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040791143
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/s0301-472x(99)00090-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012220077
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/s0301-472x(99)00101-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049023965
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1046/j.1365-2141.2001.03084.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007831246
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1056/nejm200102013440516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036384897
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1073/pnas.92.11.4857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008119461
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1073/pnas.95.3.1142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026269780
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1073/pnas.95.7.3908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030900025
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1073/pnas.96.13.7294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014150838
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1073/pnas.97.7.3213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042755493
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1089/152581600319388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059213047
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1089/hum.1997.8.2-137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059271985
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1097/00007890-197802000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039009084
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1097/00007890-198508000-00018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020621887
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1097/00062752-200011000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013565184
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1111/j.1365-2141.1980.tb01200.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015883187
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1111/j.1365-2141.1983.tb02097.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019465994
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1111/j.1365-2141.1991.tb08041.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025288128
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1111/j.1365-2141.1994.tb04764.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042446866
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1111/j.1365-2184.1970.tb00343.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049176200
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1111/j.1749-6632.2001.tb03569.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039852549
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1126/science.276.5309.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556263
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1159/000047856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027744286
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1182/blood.v97.5.1227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017153300
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1182/blood.v99.5.1585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018135274
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1359/jbmr.1999.14.5.700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012309145
340 rdf:type schema:CreativeWork
341 https://doi.org/10.2307/3576958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070379676
342 rdf:type schema:CreativeWork
343 https://www.grid.ac/institutes/grid.5645.2 schema:alternateName Erasmus University Medical Center
344 schema:name Dept of Haematology, Erasmus Medical Center, Rotterdam, The Netherlands
345 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...