Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-08

AUTHORS

S Teller, D Krämer, S-A Böhmer, KF Tse, D Small, S Mahboobi, C Wallrapp, T Beckers, K Kratz-Albers, J Schwäble, H Serve, F-D Böhmer

ABSTRACT

Aberrant expression and activating mutations of the class III receptor tyrosine kinase Flt3 (Flk-2, STK-1) have been linked to poor prognosis in acute myeloid leukemia (AML). Inhibitors of Flt3 tyrosine kinase activity are, therefore, of interest as potential therapeutic compounds. We previously described bis(1H-2-indolyl)-1-methanones as a novel class of selective inhibitors for platelet-derived growth factor receptors (PDGFR). Several bis(1H-2-indolyl)-1-methanone derivatives, represented by the compounds D-64406 and D-65476, are also potent inhibitors of Flt3. They inhibit proliferation of TEL-Flt3-transfected BA/F3 cells with IC(50) values of 0.2-0.3 microM in the absence of IL-3 but >10 microM in the presence of IL-3. Ligand-stimulated autophosphorylation of Flt3 in EOL-1 cells and corresponding downstream activation of Akt/PKB are effectively inhibited by bis(1H-2-indolyl)-1-methanones whereas autophosphorylation of c-Kit/SCF receptor or c-Fms/CSF-1 receptor is less sensitive or insensitive, respectively. Flt3 kinase purified by different methods is potently inhibited in vitro, demonstrating a direct mechanism of inhibition. 32D cells, expressing a constitutively active Flt3 variant with internal tandem duplication are greatly sensitized to radiation-induced apoptosis in the presence of D-64406 or D-65476 in the absence but not in the presence of IL-3. Thus, bis(1H-2-indolyl)-1-methanones are potential candidates for the treatment of Flt3-driven leukemias. More... »

PAGES

2402630

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2402630

DOI

http://dx.doi.org/10.1038/sj.leu.2402630

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038221442

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12145694


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Becaplermin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Transformed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Screening Assays, Antitumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplastic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins, Fusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet-Derived Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Processing, Post-Translational", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-akt", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-kit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-sis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Macrophage Colony-Stimulating Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Platelet-Derived Growth Factor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "fms-Like Tyrosine Kinase 3", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Friedrich Schiller University Jena", 
          "id": "https://www.grid.ac/institutes/grid.9613.d", 
          "name": [
            "Research Unit Molecular Cell Biology, Medical Faculty, Friedrich Schiller University, Jena, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teller", 
        "givenName": "S", 
        "id": "sg:person.0631072417.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631072417.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Friedrich Schiller University Jena", 
          "id": "https://www.grid.ac/institutes/grid.9613.d", 
          "name": [
            "Research Unit Molecular Cell Biology, Medical Faculty, Friedrich Schiller University, Jena, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kr\u00e4mer", 
        "givenName": "D", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Friedrich Schiller University Jena", 
          "id": "https://www.grid.ac/institutes/grid.9613.d", 
          "name": [
            "Research Unit Molecular Cell Biology, Medical Faculty, Friedrich Schiller University, Jena, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00f6hmer", 
        "givenName": "S-A", 
        "id": "sg:person.0615707017.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615707017.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Johns Hopkins University, School of Medicine, Pediatric Oncology, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tse", 
        "givenName": "KF", 
        "id": "sg:person.0632704464.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632704464.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Johns Hopkins University, School of Medicine, Pediatric Oncology, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Small", 
        "givenName": "D", 
        "id": "sg:person.01226411152.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226411152.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Regensburg", 
          "id": "https://www.grid.ac/institutes/grid.7727.5", 
          "name": [
            "Faculty of Chemistry and Pharmacy, Institute of Pharmacy, University of Regensburg, Regensburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mahboobi", 
        "givenName": "S", 
        "id": "sg:person.0775542131.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775542131.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Evonik (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420017.0", 
          "name": [
            "ASTA Medica AG, Frankfurt/Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wallrapp", 
        "givenName": "C", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Evonik (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420017.0", 
          "name": [
            "ASTA Medica AG, Frankfurt/Main, Germany", 
            "Current address: Byk Gulden GmbH, Disease Area Oncology, Konstanz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beckers", 
        "givenName": "T", 
        "id": "sg:person.0616434555.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616434555.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of M\u00fcnster", 
          "id": "https://www.grid.ac/institutes/grid.5949.1", 
          "name": [
            "Department of Medicine/Hematology and Oncology, University of M\u00fcnster, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kratz-Albers", 
        "givenName": "K", 
        "id": "sg:person.01326152273.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326152273.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of M\u00fcnster", 
          "id": "https://www.grid.ac/institutes/grid.5949.1", 
          "name": [
            "Department of Medicine/Hematology and Oncology, University of M\u00fcnster, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schw\u00e4ble", 
        "givenName": "J", 
        "id": "sg:person.01331061752.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331061752.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of M\u00fcnster", 
          "id": "https://www.grid.ac/institutes/grid.5949.1", 
          "name": [
            "Department of Medicine/Hematology and Oncology, University of M\u00fcnster, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Serve", 
        "givenName": "H", 
        "id": "sg:person.01342335064.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342335064.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Friedrich Schiller University Jena", 
          "id": "https://www.grid.ac/institutes/grid.9613.d", 
          "name": [
            "Research Unit Molecular Cell Biology, Medical Faculty, Friedrich Schiller University, Jena, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00f6hmer", 
        "givenName": "F-D", 
        "id": "sg:person.01274332331.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274332331.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.leu.2401130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002471707", 
          "https://doi.org/10.1038/sj.leu.2401130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002471707", 
          "https://doi.org/10.1038/sj.leu.2401130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004579728", 
          "https://doi.org/10.1038/sj.onc.1203354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004579728", 
          "https://doi.org/10.1038/sj.onc.1203354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1999.01284.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010830812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/368643a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012820743", 
          "https://doi.org/10.1038/368643a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90322-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013805670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.8.2434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014730117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.3.885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019011103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2000.01831.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021586389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0145-2126(90)90143-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022987061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023193897", 
          "https://doi.org/10.1038/sj.leu.2401680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023193897", 
          "https://doi.org/10.1038/sj.leu.2401680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024534677", 
          "https://doi.org/10.1038/sj.leu.2402199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024534677", 
          "https://doi.org/10.1038/sj.leu.2402199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(95)00809-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029495822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.6-3-233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031236088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2400770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031254959", 
          "https://doi.org/10.1038/sj.leu.2400770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2400770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031254959", 
          "https://doi.org/10.1038/sj.leu.2400770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81683-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031899717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35077225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037528958", 
          "https://doi.org/10.1038/35077225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35077225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037528958", 
          "https://doi.org/10.1038/35077225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(95)90167-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038314822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042964573", 
          "https://doi.org/10.1038/sj.leu.2401241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042964573", 
          "https://doi.org/10.1038/sj.leu.2401241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048114071", 
          "https://doi.org/10.1038/sj.leu.2401905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048114071", 
          "https://doi.org/10.1038/sj.leu.2401905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1998.9959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050764414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi962553l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055213061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi962553l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055213061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm010988n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055946921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm010988n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055946921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm950727b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055957282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm950727b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055957282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlb.65.3.372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074265597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074699260", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074731723", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076033780", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082390833", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082406598", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082422064", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082446965", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082472499", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082581510", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082852522", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082879377", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082888284", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082990699", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083009621", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083207387", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083314031", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-08", 
    "datePublishedReg": "2002-08-01", 
    "description": "Aberrant expression and activating mutations of the class III receptor tyrosine kinase Flt3 (Flk-2, STK-1) have been linked to poor prognosis in acute myeloid leukemia (AML). Inhibitors of Flt3 tyrosine kinase activity are, therefore, of interest as potential therapeutic compounds. We previously described bis(1H-2-indolyl)-1-methanones as a novel class of selective inhibitors for platelet-derived growth factor receptors (PDGFR). Several bis(1H-2-indolyl)-1-methanone derivatives, represented by the compounds D-64406 and D-65476, are also potent inhibitors of Flt3. They inhibit proliferation of TEL-Flt3-transfected BA/F3 cells with IC(50) values of 0.2-0.3 microM in the absence of IL-3 but >10 microM in the presence of IL-3. Ligand-stimulated autophosphorylation of Flt3 in EOL-1 cells and corresponding downstream activation of Akt/PKB are effectively inhibited by bis(1H-2-indolyl)-1-methanones whereas autophosphorylation of c-Kit/SCF receptor or c-Fms/CSF-1 receptor is less sensitive or insensitive, respectively. Flt3 kinase purified by different methods is potently inhibited in vitro, demonstrating a direct mechanism of inhibition. 32D cells, expressing a constitutively active Flt3 variant with internal tandem duplication are greatly sensitized to radiation-induced apoptosis in the presence of D-64406 or D-65476 in the absence but not in the presence of IL-3. Thus, bis(1H-2-indolyl)-1-methanones are potential candidates for the treatment of Flt3-driven leukemias.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.leu.2402630", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2435664", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3", 
    "pagination": "2402630", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b6133458474867c5f6ca4e64639b03a27d7ea624e227a49de6dbf087db6eb386"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12145694"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.leu.2402630"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038221442"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.leu.2402630", 
      "https://app.dimensions.ai/details/publication/pub.1038221442"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29222_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/2402630"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2402630'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2402630'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2402630'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2402630'


 

This table displays all metadata directly associated to this object as RDF triples.

380 TRIPLES      21 PREDICATES      96 URIs      48 LITERALS      36 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.leu.2402630 schema:about N06847ef8d988479c991eaf5a1c296bdb
2 N08f2e5b50afc432ba043eed9edba193e
3 N095a7451206840a793d3add32fd0a53a
4 N142abc84b3e64d10bd5ffd94972847bd
5 N35c83f2d1c99476683da4b764cdb1f2a
6 N3d73f816e626488bab6d8be6d15e64c1
7 N3dea0489c5034758a2ce7e9fc795f299
8 N4a4cccfd1770428595e3117c4ebc4121
9 N4c0edc79884f42678708915bafa5bffa
10 N4c761457488f4333910026d4581f10be
11 N5d154cec047240db8b0f5a8810f47b0c
12 N5ec81e5db30b4cde8567b1a34e15c189
13 N611149703d8b4c428b65aee763767652
14 N65054c376c2b4f16a5f0dd1bb33f4347
15 N702f91ab15b54b988b2ddeb24a4f2690
16 N7c69904a4c4e4d159dd23bed74a51e90
17 N860951c345494aa6abe830c68003f1be
18 N9b27e1a68ba44a7696d0d8ea3b1142c8
19 Nb15e9dcbaa4947fa83b154059d006460
20 Nb2af2fc4e9f1472bb45d24b9b3f125fc
21 Nb6d864edf7454161bbf90caf0f2bf70f
22 Nb96f1f994a6d47aaba421ee6f239f8a6
23 Nc87169a2942441a1b378c7a9c3a23621
24 Nd2d0181c42da4eb6814b1441c8b8bfb2
25 Nd44fe1267bf642c7b35113532d4c2fe4
26 Ne681178d5046446dbacaa35c70d5f6fe
27 Nec46914c63da4956ad8018f4bf4921f6
28 anzsrc-for:11
29 anzsrc-for:1112
30 schema:author N626aa40218514cc49acc59b6a1e01e2d
31 schema:citation sg:pub.10.1038/35077225
32 sg:pub.10.1038/368643a0
33 sg:pub.10.1038/sj.leu.2400770
34 sg:pub.10.1038/sj.leu.2401130
35 sg:pub.10.1038/sj.leu.2401241
36 sg:pub.10.1038/sj.leu.2401680
37 sg:pub.10.1038/sj.leu.2401905
38 sg:pub.10.1038/sj.leu.2402199
39 sg:pub.10.1038/sj.onc.1203354
40 https://app.dimensions.ai/details/publication/pub.1074699260
41 https://app.dimensions.ai/details/publication/pub.1074731723
42 https://app.dimensions.ai/details/publication/pub.1076033780
43 https://app.dimensions.ai/details/publication/pub.1082390833
44 https://app.dimensions.ai/details/publication/pub.1082406598
45 https://app.dimensions.ai/details/publication/pub.1082422064
46 https://app.dimensions.ai/details/publication/pub.1082446965
47 https://app.dimensions.ai/details/publication/pub.1082472499
48 https://app.dimensions.ai/details/publication/pub.1082581510
49 https://app.dimensions.ai/details/publication/pub.1082852522
50 https://app.dimensions.ai/details/publication/pub.1082879377
51 https://app.dimensions.ai/details/publication/pub.1082888284
52 https://app.dimensions.ai/details/publication/pub.1082990699
53 https://app.dimensions.ai/details/publication/pub.1083009621
54 https://app.dimensions.ai/details/publication/pub.1083207387
55 https://app.dimensions.ai/details/publication/pub.1083314031
56 https://doi.org/10.1002/jlb.65.3.372
57 https://doi.org/10.1006/bbrc.1998.9959
58 https://doi.org/10.1016/0092-8674(94)90322-0
59 https://doi.org/10.1016/0145-2126(90)90143-w
60 https://doi.org/10.1016/0378-1119(95)00809-8
61 https://doi.org/10.1016/1074-7613(95)90167-1
62 https://doi.org/10.1016/s0092-8674(00)81683-9
63 https://doi.org/10.1021/bi962553l
64 https://doi.org/10.1021/jm010988n
65 https://doi.org/10.1021/jm950727b
66 https://doi.org/10.1046/j.1365-2141.2000.01831.x
67 https://doi.org/10.1111/j.1365-2141.1999.01284.x
68 https://doi.org/10.1182/blood.v97.8.2434
69 https://doi.org/10.1182/blood.v98.3.885
70 https://doi.org/10.1634/theoncologist.6-3-233
71 schema:datePublished 2002-08
72 schema:datePublishedReg 2002-08-01
73 schema:description Aberrant expression and activating mutations of the class III receptor tyrosine kinase Flt3 (Flk-2, STK-1) have been linked to poor prognosis in acute myeloid leukemia (AML). Inhibitors of Flt3 tyrosine kinase activity are, therefore, of interest as potential therapeutic compounds. We previously described bis(1H-2-indolyl)-1-methanones as a novel class of selective inhibitors for platelet-derived growth factor receptors (PDGFR). Several bis(1H-2-indolyl)-1-methanone derivatives, represented by the compounds D-64406 and D-65476, are also potent inhibitors of Flt3. They inhibit proliferation of TEL-Flt3-transfected BA/F3 cells with IC(50) values of 0.2-0.3 microM in the absence of IL-3 but >10 microM in the presence of IL-3. Ligand-stimulated autophosphorylation of Flt3 in EOL-1 cells and corresponding downstream activation of Akt/PKB are effectively inhibited by bis(1H-2-indolyl)-1-methanones whereas autophosphorylation of c-Kit/SCF receptor or c-Fms/CSF-1 receptor is less sensitive or insensitive, respectively. Flt3 kinase purified by different methods is potently inhibited in vitro, demonstrating a direct mechanism of inhibition. 32D cells, expressing a constitutively active Flt3 variant with internal tandem duplication are greatly sensitized to radiation-induced apoptosis in the presence of D-64406 or D-65476 in the absence but not in the presence of IL-3. Thus, bis(1H-2-indolyl)-1-methanones are potential candidates for the treatment of Flt3-driven leukemias.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree true
77 schema:isPartOf N3f627ebe1a6e4747a698bd6a12b1e751
78 Na8060720c37e4a96a49b0319a311d3e3
79 sg:journal.1097065
80 schema:name Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3
81 schema:pagination 2402630
82 schema:productId N67b25a0a9c17482f886242259d1efbe5
83 N6c91acbf95e84663b8f0e86ad596b278
84 Ncc6ca1a8d18c47fc91f01e910f12de09
85 Nf3a765b861514bffae699b0f64302462
86 Nf508005db3d04932add2b58bed805e89
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038221442
88 https://doi.org/10.1038/sj.leu.2402630
89 schema:sdDatePublished 2019-04-11T11:58
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N717086091e6143dd9ea4a1167858c47f
92 schema:url http://www.nature.com/articles/2402630
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N06847ef8d988479c991eaf5a1c296bdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Proto-Oncogene Proteins
98 rdf:type schema:DefinedTerm
99 N08f2e5b50afc432ba043eed9edba193e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Proto-Oncogene Proteins c-akt
101 rdf:type schema:DefinedTerm
102 N095a7451206840a793d3add32fd0a53a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Signal Transduction
104 rdf:type schema:DefinedTerm
105 N142abc84b3e64d10bd5ffd94972847bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Transfection
107 rdf:type schema:DefinedTerm
108 N160341e54b544921a8652d38d5156039 rdf:first sg:person.0632704464.18
109 rdf:rest N1bd3dc604cf343298d3b6e572b62d073
110 N1bd3dc604cf343298d3b6e572b62d073 rdf:first sg:person.01226411152.62
111 rdf:rest N86ab957fbb404282a8761aa213dfadf8
112 N340464fb39494bb386b1dfb5a62059b5 rdf:first Na5737fd71dd947e2a0a8cc5d1928a542
113 rdf:rest N98f46cd4a3c9461fb79fbdf12647e225
114 N35c83f2d1c99476683da4b764cdb1f2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Becaplermin
116 rdf:type schema:DefinedTerm
117 N3d73f816e626488bab6d8be6d15e64c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Neoplastic Stem Cells
119 rdf:type schema:DefinedTerm
120 N3dea0489c5034758a2ce7e9fc795f299 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Proto-Oncogene Proteins c-kit
122 rdf:type schema:DefinedTerm
123 N3f627ebe1a6e4747a698bd6a12b1e751 schema:issueNumber 8
124 rdf:type schema:PublicationIssue
125 N4a4cccfd1770428595e3117c4ebc4121 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Proto-Oncogene Proteins c-sis
127 rdf:type schema:DefinedTerm
128 N4bd0ed5eee234cfe98d98140124b1404 schema:affiliation https://www.grid.ac/institutes/grid.9613.d
129 schema:familyName Krämer
130 schema:givenName D
131 rdf:type schema:Person
132 N4c0edc79884f42678708915bafa5bffa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Recombinant Fusion Proteins
134 rdf:type schema:DefinedTerm
135 N4c761457488f4333910026d4581f10be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Interleukin-3
137 rdf:type schema:DefinedTerm
138 N5725d7f8de744111bf806c98495f6536 rdf:first sg:person.01274332331.30
139 rdf:rest rdf:nil
140 N5d154cec047240db8b0f5a8810f47b0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Antineoplastic Agents
142 rdf:type schema:DefinedTerm
143 N5ec81e5db30b4cde8567b1a34e15c189 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Animals
145 rdf:type schema:DefinedTerm
146 N611149703d8b4c428b65aee763767652 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Receptor, Macrophage Colony-Stimulating Factor
148 rdf:type schema:DefinedTerm
149 N626aa40218514cc49acc59b6a1e01e2d rdf:first sg:person.0631072417.60
150 rdf:rest Na73861262780424a9f8bb39bacc36ddf
151 N65054c376c2b4f16a5f0dd1bb33f4347 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Indoles
153 rdf:type schema:DefinedTerm
154 N67b25a0a9c17482f886242259d1efbe5 schema:name nlm_unique_id
155 schema:value 8704895
156 rdf:type schema:PropertyValue
157 N694ab27a9d024f5f82c1c91125ed6035 rdf:first sg:person.01342335064.96
158 rdf:rest N5725d7f8de744111bf806c98495f6536
159 N6c91acbf95e84663b8f0e86ad596b278 schema:name pubmed_id
160 schema:value 12145694
161 rdf:type schema:PropertyValue
162 N702f91ab15b54b988b2ddeb24a4f2690 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Cell Line, Transformed
164 rdf:type schema:DefinedTerm
165 N717086091e6143dd9ea4a1167858c47f schema:name Springer Nature - SN SciGraph project
166 rdf:type schema:Organization
167 N7c69904a4c4e4d159dd23bed74a51e90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name fms-Like Tyrosine Kinase 3
169 rdf:type schema:DefinedTerm
170 N860951c345494aa6abe830c68003f1be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Drug Screening Assays, Antitumor
172 rdf:type schema:DefinedTerm
173 N86ab957fbb404282a8761aa213dfadf8 rdf:first sg:person.0775542131.70
174 rdf:rest N340464fb39494bb386b1dfb5a62059b5
175 N98f46cd4a3c9461fb79fbdf12647e225 rdf:first sg:person.0616434555.39
176 rdf:rest N9cfdd9d7aea045eab8439d9544ec3b61
177 N9b27e1a68ba44a7696d0d8ea3b1142c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Protein Processing, Post-Translational
179 rdf:type schema:DefinedTerm
180 N9cfdd9d7aea045eab8439d9544ec3b61 rdf:first sg:person.01326152273.18
181 rdf:rest Nf0519e18ee5b443ca6469466bfe2ab7d
182 Na5737fd71dd947e2a0a8cc5d1928a542 schema:affiliation https://www.grid.ac/institutes/grid.420017.0
183 schema:familyName Wallrapp
184 schema:givenName C
185 rdf:type schema:Person
186 Na73861262780424a9f8bb39bacc36ddf rdf:first N4bd0ed5eee234cfe98d98140124b1404
187 rdf:rest Nbeaec7ec4a194562acf349c37022ad03
188 Na8060720c37e4a96a49b0319a311d3e3 schema:volumeNumber 16
189 rdf:type schema:PublicationVolume
190 Nb15e9dcbaa4947fa83b154059d006460 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Phosphorylation
192 rdf:type schema:DefinedTerm
193 Nb2af2fc4e9f1472bb45d24b9b3f125fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Protein-Serine-Threonine Kinases
195 rdf:type schema:DefinedTerm
196 Nb6d864edf7454161bbf90caf0f2bf70f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Receptor Protein-Tyrosine Kinases
198 rdf:type schema:DefinedTerm
199 Nb96f1f994a6d47aaba421ee6f239f8a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Platelet-Derived Growth Factor
201 rdf:type schema:DefinedTerm
202 Nbeaec7ec4a194562acf349c37022ad03 rdf:first sg:person.0615707017.48
203 rdf:rest N160341e54b544921a8652d38d5156039
204 Nc87169a2942441a1b378c7a9c3a23621 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Receptor, Platelet-Derived Growth Factor beta
206 rdf:type schema:DefinedTerm
207 Ncc6ca1a8d18c47fc91f01e910f12de09 schema:name dimensions_id
208 schema:value pub.1038221442
209 rdf:type schema:PropertyValue
210 Nd2d0181c42da4eb6814b1441c8b8bfb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Hematopoietic Stem Cells
212 rdf:type schema:DefinedTerm
213 Nd44fe1267bf642c7b35113532d4c2fe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Enzyme Inhibitors
215 rdf:type schema:DefinedTerm
216 Ne681178d5046446dbacaa35c70d5f6fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Oncogene Proteins, Fusion
218 rdf:type schema:DefinedTerm
219 Nec46914c63da4956ad8018f4bf4921f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Mice
221 rdf:type schema:DefinedTerm
222 Nf0519e18ee5b443ca6469466bfe2ab7d rdf:first sg:person.01331061752.54
223 rdf:rest N694ab27a9d024f5f82c1c91125ed6035
224 Nf3a765b861514bffae699b0f64302462 schema:name readcube_id
225 schema:value b6133458474867c5f6ca4e64639b03a27d7ea624e227a49de6dbf087db6eb386
226 rdf:type schema:PropertyValue
227 Nf508005db3d04932add2b58bed805e89 schema:name doi
228 schema:value 10.1038/sj.leu.2402630
229 rdf:type schema:PropertyValue
230 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
231 schema:name Medical and Health Sciences
232 rdf:type schema:DefinedTerm
233 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
234 schema:name Oncology and Carcinogenesis
235 rdf:type schema:DefinedTerm
236 sg:grant.2435664 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.leu.2402630
237 rdf:type schema:MonetaryGrant
238 sg:journal.1097065 schema:issn 0887-6924
239 1476-5551
240 schema:name Leukemia
241 rdf:type schema:Periodical
242 sg:person.01226411152.62 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
243 schema:familyName Small
244 schema:givenName D
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226411152.62
246 rdf:type schema:Person
247 sg:person.01274332331.30 schema:affiliation https://www.grid.ac/institutes/grid.9613.d
248 schema:familyName Böhmer
249 schema:givenName F-D
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274332331.30
251 rdf:type schema:Person
252 sg:person.01326152273.18 schema:affiliation https://www.grid.ac/institutes/grid.5949.1
253 schema:familyName Kratz-Albers
254 schema:givenName K
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326152273.18
256 rdf:type schema:Person
257 sg:person.01331061752.54 schema:affiliation https://www.grid.ac/institutes/grid.5949.1
258 schema:familyName Schwäble
259 schema:givenName J
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331061752.54
261 rdf:type schema:Person
262 sg:person.01342335064.96 schema:affiliation https://www.grid.ac/institutes/grid.5949.1
263 schema:familyName Serve
264 schema:givenName H
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342335064.96
266 rdf:type schema:Person
267 sg:person.0615707017.48 schema:affiliation https://www.grid.ac/institutes/grid.9613.d
268 schema:familyName Böhmer
269 schema:givenName S-A
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615707017.48
271 rdf:type schema:Person
272 sg:person.0616434555.39 schema:affiliation https://www.grid.ac/institutes/grid.420017.0
273 schema:familyName Beckers
274 schema:givenName T
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616434555.39
276 rdf:type schema:Person
277 sg:person.0631072417.60 schema:affiliation https://www.grid.ac/institutes/grid.9613.d
278 schema:familyName Teller
279 schema:givenName S
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631072417.60
281 rdf:type schema:Person
282 sg:person.0632704464.18 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
283 schema:familyName Tse
284 schema:givenName KF
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632704464.18
286 rdf:type schema:Person
287 sg:person.0775542131.70 schema:affiliation https://www.grid.ac/institutes/grid.7727.5
288 schema:familyName Mahboobi
289 schema:givenName S
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775542131.70
291 rdf:type schema:Person
292 sg:pub.10.1038/35077225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037528958
293 https://doi.org/10.1038/35077225
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/368643a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012820743
296 https://doi.org/10.1038/368643a0
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/sj.leu.2400770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031254959
299 https://doi.org/10.1038/sj.leu.2400770
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/sj.leu.2401130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002471707
302 https://doi.org/10.1038/sj.leu.2401130
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/sj.leu.2401241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042964573
305 https://doi.org/10.1038/sj.leu.2401241
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/sj.leu.2401680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023193897
308 https://doi.org/10.1038/sj.leu.2401680
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/sj.leu.2401905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048114071
311 https://doi.org/10.1038/sj.leu.2401905
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/sj.leu.2402199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024534677
314 https://doi.org/10.1038/sj.leu.2402199
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/sj.onc.1203354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004579728
317 https://doi.org/10.1038/sj.onc.1203354
318 rdf:type schema:CreativeWork
319 https://app.dimensions.ai/details/publication/pub.1074699260 schema:CreativeWork
320 https://app.dimensions.ai/details/publication/pub.1074731723 schema:CreativeWork
321 https://app.dimensions.ai/details/publication/pub.1076033780 schema:CreativeWork
322 https://app.dimensions.ai/details/publication/pub.1082390833 schema:CreativeWork
323 https://app.dimensions.ai/details/publication/pub.1082406598 schema:CreativeWork
324 https://app.dimensions.ai/details/publication/pub.1082422064 schema:CreativeWork
325 https://app.dimensions.ai/details/publication/pub.1082446965 schema:CreativeWork
326 https://app.dimensions.ai/details/publication/pub.1082472499 schema:CreativeWork
327 https://app.dimensions.ai/details/publication/pub.1082581510 schema:CreativeWork
328 https://app.dimensions.ai/details/publication/pub.1082852522 schema:CreativeWork
329 https://app.dimensions.ai/details/publication/pub.1082879377 schema:CreativeWork
330 https://app.dimensions.ai/details/publication/pub.1082888284 schema:CreativeWork
331 https://app.dimensions.ai/details/publication/pub.1082990699 schema:CreativeWork
332 https://app.dimensions.ai/details/publication/pub.1083009621 schema:CreativeWork
333 https://app.dimensions.ai/details/publication/pub.1083207387 schema:CreativeWork
334 https://app.dimensions.ai/details/publication/pub.1083314031 schema:CreativeWork
335 https://doi.org/10.1002/jlb.65.3.372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074265597
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1006/bbrc.1998.9959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050764414
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/0092-8674(94)90322-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013805670
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/0145-2126(90)90143-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1022987061
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/0378-1119(95)00809-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029495822
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/1074-7613(95)90167-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038314822
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/s0092-8674(00)81683-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031899717
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1021/bi962553l schema:sameAs https://app.dimensions.ai/details/publication/pub.1055213061
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1021/jm010988n schema:sameAs https://app.dimensions.ai/details/publication/pub.1055946921
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1021/jm950727b schema:sameAs https://app.dimensions.ai/details/publication/pub.1055957282
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1046/j.1365-2141.2000.01831.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021586389
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1111/j.1365-2141.1999.01284.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010830812
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1182/blood.v97.8.2434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014730117
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1182/blood.v98.3.885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019011103
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1634/theoncologist.6-3-233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031236088
364 rdf:type schema:CreativeWork
365 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
366 schema:name Johns Hopkins University, School of Medicine, Pediatric Oncology, Baltimore, MD, USA
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.420017.0 schema:alternateName Evonik (Germany)
369 schema:name ASTA Medica AG, Frankfurt/Main, Germany
370 Current address: Byk Gulden GmbH, Disease Area Oncology, Konstanz, Germany
371 rdf:type schema:Organization
372 https://www.grid.ac/institutes/grid.5949.1 schema:alternateName University of Münster
373 schema:name Department of Medicine/Hematology and Oncology, University of Münster, Germany
374 rdf:type schema:Organization
375 https://www.grid.ac/institutes/grid.7727.5 schema:alternateName University of Regensburg
376 schema:name Faculty of Chemistry and Pharmacy, Institute of Pharmacy, University of Regensburg, Regensburg, Germany
377 rdf:type schema:Organization
378 https://www.grid.ac/institutes/grid.9613.d schema:alternateName Friedrich Schiller University Jena
379 schema:name Research Unit Molecular Cell Biology, Medical Faculty, Friedrich Schiller University, Jena, Germany
380 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...