Chromosomal changes pattern and gene amplification in T cell non-Hodgkin's lymphomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-10-01

AUTHORS

M Renedo, B Martinez-Delgado, E Arranz, MJ Garcia, M Urioste, A Martinez-Ramirez, C Rivas, JC Cigudosa, J Benitez

ABSTRACT

T cell non-Hodgkin's lymphomas are a heterogeneous group of lymphomas with poor prognosis, and whose genetic alterations are not well understood. Comparative genomic hybridization (CGH) is a technique that allows the identification of DNA imbalances without cytogenetic studies. We have studied 37 samples from 29 T cell non-Hodgkin's lymphomas (25 peripheral and four lymphoblastic lymphomas) by CGH in order to detect DNA sequence copy number changes of putative importance in the biology and prognosis of these neoplasms. We detected abnormal CGH profiles in 16/27 (59%) of samples at diagnosis, a ratio that increased to 66% (23/37) when we included the relapsed samples. The most common recurrent changes were gains related to the X chromosome, either the whole chromosome or partially the Xq26–27 bands (19%). Other recurrent changes included gains of bands 9q34, gains of chromosomes 17, 19, and 20, and complete or partial deletions of chromosome 13 (10%). Cancer-related genes located at Xq26–28 region were analyzed by Southern blot and fluorescence in situ hybridization (FISH). Low level amplification of some of these genes was detected by this technique confirming the results obtained by CGH in this region. The detection of abnormal CGH profiles in these T cell lymphomas could have clinical implications. Patients with abnormal CGH profiles showed significant associations with advanced stage of disease, overexpression of P53, and higher proliferative index. More... »

PAGES

1627-1632

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2402248

DOI

http://dx.doi.org/10.1038/sj.leu.2402248

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043483902

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11587222


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Southern", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Aberrations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Amplification", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunophenotyping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, Non-Hodgkin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, T-Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleic Acid Hybridization", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "GEMOLAB, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "GEMOLAB, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Renedo", 
        "givenName": "M", 
        "id": "sg:person.0632740613.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632740613.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martinez-Delgado", 
        "givenName": "B", 
        "id": "sg:person.0724321734.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724321734.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GEMOLAB, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain", 
            "GEMOLAB, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arranz", 
        "givenName": "E", 
        "id": "sg:person.01026013760.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026013760.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Fundaci\u00f3n Jimenez D\u00edaz, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.419651.e", 
          "name": [
            "Department of Pathology, Fundaci\u00f3n Jimenez D\u00edaz, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garcia", 
        "givenName": "MJ", 
        "id": "sg:person.0776425360.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776425360.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Urioste", 
        "givenName": "M", 
        "id": "sg:person.0765665046.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765665046.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martinez-Ramirez", 
        "givenName": "A", 
        "id": "sg:person.01172261222.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172261222.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Fundaci\u00f3n Jimenez D\u00edaz, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.419651.e", 
          "name": [
            "Department of Pathology, Fundaci\u00f3n Jimenez D\u00edaz, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rivas", 
        "givenName": "C", 
        "id": "sg:person.01340511536.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340511536.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cigudosa", 
        "givenName": "JC", 
        "id": "sg:person.01246512175.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246512175.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benitez", 
        "givenName": "J", 
        "id": "sg:person.01333446703.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333446703.24"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.leu.2400635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015657269", 
          "https://doi.org/10.1038/sj.leu.2400635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050371000", 
          "https://doi.org/10.1038/sj.leu.2401784"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-10-01", 
    "datePublishedReg": "2001-10-01", 
    "description": "T cell non-Hodgkin's lymphomas are a heterogeneous group of lymphomas with poor prognosis, and whose genetic alterations are not well understood. Comparative genomic hybridization (CGH) is a technique that allows the identification of DNA imbalances without cytogenetic studies. We have studied 37 samples from 29 T cell non-Hodgkin's lymphomas (25 peripheral and four lymphoblastic lymphomas) by CGH in order to detect DNA sequence copy number changes of putative importance in the biology and prognosis of these neoplasms. We detected abnormal CGH profiles in 16/27 (59%) of samples at diagnosis, a ratio that increased to 66% (23/37) when we included the relapsed samples. The most common recurrent changes were gains related to the X chromosome, either the whole chromosome or partially the Xq26\u201327 bands (19%). Other recurrent changes included gains of bands 9q34, gains of chromosomes 17, 19, and 20, and complete or partial deletions of chromosome 13 (10%). Cancer-related genes located at Xq26\u201328 region were analyzed by Southern blot and fluorescence in situ hybridization (FISH). Low level amplification of some of these genes was detected by this technique confirming the results obtained by CGH in this region. The detection of abnormal CGH profiles in these T cell lymphomas could have clinical implications. Patients with abnormal CGH profiles showed significant associations with advanced stage of disease, overexpression of P53, and higher proliferative index.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.leu.2402248", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "keywords": [
      "abnormal CGH profiles", 
      "comparative genomic hybridization", 
      "CGH profiles", 
      "DNA sequence copy number changes", 
      "copy number changes", 
      "cancer-related genes", 
      "whole chromosomes", 
      "X chromosome", 
      "recurrent changes", 
      "DNA imbalances", 
      "Hodgkin's lymphoma", 
      "Southern blot", 
      "T cells", 
      "putative importance", 
      "chromosome 17", 
      "chromosome 13", 
      "genomic hybridization", 
      "number changes", 
      "genetic alterations", 
      "situ hybridization", 
      "low-level amplification", 
      "chromosomes", 
      "gene amplification", 
      "genes", 
      "partial deletion", 
      "band 9q34", 
      "T-cell lymphoma", 
      "cytogenetic studies", 
      "high proliferative index", 
      "hybridization", 
      "overexpression of p53", 
      "cells", 
      "poor prognosis", 
      "relapsed samples", 
      "cell lymphoma", 
      "proliferative index", 
      "lymphoma", 
      "advanced stage", 
      "clinical implications", 
      "significant association", 
      "biology", 
      "heterogeneous group", 
      "amplification", 
      "overexpression", 
      "deletion", 
      "prognosis", 
      "p53", 
      "blot", 
      "region", 
      "fluorescence", 
      "identification", 
      "alterations", 
      "patients", 
      "neoplasms", 
      "changes", 
      "profile", 
      "disease", 
      "diagnosis", 
      "patterns", 
      "association", 
      "stage", 
      "group", 
      "samples", 
      "importance", 
      "imbalance", 
      "index", 
      "gain", 
      "change patterns", 
      "study", 
      "implications", 
      "results", 
      "detection", 
      "ratio", 
      "technique", 
      "band", 
      "order"
    ], 
    "name": "Chromosomal changes pattern and gene amplification in T cell non-Hodgkin's lymphomas", 
    "pagination": "1627-1632", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043483902"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.leu.2402248"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11587222"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.leu.2402248", 
      "https://app.dimensions.ai/details/publication/pub.1043483902"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T09:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_319.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.leu.2402248"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2402248'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2402248'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2402248'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2402248'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      22 PREDICATES      116 URIs      106 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.leu.2402248 schema:about N1267bb7a5a384d51a93a5159fb2a6229
2 N31270ef965414e4c939bb176e12e1ac2
3 N47d1b807b8324c6d8b3c5025fe4fc5fe
4 N4a13584ab7834a4bb0db0b79d3dc7c7c
5 N4f8063644a314b68a247d1befa1a1826
6 N68a7c738e305445d931da826807590d4
7 N7823b3f8c56f4c579053d37be3a7da6b
8 N7ecb6db1b4c044ad9da8ca86de2b88ee
9 N8f78d7b703734c0daa5e4a07944b187e
10 Nc95bc0a001eb40269b2f949e89977cd2
11 Nd28bf766e9694f1dba29ec9034261180
12 Nee0038145edd495391866e21b20b2e19
13 anzsrc-for:11
14 anzsrc-for:1112
15 schema:author N26d208ad165043a7b89781a8f9d91e62
16 schema:citation sg:pub.10.1038/sj.leu.2400635
17 sg:pub.10.1038/sj.leu.2401784
18 schema:datePublished 2001-10-01
19 schema:datePublishedReg 2001-10-01
20 schema:description T cell non-Hodgkin's lymphomas are a heterogeneous group of lymphomas with poor prognosis, and whose genetic alterations are not well understood. Comparative genomic hybridization (CGH) is a technique that allows the identification of DNA imbalances without cytogenetic studies. We have studied 37 samples from 29 T cell non-Hodgkin's lymphomas (25 peripheral and four lymphoblastic lymphomas) by CGH in order to detect DNA sequence copy number changes of putative importance in the biology and prognosis of these neoplasms. We detected abnormal CGH profiles in 16/27 (59%) of samples at diagnosis, a ratio that increased to 66% (23/37) when we included the relapsed samples. The most common recurrent changes were gains related to the X chromosome, either the whole chromosome or partially the Xq26–27 bands (19%). Other recurrent changes included gains of bands 9q34, gains of chromosomes 17, 19, and 20, and complete or partial deletions of chromosome 13 (10%). Cancer-related genes located at Xq26–28 region were analyzed by Southern blot and fluorescence in situ hybridization (FISH). Low level amplification of some of these genes was detected by this technique confirming the results obtained by CGH in this region. The detection of abnormal CGH profiles in these T cell lymphomas could have clinical implications. Patients with abnormal CGH profiles showed significant associations with advanced stage of disease, overexpression of P53, and higher proliferative index.
21 schema:genre article
22 schema:inLanguage en
23 schema:isAccessibleForFree true
24 schema:isPartOf N3abad4cb3686400ebc1ceb94f19f1b34
25 N42635a0a59a94880ac4d8fd229097b01
26 sg:journal.1097065
27 schema:keywords CGH profiles
28 DNA imbalances
29 DNA sequence copy number changes
30 Hodgkin's lymphoma
31 Southern blot
32 T cells
33 T-cell lymphoma
34 X chromosome
35 abnormal CGH profiles
36 advanced stage
37 alterations
38 amplification
39 association
40 band
41 band 9q34
42 biology
43 blot
44 cancer-related genes
45 cell lymphoma
46 cells
47 change patterns
48 changes
49 chromosome 13
50 chromosome 17
51 chromosomes
52 clinical implications
53 comparative genomic hybridization
54 copy number changes
55 cytogenetic studies
56 deletion
57 detection
58 diagnosis
59 disease
60 fluorescence
61 gain
62 gene amplification
63 genes
64 genetic alterations
65 genomic hybridization
66 group
67 heterogeneous group
68 high proliferative index
69 hybridization
70 identification
71 imbalance
72 implications
73 importance
74 index
75 low-level amplification
76 lymphoma
77 neoplasms
78 number changes
79 order
80 overexpression
81 overexpression of p53
82 p53
83 partial deletion
84 patients
85 patterns
86 poor prognosis
87 profile
88 prognosis
89 proliferative index
90 putative importance
91 ratio
92 recurrent changes
93 region
94 relapsed samples
95 results
96 samples
97 significant association
98 situ hybridization
99 stage
100 study
101 technique
102 whole chromosomes
103 schema:name Chromosomal changes pattern and gene amplification in T cell non-Hodgkin's lymphomas
104 schema:pagination 1627-1632
105 schema:productId N7a97d5f4744f454c9656fc0cfca29791
106 N98ff1b95ad94418b8b61e88a72410b1e
107 Nc99f595e81124710931c703e29a4848f
108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043483902
109 https://doi.org/10.1038/sj.leu.2402248
110 schema:sdDatePublished 2022-05-10T09:48
111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
112 schema:sdPublisher Nea01a3b8712442b88558a8919930e353
113 schema:url https://doi.org/10.1038/sj.leu.2402248
114 sgo:license sg:explorer/license/
115 sgo:sdDataset articles
116 rdf:type schema:ScholarlyArticle
117 N08d6d98fb43d4dec8355d2bb7e3b6000 rdf:first sg:person.01340511536.71
118 rdf:rest N47c2241f2928483881f44a6a3c2ddd04
119 N0f697f128eac440ab4034a23b4d794ba rdf:first sg:person.0724321734.42
120 rdf:rest Nfcddd584cacc4fcf8c6254773a278c06
121 N1267bb7a5a384d51a93a5159fb2a6229 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Lymphoma, T-Cell
123 rdf:type schema:DefinedTerm
124 N26d208ad165043a7b89781a8f9d91e62 rdf:first sg:person.0632740613.65
125 rdf:rest N0f697f128eac440ab4034a23b4d794ba
126 N30bcf13d3b294a93aef43cb21457322f rdf:first sg:person.0776425360.92
127 rdf:rest N9e09bf71ee574670af13fb3fcd59695a
128 N31270ef965414e4c939bb176e12e1ac2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Blotting, Southern
130 rdf:type schema:DefinedTerm
131 N3abad4cb3686400ebc1ceb94f19f1b34 schema:issueNumber 10
132 rdf:type schema:PublicationIssue
133 N42635a0a59a94880ac4d8fd229097b01 schema:volumeNumber 15
134 rdf:type schema:PublicationVolume
135 N47c2241f2928483881f44a6a3c2ddd04 rdf:first sg:person.01246512175.01
136 rdf:rest Nfbd8a93d15864ca19e950ba208107e0b
137 N47d1b807b8324c6d8b3c5025fe4fc5fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Male
139 rdf:type schema:DefinedTerm
140 N4a13584ab7834a4bb0db0b79d3dc7c7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Nucleic Acid Hybridization
142 rdf:type schema:DefinedTerm
143 N4f8063644a314b68a247d1befa1a1826 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Gene Amplification
145 rdf:type schema:DefinedTerm
146 N68a7c738e305445d931da826807590d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Immunophenotyping
148 rdf:type schema:DefinedTerm
149 N7823b3f8c56f4c579053d37be3a7da6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Chromosome Aberrations
151 rdf:type schema:DefinedTerm
152 N7a97d5f4744f454c9656fc0cfca29791 schema:name pubmed_id
153 schema:value 11587222
154 rdf:type schema:PropertyValue
155 N7ecb6db1b4c044ad9da8ca86de2b88ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Female
157 rdf:type schema:DefinedTerm
158 N8f78d7b703734c0daa5e4a07944b187e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Chromosome Disorders
160 rdf:type schema:DefinedTerm
161 N98ff1b95ad94418b8b61e88a72410b1e schema:name dimensions_id
162 schema:value pub.1043483902
163 rdf:type schema:PropertyValue
164 N9e09bf71ee574670af13fb3fcd59695a rdf:first sg:person.0765665046.58
165 rdf:rest Nfe330595cdd848dd910546b5914b9f5b
166 Nc95bc0a001eb40269b2f949e89977cd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Humans
168 rdf:type schema:DefinedTerm
169 Nc99f595e81124710931c703e29a4848f schema:name doi
170 schema:value 10.1038/sj.leu.2402248
171 rdf:type schema:PropertyValue
172 Nd28bf766e9694f1dba29ec9034261180 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Lymphoma, Non-Hodgkin
174 rdf:type schema:DefinedTerm
175 Nea01a3b8712442b88558a8919930e353 schema:name Springer Nature - SN SciGraph project
176 rdf:type schema:Organization
177 Nee0038145edd495391866e21b20b2e19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name In Situ Hybridization, Fluorescence
179 rdf:type schema:DefinedTerm
180 Nfbd8a93d15864ca19e950ba208107e0b rdf:first sg:person.01333446703.24
181 rdf:rest rdf:nil
182 Nfcddd584cacc4fcf8c6254773a278c06 rdf:first sg:person.01026013760.89
183 rdf:rest N30bcf13d3b294a93aef43cb21457322f
184 Nfe330595cdd848dd910546b5914b9f5b rdf:first sg:person.01172261222.44
185 rdf:rest N08d6d98fb43d4dec8355d2bb7e3b6000
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
190 schema:name Oncology and Carcinogenesis
191 rdf:type schema:DefinedTerm
192 sg:journal.1097065 schema:issn 0887-6924
193 1476-5551
194 schema:name Leukemia
195 schema:publisher Springer Nature
196 rdf:type schema:Periodical
197 sg:person.01026013760.89 schema:affiliation grid-institutes:None
198 schema:familyName Arranz
199 schema:givenName E
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026013760.89
201 rdf:type schema:Person
202 sg:person.01172261222.44 schema:affiliation grid-institutes:grid.7719.8
203 schema:familyName Martinez-Ramirez
204 schema:givenName A
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172261222.44
206 rdf:type schema:Person
207 sg:person.01246512175.01 schema:affiliation grid-institutes:grid.7719.8
208 schema:familyName Cigudosa
209 schema:givenName JC
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246512175.01
211 rdf:type schema:Person
212 sg:person.01333446703.24 schema:affiliation grid-institutes:grid.7719.8
213 schema:familyName Benitez
214 schema:givenName J
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333446703.24
216 rdf:type schema:Person
217 sg:person.01340511536.71 schema:affiliation grid-institutes:grid.419651.e
218 schema:familyName Rivas
219 schema:givenName C
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340511536.71
221 rdf:type schema:Person
222 sg:person.0632740613.65 schema:affiliation grid-institutes:None
223 schema:familyName Renedo
224 schema:givenName M
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632740613.65
226 rdf:type schema:Person
227 sg:person.0724321734.42 schema:affiliation grid-institutes:grid.7719.8
228 schema:familyName Martinez-Delgado
229 schema:givenName B
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724321734.42
231 rdf:type schema:Person
232 sg:person.0765665046.58 schema:affiliation grid-institutes:grid.7719.8
233 schema:familyName Urioste
234 schema:givenName M
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765665046.58
236 rdf:type schema:Person
237 sg:person.0776425360.92 schema:affiliation grid-institutes:grid.419651.e
238 schema:familyName Garcia
239 schema:givenName MJ
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776425360.92
241 rdf:type schema:Person
242 sg:pub.10.1038/sj.leu.2400635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015657269
243 https://doi.org/10.1038/sj.leu.2400635
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/sj.leu.2401784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050371000
246 https://doi.org/10.1038/sj.leu.2401784
247 rdf:type schema:CreativeWork
248 grid-institutes:None schema:alternateName GEMOLAB, Madrid, Spain
249 schema:name Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
250 GEMOLAB, Madrid, Spain
251 rdf:type schema:Organization
252 grid-institutes:grid.419651.e schema:alternateName Department of Pathology, Fundación Jimenez Díaz, Madrid, Spain
253 schema:name Department of Pathology, Fundación Jimenez Díaz, Madrid, Spain
254 rdf:type schema:Organization
255 grid-institutes:grid.7719.8 schema:alternateName Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
256 schema:name Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...