Ontology type: schema:ScholarlyArticle Open Access: True
2000-10
AUTHORS ABSTRACTAberrant expression of FLT3 has been found in most cases of B-lineage ALL and AML, and subsets of T cell ALL, CML in blast crisis and CLL. In 20% of patients with AML the receptor has small internal tandem duplications of the juxtamembrane region which appear to contitutively activate the receptor. To investigate whether FLT3 activation could play a role in leukemia, we generated a constitutively activated FLT3 by fusing its cytoplasmic domain to the helix-loop-helix domain of TEL in analogy to the fusion that occurs with TEL-PDGFR in CMML. In vitro translation assays demonstrated oligomerization and intrinsic tyrosine kinase activity of the TEL-FLT3 chimeric receptor. Constitutively activated TEL-FLT3 conferred IL-3 independence and long-term proliferation to transfected Ba/F3 cells. Immunoblot analyses showed that JAK 2, STAT 3, STAT 5a, STAT 5b and CBL were tyrosine-phosphorylated in TEL-FLT3 expressing Ba/F3 cells in the absence of IL-3. These data suggest a possible role for the JAK/STAT pathway in FLT3 signaling. Transplantation of TEL-FLT3 expressing Ba/F3 cells into syngeneic mice caused mortality in all mice by 3 weeks after injection. Histopathologic analysis demonstrated a massive infiltration of mononuclear cells in the liver, spleen and bone marrow. The mimicking of naturally occurring TEL fusions provides an approach to assess aspects of the biology of activated FLT3, or other receptor-type tyrosine kinases (RTKs) in leukemic transformation. More... »
PAGES2401905
http://scigraph.springernature.com/pub.10.1038/sj.leu.2401905
DOIhttp://dx.doi.org/10.1038/sj.leu.2401905
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1048114071
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/11021752
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Base Sequence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Transformation, Neoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA Primers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred BALB C",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oncogene Proteins, Fusion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphorylation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptor Protein-Tyrosine Kinases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Cell Surface",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Recombinant Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Signal Transduction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tyrosine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "fms-Like Tyrosine Kinase 3",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Oncology, John Hopkins University School of Medicine, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Tse",
"givenName": "K-F",
"id": "sg:person.0632704464.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632704464.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Comparative Medicine, John Hopkins University School of Medicine, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Mukherjee",
"givenName": "G",
"id": "sg:person.01164524540.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164524540.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Oncology, John Hopkins University School of Medicine, Baltimore, MD, USA",
"Department of Pediatrics, John Hopkins University School of Medicine, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Small",
"givenName": "D",
"id": "sg:person.01226411152.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226411152.62"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/978-3-642-85232-9_28",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000318360",
"https://doi.org/10.1007/978-3-642-85232-9_28"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.271.1.17",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001304360"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1749-6632.1995.tb32334.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001858298"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2401130",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002471707",
"https://doi.org/10.1038/sj.leu.2401130"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2401130",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002471707",
"https://doi.org/10.1038/sj.leu.2401130"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.271.31.18350",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003949323"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203354",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004579728",
"https://doi.org/10.1038/sj.onc.1203354"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203354",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004579728",
"https://doi.org/10.1038/sj.onc.1203354"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.iy.10.040192.001455",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007506132"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0955-0674(94)90048-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008776182"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2401635",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010107490",
"https://doi.org/10.1038/sj.leu.2401635"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2401635",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010107490",
"https://doi.org/10.1038/sj.leu.2401635"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.cb.10.110194.001343",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010574332"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2141.1999.01284.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010830812"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/stem.140605",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011968834"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/stem.140605",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011968834"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/emboj/16.1.69",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012138154"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/368643a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012820743",
"https://doi.org/10.1038/368643a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(94)90322-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013805670"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(95)90404-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018000345"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)81469-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021258028"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj3270073",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021388482"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj3270073",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021388482"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0145-2126(90)90143-w",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022987061"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2401680",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023193897",
"https://doi.org/10.1038/sj.leu.2401680"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2401680",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023193897",
"https://doi.org/10.1038/sj.leu.2401680"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2400812",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025757807",
"https://doi.org/10.1038/sj.leu.2400812"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2400812",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025757807",
"https://doi.org/10.1038/sj.leu.2400812"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.91.2.459",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028051421"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.86.4.1168",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030033961"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.16.8.4107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030726927"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2400770",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031254959",
"https://doi.org/10.1038/sj.leu.2400770"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2400770",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031254959",
"https://doi.org/10.1038/sj.leu.2400770"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.270.37.21468",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032466644"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2400921",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033772731",
"https://doi.org/10.1038/sj.leu.2400921"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2400921",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033772731",
"https://doi.org/10.1038/sj.leu.2400921"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.13.10.6572",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034612821"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/1074-7613(95)90167-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038314822"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.270.32.19141",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040476221"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.16.1.45",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041093139"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1202694",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042573737",
"https://doi.org/10.1038/sj.onc.1202694"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1202694",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042573737",
"https://doi.org/10.1038/sj.onc.1202694"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2401241",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042964573",
"https://doi.org/10.1038/sj.leu.2401241"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2401241",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042964573",
"https://doi.org/10.1038/sj.leu.2401241"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.273.24.14962",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043986984"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.93.25.14845",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044181811"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.270.18.10800",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044905366"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.bi.57.070188.002303",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047193680"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/bbrc.1998.9959",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050764414"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.278.5341.1309",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062558683"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.286.5438.309",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062566889"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.3291115",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062604905"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.8140422",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062652919"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.8197455",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062653086"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jlb.65.3.372",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074265597"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074561775",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076033780",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076061311",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078485622",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079170576",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082390833",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082406598",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082422064",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082441684",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082446965",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082472499",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082515583",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082565360",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082643382",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082690816",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082852522",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082860419",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082879377",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082886873",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082888284",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082888287",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082900503",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082990699",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082997653",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083009621",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083033868",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083081327",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083081849",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083111422",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083157825",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083207387",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083222339",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083314031",
"type": "CreativeWork"
}
],
"datePublished": "2000-10",
"datePublishedReg": "2000-10-01",
"description": "Aberrant expression of FLT3 has been found in most cases of B-lineage ALL and AML, and subsets of T cell ALL, CML in blast crisis and CLL. In 20% of patients with AML the receptor has small internal tandem duplications of the juxtamembrane region which appear to contitutively activate the receptor. To investigate whether FLT3 activation could play a role in leukemia, we generated a constitutively activated FLT3 by fusing its cytoplasmic domain to the helix-loop-helix domain of TEL in analogy to the fusion that occurs with TEL-PDGFR in CMML. In vitro translation assays demonstrated oligomerization and intrinsic tyrosine kinase activity of the TEL-FLT3 chimeric receptor. Constitutively activated TEL-FLT3 conferred IL-3 independence and long-term proliferation to transfected Ba/F3 cells. Immunoblot analyses showed that JAK 2, STAT 3, STAT 5a, STAT 5b and CBL were tyrosine-phosphorylated in TEL-FLT3 expressing Ba/F3 cells in the absence of IL-3. These data suggest a possible role for the JAK/STAT pathway in FLT3 signaling. Transplantation of TEL-FLT3 expressing Ba/F3 cells into syngeneic mice caused mortality in all mice by 3 weeks after injection. Histopathologic analysis demonstrated a massive infiltration of mononuclear cells in the liver, spleen and bone marrow. The mimicking of naturally occurring TEL fusions provides an approach to assess aspects of the biology of activated FLT3, or other receptor-type tyrosine kinases (RTKs) in leukemic transformation.",
"genre": "research_article",
"id": "sg:pub.10.1038/sj.leu.2401905",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2435664",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1097065",
"issn": [
"0887-6924",
"1476-5551"
],
"name": "Leukemia",
"type": "Periodical"
},
{
"issueNumber": "10",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "14"
}
],
"name": "Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation",
"pagination": "2401905",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"e534f9094feff9d9ffce27062dc1041c4977acfec1b8929eafb0f93bd98136fc"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"11021752"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8704895"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/sj.leu.2401905"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1048114071"
]
}
],
"sameAs": [
"https://doi.org/10.1038/sj.leu.2401905",
"https://app.dimensions.ai/details/publication/pub.1048114071"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:54",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29200_00000002.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/2401905"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2401905'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2401905'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2401905'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2401905'
This table displays all metadata directly associated to this object as RDF triples.
360 TRIPLES
21 PREDICATES
122 URIs
37 LITERALS
25 BLANK NODES