Concurrent disruption of p16INK4a and the ARF-p53 pathway predicts poor prognosis in aggressive non-Hodgkin's lymphoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-10

AUTHORS

K Grønbæk, P de Nully Brown, MB Møller, T Nedergaard, E Ralfkiaer, P Møller, J Zeuthen, P Guldberg

ABSTRACT

The INK4a/ARF locus at chromosome 9p21 encodes two structurally and functionally distinct molecules with tumor-suppressive properties. p16INK4a controls cell cycle progression by inhibiting phosphorylation of the retinoblastoma protein (Rb), while ARF prevents MDM2-mediated degradation of p53. By using a panel of PCR-based methods, we have examined the status of the p16INK4a, ARF and p53 genes in 123 cases of non-Hodgkin's lymphoma (NHL) at diagnosis. Alterations of one or more of these genes were detected in seven of 36 (19%) cases with low- to intermediate-grade histology, and in 35 of 87 (40%) cases with aggressive histology. For the aggressive lymphomas, the Kaplan-Meier estimate of overall survival for cases with disruption of either p16INK4a or the ARF-p53 pathway was not different from cases with retention of both pathways (5 year survival 45% vs 35%; P= 0.85), suggesting that selective inactivation of one of the pathways does not significantly influence overall survival. By contrast, the 5-year survival was only 7% for cases with concurrent disruption of p16INK4a and the ARF-p53 pathway vs 38% for cases with retention of one or both pathways (P = 0.005). Similar results were obtained when the analysis was confined to diffuse large B cell lymphomas (P= 0.019). On stepwise multivariate regression analysis including factors from the international prognostic index, concurrent disruption of p16INK4a and the ARF-p53 pathway was an independent negative prognostic factor in NHL with aggressive histology (P = 0.006). Our results suggest that the compound status of the p16INK4a and ARF-p53 pathways is a major determinant of outcome in NHL. More... »

PAGES

2401901

References to SciGraph publications

  • 1999-05. Nucleolar Arf sequesters Mdm2 and activates p53 in NATURE CELL BIOLOGY
  • 1993-12. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 in NATURE
  • 1998-09. p14ARF links the tumour suppressors RB and p53 in NATURE
  • 1994-09. Germline p16 mutations in familial melanoma in NATURE GENETICS
  • 1992-03. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours in NATURE
  • 1997-11. The human protein p19ARF is not detected in hemopoietic human cell lines that abundantly express the alternative β transcript of the p16INK4a/MTS1 gene in ONCOGENE
  • 1998-08. Concurrent disruption of cell cycle associated genes in mantle cell lymphoma: a genotypic and phenotypic study of cyclin D1, p16, p15, p53 and pRb in LEUKEMIA
  • 1997-11. Deletions and rearrangements of cyclin-dependent kinase 4 inhibitor gene p16 are associated with poor prognosis in B cell non-Hodgkin’s lymphomas in LEUKEMIA
  • 1993-12. p21 is a universal inhibitor of cyclin kinases in NATURE
  • 1999-03. Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma in LEUKEMIA
  • 1992. Regression Models and Life-Tables in BREAKTHROUGHS IN STATISTICS
  • 1998-02. Inactivations of p16INK4a-α, p16INK4a-β and p15INK4b genes in 2′, 3′-dideoxycytidine- and 1,3-butadiene-induced murine lymphomas in ONCOGENE
  • 1995-07. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.leu.2401901

    DOI

    http://dx.doi.org/10.1038/sj.leu.2401901

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035052121

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11021747


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