Role of MRP1 in multidrug resistance in acute myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-04-01

AUTHORS

O Legrand, R Zittoun, J-P Marie

ABSTRACT

The best characterized resistance mechanism in adult acute myeloid leukemia (AML) is the one mediated by the MDR1 gene which has been shown to be associated with poor outcome. However, alternative proteins such as the more recently recognized multidrug-associated protein (MRP1), may also contribute to the resistance to anthracyclines and etoposide in AML. Recently, the role of this protein was discussed and was unclear in AML. However, recent data concerning the functionality and the modulation of the activity of MRP1 may elucidate its role in comparison with other mechanisms of resistance. In this paper, we will review these recent data concerning the role of MRP1 in adult AML. More... »

PAGES

578-584

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2401361

DOI

http://dx.doi.org/10.1038/sj.leu.2401361

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023990582

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10214864


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