Immunophenotypic and immunogenotypic characteristics of TCRγδ+ T cell acute lymphoblastic leukemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-02-05

AUTHORS

AW Langerak, ILM Wolvers-Tettero, MWM van den Beemd, ER van Wering, W-D Ludwig, K Hählen, A Necker, JJM van Dongen

ABSTRACT

Thirty T cell receptor (TCR)γδ+ T cell acute lymphoblastic leukemias (T-ALL) were analyzed for their immunophenotype, as well as for the rearrangements and junctional regions of the TCRG and TCRD genes. In 15 cases membrane expression of TCRγδ proteins could be studied extensively by flow cytometry with a new Vγ/Vδ antibody panel. Virtually all TCRγδ+ T-ALLs expressed TdT, CD2, CD3, CD5, CD6, and CD7, but they were heterogeneous in their CD1/CD4/CD8 immunophenotype. The majority expressed either CD4+/CD8− or CD4+/CD8+, whereas only 7/30 TCRγδ+ T-ALLs lacked both antigens. Despite heterogeneity in the rearranged TCRG and TCRD genes, we found preferential protein expression of VγI (21/30), Jγ2.3 (19/30) and Cγ2 (21/30) gene products in the TCRγδ+ T-ALL. Expressed TCRD genes were largely limited to Vδ1-Jδ1, except for six patients who expressed non-Vδ1 TCRδ chains (Vδ2-Jδ1, Vδ2-Jδ3, Vδ3-Jδ1, Vδ6-Jδ2, and two Vα-Jδ1). In spite of the relatively limited combinatorial repertoire of the TCRG and TCRD genes, the junctional region diversity of the expressed genes was extensive. The Vγ/Vδ antibody panel confirmed the predominant, but not exclusive, expression of VγI and Vδ1 proteins. Importantly, not a single T-ALL expressed the common peripheral blood Vγ9+/Vδ2+ phenotype. These immunogenotypic and immunophenotypic characteristics represent excellent targets for flow cytometric and PCR-based detection of 'minimal residual disease' in all TCRγδ+ T-ALL. Comparison of non-Vδ1+ TCRγδ T-ALLs with the more common Vδ1+ type showed a trend towards a more mature immunogenotype in the former. Firstly, more complete TCRD rearrangements were identified on the non-expressed allele in the non-Vδ1+ group (83% vs 43%); secondly, a higher frequency of 'end-stage' Jγ2.3 gene rearrangements was found in non-Vδ1 cases on both TCRG alleles (83% vs 66%); thirdly, a higher frequency of complete TCRB rearrangements was found in non-Vδ1 cases (79% vs 50%). More... »

PAGES

206-214

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2401276

DOI

http://dx.doi.org/10.1038/sj.leu.2401276

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022578009

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10025894


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Rearrangement, T-Lymphocyte", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Heterogeneity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunogenetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunophenotyping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia-Lymphoma, Adult T-Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Antigen, T-Cell, gamma-delta", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Immunology, University Hospital Dijkzigt/Erasmus University Rotterdam, Rotterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.6906.9", 
          "name": [
            "Department of Immunology, University Hospital Dijkzigt/Erasmus University Rotterdam, Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Langerak", 
        "givenName": "AW", 
        "id": "sg:person.01014146375.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014146375.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, University Hospital Dijkzigt/Erasmus University Rotterdam, Rotterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.6906.9", 
          "name": [
            "Department of Immunology, University Hospital Dijkzigt/Erasmus University Rotterdam, Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolvers-Tettero", 
        "givenName": "ILM", 
        "id": "sg:person.015516437724.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015516437724.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, University Hospital Dijkzigt/Erasmus University Rotterdam, Rotterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.6906.9", 
          "name": [
            "Department of Immunology, University Hospital Dijkzigt/Erasmus University Rotterdam, Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van den Beemd", 
        "givenName": "MWM", 
        "id": "sg:person.01066263431.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066263431.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dutch Childhood Leukemia Study Group, The Hague, The Netherlands", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Dutch Childhood Leukemia Study Group, The Hague, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Wering", 
        "givenName": "ER", 
        "id": "sg:person.016161437457.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016161437457.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Oncology, and Tumor Immunology, Robert-R\u00f6ssle-Clinic, Humboldt University of Berlin, Berlin, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7468.d", 
          "name": [
            "Department of Hematology, Oncology, and Tumor Immunology, Robert-R\u00f6ssle-Clinic, Humboldt University of Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ludwig", 
        "givenName": "W-D", 
        "id": "sg:person.0701342440.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701342440.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Divison of Hematology-Oncology, Sophia's Children Hospital/Erasmus University Rotterdam, Rotterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.6906.9", 
          "name": [
            "Dutch Childhood Leukemia Study Group, The Hague, The Netherlands", 
            "Department of Pediatrics, Divison of Hematology-Oncology, Sophia's Children Hospital/Erasmus University Rotterdam, Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00e4hlen", 
        "givenName": "K", 
        "id": "sg:person.0742333245.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742333245.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Immunotech, Marseille, France", 
          "id": "http://www.grid.ac/institutes/grid.424937.f", 
          "name": [
            "Immunotech, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Necker", 
        "givenName": "A", 
        "id": "sg:person.01276001564.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276001564.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, University Hospital Dijkzigt/Erasmus University Rotterdam, Rotterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.6906.9", 
          "name": [
            "Department of Immunology, University Hospital Dijkzigt/Erasmus University Rotterdam, Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Dongen", 
        "givenName": "JJM", 
        "id": "sg:person.014022412277.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014022412277.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/331627a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006722092", 
          "https://doi.org/10.1038/331627a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/326085a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021950848", 
          "https://doi.org/10.1038/326085a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01744133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009593643", 
          "https://doi.org/10.1007/bf01744133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/334395a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024802262", 
          "https://doi.org/10.1038/334395a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-02-05", 
    "datePublishedReg": "1999-02-05", 
    "description": "Thirty T cell receptor (TCR)\u03b3\u03b4+ T cell acute lymphoblastic leukemias (T-ALL) were analyzed for their immunophenotype, as well as for the rearrangements and junctional regions of the TCRG and TCRD genes. In 15 cases membrane expression of TCR\u03b3\u03b4 proteins could be studied extensively by flow cytometry with a new V\u03b3/V\u03b4 antibody panel. Virtually all TCR\u03b3\u03b4+ T-ALLs expressed TdT, CD2, CD3, CD5, CD6, and CD7, but they were heterogeneous in their CD1/CD4/CD8 immunophenotype. The majority expressed either CD4+/CD8\u2212 or CD4+/CD8+, whereas only 7/30 TCR\u03b3\u03b4+ T-ALLs lacked both antigens. Despite heterogeneity in the rearranged TCRG and TCRD genes, we found preferential protein expression of V\u03b3I (21/30), J\u03b32.3 (19/30) and C\u03b32 (21/30) gene products in the TCR\u03b3\u03b4+ T-ALL. Expressed TCRD genes were largely limited to V\u03b41-J\u03b41, except for six patients who expressed non-V\u03b41 TCR\u03b4 chains (V\u03b42-J\u03b41, V\u03b42-J\u03b43, V\u03b43-J\u03b41, V\u03b46-J\u03b42, and two V\u03b1-J\u03b41). In spite of the relatively limited combinatorial repertoire of the TCRG and TCRD genes, the junctional region diversity of the expressed genes was extensive. The V\u03b3/V\u03b4 antibody panel confirmed the predominant, but not exclusive, expression of V\u03b3I and V\u03b41 proteins. Importantly, not a single T-ALL expressed the common peripheral blood V\u03b39+/V\u03b42+ phenotype. These immunogenotypic and immunophenotypic characteristics represent excellent targets for flow cytometric and PCR-based detection of 'minimal residual disease' in all TCR\u03b3\u03b4+ T-ALL. Comparison of non-V\u03b41+ TCR\u03b3\u03b4 T-ALLs with the more common V\u03b41+ type showed a trend towards a more mature immunogenotype in the former. Firstly, more complete TCRD rearrangements were identified on the non-expressed allele in the non-V\u03b41+ group (83% vs 43%); secondly, a higher frequency of 'end-stage' J\u03b32.3 gene rearrangements was found in non-V\u03b41 cases on both TCRG alleles (83% vs 66%); thirdly, a higher frequency of complete TCRB rearrangements was found in non-V\u03b41 cases (79% vs 50%).", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.leu.2401276", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "keywords": [
      "cell acute lymphoblastic leukemia", 
      "acute lymphoblastic leukemia", 
      "lymphoblastic leukemia", 
      "antibody panel", 
      "TCRD genes", 
      "minimal residual disease", 
      "CD8 immunophenotype", 
      "TCR\u03b3\u03b4 T", 
      "peripheral blood", 
      "residual disease", 
      "immunophenotypic characteristics", 
      "non-expressed allele", 
      "cell receptor", 
      "flow cytometry", 
      "flow cytometric", 
      "gene products", 
      "protein expression", 
      "ALLs", 
      "region diversity", 
      "gene rearrangements", 
      "membrane expression", 
      "genes", 
      "TCR\u03b4 chains", 
      "TCRB rearrangements", 
      "immunophenotype", 
      "high frequency", 
      "junctional region", 
      "combinatorial repertoire", 
      "leukemia", 
      "TCRG", 
      "mature immunogenotype", 
      "excellent target", 
      "protein", 
      "TCRD rearrangements", 
      "expression", 
      "rearrangement", 
      "alleles", 
      "V\u03b41", 
      "patients", 
      "CD3", 
      "CD7", 
      "CD5", 
      "ALL", 
      "antigen", 
      "disease", 
      "blood", 
      "immunogenotype", 
      "receptors", 
      "cytometry", 
      "cytometric", 
      "CD6", 
      "cases", 
      "diversity", 
      "TdT", 
      "phenotype", 
      "PCR", 
      "panel", 
      "group", 
      "majority", 
      "repertoire", 
      "frequency", 
      "target", 
      "heterogeneity", 
      "characteristics", 
      "region", 
      "spite", 
      "formers", 
      "Cd2", 
      "detection", 
      "chain", 
      "types", 
      "comparison", 
      "trends", 
      "products", 
      "cases membrane expression", 
      "TCR\u03b3\u03b4 proteins", 
      "new V\u03b3/V\u03b4 antibody panel", 
      "V\u03b3/V\u03b4 antibody panel", 
      "V\u03b4 antibody panel", 
      "CD1/CD4/CD8 immunophenotype", 
      "CD4/CD8 immunophenotype", 
      "preferential protein expression", 
      "V\u03b3I", 
      "J\u03b32.3", 
      "C\u03b32 (21/30) gene products", 
      "V\u03b41-J\u03b41", 
      "non-V\u03b41 TCR\u03b4 chains", 
      "limited combinatorial repertoire", 
      "junctional region diversity", 
      "expression of V\u03b3I", 
      "V\u03b41 proteins", 
      "common peripheral blood", 
      "common V\u03b41", 
      "complete TCRD rearrangements", 
      "J\u03b32.3 gene rearrangements", 
      "non-V\u03b41 cases", 
      "TCRG alleles", 
      "complete TCRB rearrangements", 
      "immunogenotypic characteristics"
    ], 
    "name": "Immunophenotypic and immunogenotypic characteristics of TCR\u03b3\u03b4+ T cell acute lymphoblastic leukemia", 
    "pagination": "206-214", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022578009"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.leu.2401276"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10025894"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.leu.2401276", 
      "https://app.dimensions.ai/details/publication/pub.1022578009"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_323.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.leu.2401276"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2401276'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2401276'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2401276'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2401276'


 

This table displays all metadata directly associated to this object as RDF triples.

274 TRIPLES      22 PREDICATES      138 URIs      126 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.leu.2401276 schema:about N11ab2d6acb6e48888b17f8d34b159cca
2 N4c7db975919847cd9914d95dd9638b3f
3 N57d5148bef2344efbdaf12c0dbfdb1f9
4 N57e35f5ff0c948d8be30ef42c314be66
5 N771b27d68bbb4471a303394655c25378
6 N80f588b6eb004646a94367d0379a66c2
7 N9b71c359a1c846989e19d715b29a74d5
8 N9b9c98d43c66432caf6322b2048dcd31
9 Nfcf54b2ee8b34e7cbed2b00e1c164529
10 anzsrc-for:11
11 anzsrc-for:1107
12 schema:author Na0206bb77ad04515a5ab2efa4468f349
13 schema:citation sg:pub.10.1007/bf01744133
14 sg:pub.10.1038/326085a0
15 sg:pub.10.1038/331627a0
16 sg:pub.10.1038/334395a0
17 schema:datePublished 1999-02-05
18 schema:datePublishedReg 1999-02-05
19 schema:description Thirty T cell receptor (TCR)γδ+ T cell acute lymphoblastic leukemias (T-ALL) were analyzed for their immunophenotype, as well as for the rearrangements and junctional regions of the TCRG and TCRD genes. In 15 cases membrane expression of TCRγδ proteins could be studied extensively by flow cytometry with a new Vγ/Vδ antibody panel. Virtually all TCRγδ+ T-ALLs expressed TdT, CD2, CD3, CD5, CD6, and CD7, but they were heterogeneous in their CD1/CD4/CD8 immunophenotype. The majority expressed either CD4+/CD8− or CD4+/CD8+, whereas only 7/30 TCRγδ+ T-ALLs lacked both antigens. Despite heterogeneity in the rearranged TCRG and TCRD genes, we found preferential protein expression of VγI (21/30), Jγ2.3 (19/30) and Cγ2 (21/30) gene products in the TCRγδ+ T-ALL. Expressed TCRD genes were largely limited to Vδ1-Jδ1, except for six patients who expressed non-Vδ1 TCRδ chains (Vδ2-Jδ1, Vδ2-Jδ3, Vδ3-Jδ1, Vδ6-Jδ2, and two Vα-Jδ1). In spite of the relatively limited combinatorial repertoire of the TCRG and TCRD genes, the junctional region diversity of the expressed genes was extensive. The Vγ/Vδ antibody panel confirmed the predominant, but not exclusive, expression of VγI and Vδ1 proteins. Importantly, not a single T-ALL expressed the common peripheral blood Vγ9+/Vδ2+ phenotype. These immunogenotypic and immunophenotypic characteristics represent excellent targets for flow cytometric and PCR-based detection of 'minimal residual disease' in all TCRγδ+ T-ALL. Comparison of non-Vδ1+ TCRγδ T-ALLs with the more common Vδ1+ type showed a trend towards a more mature immunogenotype in the former. Firstly, more complete TCRD rearrangements were identified on the non-expressed allele in the non-Vδ1+ group (83% vs 43%); secondly, a higher frequency of 'end-stage' Jγ2.3 gene rearrangements was found in non-Vδ1 cases on both TCRG alleles (83% vs 66%); thirdly, a higher frequency of complete TCRB rearrangements was found in non-Vδ1 cases (79% vs 50%).
20 schema:genre article
21 schema:inLanguage en
22 schema:isAccessibleForFree true
23 schema:isPartOf N57d25be9d583499bb4e8c415e39191dd
24 Nc1fc10a57cac430690707e0ae5f695db
25 sg:journal.1097065
26 schema:keywords ALL
27 ALLs
28 CD1/CD4/CD8 immunophenotype
29 CD3
30 CD4/CD8 immunophenotype
31 CD5
32 CD6
33 CD7
34 CD8 immunophenotype
35 Cd2
36 Cγ2 (21/30) gene products
37 Jγ2.3
38 Jγ2.3 gene rearrangements
39 PCR
40 TCRB rearrangements
41 TCRD genes
42 TCRD rearrangements
43 TCRG
44 TCRG alleles
45 TCRγδ T
46 TCRγδ proteins
47 TCRδ chains
48 TdT
49 Vγ/Vδ antibody panel
50 VγI
51 Vδ antibody panel
52 Vδ1
53 Vδ1 proteins
54 Vδ1-Jδ1
55 acute lymphoblastic leukemia
56 alleles
57 antibody panel
58 antigen
59 blood
60 cases
61 cases membrane expression
62 cell acute lymphoblastic leukemia
63 cell receptor
64 chain
65 characteristics
66 combinatorial repertoire
67 common Vδ1
68 common peripheral blood
69 comparison
70 complete TCRB rearrangements
71 complete TCRD rearrangements
72 cytometric
73 cytometry
74 detection
75 disease
76 diversity
77 excellent target
78 expression
79 expression of VγI
80 flow cytometric
81 flow cytometry
82 formers
83 frequency
84 gene products
85 gene rearrangements
86 genes
87 group
88 heterogeneity
89 high frequency
90 immunogenotype
91 immunogenotypic characteristics
92 immunophenotype
93 immunophenotypic characteristics
94 junctional region
95 junctional region diversity
96 leukemia
97 limited combinatorial repertoire
98 lymphoblastic leukemia
99 majority
100 mature immunogenotype
101 membrane expression
102 minimal residual disease
103 new Vγ/Vδ antibody panel
104 non-Vδ1 TCRδ chains
105 non-Vδ1 cases
106 non-expressed allele
107 panel
108 patients
109 peripheral blood
110 phenotype
111 preferential protein expression
112 products
113 protein
114 protein expression
115 rearrangement
116 receptors
117 region
118 region diversity
119 repertoire
120 residual disease
121 spite
122 target
123 trends
124 types
125 schema:name Immunophenotypic and immunogenotypic characteristics of TCRγδ+ T cell acute lymphoblastic leukemia
126 schema:pagination 206-214
127 schema:productId N0477dfe570cf4938863229419080ffab
128 N64d35fb16071472faa8fdf68211afa34
129 Nc5f8b0fdebee4e0ca043fcac97d10aa7
130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022578009
131 https://doi.org/10.1038/sj.leu.2401276
132 schema:sdDatePublished 2021-12-01T19:11
133 schema:sdLicense https://scigraph.springernature.com/explorer/license/
134 schema:sdPublisher Nce72f711037a4b6ba0788277fd277b08
135 schema:url https://doi.org/10.1038/sj.leu.2401276
136 sgo:license sg:explorer/license/
137 sgo:sdDataset articles
138 rdf:type schema:ScholarlyArticle
139 N0477dfe570cf4938863229419080ffab schema:name pubmed_id
140 schema:value 10025894
141 rdf:type schema:PropertyValue
142 N11ab2d6acb6e48888b17f8d34b159cca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Antibodies, Monoclonal
144 rdf:type schema:DefinedTerm
145 N4c1dda91b19149fcb6386a8d8d134cc2 rdf:first sg:person.015516437724.31
146 rdf:rest Naf762eae858c41c483c2cd8a77602f4d
147 N4c7db975919847cd9914d95dd9638b3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Gene Rearrangement, T-Lymphocyte
149 rdf:type schema:DefinedTerm
150 N57d25be9d583499bb4e8c415e39191dd schema:issueNumber 2
151 rdf:type schema:PublicationIssue
152 N57d5148bef2344efbdaf12c0dbfdb1f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Immunophenotyping
154 rdf:type schema:DefinedTerm
155 N57e35f5ff0c948d8be30ef42c314be66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Humans
157 rdf:type schema:DefinedTerm
158 N64d35fb16071472faa8fdf68211afa34 schema:name doi
159 schema:value 10.1038/sj.leu.2401276
160 rdf:type schema:PropertyValue
161 N771b27d68bbb4471a303394655c25378 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Immunogenetics
163 rdf:type schema:DefinedTerm
164 N80f588b6eb004646a94367d0379a66c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Genetic Heterogeneity
166 rdf:type schema:DefinedTerm
167 N9b71c359a1c846989e19d715b29a74d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Leukemia-Lymphoma, Adult T-Cell
169 rdf:type schema:DefinedTerm
170 N9b9c98d43c66432caf6322b2048dcd31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Receptors, Antigen, T-Cell, gamma-delta
172 rdf:type schema:DefinedTerm
173 Na0206bb77ad04515a5ab2efa4468f349 rdf:first sg:person.01014146375.07
174 rdf:rest N4c1dda91b19149fcb6386a8d8d134cc2
175 Na107c06d8363404ea3d154abd341dcb0 rdf:first sg:person.0742333245.79
176 rdf:rest Nee251ca83cee4c5d83796335b5a0122a
177 Naf762eae858c41c483c2cd8a77602f4d rdf:first sg:person.01066263431.34
178 rdf:rest Ndf16e8f14beb49149651615f73a5521c
179 Nc1fc10a57cac430690707e0ae5f695db schema:volumeNumber 13
180 rdf:type schema:PublicationVolume
181 Nc5f8b0fdebee4e0ca043fcac97d10aa7 schema:name dimensions_id
182 schema:value pub.1022578009
183 rdf:type schema:PropertyValue
184 Nce72f711037a4b6ba0788277fd277b08 schema:name Springer Nature - SN SciGraph project
185 rdf:type schema:Organization
186 Ndf16e8f14beb49149651615f73a5521c rdf:first sg:person.016161437457.59
187 rdf:rest Nf9c24c3a008e450682e31be73bd85337
188 Ne09797418f5b4c31b26b86e67f29da92 rdf:first sg:person.014022412277.73
189 rdf:rest rdf:nil
190 Nee251ca83cee4c5d83796335b5a0122a rdf:first sg:person.01276001564.87
191 rdf:rest Ne09797418f5b4c31b26b86e67f29da92
192 Nf9c24c3a008e450682e31be73bd85337 rdf:first sg:person.0701342440.01
193 rdf:rest Na107c06d8363404ea3d154abd341dcb0
194 Nfcf54b2ee8b34e7cbed2b00e1c164529 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Polymerase Chain Reaction
196 rdf:type schema:DefinedTerm
197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
198 schema:name Medical and Health Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
201 schema:name Immunology
202 rdf:type schema:DefinedTerm
203 sg:journal.1097065 schema:issn 0887-6924
204 1476-5551
205 schema:name Leukemia
206 schema:publisher Springer Nature
207 rdf:type schema:Periodical
208 sg:person.01014146375.07 schema:affiliation grid-institutes:grid.6906.9
209 schema:familyName Langerak
210 schema:givenName AW
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014146375.07
212 rdf:type schema:Person
213 sg:person.01066263431.34 schema:affiliation grid-institutes:grid.6906.9
214 schema:familyName van den Beemd
215 schema:givenName MWM
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066263431.34
217 rdf:type schema:Person
218 sg:person.01276001564.87 schema:affiliation grid-institutes:grid.424937.f
219 schema:familyName Necker
220 schema:givenName A
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276001564.87
222 rdf:type schema:Person
223 sg:person.014022412277.73 schema:affiliation grid-institutes:grid.6906.9
224 schema:familyName van Dongen
225 schema:givenName JJM
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014022412277.73
227 rdf:type schema:Person
228 sg:person.015516437724.31 schema:affiliation grid-institutes:grid.6906.9
229 schema:familyName Wolvers-Tettero
230 schema:givenName ILM
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015516437724.31
232 rdf:type schema:Person
233 sg:person.016161437457.59 schema:affiliation grid-institutes:None
234 schema:familyName van Wering
235 schema:givenName ER
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016161437457.59
237 rdf:type schema:Person
238 sg:person.0701342440.01 schema:affiliation grid-institutes:grid.7468.d
239 schema:familyName Ludwig
240 schema:givenName W-D
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701342440.01
242 rdf:type schema:Person
243 sg:person.0742333245.79 schema:affiliation grid-institutes:grid.6906.9
244 schema:familyName Hählen
245 schema:givenName K
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742333245.79
247 rdf:type schema:Person
248 sg:pub.10.1007/bf01744133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009593643
249 https://doi.org/10.1007/bf01744133
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/326085a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021950848
252 https://doi.org/10.1038/326085a0
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/331627a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006722092
255 https://doi.org/10.1038/331627a0
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/334395a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024802262
258 https://doi.org/10.1038/334395a0
259 rdf:type schema:CreativeWork
260 grid-institutes:None schema:alternateName Dutch Childhood Leukemia Study Group, The Hague, The Netherlands
261 schema:name Dutch Childhood Leukemia Study Group, The Hague, The Netherlands
262 rdf:type schema:Organization
263 grid-institutes:grid.424937.f schema:alternateName Immunotech, Marseille, France
264 schema:name Immunotech, Marseille, France
265 rdf:type schema:Organization
266 grid-institutes:grid.6906.9 schema:alternateName Department of Immunology, University Hospital Dijkzigt/Erasmus University Rotterdam, Rotterdam, The Netherlands
267 Department of Pediatrics, Divison of Hematology-Oncology, Sophia's Children Hospital/Erasmus University Rotterdam, Rotterdam, The Netherlands
268 schema:name Department of Immunology, University Hospital Dijkzigt/Erasmus University Rotterdam, Rotterdam, The Netherlands
269 Department of Pediatrics, Divison of Hematology-Oncology, Sophia's Children Hospital/Erasmus University Rotterdam, Rotterdam, The Netherlands
270 Dutch Childhood Leukemia Study Group, The Hague, The Netherlands
271 rdf:type schema:Organization
272 grid-institutes:grid.7468.d schema:alternateName Department of Hematology, Oncology, and Tumor Immunology, Robert-Rössle-Clinic, Humboldt University of Berlin, Berlin, Germany
273 schema:name Department of Hematology, Oncology, and Tumor Immunology, Robert-Rössle-Clinic, Humboldt University of Berlin, Berlin, Germany
274 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...