Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-09

AUTHORS

H Kiyoi, M Towatari, S Yokota, M Hamaguchi, R Ohno, H Saito, T Naoe

ABSTRACT

An internal tandem duplication (ITD) of the FLT3 gene is found in nearly 20% of acute myeloid leukemia (AML) and 5% of myelodysplastic syndrome cases. Our serial studies on 51 samples with the FLT3 gene mutation indicated that the ITD was frequently (47/51) clustered in the tyrosine-rich stretch from codon 589 to 599 and rarely (3/51) in its downstream region, both of which are located within the juxtamembrane (JM) domain. One remaining sample had an insertion into the JM domain of nucleotides of unknown origin. To elucidate the biological relevance of the ITD or the insertion, we expressed various types of mutant FLT3 in Cos 7 cells. All mutant FLT3 studied were ligand-independently dimerized and their tyrosine residues were phosphorylated. The Y589 of FLT3 was essential for the phosphorylation in the wild FLT3, but a Y589F conversion did not affect the phosphorylation status of the mutant FLT3. These findings suggest that the elongation of the JM domain rather than increase of tyrosine residues causes gain-of-function of FLT3. Thus, ITD is a novel modality of somatic mutation which activates its product. Since the DNA corresponding to codon 593 to 602 potentially forms a palindromic intermediate, we propose that a DNA-replication error might be associated with generating the ITD of the FLT3 gene. More... »

PAGES

2401130

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2401130

DOI

http://dx.doi.org/10.1038/sj.leu.2401130

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002471707

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9737679


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "COS Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myelodysplastic Syndromes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Platelet-Derived Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "fms-Like Tyrosine Kinase 3", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kiyoi", 
        "givenName": "H", 
        "id": "sg:person.0577356402.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577356402.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Towatari", 
        "givenName": "M", 
        "id": "sg:person.0774366752.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774366752.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto Prefectural University of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yokota", 
        "givenName": "S", 
        "id": "sg:person.07521036142.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07521036142.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamaguchi", 
        "givenName": "M", 
        "id": "sg:person.014232652072.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014232652072.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hamamatsu University", 
          "id": "https://www.grid.ac/institutes/grid.411951.9", 
          "name": [
            "Department of Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohno", 
        "givenName": "R", 
        "id": "sg:person.01164042216.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164042216.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saito", 
        "givenName": "H", 
        "id": "sg:person.011771162672.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011771162672.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naoe", 
        "givenName": "T", 
        "id": "sg:person.0617447237.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617447237.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1172/jci116761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009112455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0695-213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009710850", 
          "https://doi.org/10.1038/ng0695-213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.1.69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012138154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.14.7120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024895788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2400812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025757807", 
          "https://doi.org/10.1038/sj.leu.2400812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2400812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025757807", 
          "https://doi.org/10.1038/sj.leu.2400812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.2.459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028051421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2400770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031254959", 
          "https://doi.org/10.1038/sj.leu.2400770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2400770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031254959", 
          "https://doi.org/10.1038/sj.leu.2400770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.10.6572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034612821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90010-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034750830"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-09", 
    "datePublishedReg": "1998-09-01", 
    "description": "An internal tandem duplication (ITD) of the FLT3 gene is found in nearly 20% of acute myeloid leukemia (AML) and 5% of myelodysplastic syndrome cases. Our serial studies on 51 samples with the FLT3 gene mutation indicated that the ITD was frequently (47/51) clustered in the tyrosine-rich stretch from codon 589 to 599 and rarely (3/51) in its downstream region, both of which are located within the juxtamembrane (JM) domain. One remaining sample had an insertion into the JM domain of nucleotides of unknown origin. To elucidate the biological relevance of the ITD or the insertion, we expressed various types of mutant FLT3 in Cos 7 cells. All mutant FLT3 studied were ligand-independently dimerized and their tyrosine residues were phosphorylated. The Y589 of FLT3 was essential for the phosphorylation in the wild FLT3, but a Y589F conversion did not affect the phosphorylation status of the mutant FLT3. These findings suggest that the elongation of the JM domain rather than increase of tyrosine residues causes gain-of-function of FLT3. Thus, ITD is a novel modality of somatic mutation which activates its product. Since the DNA corresponding to codon 593 to 602 potentially forms a palindromic intermediate, we propose that a DNA-replication error might be associated with generating the ITD of the FLT3 gene.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.leu.2401130", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product", 
    "pagination": "2401130", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0bc490fc49d2da4207f8a6008207bd79fe12a9fc0400e72e60915f63e794d48d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9737679"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.leu.2401130"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002471707"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.leu.2401130", 
      "https://app.dimensions.ai/details/publication/pub.1002471707"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29222_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/2401130"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2401130'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2401130'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2401130'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2401130'


 

This table displays all metadata directly associated to this object as RDF triples.

209 TRIPLES      21 PREDICATES      53 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.leu.2401130 schema:about N0b751961a1814eb3bc9230d277a6a451
2 N3aa051b55b494b1b890c9240df1a3348
3 N436d52a469114e168486f93ac644a478
4 N4428ab004c8d4d1aaf88dcaa07e48b81
5 N4a8753910bee45e68dc6101ccde23610
6 N612859fb7465467e8d0eb31e41fe7132
7 N625a36d37af942eb9cb5174f47e7ec1d
8 N898876d22b094092a063cf9b46f84be0
9 N969b28a43e164004bdf5659b6fa15837
10 N99d6734b69104d7898393a4bc8728371
11 N9db18b993aa84073a90e66440b1ea200
12 Nac888902b603439c82b6c015f9cd382f
13 Ncd2cf1f05f2a4af3b59823c5cb359418
14 Ndf30b250e5b24fd09699b12ce3d05414
15 Nfed091089838476bae8eae82c2f8242b
16 anzsrc-for:06
17 anzsrc-for:0604
18 schema:author Na748b83b11664c3a98a3de2165ae9652
19 schema:citation sg:pub.10.1038/ng0695-213
20 sg:pub.10.1038/sj.leu.2400770
21 sg:pub.10.1038/sj.leu.2400812
22 https://doi.org/10.1016/0092-8674(91)90010-v
23 https://doi.org/10.1073/pnas.91.2.459
24 https://doi.org/10.1073/pnas.93.14.7120
25 https://doi.org/10.1093/emboj/16.1.69
26 https://doi.org/10.1128/mcb.13.10.6572
27 https://doi.org/10.1172/jci116761
28 schema:datePublished 1998-09
29 schema:datePublishedReg 1998-09-01
30 schema:description An internal tandem duplication (ITD) of the FLT3 gene is found in nearly 20% of acute myeloid leukemia (AML) and 5% of myelodysplastic syndrome cases. Our serial studies on 51 samples with the FLT3 gene mutation indicated that the ITD was frequently (47/51) clustered in the tyrosine-rich stretch from codon 589 to 599 and rarely (3/51) in its downstream region, both of which are located within the juxtamembrane (JM) domain. One remaining sample had an insertion into the JM domain of nucleotides of unknown origin. To elucidate the biological relevance of the ITD or the insertion, we expressed various types of mutant FLT3 in Cos 7 cells. All mutant FLT3 studied were ligand-independently dimerized and their tyrosine residues were phosphorylated. The Y589 of FLT3 was essential for the phosphorylation in the wild FLT3, but a Y589F conversion did not affect the phosphorylation status of the mutant FLT3. These findings suggest that the elongation of the JM domain rather than increase of tyrosine residues causes gain-of-function of FLT3. Thus, ITD is a novel modality of somatic mutation which activates its product. Since the DNA corresponding to codon 593 to 602 potentially forms a palindromic intermediate, we propose that a DNA-replication error might be associated with generating the ITD of the FLT3 gene.
31 schema:genre research_article
32 schema:inLanguage en
33 schema:isAccessibleForFree true
34 schema:isPartOf Ne0bfc9a7865f4a9aa27356dcd0ade45c
35 Neb5036fe15db43bb857dadf9931f7c94
36 sg:journal.1097065
37 schema:name Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
38 schema:pagination 2401130
39 schema:productId N1494936bd1f54b6d9477f78c24f619c0
40 N2ed85d830dd14cfeb1f900cd2992fa64
41 N94112ec9649e4b2eb259234410e1c14f
42 Ne0d3e733a1fc4e50ba4ab80d4c437cb5
43 Ned4c1b447f3b48b39161e64089c7944e
44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002471707
45 https://doi.org/10.1038/sj.leu.2401130
46 schema:sdDatePublished 2019-04-11T11:57
47 schema:sdLicense https://scigraph.springernature.com/explorer/license/
48 schema:sdPublisher Nd566fe13816445b786dc91285cdbe76d
49 schema:url http://www.nature.com/articles/2401130
50 sgo:license sg:explorer/license/
51 sgo:sdDataset articles
52 rdf:type schema:ScholarlyArticle
53 N06d2078e6d5d4b819c104ab00ec4be0e rdf:first sg:person.01164042216.18
54 rdf:rest N5c0bc0b8eb504a959b2cfe4c7beee783
55 N0b751961a1814eb3bc9230d277a6a451 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name Proto-Oncogene Proteins
57 rdf:type schema:DefinedTerm
58 N1494936bd1f54b6d9477f78c24f619c0 schema:name dimensions_id
59 schema:value pub.1002471707
60 rdf:type schema:PropertyValue
61 N2ed85d830dd14cfeb1f900cd2992fa64 schema:name doi
62 schema:value 10.1038/sj.leu.2401130
63 rdf:type schema:PropertyValue
64 N3aa051b55b494b1b890c9240df1a3348 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Receptor Protein-Tyrosine Kinases
66 rdf:type schema:DefinedTerm
67 N436d52a469114e168486f93ac644a478 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Leukemia, Myeloid
69 rdf:type schema:DefinedTerm
70 N4428ab004c8d4d1aaf88dcaa07e48b81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Sequence Analysis
72 rdf:type schema:DefinedTerm
73 N4a8753910bee45e68dc6101ccde23610 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Animals
75 rdf:type schema:DefinedTerm
76 N4a9b5598c221481e9631ffb3ca5f678b rdf:first sg:person.07521036142.13
77 rdf:rest Nc38baf5ce478492c84c25ff804e35979
78 N5c0bc0b8eb504a959b2cfe4c7beee783 rdf:first sg:person.011771162672.81
79 rdf:rest Nc2c0d57d5a2a426f8ebd4a2bdd885034
80 N612859fb7465467e8d0eb31e41fe7132 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Acute Disease
82 rdf:type schema:DefinedTerm
83 N625a36d37af942eb9cb5174f47e7ec1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Neoplasm Proteins
85 rdf:type schema:DefinedTerm
86 N898876d22b094092a063cf9b46f84be0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Mutation
88 rdf:type schema:DefinedTerm
89 N94112ec9649e4b2eb259234410e1c14f schema:name readcube_id
90 schema:value 0bc490fc49d2da4207f8a6008207bd79fe12a9fc0400e72e60915f63e794d48d
91 rdf:type schema:PropertyValue
92 N969b28a43e164004bdf5659b6fa15837 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Receptors, Platelet-Derived Growth Factor
94 rdf:type schema:DefinedTerm
95 N99d6734b69104d7898393a4bc8728371 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Myelodysplastic Syndromes
97 rdf:type schema:DefinedTerm
98 N9db18b993aa84073a90e66440b1ea200 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name fms-Like Tyrosine Kinase 3
100 rdf:type schema:DefinedTerm
101 Na57af5c4a7274d5c85f2de8606a9f882 rdf:first sg:person.0774366752.91
102 rdf:rest N4a9b5598c221481e9631ffb3ca5f678b
103 Na748b83b11664c3a98a3de2165ae9652 rdf:first sg:person.0577356402.63
104 rdf:rest Na57af5c4a7274d5c85f2de8606a9f882
105 Nac888902b603439c82b6c015f9cd382f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Humans
107 rdf:type schema:DefinedTerm
108 Nc2c0d57d5a2a426f8ebd4a2bdd885034 rdf:first sg:person.0617447237.02
109 rdf:rest rdf:nil
110 Nc38baf5ce478492c84c25ff804e35979 rdf:first sg:person.014232652072.10
111 rdf:rest N06d2078e6d5d4b819c104ab00ec4be0e
112 Ncd2cf1f05f2a4af3b59823c5cb359418 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Phosphorylation
114 rdf:type schema:DefinedTerm
115 Nd566fe13816445b786dc91285cdbe76d schema:name Springer Nature - SN SciGraph project
116 rdf:type schema:Organization
117 Ndf30b250e5b24fd09699b12ce3d05414 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Chromosome Mapping
119 rdf:type schema:DefinedTerm
120 Ne0bfc9a7865f4a9aa27356dcd0ade45c schema:issueNumber 9
121 rdf:type schema:PublicationIssue
122 Ne0d3e733a1fc4e50ba4ab80d4c437cb5 schema:name pubmed_id
123 schema:value 9737679
124 rdf:type schema:PropertyValue
125 Neb5036fe15db43bb857dadf9931f7c94 schema:volumeNumber 12
126 rdf:type schema:PublicationVolume
127 Ned4c1b447f3b48b39161e64089c7944e schema:name nlm_unique_id
128 schema:value 8704895
129 rdf:type schema:PropertyValue
130 Nfed091089838476bae8eae82c2f8242b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name COS Cells
132 rdf:type schema:DefinedTerm
133 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
134 schema:name Biological Sciences
135 rdf:type schema:DefinedTerm
136 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
137 schema:name Genetics
138 rdf:type schema:DefinedTerm
139 sg:journal.1097065 schema:issn 0887-6924
140 1476-5551
141 schema:name Leukemia
142 rdf:type schema:Periodical
143 sg:person.01164042216.18 schema:affiliation https://www.grid.ac/institutes/grid.411951.9
144 schema:familyName Ohno
145 schema:givenName R
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164042216.18
147 rdf:type schema:Person
148 sg:person.011771162672.81 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
149 schema:familyName Saito
150 schema:givenName H
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011771162672.81
152 rdf:type schema:Person
153 sg:person.014232652072.10 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
154 schema:familyName Hamaguchi
155 schema:givenName M
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014232652072.10
157 rdf:type schema:Person
158 sg:person.0577356402.63 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
159 schema:familyName Kiyoi
160 schema:givenName H
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577356402.63
162 rdf:type schema:Person
163 sg:person.0617447237.02 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
164 schema:familyName Naoe
165 schema:givenName T
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617447237.02
167 rdf:type schema:Person
168 sg:person.07521036142.13 schema:affiliation https://www.grid.ac/institutes/grid.272458.e
169 schema:familyName Yokota
170 schema:givenName S
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07521036142.13
172 rdf:type schema:Person
173 sg:person.0774366752.91 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
174 schema:familyName Towatari
175 schema:givenName M
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774366752.91
177 rdf:type schema:Person
178 sg:pub.10.1038/ng0695-213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009710850
179 https://doi.org/10.1038/ng0695-213
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/sj.leu.2400770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031254959
182 https://doi.org/10.1038/sj.leu.2400770
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/sj.leu.2400812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025757807
185 https://doi.org/10.1038/sj.leu.2400812
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/0092-8674(91)90010-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1034750830
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1073/pnas.91.2.459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028051421
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1073/pnas.93.14.7120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024895788
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1093/emboj/16.1.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012138154
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1128/mcb.13.10.6572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034612821
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1172/jci116761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009112455
198 rdf:type schema:CreativeWork
199 https://www.grid.ac/institutes/grid.272458.e schema:alternateName Kyoto Prefectural University of Medicine
200 schema:name Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
201 rdf:type schema:Organization
202 https://www.grid.ac/institutes/grid.27476.30 schema:alternateName Nagoya University
203 schema:name Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan
204 First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
205 Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
206 rdf:type schema:Organization
207 https://www.grid.ac/institutes/grid.411951.9 schema:alternateName Hamamatsu University
208 schema:name Department of Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan
209 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...