Concurrent disruption of cell cycle associated genes in mantle cell lymphoma: a genotypic and phenotypic study of cyclin D1, p16, ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-08

AUTHORS

K Grønbæk, T Nedergaard, MK Andersen, P thor Straten, P Guldberg, P Møller, J Zeuthen, N Ebbe Hansen, K Hou-Jensen, E Ralfkiaer

ABSTRACT

Mantle cell lymphomas (MCL) are morphologically and immunophenotypically distinctive lymphoid neoplasms characterised by overexpression of cyclin D1. Recent studies have suggested that co-operating aberrations of cell cycle associated genes may provide a growth advantage to a tumour. To address this issue further, we investigated five typical and three aggressive (blastoid) MCL for alterations in the cell cycle regulating genes p15, p16, CDK4, Rb and p53. In 3/3 aggressive cases with cyclin D1 overexpression we found aberration of at least one additional gene. One case showed diminished expression of the retinoblastoma protein (pRb); one case harboured deletion of both p15 and p16; and one case exhibited both deletion of p16 and point mutation of p53. However, we also identified two typical cases which in addition to cyclin D1 overexpression exhibited diminished pRb expression and p15 and p16 hypermethylation, respectively. Our findings confirm and extend other recent investigations and indicate that co-operating genetic alterations of cell cycle-associated genes may contribute to the pathogenesis of MCL. More... »

PAGES

1266

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2401090

DOI

http://dx.doi.org/10.1038/sj.leu.2401090

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042847125

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9697882


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