Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-09

AUTHORS

S Horiike, S Yokota, M Nakao, T Iwai, Y Sasai, H Kaneko, M Taniwaki, K Kashima, H Fujii, T Abe, S Misawa

ABSTRACT

We recently reported an internal tandem duplication of the human flt3 receptor gene (FLT3) as a somatic mutation in 17% of acute myelogenous leukemia (AML). The present study revealed the duplication at the juxtamembrane and the first tyrosine kinase domains of FLT3 in seven of 92 (8%) patients with myelodysplastic syndrome (MDS) and AML with trilineage myelodysplasia (AML/TMDS), the diseases which may represent neoplastic changes of pluripotent stem cells. A tandem duplication of exon 11 of FLT3 was harbored by two of 58 (3%) patients with MDS and five of 34 (15%) with overt leukemia, including MDS-derived leukemia, AML/TMDS and therapy-related leukemia. Although the duplicated regions varied within exon 11 in each case, they occurred in-frame, and altered mRNA expressions were demonstrated by reverse-transcription polymerase chain reaction. Two cases of MDS with a FLT3 duplication transformed to overt leukemia within a few months. Longitudinal analyses in two other patients with leukemia revealed that the duplication was a late genetic event during the disease course; one of whom showed two independent duplications of FLT3 at the terminal therapy-resistant phase. Of seven patients with the FLT3 duplication, six had abnormal karyotypes, and four harbored a point mutation of the N-RAS and/or TP53 genes. Patients with FLT3 mutations have poor prognoses. This study uncovered the fact that the accumulation of genetic events, including FLT3 duplication, correlates with leukemic transformation from antecedent myelodysplasia and with subsequent disease progression. More... »

PAGES

1442

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2400770

DOI

http://dx.doi.org/10.1038/sj.leu.2400770

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031254959

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9305595


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multigene Family", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myelodysplastic Syndromes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "fms-Like Tyrosine Kinase 3", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kyoto Prefectural University of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Internal Medicine III, Kyoto Prefectural University of Medicine, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horiike", 
        "givenName": "S", 
        "id": "sg:person.01030457735.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030457735.59"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Yokota", 
        "givenName": "S", 
        "id": "sg:person.0654573623.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654573623.26"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Nakao", 
        "givenName": "M", 
        "id": "sg:person.0756710020.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756710020.21"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Iwai", 
        "givenName": "T", 
        "id": "sg:person.011365414042.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011365414042.29"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Sasai", 
        "givenName": "Y", 
        "id": "sg:person.01305161323.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305161323.40"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kaneko", 
        "givenName": "H", 
        "id": "sg:person.0757160060.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757160060.84"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Taniwaki", 
        "givenName": "M", 
        "id": "sg:person.01320436003.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320436003.92"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kashima", 
        "givenName": "K", 
        "id": "sg:person.01315524472.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315524472.14"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Fujii", 
        "givenName": "H", 
        "id": "sg:person.010572466152.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010572466152.21"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Abe", 
        "givenName": "T", 
        "id": "sg:person.07536132772.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07536132772.78"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Misawa", 
        "givenName": "S", 
        "id": "sg:person.0644335631.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644335631.56"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/1097-0142(19880915)62:6<1129::aid-cncr2820620616>3.0.co;2-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002736947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1987.tb01325.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004932480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1982.tb02771.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019519595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(85)90388-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024265674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1988.tb06188.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031947636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-4608(92)90098-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033942067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90010-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034750830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(94)90021-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042308687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(94)90021-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042308687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-103-4-620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073690404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1990.8.8.1424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077294546"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-09", 
    "datePublishedReg": "1997-09-01", 
    "description": "We recently reported an internal tandem duplication of the human flt3 receptor gene (FLT3) as a somatic mutation in 17% of acute myelogenous leukemia (AML). The present study revealed the duplication at the juxtamembrane and the first tyrosine kinase domains of FLT3 in seven of 92 (8%) patients with myelodysplastic syndrome (MDS) and AML with trilineage myelodysplasia (AML/TMDS), the diseases which may represent neoplastic changes of pluripotent stem cells. A tandem duplication of exon 11 of FLT3 was harbored by two of 58 (3%) patients with MDS and five of 34 (15%) with overt leukemia, including MDS-derived leukemia, AML/TMDS and therapy-related leukemia. Although the duplicated regions varied within exon 11 in each case, they occurred in-frame, and altered mRNA expressions were demonstrated by reverse-transcription polymerase chain reaction. Two cases of MDS with a FLT3 duplication transformed to overt leukemia within a few months. Longitudinal analyses in two other patients with leukemia revealed that the duplication was a late genetic event during the disease course; one of whom showed two independent duplications of FLT3 at the terminal therapy-resistant phase. Of seven patients with the FLT3 duplication, six had abnormal karyotypes, and four harbored a point mutation of the N-RAS and/or TP53 genes. Patients with FLT3 mutations have poor prognoses. This study uncovered the fact that the accumulation of genetic events, including FLT3 duplication, correlates with leukemic transformation from antecedent myelodysplasia and with subsequent disease progression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.leu.2400770", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia", 
    "pagination": "1442", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "94e4f426fd82ce0ad4a2f723fa025368b0eeec14cc6fb926937520c2daeec1bc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9305595"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.leu.2400770"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031254959"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.leu.2400770", 
      "https://app.dimensions.ai/details/publication/pub.1031254959"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29194_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/2400770"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2400770'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2400770'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2400770'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2400770'


 

This table displays all metadata directly associated to this object as RDF triples.

227 TRIPLES      21 PREDICATES      56 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.leu.2400770 schema:about N1a6de1f2145f427cb8148c8018ba7eaf
2 N1dab6d650a6a49a79d67c27479085df5
3 N1dee2e6c72a746e09ef1704f3f3944d0
4 N1f37767cfb5349bb8023d561995e06ac
5 N356ef1753ad9498ea56c5a4a794a22a6
6 N58e80060ab6645409c2789d70471a4c2
7 N5fb7adccb5534fceb780bb7671244b19
8 N66fb1752946945f993446d2ce460c075
9 N768339d121184390b9dd9f5b86670ac4
10 N85658045b8e4437ab92d34d2c5e27260
11 N8f1b7c67c8d4475bb197a674d50fbcc7
12 N96ad8e858580467dae57c7a549df9219
13 Na1a3cb437e684e869bf4e2f8e9bfa897
14 Nae451656277d486a9ed69a5a00596e80
15 Nbe1a1da9d48e43c0acad3c4df438842e
16 Nc9fa767cc05842c6b458945e887927ff
17 Nfe0bb55206f84e3b93504a365e94dac8
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author N71a6c6cd7c534ef3aeffcab8b64d4e2c
21 schema:citation https://doi.org/10.1002/1097-0142(19880915)62:6<1129::aid-cncr2820620616>3.0.co;2-c
22 https://doi.org/10.1016/0022-2836(85)90388-2
23 https://doi.org/10.1016/0092-8674(91)90010-v
24 https://doi.org/10.1016/0165-4608(92)90098-s
25 https://doi.org/10.1016/0378-1119(94)90021-3
26 https://doi.org/10.1111/j.1365-2141.1982.tb02771.x
27 https://doi.org/10.1111/j.1365-2141.1987.tb01325.x
28 https://doi.org/10.1111/j.1365-2141.1988.tb06188.x
29 https://doi.org/10.1200/jco.1990.8.8.1424
30 https://doi.org/10.7326/0003-4819-103-4-620
31 schema:datePublished 1997-09
32 schema:datePublishedReg 1997-09-01
33 schema:description We recently reported an internal tandem duplication of the human flt3 receptor gene (FLT3) as a somatic mutation in 17% of acute myelogenous leukemia (AML). The present study revealed the duplication at the juxtamembrane and the first tyrosine kinase domains of FLT3 in seven of 92 (8%) patients with myelodysplastic syndrome (MDS) and AML with trilineage myelodysplasia (AML/TMDS), the diseases which may represent neoplastic changes of pluripotent stem cells. A tandem duplication of exon 11 of FLT3 was harbored by two of 58 (3%) patients with MDS and five of 34 (15%) with overt leukemia, including MDS-derived leukemia, AML/TMDS and therapy-related leukemia. Although the duplicated regions varied within exon 11 in each case, they occurred in-frame, and altered mRNA expressions were demonstrated by reverse-transcription polymerase chain reaction. Two cases of MDS with a FLT3 duplication transformed to overt leukemia within a few months. Longitudinal analyses in two other patients with leukemia revealed that the duplication was a late genetic event during the disease course; one of whom showed two independent duplications of FLT3 at the terminal therapy-resistant phase. Of seven patients with the FLT3 duplication, six had abnormal karyotypes, and four harbored a point mutation of the N-RAS and/or TP53 genes. Patients with FLT3 mutations have poor prognoses. This study uncovered the fact that the accumulation of genetic events, including FLT3 duplication, correlates with leukemic transformation from antecedent myelodysplasia and with subsequent disease progression.
34 schema:genre research_article
35 schema:inLanguage en
36 schema:isAccessibleForFree true
37 schema:isPartOf N9a8049dd3ddf4eab81c506baaad2403d
38 N9c7f6a43e9d1401c8b3db0e0956bf293
39 sg:journal.1097065
40 schema:name Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia
41 schema:pagination 1442
42 schema:productId N395147afb7c3495997d3233f55a85053
43 N3a26d53ed54548eca6fb7aedfd0cd418
44 N6f40e54517924d6996fcdaffd2e8945d
45 Ncb7dab41fd104e8f8195b6be953f93da
46 Nf03ee1a2a07d486fb219d890793a6a83
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031254959
48 https://doi.org/10.1038/sj.leu.2400770
49 schema:sdDatePublished 2019-04-11T11:52
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher N477d66bb48c4421294c7c431db2e2542
52 schema:url https://www.nature.com/articles/2400770
53 sgo:license sg:explorer/license/
54 sgo:sdDataset articles
55 rdf:type schema:ScholarlyArticle
56 N1a6de1f2145f427cb8148c8018ba7eaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Male
58 rdf:type schema:DefinedTerm
59 N1dab6d650a6a49a79d67c27479085df5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Myelodysplastic Syndromes
61 rdf:type schema:DefinedTerm
62 N1dee2e6c72a746e09ef1704f3f3944d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Middle Aged
64 rdf:type schema:DefinedTerm
65 N1f37767cfb5349bb8023d561995e06ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name RNA, Messenger
67 rdf:type schema:DefinedTerm
68 N307a19647b324659adbafa512f4f6403 rdf:first sg:person.01305161323.40
69 rdf:rest N6311f02e9d03456cb801297a303dad5b
70 N356ef1753ad9498ea56c5a4a794a22a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Molecular Sequence Data
72 rdf:type schema:DefinedTerm
73 N395147afb7c3495997d3233f55a85053 schema:name doi
74 schema:value 10.1038/sj.leu.2400770
75 rdf:type schema:PropertyValue
76 N3a26d53ed54548eca6fb7aedfd0cd418 schema:name pubmed_id
77 schema:value 9305595
78 rdf:type schema:PropertyValue
79 N477d66bb48c4421294c7c431db2e2542 schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N58e80060ab6645409c2789d70471a4c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Base Sequence
83 rdf:type schema:DefinedTerm
84 N5fb7adccb5534fceb780bb7671244b19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Gene Expression Regulation, Neoplastic
86 rdf:type schema:DefinedTerm
87 N61899c2eb83c4dda8449ac3ba529f1bc rdf:first sg:person.01320436003.92
88 rdf:rest Nb8d2d8bed259473a9a593028e0cdee85
89 N6311f02e9d03456cb801297a303dad5b rdf:first sg:person.0757160060.84
90 rdf:rest N61899c2eb83c4dda8449ac3ba529f1bc
91 N66fb1752946945f993446d2ce460c075 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Humans
93 rdf:type schema:DefinedTerm
94 N6f40e54517924d6996fcdaffd2e8945d schema:name readcube_id
95 schema:value 94e4f426fd82ce0ad4a2f723fa025368b0eeec14cc6fb926937520c2daeec1bc
96 rdf:type schema:PropertyValue
97 N71a6c6cd7c534ef3aeffcab8b64d4e2c rdf:first sg:person.01030457735.59
98 rdf:rest Na06dbf93381d44cbbfa1643be81f028e
99 N768339d121184390b9dd9f5b86670ac4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name RNA, Neoplasm
101 rdf:type schema:DefinedTerm
102 N841c15eaccd34c0a98b4df7a5ea825dc rdf:first sg:person.011365414042.29
103 rdf:rest N307a19647b324659adbafa512f4f6403
104 N85658045b8e4437ab92d34d2c5e27260 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Amino Acid Sequence
106 rdf:type schema:DefinedTerm
107 N8f1b7c67c8d4475bb197a674d50fbcc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Aged
109 rdf:type schema:DefinedTerm
110 N96ad8e858580467dae57c7a549df9219 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name fms-Like Tyrosine Kinase 3
112 rdf:type schema:DefinedTerm
113 N9a8049dd3ddf4eab81c506baaad2403d schema:volumeNumber 11
114 rdf:type schema:PublicationVolume
115 N9c7f6a43e9d1401c8b3db0e0956bf293 schema:issueNumber 9
116 rdf:type schema:PublicationIssue
117 Na05c4ee42eb64f12a01e8c4125613e8d rdf:first sg:person.0644335631.56
118 rdf:rest rdf:nil
119 Na06dbf93381d44cbbfa1643be81f028e rdf:first sg:person.0654573623.26
120 rdf:rest Nf149c36dc81846608d510f62611d67af
121 Na1a3cb437e684e869bf4e2f8e9bfa897 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Proto-Oncogene Proteins
123 rdf:type schema:DefinedTerm
124 Nae451656277d486a9ed69a5a00596e80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Leukemia
126 rdf:type schema:DefinedTerm
127 Nb71cd72794694bf3a4120ae926948240 rdf:first sg:person.07536132772.78
128 rdf:rest Na05c4ee42eb64f12a01e8c4125613e8d
129 Nb8d2d8bed259473a9a593028e0cdee85 rdf:first sg:person.01315524472.14
130 rdf:rest Nbe28387647424b03906de3a5649f52cd
131 Nbe1a1da9d48e43c0acad3c4df438842e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Receptor Protein-Tyrosine Kinases
133 rdf:type schema:DefinedTerm
134 Nbe28387647424b03906de3a5649f52cd rdf:first sg:person.010572466152.21
135 rdf:rest Nb71cd72794694bf3a4120ae926948240
136 Nc9fa767cc05842c6b458945e887927ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Multigene Family
138 rdf:type schema:DefinedTerm
139 Ncb7dab41fd104e8f8195b6be953f93da schema:name dimensions_id
140 schema:value pub.1031254959
141 rdf:type schema:PropertyValue
142 Nf03ee1a2a07d486fb219d890793a6a83 schema:name nlm_unique_id
143 schema:value 8704895
144 rdf:type schema:PropertyValue
145 Nf149c36dc81846608d510f62611d67af rdf:first sg:person.0756710020.21
146 rdf:rest N841c15eaccd34c0a98b4df7a5ea825dc
147 Nfe0bb55206f84e3b93504a365e94dac8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Female
149 rdf:type schema:DefinedTerm
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
154 schema:name Oncology and Carcinogenesis
155 rdf:type schema:DefinedTerm
156 sg:journal.1097065 schema:issn 0887-6924
157 1476-5551
158 schema:name Leukemia
159 rdf:type schema:Periodical
160 sg:person.01030457735.59 schema:affiliation https://www.grid.ac/institutes/grid.272458.e
161 schema:familyName Horiike
162 schema:givenName S
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030457735.59
164 rdf:type schema:Person
165 sg:person.010572466152.21 schema:familyName Fujii
166 schema:givenName H
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010572466152.21
168 rdf:type schema:Person
169 sg:person.011365414042.29 schema:familyName Iwai
170 schema:givenName T
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011365414042.29
172 rdf:type schema:Person
173 sg:person.01305161323.40 schema:familyName Sasai
174 schema:givenName Y
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305161323.40
176 rdf:type schema:Person
177 sg:person.01315524472.14 schema:familyName Kashima
178 schema:givenName K
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315524472.14
180 rdf:type schema:Person
181 sg:person.01320436003.92 schema:familyName Taniwaki
182 schema:givenName M
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320436003.92
184 rdf:type schema:Person
185 sg:person.0644335631.56 schema:familyName Misawa
186 schema:givenName S
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644335631.56
188 rdf:type schema:Person
189 sg:person.0654573623.26 schema:familyName Yokota
190 schema:givenName S
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654573623.26
192 rdf:type schema:Person
193 sg:person.07536132772.78 schema:familyName Abe
194 schema:givenName T
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07536132772.78
196 rdf:type schema:Person
197 sg:person.0756710020.21 schema:familyName Nakao
198 schema:givenName M
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756710020.21
200 rdf:type schema:Person
201 sg:person.0757160060.84 schema:familyName Kaneko
202 schema:givenName H
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757160060.84
204 rdf:type schema:Person
205 https://doi.org/10.1002/1097-0142(19880915)62:6<1129::aid-cncr2820620616>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1002736947
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/0022-2836(85)90388-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024265674
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/0092-8674(91)90010-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1034750830
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/0165-4608(92)90098-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1033942067
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/0378-1119(94)90021-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042308687
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1111/j.1365-2141.1982.tb02771.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019519595
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1111/j.1365-2141.1987.tb01325.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004932480
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1111/j.1365-2141.1988.tb06188.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031947636
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1200/jco.1990.8.8.1424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077294546
222 rdf:type schema:CreativeWork
223 https://doi.org/10.7326/0003-4819-103-4-620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073690404
224 rdf:type schema:CreativeWork
225 https://www.grid.ac/institutes/grid.272458.e schema:alternateName Kyoto Prefectural University of Medicine
226 schema:name Department of Internal Medicine III, Kyoto Prefectural University of Medicine, Japan.
227 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...