Hypermethylation of a 5′ CpG island of p16 is a frequent event in non-Hodgkin’s lymphoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-03

AUTHORS

B Martinez-Delgado, J Fernandez-Piqueras, M J Garcia, E Arranz, J Gallego, C Rivas, M Robledo, J Benitez

ABSTRACT

Hypermethylation of a 5' CpG island of p16 gene has been recently described as a possible way of inactivation of this tumor suppressor gene, alternative to deletions and mutations. We have investigated if hypermethylation of a 5' CpG island of p16 occurs in non-Hodgkin's lymphoma (NHL) and normal lymphoid tissue. A total of 82 NHLs were examined for p16 methylation by Southern blot and PCR analysis. Hypermethylation was detected in approximately 20% of B cell lymphomas of both low and high grade and in 15% of T cell NHL. The highest rate of p16 gene methylation in tumors was found among MALT (mucosa-associated lymphoid tissue) lymphomas in which the percentage of cases with p16 gene methylation reached 67%. However, normal lymphoid tissue was always unmethylated at p16 locus. These results indicate that p16 gene methylation is a frequent event in NHLs, mainly in MALT lymphomas, and suggest that it could be an important mechanism of inactivation of this gene. More... »

PAGES

425

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2400579

DOI

http://dx.doi.org/10.1038/sj.leu.2400579

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030812017

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9067584


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