Genome-wide scan for type 1 diabetic nephropathy in the Finnish population reveals suggestive linkage to a single locus on chromosome ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-01

AUTHORS

A-M Osterholm, B He, J Pitkaniemi, L Albinsson, T Berg, C Sarti, J Tuomilehto, K Tryggvason

ABSTRACT

Diabetic nephropathy (DN) is the primary cause of morbidity and mortality in patients with type 1 as well as type 2 diabetes, and accounts for 40% of end-stage renal disease in the Western world. Familial clustering of DN suggests importance of genetic factors in the development of the disease. In the present study, we performed a two-stage genome-wide scan to search for chromosomal loci containing susceptibility genes for nephropathy in patients with type 1 diabetes. In total, 83 discordant sib pairs (DSPs), sibs concordant for type 1 diabetes but discordant for nephropathy, were collected from Finland, a homogeneous population with one of the highest incidences of type 1 diabetes. To map loci for DN, we applied DSP analysis to detect linkage. In the initial scan, 73 DSPs were typed using 900 markers with an average intermarker distance of approximately 4 cM. Multipoint DSP analysis identified five chromosome regions (3q, 4p, 9q, 16q, and 22p) with maximum logarithm of odds (LOD) score (MLS) >or=1.0 (corresponding to a nominal P-value More... »

PAGES

140-145

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.ki.5001933

DOI

http://dx.doi.org/10.1038/sj.ki.5001933

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036689968

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17021601


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