Lipopolysaccharide-binding protein in noninfected neonates and those with suspected early-onset bacterial infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-02

AUTHORS

T W Orlikowsky, C Trüg, F Neunhoeffer, M Deperschmidt, M Eichner, C F Poets

ABSTRACT

OBJECTIVES: To investigate postnatal lipopolysaccharide-binding protein (LBP) kinetics in term neonates and to test its diagnostic accuracy for early-onset bacterial infection (EOBI). STUDY DESIGN: A total of 99 neonates with clinical and serological signs of EOBI comprised the study group; 198 neonates with risk factors, but without EOBI, served as controls. LBP, C-reactive protein (CRP) and interleukin-8 (IL-8) were determined. RESULTS: LBP in the noninfected group increased until 24 h after birth (P < 0.05 vs 6 h). LBP and CRP correlated strongly in neonates with suspected EOBI (r = 0.63). Although LBP reached a higher sensitivity than CRP 6 and 12 h after clinical suspicion (45 (24-68) and 79% (54-94) vs 9 (0-24) and 39% (17-64); P < 0.05)), EOBI was most reliably detected by IL-8. CONCLUSION: LBP kinetics were age-dependent. LBP was not sufficiently sensitive in the prediction of EOBI. More... »

PAGES

115

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.jp.7211422

DOI

http://dx.doi.org/10.1038/sj.jp.7211422

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048064804

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16407966


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