Versican, a Major Hyaluronan-Binding Component in the Dermis, Loses its Hyaluronan-Binding Ability in Solar Elastosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-07

AUTHORS

Keiko Hasegawa, Masahiko Yoneda, Hiroko Kuwabara, Osamu Miyaishi, Naoki Itano, Akiko Ohno, Masahiro Zako, Zenzo Isogai

ABSTRACT

Versican interacts with hyaluronan (HA) at its N-terminus and with fibrillin-1 at its C terminus. As versican in the dermis connects microfibrils to the HA-rich matrix for viscoelasticity, dermal diseases may involve destruction of these complexes. A recombinant versican protein, rVN, covering the HA binding region (HABR) of human versican and a polyclonal antibody, 6084, against rVN were prepared and characterized. Blotting analyses of skin extracts with 6084 and biotin-conjugated HA revealed that versican was a major HA-binding component in the dermis. Matrix metalloprotease-12, which is expressed in areas of solar elastosis, degraded versican and abrogated its HA-binding ability. Immunohistochemical analyses revealed that the elastic materials in solar elastosis lesions were negative for 6084, but positive for 2B1, an antibody recognizing the C-terminus of versican, indicating loss of the HABR in the aggregated elastic fibers. This loss of the HA-binding ability of versican followed by HA exclusion may be responsible for the pathological and phenotypical changes observed in solar elastosis. More... »

PAGES

1657-1663

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.jid.5700754

DOI

http://dx.doi.org/10.1038/sj.jid.5700754

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036357570

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17363913


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