Waist circumference and body composition in relation to all-cause mortality in middle-aged men and women View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-05-03

AUTHORS

J Bigaard, K Frederiksen, A Tjønneland, B L Thomsen, K Overvad, B L Heitmann, T I A Sørensen

ABSTRACT

OBJECTIVE:Waist circumference is directly related to all-cause mortality when adjusted for body mass index (BMI). Body fat and fat-free body mass, when mutually adjusted, show with increasing values an increasing and decreasing relation to all-cause mortality. We investigated the association of waist circumference and body composition (body fat and fat-free mass), mutually adjusted, to all-cause mortality.DESIGN:A Danish prospective cohort study with a median follow-up period of 5.8 y.SUBJECTS:In all, 27 178 men and 29 875 women, born in Denmark, aged 50–64 y, and without diagnosis of cancer at the time of invitation.MEASUREMENTS:Waist circumference and body composition estimated from impedance measurements. Cox's regression models were used to estimate the mortality rate ratios (RR).RESULTS:Waist circumference was strongly associated with all-cause mortality after adjustment for body composition; the mortality RR was 1.36 (95% confidence intervals (CI): 1.22–1.52) times higher per 10% larger waist circumference among men and 1.30 (95% CI: 1.17–1.44) times higher among women. Adjustment for waist circumference eliminated the association between high values of the body fat mass index (BFMI) and all-cause mortality. The association between fat-free mass index (FFMI) and mortality remained unaltered.CONCLUSION:Waist circumference accounted for the mortality risk associated with excess body fat and not fat-free mass. Waist circumference remained strongly and directly associated with all-cause mortality when adjusted for total body fat in middle-aged men and women, suggesting that the increased mortality risk related to excess body fat is mainly due to abdominal adiposity. More... »

PAGES

778-784

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.ijo.0802976

DOI

http://dx.doi.org/10.1038/sj.ijo.0802976

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010775213

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15917857


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