Endogenous cannabinoid system as a modulator of food intake View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-03

AUTHORS

D Cota, G Marsicano, B Lutz, V Vicennati, G K Stalla, R Pasquali, U Pagotto

ABSTRACT

The ability of Cannabis sativa (marijuana) to increase hunger has been noticed for centuries, although intensive research on its molecular mode of action started only after the characterization of its main psychoactive component Delta(9)-tetrahydrocannabinol in the late 1960s. Despite the public concern related to the abuse of marijuana and its derivatives, scientific studies have pointed to the therapeutic potentials of cannabinoid compounds and have highlighted their ability to stimulate appetite, especially for sweet and palatable food. Later, the discovery of specific receptors and their endogenous ligands (endocannabinoids) suggested the existence of an endogenous cannabinoid system, providing a physiological basis for biological effects induced by marijuana and other cannabinoids. Epidemiological reports describing the appetite-stimulating properties of cannabinoids and the recent insights into the molecular mechanisms underlying cannabinoid action have proposed a central role of the cannabinoid system in obesity. The aim of this review is to provide an extensive overview on the role of this neuromodulatory system in feeding behavior by summarizing the most relevant data obtained from human and animal studies and by elucidating the interactions of the cannabinoid system with the most important neuronal networks and metabolic pathways involved in the control of food intake. Finally, a critical evaluation of future potential therapeutical applications of cannabinoid antagonists in the therapy of obesity and eating disorders will be discussed. More... »

PAGES

0802250

References to SciGraph publications

  • 2001-04. Leptin-regulated endocannabinoids are involved in maintaining food intake in NATURE
  • 2000-04. Central nervous system control of food intake in NATURE
  • 1988-09. Enantiomeric cannabinoids: stereospecificity of psychotropic activity in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2001-11. An anorexic lipid mediator regulated by feeding in NATURE
  • 1970-05. Marijuana Intoxication : Common Experiences in NATURE
  • 1999-04. Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors in PSYCHOPHARMACOLOGY
  • 1976-01. Effects of marihuana use on body weight and caloric intake in humans in PSYCHOPHARMACOLOGY
  • 2000-03. Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation in NATURE MEDICINE
  • 1999-03. The motivation for beer in rats: effects of ritanserin, naloxone and SR 141716 in PSYCHOPHARMACOLOGY
  • 1974-09. Acute and chronic effects of δ9-tetrahydrocannabinol on food intake by rats in PSYCHOPHARMACOLOGIA
  • 2002-08. The endogenous cannabinoid system controls extinction of aversive memories in NATURE
  • 1997-03. Hantavirus in Argentina in NATURE
  • 2001-12. Effects of the cannabinoid receptor antagonist SR 141716, alone and in combination with dexfenfluramine or naloxone, on food intake in rats in PSYCHOPHARMACOLOGY
  • 1993-09. Molecular characterization of a peripheral receptor for cannabinoids in NATURE
  • 2001-01. Synergistic efects of opioid and cannabinoid antagonists on food intake in PSYCHOPHARMACOLOGY
  • 1997-08. A second endogenous cannabinoid that modulates long-term potentiation in NATURE
  • 1997-07. Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors in PSYCHOPHARMACOLOGY
  • 2002-06. Targeting the endocannabinoid system in cancer therapy: A call for further research in NATURE MEDICINE
  • 1974-12. Modification of Δ9-THC-actions by cannabinol and cannabidiol in the rat in PSYCHOPHARMACOLOGIA
  • 1994-12. Formation and inactivation of endogenous cannabinoid anandamide in central neurons in NATURE
  • 1999-06. Design and synthesis of the CB1 selective cannabinoid antagonist AM281: A potential human SPECT ligand in THE AAPS JOURNAL
  • 1990-08. Structure of a cannabinoid receptor and functional expression of the cloned cDNA in NATURE
  • 1999. Cannabinoids and the Control of Chemotherapy-Induced Nausea and Vomiting in MARIHUANA AND MEDICINE
  • 1965-05. Effects of Cannabis sativa (marihuana) on maze performance of the rat in PSYCHOPHARMACOLOGY
  • 1979-09. Cannabinols and feeding in sheep in PSYCHOPHARMACOLOGY
  • 2001-09. Novel Physiologic Functions of Endocannabinoids as Revealed Through the Use of Mutant Mice in NEUROCHEMICAL RESEARCH
  • 2001-10. An endogenous cannabinoid (2-AG) is neuroprotective after brain injury in NATURE
  • 1991-02. Facilitory effect of Δ9-tetrahydrocannabinol on hypothalamically induced feeding in PSYCHOPHARMACOLOGY
  • 1993. Opioid Mechanisms in the Control of Food Consumption and Taste Preferences in OPIOIDS II
  • 1997-03. Marijuana as a medicine in NATURE
  • 1996-05. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y in NATURE
  • 2000-11. Bidirectional control of airway responsiveness by endogenous cannabinoids in NATURE
  • 1971-05. Effects of Marihuana on the Solution of Anagrams, Memory and Appetite in NATURE
  • 2001-04. Physiology: A hunger for cannabinoids in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.ijo.0802250

    DOI

    http://dx.doi.org/10.1038/sj.ijo.0802250

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009659911

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12629555


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