The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-03

AUTHORS

K Clement, S Hercberg, B Passinge, P Galan, M Varroud-Vial, AR Shuldiner, BA Beamer, G Charpentier, B Guy-Grand, P Froguel, C Vaisse

ABSTRACT

OBJECTIVE: Peroxisome-proliferator-activated receptors gamma (PPAR gamma), is a key regulator of adipocyte differentiation and energy balance. Two naturally occurring mutations in the PPAR gamma gene, Pro115Gln and Pro12Ala, have recently been shown to impair the function of the PPAR gamma2 isoform of the receptor and to be associated with obesity or diabetes-related phenotypes in different populations. SUBJECTS: We studied the occurrence and possible associations of the Pro115Gln and Pro12Ala in the PPAR gamma2 gene with several clinical and metabolic phenotypes in three independent large populations of non-obese non-diabetic, type 2 diabetic, and morbidly obese French Caucasians. RESULTS: The Pro115Gln mutation was not found in any of the 1069 subjects screened including 626 obese patients. The frequency of the Pro12Ala mutation was similar in all groups (0.08, 0.11, 0.09) and was not associated with BMI or any of the clinical parameters tested. CONCLUSIONS: We conclude that the Pro115Gln mutation is not a frequent cause of morbid obesity in Caucasians and that the Pro12Ala mutation is not associated with clinically significant changes in these populations. More... »

PAGES

0801191

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.ijo.0801191

DOI

http://dx.doi.org/10.1038/sj.ijo.0801191

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034510307

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10757637


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alanine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity, Morbid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proline", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cytoplasmic and Nuclear", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Laboratoire de Nutrition et Service de M\u00e9decine et Nutrition, H\u00f4tel-Dieu place du Parvis Notre Dame 75004 Paris", 
            "CNRS UPRESA 80-90 Institut de Biologie Lille rue Calmette 59000 Lille"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clement", 
        "givenName": "K", 
        "id": "sg:person.01014410227.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014410227.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "ISNTA CNAM, rue Conte Paris 75004, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hercberg", 
        "givenName": "S", 
        "id": "sg:person.01042142266.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042142266.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de Nutrition et Service de M\u00e9decine et Nutrition, H\u00f4tel-Dieu place du Parvis Notre Dame 75004 Paris", 
            "CNRS UPRESA 80-90 Institut de Biologie Lille rue Calmette 59000 Lille"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Passinge", 
        "givenName": "B", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "ISNTA CNAM, rue Conte Paris 75004, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galan", 
        "givenName": "P", 
        "id": "sg:person.01000437634.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000437634.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Sud Francilien", 
          "id": "https://www.grid.ac/institutes/grid.477082.e", 
          "name": [
            "Service de Diabetologie, Centre Hospitalier Sud-Francilien, 59 Bld Henry Dunand, 91108 Corbeil-Essonnes Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Varroud-Vial", 
        "givenName": "M", 
        "id": "sg:person.01126115631.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126115631.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of endocrinology, diabetes and nutrition, University of Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shuldiner", 
        "givenName": "AR", 
        "id": "sg:person.01224753513.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224753513.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Geriatric Medicine, John Hopkins University, Baltimore, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beamer", 
        "givenName": "BA", 
        "id": "sg:person.01170703017.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170703017.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Sud Francilien", 
          "id": "https://www.grid.ac/institutes/grid.477082.e", 
          "name": [
            "Service de Diabetologie, Centre Hospitalier Sud-Francilien, 59 Bld Henry Dunand, 91108 Corbeil-Essonnes Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Charpentier", 
        "givenName": "G", 
        "id": "sg:person.01122664436.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122664436.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de Nutrition et Service de M\u00e9decine et Nutrition, H\u00f4tel-Dieu place du Parvis Notre Dame 75004 Paris"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guy-Grand", 
        "givenName": "B", 
        "id": "sg:person.0106655163.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0106655163.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de Nutrition et Service de M\u00e9decine et Nutrition, H\u00f4tel-Dieu place du Parvis Notre Dame 75004 Paris", 
            "CNRS UPRESA 80-90 Institut de Biologie Lille rue Calmette 59000 Lille"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Froguel", 
        "givenName": "P", 
        "id": "sg:person.011675646602.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011675646602.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Sud Francilien", 
          "id": "https://www.grid.ac/institutes/grid.477082.e", 
          "name": [
            "Laboratoire de Nutrition et Service de M\u00e9decine et Nutrition, H\u00f4tel-Dieu place du Parvis Notre Dame 75004 Paris", 
            "CNRS UPRESA 80-90 Institut de Biologie Lille rue Calmette 59000 Lille", 
            "Service de Diabetologie, Centre Hospitalier Sud-Francilien, 59 Bld Henry Dunand, 91108 Corbeil-Essonnes Cedex, France", 
            "Present address: Dept of medicine, VCSF, San Francisco, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vaisse", 
        "givenName": "C", 
        "id": "sg:person.0751276106.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751276106.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejm199810013391403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000019853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81359-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001926405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0149-2918(98)80086-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005707000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.22.12953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015129002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1998.9421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020387237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/3099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021923714", 
          "https://doi.org/10.1038/3099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/3099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021923714", 
          "https://doi.org/10.1038/3099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024911463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1998.9962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025444819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-9084(97)81496-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029532663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijo.0800440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032661014", 
          "https://doi.org/10.1038/sj.ijo.0800440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijo.0800440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032661014", 
          "https://doi.org/10.1038/sj.ijo.0800440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1997.7798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034314910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90193-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035230198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1353/pbm.1998.0060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035429838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-2456(98)00015-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042540944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.47.11.1806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070743737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.48.2.398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070744082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.48.7.1466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070744233"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-03", 
    "datePublishedReg": "2000-03-01", 
    "description": "OBJECTIVE: Peroxisome-proliferator-activated receptors gamma (PPAR gamma), is a key regulator of adipocyte differentiation and energy balance. Two naturally occurring mutations in the PPAR gamma gene, Pro115Gln and Pro12Ala, have recently been shown to impair the function of the PPAR gamma2 isoform of the receptor and to be associated with obesity or diabetes-related phenotypes in different populations.\nSUBJECTS: We studied the occurrence and possible associations of the Pro115Gln and Pro12Ala in the PPAR gamma2 gene with several clinical and metabolic phenotypes in three independent large populations of non-obese non-diabetic, type 2 diabetic, and morbidly obese French Caucasians.\nRESULTS: The Pro115Gln mutation was not found in any of the 1069 subjects screened including 626 obese patients. The frequency of the Pro12Ala mutation was similar in all groups (0.08, 0.11, 0.09) and was not associated with BMI or any of the clinical parameters tested.\nCONCLUSIONS: We conclude that the Pro115Gln mutation is not a frequent cause of morbid obesity in Caucasians and that the Pro12Ala mutation is not associated with clinically significant changes in these populations.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.ijo.0801191", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1035838", 
        "issn": [
          "0307-0565", 
          "1476-5497"
        ], 
        "name": "International Journal of Obesity", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "name": "The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes", 
    "pagination": "0801191", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a46523f795686d092a24d0080c9d0c4bbd8d20ba98b28dbbf521dcb7eb4fb9c2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10757637"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9313169"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.ijo.0801191"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034510307"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.ijo.0801191", 
      "https://app.dimensions.ai/details/publication/pub.1034510307"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53978_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/0801191"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.ijo.0801191'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.ijo.0801191'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.ijo.0801191'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.ijo.0801191'


 

This table displays all metadata directly associated to this object as RDF triples.

274 TRIPLES      21 PREDICATES      61 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.ijo.0801191 schema:about N438a9ebd30fb429dac32e05fff0684bb
2 N4444de32d0854c8eb51b8e897261b0a3
3 N4f511ff0ba9c4573bf659e6af26d4540
4 N51550534471f456eaee8ebb19ec49a27
5 N61dff8de20254a3baa03329fb8a9a9d4
6 N67219b521c454180a9a17a0f4a6ee434
7 N6dcf85841497494584ef07dcf76debaf
8 N74519fa50f8a4293bddb8fa439996934
9 N7f164cb5dbac47f1b332195709c73950
10 N83b238dc339e434592907223ce07f637
11 N9aa2b4069c2c4db4beb90dd2cf09b7e1
12 Na9a100fc3e8e489897fbec59990941ae
13 Nbdd7e3657e9944eaaa7b4166ab18392f
14 Nbf545486ef9c4ff58b5fba4924bce4ef
15 Nbfd4d9cf21604523bce3c9ae5666f84a
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N6d103238e8d64f15b95ce815f0adfaae
19 schema:citation sg:pub.10.1038/3099
20 sg:pub.10.1038/sj.ijo.0800440
21 https://doi.org/10.1006/bbrc.1997.7798
22 https://doi.org/10.1006/bbrc.1998.9421
23 https://doi.org/10.1006/bbrc.1998.9962
24 https://doi.org/10.1016/0092-8674(95)90193-0
25 https://doi.org/10.1016/s0092-8674(00)81359-8
26 https://doi.org/10.1016/s0149-2918(98)80086-6
27 https://doi.org/10.1016/s0197-2456(98)00015-4
28 https://doi.org/10.1016/s0300-9084(97)81496-4
29 https://doi.org/10.1056/nejm199810013391403
30 https://doi.org/10.1074/jbc.270.22.12953
31 https://doi.org/10.1172/jci119424
32 https://doi.org/10.1353/pbm.1998.0060
33 https://doi.org/10.2337/diabetes.47.11.1806
34 https://doi.org/10.2337/diabetes.48.2.398
35 https://doi.org/10.2337/diabetes.48.7.1466
36 schema:datePublished 2000-03
37 schema:datePublishedReg 2000-03-01
38 schema:description OBJECTIVE: Peroxisome-proliferator-activated receptors gamma (PPAR gamma), is a key regulator of adipocyte differentiation and energy balance. Two naturally occurring mutations in the PPAR gamma gene, Pro115Gln and Pro12Ala, have recently been shown to impair the function of the PPAR gamma2 isoform of the receptor and to be associated with obesity or diabetes-related phenotypes in different populations. SUBJECTS: We studied the occurrence and possible associations of the Pro115Gln and Pro12Ala in the PPAR gamma2 gene with several clinical and metabolic phenotypes in three independent large populations of non-obese non-diabetic, type 2 diabetic, and morbidly obese French Caucasians. RESULTS: The Pro115Gln mutation was not found in any of the 1069 subjects screened including 626 obese patients. The frequency of the Pro12Ala mutation was similar in all groups (0.08, 0.11, 0.09) and was not associated with BMI or any of the clinical parameters tested. CONCLUSIONS: We conclude that the Pro115Gln mutation is not a frequent cause of morbid obesity in Caucasians and that the Pro12Ala mutation is not associated with clinically significant changes in these populations.
39 schema:genre research_article
40 schema:inLanguage en
41 schema:isAccessibleForFree true
42 schema:isPartOf N15a713edec534110922da876f5c4876f
43 Ndb3d3b2a2a71446aa53be501cb19ab83
44 sg:journal.1035838
45 schema:name The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes
46 schema:pagination 0801191
47 schema:productId N061a2918f1b743f8bfb3fa80db442611
48 N41162cf8aec847bead7cd88c506331de
49 N5509703ba70e481ca9aae31b7da8747b
50 Na50693ca3c2845209e4fe95302b60310
51 Ne240292eb17b47d088f7d167c2d7ee4a
52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034510307
53 https://doi.org/10.1038/sj.ijo.0801191
54 schema:sdDatePublished 2019-04-11T12:11
55 schema:sdLicense https://scigraph.springernature.com/explorer/license/
56 schema:sdPublisher N1ff3b9e846364030a8f7207d1a01e70f
57 schema:url http://www.nature.com/articles/0801191
58 sgo:license sg:explorer/license/
59 sgo:sdDataset articles
60 rdf:type schema:ScholarlyArticle
61 N00a2d1fc355a40da8ac8e6f27139a5df schema:name Division of endocrinology, diabetes and nutrition, University of Maryland
62 rdf:type schema:Organization
63 N061a2918f1b743f8bfb3fa80db442611 schema:name dimensions_id
64 schema:value pub.1034510307
65 rdf:type schema:PropertyValue
66 N0c9eea1fdf8c47a1b3d63ef28a493f77 schema:name ISNTA CNAM, rue Conte Paris 75004, France
67 rdf:type schema:Organization
68 N134828491f0c414e842ae4737eb0a4fb rdf:first N28b076ef02194023a226e1307ae4691a
69 rdf:rest Nabd5311d92c544ccae45d47b9b1b739e
70 N15a713edec534110922da876f5c4876f schema:issueNumber 3
71 rdf:type schema:PublicationIssue
72 N1ff3b9e846364030a8f7207d1a01e70f schema:name Springer Nature - SN SciGraph project
73 rdf:type schema:Organization
74 N28b076ef02194023a226e1307ae4691a schema:affiliation N90b2ce3b14034d7e8248e4b1e99af8de
75 schema:familyName Passinge
76 schema:givenName B
77 rdf:type schema:Person
78 N41162cf8aec847bead7cd88c506331de schema:name readcube_id
79 schema:value a46523f795686d092a24d0080c9d0c4bbd8d20ba98b28dbbf521dcb7eb4fb9c2
80 rdf:type schema:PropertyValue
81 N438a9ebd30fb429dac32e05fff0684bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Female
83 rdf:type schema:DefinedTerm
84 N4444de32d0854c8eb51b8e897261b0a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Middle Aged
86 rdf:type schema:DefinedTerm
87 N4564128347b04a43b6b75be9a24ed693 rdf:first sg:person.01224753513.32
88 rdf:rest Nb21c8c8dace64ad691427e9e2928af7f
89 N4ece11cac94d48ce903d3f01b6abefe3 schema:name Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel-Dieu place du Parvis Notre Dame 75004 Paris
90 rdf:type schema:Organization
91 N4f511ff0ba9c4573bf659e6af26d4540 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Aged
93 rdf:type schema:DefinedTerm
94 N51550534471f456eaee8ebb19ec49a27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Adult
96 rdf:type schema:DefinedTerm
97 N5509703ba70e481ca9aae31b7da8747b schema:name nlm_unique_id
98 schema:value 9313169
99 rdf:type schema:PropertyValue
100 N5d8e7bbc12554580a1b290aa8ad1a262 schema:name CNRS UPRESA 80-90 Institut de Biologie Lille rue Calmette 59000 Lille
101 Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel-Dieu place du Parvis Notre Dame 75004 Paris
102 rdf:type schema:Organization
103 N61dff8de20254a3baa03329fb8a9a9d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Proline
105 rdf:type schema:DefinedTerm
106 N67219b521c454180a9a17a0f4a6ee434 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Humans
108 rdf:type schema:DefinedTerm
109 N6d103238e8d64f15b95ce815f0adfaae rdf:first sg:person.01014410227.71
110 rdf:rest Ne544baa04d514f3c84a230f6f5b5854e
111 N6dcf85841497494584ef07dcf76debaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Receptors, Cytoplasmic and Nuclear
113 rdf:type schema:DefinedTerm
114 N73daacdb438c4fd38edec67618af53ac schema:name CNRS UPRESA 80-90 Institut de Biologie Lille rue Calmette 59000 Lille
115 Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel-Dieu place du Parvis Notre Dame 75004 Paris
116 rdf:type schema:Organization
117 N74519fa50f8a4293bddb8fa439996934 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Mutation
119 rdf:type schema:DefinedTerm
120 N7f164cb5dbac47f1b332195709c73950 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Diabetes Mellitus, Type 2
122 rdf:type schema:DefinedTerm
123 N83b238dc339e434592907223ce07f637 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Male
125 rdf:type schema:DefinedTerm
126 N90b2ce3b14034d7e8248e4b1e99af8de schema:name CNRS UPRESA 80-90 Institut de Biologie Lille rue Calmette 59000 Lille
127 Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel-Dieu place du Parvis Notre Dame 75004 Paris
128 rdf:type schema:Organization
129 N9aa2b4069c2c4db4beb90dd2cf09b7e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Transcription Factors
131 rdf:type schema:DefinedTerm
132 N9f5d8a3bc0b24a07908297a39b5d45db rdf:first sg:person.0106655163.74
133 rdf:rest Nf93840dc15134cb3a24b7739106806d9
134 Na50693ca3c2845209e4fe95302b60310 schema:name pubmed_id
135 schema:value 10757637
136 rdf:type schema:PropertyValue
137 Na9a100fc3e8e489897fbec59990941ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Glutamine
139 rdf:type schema:DefinedTerm
140 Nabd5311d92c544ccae45d47b9b1b739e rdf:first sg:person.01000437634.10
141 rdf:rest Nb35939615cc0416697d4b0e46e972177
142 Nb21c8c8dace64ad691427e9e2928af7f rdf:first sg:person.01170703017.29
143 rdf:rest Ndd4181c9234c4c07a8c04480d8fcff7c
144 Nb35939615cc0416697d4b0e46e972177 rdf:first sg:person.01126115631.37
145 rdf:rest N4564128347b04a43b6b75be9a24ed693
146 Nbdd7e3657e9944eaaa7b4166ab18392f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Obesity, Morbid
148 rdf:type schema:DefinedTerm
149 Nbf545486ef9c4ff58b5fba4924bce4ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Genotype
151 rdf:type schema:DefinedTerm
152 Nbfd4d9cf21604523bce3c9ae5666f84a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Alanine
154 rdf:type schema:DefinedTerm
155 Nd5f38d3cde8a4a1294b3d34a225a1724 rdf:first sg:person.0751276106.35
156 rdf:rest rdf:nil
157 Ndb3d3b2a2a71446aa53be501cb19ab83 schema:volumeNumber 24
158 rdf:type schema:PublicationVolume
159 Ndd4181c9234c4c07a8c04480d8fcff7c rdf:first sg:person.01122664436.36
160 rdf:rest N9f5d8a3bc0b24a07908297a39b5d45db
161 Ne240292eb17b47d088f7d167c2d7ee4a schema:name doi
162 schema:value 10.1038/sj.ijo.0801191
163 rdf:type schema:PropertyValue
164 Ne544baa04d514f3c84a230f6f5b5854e rdf:first sg:person.01042142266.65
165 rdf:rest N134828491f0c414e842ae4737eb0a4fb
166 Nf1a8658248db4e0b82abc0fcf27c7a87 schema:name ISNTA CNAM, rue Conte Paris 75004, France
167 rdf:type schema:Organization
168 Nf93840dc15134cb3a24b7739106806d9 rdf:first sg:person.011675646602.80
169 rdf:rest Nd5f38d3cde8a4a1294b3d34a225a1724
170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
171 schema:name Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
174 schema:name Clinical Sciences
175 rdf:type schema:DefinedTerm
176 sg:journal.1035838 schema:issn 0307-0565
177 1476-5497
178 schema:name International Journal of Obesity
179 rdf:type schema:Periodical
180 sg:person.01000437634.10 schema:affiliation Nf1a8658248db4e0b82abc0fcf27c7a87
181 schema:familyName Galan
182 schema:givenName P
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000437634.10
184 rdf:type schema:Person
185 sg:person.01014410227.71 schema:affiliation N73daacdb438c4fd38edec67618af53ac
186 schema:familyName Clement
187 schema:givenName K
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014410227.71
189 rdf:type schema:Person
190 sg:person.01042142266.65 schema:affiliation N0c9eea1fdf8c47a1b3d63ef28a493f77
191 schema:familyName Hercberg
192 schema:givenName S
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042142266.65
194 rdf:type schema:Person
195 sg:person.0106655163.74 schema:affiliation N4ece11cac94d48ce903d3f01b6abefe3
196 schema:familyName Guy-Grand
197 schema:givenName B
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0106655163.74
199 rdf:type schema:Person
200 sg:person.01122664436.36 schema:affiliation https://www.grid.ac/institutes/grid.477082.e
201 schema:familyName Charpentier
202 schema:givenName G
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122664436.36
204 rdf:type schema:Person
205 sg:person.01126115631.37 schema:affiliation https://www.grid.ac/institutes/grid.477082.e
206 schema:familyName Varroud-Vial
207 schema:givenName M
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126115631.37
209 rdf:type schema:Person
210 sg:person.011675646602.80 schema:affiliation N5d8e7bbc12554580a1b290aa8ad1a262
211 schema:familyName Froguel
212 schema:givenName P
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011675646602.80
214 rdf:type schema:Person
215 sg:person.01170703017.29 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
216 schema:familyName Beamer
217 schema:givenName BA
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170703017.29
219 rdf:type schema:Person
220 sg:person.01224753513.32 schema:affiliation N00a2d1fc355a40da8ac8e6f27139a5df
221 schema:familyName Shuldiner
222 schema:givenName AR
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224753513.32
224 rdf:type schema:Person
225 sg:person.0751276106.35 schema:affiliation https://www.grid.ac/institutes/grid.477082.e
226 schema:familyName Vaisse
227 schema:givenName C
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751276106.35
229 rdf:type schema:Person
230 sg:pub.10.1038/3099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021923714
231 https://doi.org/10.1038/3099
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/sj.ijo.0800440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032661014
234 https://doi.org/10.1038/sj.ijo.0800440
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1006/bbrc.1997.7798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034314910
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1006/bbrc.1998.9421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020387237
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1006/bbrc.1998.9962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025444819
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/0092-8674(95)90193-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035230198
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0092-8674(00)81359-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001926405
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/s0149-2918(98)80086-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005707000
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/s0197-2456(98)00015-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042540944
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/s0300-9084(97)81496-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029532663
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1056/nejm199810013391403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000019853
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1074/jbc.270.22.12953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015129002
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1172/jci119424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024911463
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1353/pbm.1998.0060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035429838
259 rdf:type schema:CreativeWork
260 https://doi.org/10.2337/diabetes.47.11.1806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070743737
261 rdf:type schema:CreativeWork
262 https://doi.org/10.2337/diabetes.48.2.398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070744082
263 rdf:type schema:CreativeWork
264 https://doi.org/10.2337/diabetes.48.7.1466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070744233
265 rdf:type schema:CreativeWork
266 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
267 schema:name Geriatric Medicine, John Hopkins University, Baltimore, USA
268 rdf:type schema:Organization
269 https://www.grid.ac/institutes/grid.477082.e schema:alternateName Centre Hospitalier Sud Francilien
270 schema:name CNRS UPRESA 80-90 Institut de Biologie Lille rue Calmette 59000 Lille
271 Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel-Dieu place du Parvis Notre Dame 75004 Paris
272 Present address: Dept of medicine, VCSF, San Francisco, USA
273 Service de Diabetologie, Centre Hospitalier Sud-Francilien, 59 Bld Henry Dunand, 91108 Corbeil-Essonnes Cedex, France
274 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...