Inhibition of insulin release by enterostatin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-07-30

AUTHORS

M Ookuma, DA York

ABSTRACT

OBJECTIVE: These studies were designed to investigate the mechanism through which enterostatin inhibits insulin secretion from pancreatic islets.DESIGN: A static islet incubation method was used to study the effects of enterostatin on insulin secretion induced by various secretagogues and to investigate the effect of calcium ions and 8-Br-cyclic AMP on the response to enterostatin. Measurements of islet cAMP concentrations in response to enterostatin were also made.RESULTS: Enterostatin (10−9 to 10−5 M) inhibited insulin secretion from islets incubated in the presence of 16.7 mM glucose in a dose-dependent manner. Enterostatin also inhibited insulin secretion stimulated by glybenclamide (5.0 and 10 μM), phorbol 12-myristate-13-acetate (TPA) (50 and 100 nM), and the kappa-opioid agonist U50,488 (100 nM). The inhibitory effect of enterostatin on TPA-induced insulin secretion was attenuated but still remained in the absence of extracellular Ca2+. The enterostatin inhibition of insulin secretion was blocked by 8-Br-cAMP (1 mM) independent of extracellular Ca2+. Enterostatin reduced the increase in intracellular cyclic AMP (cAMP) content produced by U50,488 (100 nM) and the changes in cAMP content were parallel with changes in insulin release.CONCLUSION: Enterostatin may suppress insulin secretion through the reduction of cAMP, but other mechanisms may also be possible. More... »

PAGES

800-805

References to SciGraph publications

  • 1987-02. Opioid peptides and glucose metabolism in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 1994-09. Enterostatin inhibits insulin secretion from isolated perifused rat islets in ACTA DIABETOLOGICA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.ijo.0800663

    DOI

    http://dx.doi.org/10.1038/sj.ijo.0800663

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044345266

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9725641


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "8-Bromo Cyclic Adenosine Monophosphate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Analysis of Variance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Calcium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colipases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Culture Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclic AMP", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dose-Response Relationship, Drug", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enzyme Precursors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glucose", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glyburide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hypoglycemic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Insulin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Insulin Secretion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Islets of Langerhans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Precursors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Opioid, kappa", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tetradecanoylphorbol Acetate", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA", 
              "id": "http://www.grid.ac/institutes/grid.64337.35", 
              "name": [
                "Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ookuma", 
            "givenName": "M", 
            "id": "sg:person.01264456025.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264456025.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA", 
              "id": "http://www.grid.ac/institutes/grid.64337.35", 
              "name": [
                "Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "York", 
            "givenName": "DA", 
            "id": "sg:person.01337704452.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337704452.60"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf03347164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039554406", 
              "https://doi.org/10.1007/bf03347164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00570372", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039633600", 
              "https://doi.org/10.1007/bf00570372"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1998-07-30", 
        "datePublishedReg": "1998-07-30", 
        "description": "OBJECTIVE: These studies were designed to investigate the mechanism through which enterostatin inhibits insulin secretion from pancreatic islets.DESIGN: A static islet incubation method was used to study the effects of enterostatin on insulin secretion induced by various secretagogues and to investigate the effect of calcium ions and 8-Br-cyclic AMP on the response to enterostatin. Measurements of islet cAMP concentrations in response to enterostatin were also made.RESULTS: Enterostatin (10\u22129 to 10\u22125\u2005M) inhibited insulin secretion from islets incubated in the presence of 16.7\u2005mM glucose in a dose-dependent manner. Enterostatin also inhibited insulin secretion stimulated by glybenclamide (5.0 and 10\u2005\u03bcM), phorbol 12-myristate-13-acetate (TPA) (50 and 100\u2005nM), and the kappa-opioid agonist U50,488 (100\u2005nM). The inhibitory effect of enterostatin on TPA-induced insulin secretion was attenuated but still remained in the absence of extracellular Ca2+. The enterostatin inhibition of insulin secretion was blocked by 8-Br-cAMP (1\u2005mM) independent of extracellular Ca2+. Enterostatin reduced the increase in intracellular cyclic AMP (cAMP) content produced by U50,488 (100\u2005nM) and the changes in cAMP content were parallel with changes in insulin release.CONCLUSION: Enterostatin may suppress insulin secretion through the reduction of cAMP, but other mechanisms may also be possible.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/sj.ijo.0800663", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2494718", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1035838", 
            "issn": [
              "0307-0565", 
              "1476-5497"
            ], 
            "name": "International Journal of Obesity", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "22"
          }
        ], 
        "keywords": [
          "insulin secretion", 
          "insulin release", 
          "extracellular Ca2", 
          "kappa-opioid agonist", 
          "effect of enterostatin", 
          "dose-dependent manner", 
          "intracellular cyclic AMP content", 
          "cyclic AMP content", 
          "reduction of cAMP", 
          "enterostatin", 
          "enterostatin inhibition", 
          "pancreatic islets", 
          "AMP content", 
          "secretion", 
          "inhibitory effect", 
          "cAMP content", 
          "mM glucose", 
          "cAMP concentration", 
          "phorbol 12", 
          "cyclic AMP", 
          "islets", 
          "inhibition", 
          "Ca2", 
          "agonists", 
          "secretagogues", 
          "release", 
          "response", 
          "calcium ions", 
          "cAMP", 
          "AMP", 
          "effect", 
          "glucose", 
          "TPA", 
          "changes", 
          "mechanism", 
          "absence", 
          "study", 
          "increase", 
          "reduction", 
          "presence", 
          "concentration", 
          "manner", 
          "content", 
          "incubation method", 
          "method", 
          "measurements", 
          "ions"
        ], 
        "name": "Inhibition of insulin release by enterostatin", 
        "pagination": "800-805", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1044345266"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.ijo.0800663"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "9725641"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.ijo.0800663", 
          "https://app.dimensions.ai/details/publication/pub.1044345266"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T20:48", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_285.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/sj.ijo.0800663"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.ijo.0800663'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.ijo.0800663'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.ijo.0800663'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.ijo.0800663'


     

    This table displays all metadata directly associated to this object as RDF triples.

    209 TRIPLES      21 PREDICATES      95 URIs      85 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.ijo.0800663 schema:about N02d5c1c251df4fc48304066adbdfe999
    2 N0923fb3008a34b259ee2b816d612d54a
    3 N26b0ee5d75b54bfa9f16634b7f27a4e1
    4 N366c5a7067484ab2938f7e6967748594
    5 N41c94de04f8944609cc59987333184f9
    6 N41d624309e024751bdab266b7238d481
    7 N450f3913dc724dadbd165182a5f0709b
    8 N4d0594951f744fe292d1034a8c9dcc0a
    9 N66bf017fb1f043a193b2f8971bfc9ba8
    10 N68082a914c444f139a8672b9db67939c
    11 N6b77d8f220ba47c9bcf1263d8e1afb72
    12 N6b80e872fbbc476b8800220131c3d1cf
    13 N778b7fb6ba0342d196d83ce665628490
    14 N8149cb5b32db4106a73020398aa5f83c
    15 N87cb1b47ece7480daa99b51870ace48d
    16 N88baa245c0a941a98a69803b43d8ffaf
    17 N88e7a67053164a4c8af47acb5b9386e0
    18 Nac380298cd8d4b7db0f5130c5f09a65e
    19 Nb2a212115c134b2f92847162253c8bb3
    20 Ncf20301a7bc3486db2008cf0f4dc056d
    21 Nf7c6bcc7319945c985fc2bb96b281b25
    22 anzsrc-for:11
    23 anzsrc-for:1103
    24 schema:author Nb56c761ea4ac4207b40607d25868d248
    25 schema:citation sg:pub.10.1007/bf00570372
    26 sg:pub.10.1007/bf03347164
    27 schema:datePublished 1998-07-30
    28 schema:datePublishedReg 1998-07-30
    29 schema:description OBJECTIVE: These studies were designed to investigate the mechanism through which enterostatin inhibits insulin secretion from pancreatic islets.DESIGN: A static islet incubation method was used to study the effects of enterostatin on insulin secretion induced by various secretagogues and to investigate the effect of calcium ions and 8-Br-cyclic AMP on the response to enterostatin. Measurements of islet cAMP concentrations in response to enterostatin were also made.RESULTS: Enterostatin (10−9 to 10−5 M) inhibited insulin secretion from islets incubated in the presence of 16.7 mM glucose in a dose-dependent manner. Enterostatin also inhibited insulin secretion stimulated by glybenclamide (5.0 and 10 μM), phorbol 12-myristate-13-acetate (TPA) (50 and 100 nM), and the kappa-opioid agonist U50,488 (100 nM). The inhibitory effect of enterostatin on TPA-induced insulin secretion was attenuated but still remained in the absence of extracellular Ca2+. The enterostatin inhibition of insulin secretion was blocked by 8-Br-cAMP (1 mM) independent of extracellular Ca2+. Enterostatin reduced the increase in intracellular cyclic AMP (cAMP) content produced by U50,488 (100 nM) and the changes in cAMP content were parallel with changes in insulin release.CONCLUSION: Enterostatin may suppress insulin secretion through the reduction of cAMP, but other mechanisms may also be possible.
    30 schema:genre article
    31 schema:isAccessibleForFree false
    32 schema:isPartOf N29311f18464b417ba7c67a57ec316294
    33 N2b9f1c7e463e4165bc316d3ac3dc82d0
    34 sg:journal.1035838
    35 schema:keywords AMP
    36 AMP content
    37 Ca2
    38 TPA
    39 absence
    40 agonists
    41 cAMP
    42 cAMP concentration
    43 cAMP content
    44 calcium ions
    45 changes
    46 concentration
    47 content
    48 cyclic AMP
    49 cyclic AMP content
    50 dose-dependent manner
    51 effect
    52 effect of enterostatin
    53 enterostatin
    54 enterostatin inhibition
    55 extracellular Ca2
    56 glucose
    57 increase
    58 incubation method
    59 inhibition
    60 inhibitory effect
    61 insulin release
    62 insulin secretion
    63 intracellular cyclic AMP content
    64 ions
    65 islets
    66 kappa-opioid agonist
    67 mM glucose
    68 manner
    69 measurements
    70 mechanism
    71 method
    72 pancreatic islets
    73 phorbol 12
    74 presence
    75 reduction
    76 reduction of cAMP
    77 release
    78 response
    79 secretagogues
    80 secretion
    81 study
    82 schema:name Inhibition of insulin release by enterostatin
    83 schema:pagination 800-805
    84 schema:productId N2ba258c81df844f398688d3079a2eb39
    85 N8578b01a71584b99a14aa9a8249b8a59
    86 N9d2e2aaee5754ac5b2a2a2b2497cf8e7
    87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044345266
    88 https://doi.org/10.1038/sj.ijo.0800663
    89 schema:sdDatePublished 2022-11-24T20:48
    90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    91 schema:sdPublisher N8113d3fbfbd34ed29ffdc372ffb7fcf1
    92 schema:url https://doi.org/10.1038/sj.ijo.0800663
    93 sgo:license sg:explorer/license/
    94 sgo:sdDataset articles
    95 rdf:type schema:ScholarlyArticle
    96 N02d5c1c251df4fc48304066adbdfe999 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Glucose
    98 rdf:type schema:DefinedTerm
    99 N0923fb3008a34b259ee2b816d612d54a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Analysis of Variance
    101 rdf:type schema:DefinedTerm
    102 N26b0ee5d75b54bfa9f16634b7f27a4e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Tetradecanoylphorbol Acetate
    104 rdf:type schema:DefinedTerm
    105 N29311f18464b417ba7c67a57ec316294 schema:volumeNumber 22
    106 rdf:type schema:PublicationVolume
    107 N2b9f1c7e463e4165bc316d3ac3dc82d0 schema:issueNumber 8
    108 rdf:type schema:PublicationIssue
    109 N2ba258c81df844f398688d3079a2eb39 schema:name dimensions_id
    110 schema:value pub.1044345266
    111 rdf:type schema:PropertyValue
    112 N366c5a7067484ab2938f7e6967748594 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Colipases
    114 rdf:type schema:DefinedTerm
    115 N41c94de04f8944609cc59987333184f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Male
    117 rdf:type schema:DefinedTerm
    118 N41d624309e024751bdab266b7238d481 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Protein Precursors
    120 rdf:type schema:DefinedTerm
    121 N450f3913dc724dadbd165182a5f0709b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
    123 rdf:type schema:DefinedTerm
    124 N4d0594951f744fe292d1034a8c9dcc0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Calcium
    126 rdf:type schema:DefinedTerm
    127 N66bf017fb1f043a193b2f8971bfc9ba8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Cyclic AMP
    129 rdf:type schema:DefinedTerm
    130 N68082a914c444f139a8672b9db67939c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Dose-Response Relationship, Drug
    132 rdf:type schema:DefinedTerm
    133 N6b77d8f220ba47c9bcf1263d8e1afb72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Hypoglycemic Agents
    135 rdf:type schema:DefinedTerm
    136 N6b80e872fbbc476b8800220131c3d1cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Insulin Secretion
    138 rdf:type schema:DefinedTerm
    139 N778b7fb6ba0342d196d83ce665628490 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Culture Techniques
    141 rdf:type schema:DefinedTerm
    142 N8113d3fbfbd34ed29ffdc372ffb7fcf1 schema:name Springer Nature - SN SciGraph project
    143 rdf:type schema:Organization
    144 N8149cb5b32db4106a73020398aa5f83c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Islets of Langerhans
    146 rdf:type schema:DefinedTerm
    147 N8578b01a71584b99a14aa9a8249b8a59 schema:name doi
    148 schema:value 10.1038/sj.ijo.0800663
    149 rdf:type schema:PropertyValue
    150 N87cb1b47ece7480daa99b51870ace48d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Glyburide
    152 rdf:type schema:DefinedTerm
    153 N88baa245c0a941a98a69803b43d8ffaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Receptors, Opioid, kappa
    155 rdf:type schema:DefinedTerm
    156 N88e7a67053164a4c8af47acb5b9386e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name 8-Bromo Cyclic Adenosine Monophosphate
    158 rdf:type schema:DefinedTerm
    159 N9d2e2aaee5754ac5b2a2a2b2497cf8e7 schema:name pubmed_id
    160 schema:value 9725641
    161 rdf:type schema:PropertyValue
    162 Nac380298cd8d4b7db0f5130c5f09a65e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Rats
    164 rdf:type schema:DefinedTerm
    165 Nb2a212115c134b2f92847162253c8bb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Animals
    167 rdf:type schema:DefinedTerm
    168 Nb56c761ea4ac4207b40607d25868d248 rdf:first sg:person.01264456025.81
    169 rdf:rest Ncee30c90b07443ddb968390aa41aff14
    170 Ncee30c90b07443ddb968390aa41aff14 rdf:first sg:person.01337704452.60
    171 rdf:rest rdf:nil
    172 Ncf20301a7bc3486db2008cf0f4dc056d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Insulin
    174 rdf:type schema:DefinedTerm
    175 Nf7c6bcc7319945c985fc2bb96b281b25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Enzyme Precursors
    177 rdf:type schema:DefinedTerm
    178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Medical and Health Sciences
    180 rdf:type schema:DefinedTerm
    181 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    182 schema:name Clinical Sciences
    183 rdf:type schema:DefinedTerm
    184 sg:grant.2494718 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.ijo.0800663
    185 rdf:type schema:MonetaryGrant
    186 sg:journal.1035838 schema:issn 0307-0565
    187 1476-5497
    188 schema:name International Journal of Obesity
    189 schema:publisher Springer Nature
    190 rdf:type schema:Periodical
    191 sg:person.01264456025.81 schema:affiliation grid-institutes:grid.64337.35
    192 schema:familyName Ookuma
    193 schema:givenName M
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264456025.81
    195 rdf:type schema:Person
    196 sg:person.01337704452.60 schema:affiliation grid-institutes:grid.64337.35
    197 schema:familyName York
    198 schema:givenName DA
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337704452.60
    200 rdf:type schema:Person
    201 sg:pub.10.1007/bf00570372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039633600
    202 https://doi.org/10.1007/bf00570372
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1007/bf03347164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039554406
    205 https://doi.org/10.1007/bf03347164
    206 rdf:type schema:CreativeWork
    207 grid-institutes:grid.64337.35 schema:alternateName Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    208 schema:name Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    209 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...