Inhibition of HIV-1 or bacterial activation of macrophages by products of HIV-1-resistant human cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-11

AUTHORS

Guanhua Li, Sagiv Aaron, Katarzyna Kazmierczak, Adam Lesner, Yuchang Li, Anna Ivanova, Galina Bentsman, Mary Jane Potash, Malgorzata Simm

ABSTRACT

We have recently described the molecular basis of HIV-1 resistance factor (HRF)-mediated anti-viral activity in primary and transformed CD4 T cells. HRF+ cell culture supernatants or partially purified HRF were found to incapacitate the formation of the NF-kappaB/DNA complex, which is indispensable for long terminal promoter-driven transcription of virus genes. In this study, we tested whether HRF might have much broader activity against other organisms whose pathogenesis is linked to NF-kappaB activation. Specifically, we tested the effects of HRF on the NF-kappaB-mediated responses of primary macrophages to HIV-1 or several bacterial antigens. We found that exposure to HRF inhibited HIV-1 expression in macrophages and also induced the production of HRF-like activity by macrophages, which prevented replication of virus in HIV-1-infected peripheral blood lymphocytes cultured in the adjacent compartment. We investigated the mechanism of this inhibition and found that HRF impeded NF-kappaB/DNA binding in macrophages induced by either HIV-1 or lipopolysaccharide from several bacteria species, resulting in impaired tumor necrosis factor-alpha responses to these organisms. More... »

PAGES

603

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.icb.7100092

DOI

http://dx.doi.org/10.1038/sj.icb.7100092

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17637699


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