Gene therapy progress and prospects: Hydrodynamic gene delivery View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-01

AUTHORS

H Herweijer, J A Wolff

ABSTRACT

Over the last few years, hydrodynamic tail vein delivery has established itself as a simple, yet very effective method for gene transfer into small rodents. Hydrodynamic delivery of plasmid DNA expression vectors or small interfering RNA allows for a broad range of in vivo experiments, including the testing of regulatory elements, antibody generation, evaluation of gene therapy approaches, basic biology and disease model creation (non-heritable transgenics). The recent development of the hydrodynamic limb vein procedure provides a safe nucleic acid delivery technique with equally high efficiency in small and large research animals and, importantly, the prospects for clinical translation. More... »

PAGES

3302891

References to SciGraph publications

  • 2004-08. Intra-arterial delivery of endostatin gene to brain tumors prolongs survival and alters tumor vessel ultrastructure in GENE THERAPY
  • 2003-12. Intravascular naked DNA vaccine encoding glycoprotein B induces protective humoral and cellular immunity against herpes simplex virus type 1 infection in mice in GENE THERAPY
  • 2003-03. Progress and prospects: naked DNA gene transfer and therapy in GENE THERAPY
  • 2005-06. Hydrodynamic liver gene transfer mechanism involves transient sinusoidal blood stasis and massive hepatocyte endocytic vesicles in GENE THERAPY
  • 2004-05. Rat kidney-targeted naked plasmid DNA transfer by retrograde injection into the renal vein in MOLECULAR BIOTECHNOLOGY
  • 2004-04. Hydroporation as the mechanism of hydrodynamic delivery in GENE THERAPY
  • 2004-06. Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice in CANCER GENE THERAPY
  • 2005-03. DNA transposons in vertebrate functional genomics in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2004-06. Restoration of dystrophin expression in mdx mice by intravascular injection of naked DNA containing full-length dystrophin cDNA in GENE THERAPY
  • 2005-07. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system in NATURE
  • 2005-09. Wake-up call for <i>Sleeping Beauty</i> in NATURE METHODS
  • 2005-02. Comparative genomic analysis reveals a distant liver enhancer upstream of the COUP-TFII gene in MAMMALIAN GENOME
  • 2003-08. Hydrodynamics-based delivery of the viral interleukin-10 gene suppresses experimental crescentic glomerulonephritis in Wistar–Kyoto rats in GENE THERAPY
  • 2003-09. Long-term therapeutic levels of human alpha-1 antitrypsin in plasma after hydrodynamic injection of nonviral DNA in GENE THERAPY
  • Journal

    TITLE

    Gene Therapy

    ISSUE

    2

    VOLUME

    14

    Related Patents

  • Modified Polynucleotides For The Production Of Secreted Proteins
  • Engineered Nucleic Acids Encoding A Modified Erythropoietin And Their Expression
  • Application Of Mrna For Use As A Therapeutic Agent For Tumorous Diseases
  • Modified Polynucleotides For The Production Of Biologics And Proteins Associated With Human Disease
  • Modified Polynucleotides Encoding Granulysin
  • Modified Polynucleotides For Treating Galactosylceramidase Protein Deficiency
  • In Vivo Delivery Of Double Stranded Rna To A Target Cell
  • Autism-Associated Biomarkers And Uses Thereof
  • Application Of Mrna For Use As A Therapeutic Against Tumor Diseases
  • Modified Polynucleotides Encoding Apoptosis Inducing Factor 1
  • Modified Polynucleotides For The Production Of Nuclear Proteins
  • Modified Polynucleotides Encoding Cited4
  • Methods Of Treating Metabolic Disease
  • Modified Polynucleotides Encoding Septin-4
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Modified Polynucleotides For Treating Protein Deficiency
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides For The Production Of Proteins Associated With Human Disease
  • Formulation And Delivery Of Plga Microspheres
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Compositions And Methods Of Altering Cholesterol Levels
  • Method For Opening Tight Junctions
  • Modified Polynucleotides Encoding Copper Metabolism (Murr1) Domain Containing 1
  • Modified Polynucleotides Encoding Basic Helix-Loop-Helix Family Member E41
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides For The Production Of Proteins
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides For The Production Of Oncology-Related Proteins And Peptides
  • Modified Polynucleotides For The Production Of G-Csf
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Terminally Modified Rna
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides For The Production Of Cosmetic Proteins And Peptides
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Modified Polynucleotides Encoding Siah E3 Ubiquitin Protein Ligase 1
  • Dlin-Kc2-Dma Lipid Nanoparticle Delivery Of Modified Polynucleotides
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Modified Polynucleotides For The Production Of Secreted Proteins
  • Modified Polynucleotides Encoding Hepatitis A Virus Cellular Receptor 2
  • In Vivo Production Of Proteins
  • Modified Polynucleotides For The Production Of Proteins
  • Method For Producing A Protein Of Interest In A Primate
  • Method For Opening Tight Junctions
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Modified Polynucleotides Encoding Aquaporin-5
  • Modified Polynucleotides For The Production Of Proteins Associated With Blood And Lymphatic Disorders
  • Modified Polynucleotides Encoding Aryl Hydrocarbon Receptor Nuclear Translocator
  • Modified Polynucleotides For The Production Of Proteins Associated With Blood And Lymphatic Disorders
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Split Dose Administration
  • Modified Polynucleotides For The Production Of Biologics And Proteins Associated With Human Disease
  • Formulation And Delivery Of Plga Microspheres
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.gt.3302891

    DOI

    http://dx.doi.org/10.1038/sj.gt.3302891

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051944965

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17167496


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1004", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Biotechnology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Technology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Injections, Intravenous", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Muscle, Skeletal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Small Interfering", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transfection", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Mirus Bio", 
              "id": "https://www.grid.ac/institutes/grid.281617.b", 
              "name": [
                "Mirus Bio Corporation, Madison, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Herweijer", 
            "givenName": "H", 
            "id": "sg:person.01222775705.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222775705.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Wisconsin\u2013Madison", 
              "id": "https://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "Mirus Bio Corporation, Madison, WI, USA", 
                "Departments of Pediatrics and Medical Genetics, Waisman Center, University of Wisconsin-Madison, Madison, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wolff", 
            "givenName": "J A", 
            "id": "sg:person.010574530632.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010574530632.11"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/s1525-0016(03)00216-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000165918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1525-0016(03)00216-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000165918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1081/ncn-200060136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000529000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2004.04.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002145332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2004.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002161099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-11-4532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002287674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2004.06.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003669375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003679142", 
              "https://doi.org/10.1038/sj.gt.3302469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003679142", 
              "https://doi.org/10.1038/sj.gt.3302469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2003.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005671235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/mb:27:1:23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005749443", 
              "https://doi.org/10.1385/mb:27:1:23"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007468874", 
              "https://doi.org/10.1038/nature03691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007468874", 
              "https://doi.org/10.1038/nature03691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007468874", 
              "https://doi.org/10.1038/nature03691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jgm.677", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007883880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.tp.0000118404.66106.e8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009481737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.tp.0000118404.66106.e8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009481737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2005.04.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009641339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012020244", 
              "https://doi.org/10.1038/sj.gt.3302239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012020244", 
              "https://doi.org/10.1038/sj.gt.3302239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-3089.2004.00163.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012543275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-2660(05)54007-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012896591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-2660(05)54007-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012896591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jgm.920", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012926735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000160348.75918.ca", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015281264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016095499", 
              "https://doi.org/10.1038/sj.gt.3302065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016095499", 
              "https://doi.org/10.1038/sj.gt.3302065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-2660(05)54009-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016961895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-2660(05)54009-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016961895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.24.9.4004-4018.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017148426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jgm.541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017804045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00335-004-2442-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018436413", 
              "https://doi.org/10.1007/s00335-004-2442-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00335-004-2442-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018436413", 
              "https://doi.org/10.1007/s00335-004-2442-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.domaniend.2005.06.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018470409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.173.9.5361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019033111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jgm.921", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020555318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2004.03.116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020642068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2004.09.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021217568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2004.07.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024293019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2004.05.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024394631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkl609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024495324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2005.04.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025082275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025157566", 
              "https://doi.org/10.1038/sj.gt.3301988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025157566", 
              "https://doi.org/10.1038/sj.gt.3301988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20042280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025641545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20042280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025641545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-004-4232-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026119341", 
              "https://doi.org/10.1007/s00018-004-4232-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1525-0016(03)00244-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026323120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2004.12.194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026917814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2005.06.066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027908984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2005.06.066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027908984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2006.01.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029325124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/intimm/dxg045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029677135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030074222", 
              "https://doi.org/10.1038/sj.gt.3302210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030074222", 
              "https://doi.org/10.1038/sj.gt.3302210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0503877102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030167815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0503877102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030167815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth0905-637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032726258", 
              "https://doi.org/10.1038/nmeth0905-637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth0905-637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032726258", 
              "https://doi.org/10.1038/nmeth0905-637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033112474", 
              "https://doi.org/10.1038/sj.gt.3302287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033112474", 
              "https://doi.org/10.1038/sj.gt.3302287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033227650", 
              "https://doi.org/10.1038/sj.gt.3302114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033227650", 
              "https://doi.org/10.1038/sj.gt.3302114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2005.10.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033707433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2003.12.107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033766072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2005.07.699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034735451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2005.07.699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034735451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jgm.433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034757306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200425776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035584845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200425776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035584845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cgt.7700705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038056513", 
              "https://doi.org/10.1038/sj.cgt.7700705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cgt.7700705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038056513", 
              "https://doi.org/10.1038/sj.cgt.7700705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jgm.574", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040084937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2005.04.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042150251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2005.04.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042150251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-8278(03)00389-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042381997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-8278(03)00389-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042381997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0502974102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042713757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046516609", 
              "https://doi.org/10.1038/sj.gt.3301983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046516609", 
              "https://doi.org/10.1038/sj.gt.3301983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.04-3233fje", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049436301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2005.10.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049724065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1096-7192(03)00038-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050009539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1096-7192(03)00038-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050009539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2004.09.086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051244111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.hepres.2006.01.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054735929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/1043034041361271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059202681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/1043034041648408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059202685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/hum.2004.15.1279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059272403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/hum.2005.16.361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059272522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/hum.2005.16.929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059272587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/hum.2005.16.985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059272592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/hum.2005.16.985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059272592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000130565.69170.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000130565.69170.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000130565.69170.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000130565.69170.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000139479.09658.ee", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000139479.09658.ee", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000139479.09658.ee", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci21087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063416593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2144/000112088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069095249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076617363", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.175.2.693", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077077120"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2007-01", 
        "datePublishedReg": "2007-01-01", 
        "description": "Over the last few years, hydrodynamic tail vein delivery has established itself as a simple, yet very effective method for gene transfer into small rodents. Hydrodynamic delivery of plasmid DNA expression vectors or small interfering RNA allows for a broad range of in vivo experiments, including the testing of regulatory elements, antibody generation, evaluation of gene therapy approaches, basic biology and disease model creation (non-heritable transgenics). The recent development of the hydrodynamic limb vein procedure provides a safe nucleic acid delivery technique with equally high efficiency in small and large research animals and, importantly, the prospects for clinical translation.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.gt.3302891", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1105638", 
            "issn": [
              "0969-7128", 
              "1476-5462"
            ], 
            "name": "Gene Therapy", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "14"
          }
        ], 
        "name": "Gene therapy progress and prospects: Hydrodynamic gene delivery", 
        "pagination": "3302891", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "f76f681966f5106171805d24bdf19658fc4014ec7fe8eb795d386c64ad720f46"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "17167496"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9421525"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.gt.3302891"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1051944965"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.gt.3302891", 
          "https://app.dimensions.ai/details/publication/pub.1051944965"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:15", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54011_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/3302891"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3302891'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3302891'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3302891'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3302891'


     

    This table displays all metadata directly associated to this object as RDF triples.

    356 TRIPLES      21 PREDICATES      113 URIs      32 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.gt.3302891 schema:about N033782015ad746cba32c123f09ef9a9a
    2 N201c8a690ed74516a1996c20bf47cdd8
    3 N2ba4d9c48fb047edb30ca699f09c114a
    4 N66b73020905f4a489768d86c96ce97dc
    5 N8ae0dc945c0541d59a4bf4bccd9269e8
    6 N8b1fa67a1f114372b0ef2f3a092a9485
    7 N9e7f5bdb7432432fbb869a753f364009
    8 N9fec94a7fca04e618d9086a393b97514
    9 Nc74a43538a3940f1b5980cc480431fec
    10 Ne79c74a757d5424686dfdcf8bc361e4f
    11 Nec1dd53348e2488fa03d09b5f80c1312
    12 anzsrc-for:10
    13 anzsrc-for:1004
    14 schema:author Na08e77c7885745c7afba8493416ce46c
    15 schema:citation sg:pub.10.1007/s00018-004-4232-7
    16 sg:pub.10.1007/s00335-004-2442-9
    17 sg:pub.10.1038/nature03691
    18 sg:pub.10.1038/nmeth0905-637
    19 sg:pub.10.1038/sj.cgt.7700705
    20 sg:pub.10.1038/sj.gt.3301983
    21 sg:pub.10.1038/sj.gt.3301988
    22 sg:pub.10.1038/sj.gt.3302065
    23 sg:pub.10.1038/sj.gt.3302114
    24 sg:pub.10.1038/sj.gt.3302210
    25 sg:pub.10.1038/sj.gt.3302239
    26 sg:pub.10.1038/sj.gt.3302287
    27 sg:pub.10.1038/sj.gt.3302469
    28 sg:pub.10.1385/mb:27:1:23
    29 https://app.dimensions.ai/details/publication/pub.1076617363
    30 https://doi.org/10.1002/eji.200425776
    31 https://doi.org/10.1002/jgm.433
    32 https://doi.org/10.1002/jgm.541
    33 https://doi.org/10.1002/jgm.574
    34 https://doi.org/10.1002/jgm.677
    35 https://doi.org/10.1002/jgm.920
    36 https://doi.org/10.1002/jgm.921
    37 https://doi.org/10.1016/j.bbrc.2003.12.107
    38 https://doi.org/10.1016/j.bbrc.2004.01.005
    39 https://doi.org/10.1016/j.bbrc.2004.03.116
    40 https://doi.org/10.1016/j.bbrc.2004.06.044
    41 https://doi.org/10.1016/j.bbrc.2004.12.194
    42 https://doi.org/10.1016/j.bbrc.2005.06.066
    43 https://doi.org/10.1016/j.domaniend.2005.06.002
    44 https://doi.org/10.1016/j.febslet.2006.01.017
    45 https://doi.org/10.1016/j.hepres.2006.01.008
    46 https://doi.org/10.1016/j.jmb.2004.09.086
    47 https://doi.org/10.1016/j.ymthe.2003.12.003
    48 https://doi.org/10.1016/j.ymthe.2004.04.018
    49 https://doi.org/10.1016/j.ymthe.2004.05.004
    50 https://doi.org/10.1016/j.ymthe.2004.07.010
    51 https://doi.org/10.1016/j.ymthe.2004.09.016
    52 https://doi.org/10.1016/j.ymthe.2005.04.007
    53 https://doi.org/10.1016/j.ymthe.2005.04.014
    54 https://doi.org/10.1016/j.ymthe.2005.04.023
    55 https://doi.org/10.1016/j.ymthe.2005.07.699
    56 https://doi.org/10.1016/j.ymthe.2005.10.014
    57 https://doi.org/10.1016/j.ymthe.2005.10.015
    58 https://doi.org/10.1016/s0065-2660(05)54007-0
    59 https://doi.org/10.1016/s0065-2660(05)54009-4
    60 https://doi.org/10.1016/s0168-8278(03)00389-1
    61 https://doi.org/10.1016/s1096-7192(03)00038-6
    62 https://doi.org/10.1016/s1525-0016(03)00216-8
    63 https://doi.org/10.1016/s1525-0016(03)00244-2
    64 https://doi.org/10.1073/pnas.0502974102
    65 https://doi.org/10.1073/pnas.0503877102
    66 https://doi.org/10.1081/ncn-200060136
    67 https://doi.org/10.1084/jem.20042280
    68 https://doi.org/10.1089/1043034041361271
    69 https://doi.org/10.1089/1043034041648408
    70 https://doi.org/10.1089/hum.2004.15.1279
    71 https://doi.org/10.1089/hum.2005.16.361
    72 https://doi.org/10.1089/hum.2005.16.929
    73 https://doi.org/10.1089/hum.2005.16.985
    74 https://doi.org/10.1093/intimm/dxg045
    75 https://doi.org/10.1093/nar/gkl609
    76 https://doi.org/10.1096/fj.04-3233fje
    77 https://doi.org/10.1097/01.asn.0000130565.69170.85
    78 https://doi.org/10.1097/01.asn.0000139479.09658.ee
    79 https://doi.org/10.1097/01.tp.0000118404.66106.e8
    80 https://doi.org/10.1111/j.1399-3089.2004.00163.x
    81 https://doi.org/10.1128/mcb.24.9.4004-4018.2004
    82 https://doi.org/10.1161/01.cir.0000160348.75918.ca
    83 https://doi.org/10.1172/jci21087
    84 https://doi.org/10.1182/blood-2005-11-4532
    85 https://doi.org/10.2144/000112088
    86 https://doi.org/10.4049/jimmunol.173.9.5361
    87 https://doi.org/10.4049/jimmunol.175.2.693
    88 schema:datePublished 2007-01
    89 schema:datePublishedReg 2007-01-01
    90 schema:description Over the last few years, hydrodynamic tail vein delivery has established itself as a simple, yet very effective method for gene transfer into small rodents. Hydrodynamic delivery of plasmid DNA expression vectors or small interfering RNA allows for a broad range of in vivo experiments, including the testing of regulatory elements, antibody generation, evaluation of gene therapy approaches, basic biology and disease model creation (non-heritable transgenics). The recent development of the hydrodynamic limb vein procedure provides a safe nucleic acid delivery technique with equally high efficiency in small and large research animals and, importantly, the prospects for clinical translation.
    91 schema:genre research_article
    92 schema:inLanguage en
    93 schema:isAccessibleForFree true
    94 schema:isPartOf Nacea364df3074d658a110e701b6b33d5
    95 Nc332170c7c144f53a533a77b1da053e2
    96 sg:journal.1105638
    97 schema:name Gene therapy progress and prospects: Hydrodynamic gene delivery
    98 schema:pagination 3302891
    99 schema:productId N290f71a31db24953a47802adbbc61fdb
    100 N5260515ac0d94465aa3f70cfd7f9dd91
    101 Nab91f0b1129849b1a15926ae6f6a7c77
    102 Nd9de742c5a8a40119b94a6210f260de3
    103 Ne285f2051c5c42ca959c36f011021567
    104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051944965
    105 https://doi.org/10.1038/sj.gt.3302891
    106 schema:sdDatePublished 2019-04-11T12:15
    107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    108 schema:sdPublisher N43655583d718446dafecfe8e2020b4df
    109 schema:url http://www.nature.com/articles/3302891
    110 sgo:license sg:explorer/license/
    111 sgo:sdDataset articles
    112 rdf:type schema:ScholarlyArticle
    113 N033782015ad746cba32c123f09ef9a9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Injections, Intravenous
    115 rdf:type schema:DefinedTerm
    116 N201c8a690ed74516a1996c20bf47cdd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Models, Animal
    118 rdf:type schema:DefinedTerm
    119 N290f71a31db24953a47802adbbc61fdb schema:name readcube_id
    120 schema:value f76f681966f5106171805d24bdf19658fc4014ec7fe8eb795d386c64ad720f46
    121 rdf:type schema:PropertyValue
    122 N2ba4d9c48fb047edb30ca699f09c114a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name DNA
    124 rdf:type schema:DefinedTerm
    125 N43655583d718446dafecfe8e2020b4df schema:name Springer Nature - SN SciGraph project
    126 rdf:type schema:Organization
    127 N486f7d7db28d42a4a2bfe9c5ca561f33 rdf:first sg:person.010574530632.11
    128 rdf:rest rdf:nil
    129 N5260515ac0d94465aa3f70cfd7f9dd91 schema:name pubmed_id
    130 schema:value 17167496
    131 rdf:type schema:PropertyValue
    132 N66b73020905f4a489768d86c96ce97dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Transfection
    134 rdf:type schema:DefinedTerm
    135 N8ae0dc945c0541d59a4bf4bccd9269e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Mice
    137 rdf:type schema:DefinedTerm
    138 N8b1fa67a1f114372b0ef2f3a092a9485 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Animals
    140 rdf:type schema:DefinedTerm
    141 N9e7f5bdb7432432fbb869a753f364009 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Muscle, Skeletal
    143 rdf:type schema:DefinedTerm
    144 N9fec94a7fca04e618d9086a393b97514 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Humans
    146 rdf:type schema:DefinedTerm
    147 Na08e77c7885745c7afba8493416ce46c rdf:first sg:person.01222775705.22
    148 rdf:rest N486f7d7db28d42a4a2bfe9c5ca561f33
    149 Nab91f0b1129849b1a15926ae6f6a7c77 schema:name dimensions_id
    150 schema:value pub.1051944965
    151 rdf:type schema:PropertyValue
    152 Nacea364df3074d658a110e701b6b33d5 schema:issueNumber 2
    153 rdf:type schema:PublicationIssue
    154 Nc332170c7c144f53a533a77b1da053e2 schema:volumeNumber 14
    155 rdf:type schema:PublicationVolume
    156 Nc74a43538a3940f1b5980cc480431fec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Genetic Therapy
    158 rdf:type schema:DefinedTerm
    159 Nd9de742c5a8a40119b94a6210f260de3 schema:name doi
    160 schema:value 10.1038/sj.gt.3302891
    161 rdf:type schema:PropertyValue
    162 Ne285f2051c5c42ca959c36f011021567 schema:name nlm_unique_id
    163 schema:value 9421525
    164 rdf:type schema:PropertyValue
    165 Ne79c74a757d5424686dfdcf8bc361e4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Liver
    167 rdf:type schema:DefinedTerm
    168 Nec1dd53348e2488fa03d09b5f80c1312 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name RNA, Small Interfering
    170 rdf:type schema:DefinedTerm
    171 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
    172 schema:name Technology
    173 rdf:type schema:DefinedTerm
    174 anzsrc-for:1004 schema:inDefinedTermSet anzsrc-for:
    175 schema:name Medical Biotechnology
    176 rdf:type schema:DefinedTerm
    177 sg:journal.1105638 schema:issn 0969-7128
    178 1476-5462
    179 schema:name Gene Therapy
    180 rdf:type schema:Periodical
    181 sg:person.010574530632.11 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
    182 schema:familyName Wolff
    183 schema:givenName J A
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010574530632.11
    185 rdf:type schema:Person
    186 sg:person.01222775705.22 schema:affiliation https://www.grid.ac/institutes/grid.281617.b
    187 schema:familyName Herweijer
    188 schema:givenName H
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222775705.22
    190 rdf:type schema:Person
    191 sg:pub.10.1007/s00018-004-4232-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026119341
    192 https://doi.org/10.1007/s00018-004-4232-7
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1007/s00335-004-2442-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018436413
    195 https://doi.org/10.1007/s00335-004-2442-9
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/nature03691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007468874
    198 https://doi.org/10.1038/nature03691
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/nmeth0905-637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032726258
    201 https://doi.org/10.1038/nmeth0905-637
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/sj.cgt.7700705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038056513
    204 https://doi.org/10.1038/sj.cgt.7700705
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/sj.gt.3301983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046516609
    207 https://doi.org/10.1038/sj.gt.3301983
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/sj.gt.3301988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025157566
    210 https://doi.org/10.1038/sj.gt.3301988
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/sj.gt.3302065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016095499
    213 https://doi.org/10.1038/sj.gt.3302065
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/sj.gt.3302114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033227650
    216 https://doi.org/10.1038/sj.gt.3302114
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/sj.gt.3302210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030074222
    219 https://doi.org/10.1038/sj.gt.3302210
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/sj.gt.3302239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012020244
    222 https://doi.org/10.1038/sj.gt.3302239
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/sj.gt.3302287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033112474
    225 https://doi.org/10.1038/sj.gt.3302287
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/sj.gt.3302469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003679142
    228 https://doi.org/10.1038/sj.gt.3302469
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1385/mb:27:1:23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005749443
    231 https://doi.org/10.1385/mb:27:1:23
    232 rdf:type schema:CreativeWork
    233 https://app.dimensions.ai/details/publication/pub.1076617363 schema:CreativeWork
    234 https://doi.org/10.1002/eji.200425776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035584845
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1002/jgm.433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034757306
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1002/jgm.541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017804045
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1002/jgm.574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040084937
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1002/jgm.677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007883880
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1002/jgm.920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012926735
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1002/jgm.921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020555318
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.bbrc.2003.12.107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033766072
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.bbrc.2004.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002161099
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/j.bbrc.2004.03.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020642068
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/j.bbrc.2004.06.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003669375
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/j.bbrc.2004.12.194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026917814
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/j.bbrc.2005.06.066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027908984
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/j.domaniend.2005.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018470409
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/j.febslet.2006.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029325124
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/j.hepres.2006.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054735929
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/j.jmb.2004.09.086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051244111
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/j.ymthe.2003.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005671235
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.ymthe.2004.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002145332
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.ymthe.2004.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024394631
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.ymthe.2004.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024293019
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.ymthe.2004.09.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021217568
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.ymthe.2005.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009641339
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.ymthe.2005.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025082275
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.ymthe.2005.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042150251
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.ymthe.2005.07.699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034735451
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.ymthe.2005.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049724065
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.ymthe.2005.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033707433
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/s0065-2660(05)54007-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012896591
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/s0065-2660(05)54009-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016961895
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/s0168-8278(03)00389-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042381997
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/s1096-7192(03)00038-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050009539
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/s1525-0016(03)00216-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000165918
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/s1525-0016(03)00244-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026323120
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1073/pnas.0502974102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042713757
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1073/pnas.0503877102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030167815
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1081/ncn-200060136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000529000
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1084/jem.20042280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025641545
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1089/1043034041361271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202681
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1089/1043034041648408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202685
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1089/hum.2004.15.1279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272403
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1089/hum.2005.16.361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272522
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1089/hum.2005.16.929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272587
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1089/hum.2005.16.985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272592
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1093/intimm/dxg045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029677135
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1093/nar/gkl609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024495324
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1096/fj.04-3233fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1049436301
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1097/01.asn.0000130565.69170.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319635
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1097/01.asn.0000139479.09658.ee schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319721
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1097/01.tp.0000118404.66106.e8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009481737
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1111/j.1399-3089.2004.00163.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012543275
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1128/mcb.24.9.4004-4018.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017148426
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1161/01.cir.0000160348.75918.ca schema:sameAs https://app.dimensions.ai/details/publication/pub.1015281264
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1172/jci21087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416593
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1182/blood-2005-11-4532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002287674
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.2144/000112088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069095249
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.4049/jimmunol.173.9.5361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019033111
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.4049/jimmunol.175.2.693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077077120
    349 rdf:type schema:CreativeWork
    350 https://www.grid.ac/institutes/grid.14003.36 schema:alternateName University of Wisconsin–Madison
    351 schema:name Departments of Pediatrics and Medical Genetics, Waisman Center, University of Wisconsin-Madison, Madison, WI, USA
    352 Mirus Bio Corporation, Madison, WI, USA
    353 rdf:type schema:Organization
    354 https://www.grid.ac/institutes/grid.281617.b schema:alternateName Mirus Bio
    355 schema:name Mirus Bio Corporation, Madison, WI, USA
    356 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...