Gene therapy in wound healing: present status and future directions View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-01

AUTHORS

L K Branski, C T Pereira, D N Herndon, M G Jeschke

ABSTRACT

Gene therapy was traditionally considered a treatment modality for patients with congenital defects of key metabolic functions or late-stage malignancies. The realization that gene therapy applications were much vaster has opened up endless opportunities for therapeutic genetic manipulations, especially in the skin and external wounds. Cutaneous wound healing is a complicated, multistep process with numerous mediators that act in a network of activation and inhibition processes. Gene delivery in this environment poses a particular challenge. Numerous models of gene delivery have been developed, including naked DNA application, viral transfection, high-pressure injection, liposomal delivery, and more. Of the various methods for gene transfer, cationic cholesterol-containing liposomal constructs are emerging as a method with great potential for non-viral gene transfer in the wound. This article aims to review the research on gene therapy in wound healing and possible future directions in this exciting field. More... »

PAGES

3302837

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.gt.3302837

    DOI

    http://dx.doi.org/10.1038/sj.gt.3302837

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028902581

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16929353


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