Gene therapy progress and prospects: targeted gene repair View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-04

AUTHORS

H Parekh-Olmedo, L Ferrara, E Brachman, E B Kmiec

ABSTRACT

The capacity to correct a mutant gene within the context of the chromosome holds great promise as a therapy for inherited disorders but fulfilling this promise has proven to be challenging. However, steady progress is being made and the development of gene repair as a viable and robust approach is underway. Here, we present some of the recent advances that are helping to shape our thinking about the feasibility and the limitations of this technique. For the most part, these advances center on understanding the regulation of the reaction and validating its application in animal models. More... »

PAGES

3302511

References to SciGraph publications

  • 2003-01. Oligonucleotide-directed single-base DNA alterations in mouse embryonic stem cells in GENE THERAPY
  • 2002-07. Association of p53 and MSH2 with recombinative repair complexes during S phase in ONCOGENE
  • 2002-12. Mechanisms underlying targeted gene correction using chimeric RNA/DNA and single-stranded DNA oligonucleotides in JOURNAL OF MOLECULAR MEDICINE
  • 2004-10-01. Gene Targeting by Oligonucleotides in Keratinocytes in EPIDERMAL CELLS
  • 2003-10. Correction/mutation of acid α-D-glucosidase gene by modified single-stranded oligonucleotides: in vitro and in vivo studies in GENE THERAPY
  • 2004-05. Targeted conversion of the transthyretin gene in vitro and in vivo in GENE THERAPY
  • 2005-03. Implications of cell cycle progression on functional sequence correction by short single-stranded DNA oligonucleotides in GENE THERAPY
  • 2003-05. Progress and problems with the use of viral vectors for gene therapy in NATURE REVIEWS GENETICS
  • 2004-09. A LacZ-based transgenic mouse for detection of somatic gene repair events in vivo in GENE THERAPY
  • 2003-10. Branched oligonucleotides induce <i>in vivo</i> gene conversion of a mutated EGFP reporter in GENE THERAPY
  • 2005-03. Reaction parameters of targeted gene repair in mammalian cells in MOLECULAR BIOTECHNOLOGY
  • 2002-01. Targeted beta-globin gene conversion in human hematopoietic CD34+ and Lin−CD38− cells in GENE THERAPY
  • 2002-11. Site-specific genomic integration produces therapeutic Factor IX levels in mice in NATURE BIOTECHNOLOGY
  • 2003-09. A comparison of gene repair strategies in cell culture using a lacZ reporter system in GENE THERAPY
  • 2002-12. Simultaneous targeted alteration of the tyrosinase and c-kit genes by single-stranded oligonucleotides in GENE THERAPY
  • 2003-09. The development and regulation of gene repair in NATURE REVIEWS GENETICS
  • 2002-06. Optimising gene repair strategies in cell culture in GENE THERAPY
  • 2004-12-29. Using Nucleases to Stimulate Homologous Recombination in GENETIC RECOMBINATION
  • Journal

    TITLE

    Gene Therapy

    ISSUE

    8

    VOLUME

    12

    Related Patents

  • Increasing Life Span By Modulation Of Smek
  • Use Of Double Stranded Rna To Increase The Efficiency Of Targeted Gene Alteration In Plant Protoplasts
  • Focal Calcium Channel Modulation
  • Mch1r Deficient Mice
  • Methods Of Delivering Therapeutic Agents
  • Targeted Alteration Of Dna
  • Dna Vaccination For Treatment Of Multiple Sclerosis And Insulin-Dependent Diabetes Mellitus
  • Targeted Nanoparticles For Cancer And Other Disorders
  • Alternative Nucleotides For Improved Targeted Nucleotide Exchange
  • Pathotropic Targeted Gene Delivery System For Cancer And Other Disorders
  • Somatic Cloning Gene Transfer For The Production Of Recombinant Proteins, Cells And Organs
  • Process For Delivery Of Polynucleotides To The Prostate
  • Targeted Alteration Of Dna With Oligonucleotides
  • Dna Vaccination For Treatment Of Multiple Sclerosis And Insulin-Dependent Diabetes Mellitus
  • Targeted Alteration Of Dna With Oligonucleotides
  • Dna Vaccination For Treatment Of Autoimmune Disease
  • Plant Callus Populations
  • Polynucleotide Therapy
  • Increasing Life Span By Modulation Of Smek
  • Mutant Receptors And Their Use In A Nuclear Receptor-Based Inducible Gene Expression System
  • Cellular Therapy To Heal Vascular Tissue
  • Treatment Using Herpes Simplex Virus
  • Targeted Alteration Of Dna
  • Mutant Receptors And Their Use In A Nuclear Receptor-Based Inducible Gene Expression System
  • Enhancing Neurotrophin-Induced Neurogenesis By Endogenous Neural Progenitor Cells By Concurrent Overexpression Of Brain Derived Neurotrophic Factor And An Inhibitor Of A Pro-Gliogenic Bone Morphogenetic Protein
  • Targeted Alteration Of Dna
  • Robust, Inducible Cardiac Preferred Expression System For Transgenesis
  • Oncolytic Adenovirus
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.gt.3302511

    DOI

    http://dx.doi.org/10.1038/sj.gt.3302511

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045259912

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15815682


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Repair", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA, Single-Stranded", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Targeting", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Diseases, Inborn", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Point Mutation", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Delaware", 
              "id": "https://www.grid.ac/institutes/grid.33489.35", 
              "name": [
                "Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parekh-Olmedo", 
            "givenName": "H", 
            "id": "sg:person.0772201753.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772201753.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Turin", 
              "id": "https://www.grid.ac/institutes/grid.7605.4", 
              "name": [
                "Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE, USA", 
                "Department of Biology, Genetics, Biochemistry, University of Torino, Torino, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferrara", 
            "givenName": "L", 
            "id": "sg:person.0764560550.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764560550.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rockefeller University", 
              "id": "https://www.grid.ac/institutes/grid.134907.8", 
              "name": [
                "Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE, USA", 
                "The Rockefeller University, New York, NY 10021, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brachman", 
            "givenName": "E", 
            "id": "sg:person.0575472446.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575472446.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Delaware", 
              "id": "https://www.grid.ac/institutes/grid.33489.35", 
              "name": [
                "Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kmiec", 
            "givenName": "E B", 
            "id": "sg:person.0613343025.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613343025.68"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/s0962-8924(02)02380-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003061007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0962-8924(02)02380-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003061007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302079", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003086977", 
              "https://doi.org/10.1038/sj.gt.3302079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302079", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003086977", 
              "https://doi.org/10.1038/sj.gt.3302079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00109-002-0393-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003522889", 
              "https://doi.org/10.1007/s00109-002-0393-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003654890", 
              "https://doi.org/10.1038/nrg1066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003654890", 
              "https://doi.org/10.1038/nrg1066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003776746", 
              "https://doi.org/10.1038/sj.gt.3301750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003776746", 
              "https://doi.org/10.1038/sj.gt.3301750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexcr.2004.06.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005711068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(02)02749-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006862906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(02)02749-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006862906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkf397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007316789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301862", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010215360", 
              "https://doi.org/10.1038/sj.gt.3301862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301862", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010215360", 
              "https://doi.org/10.1038/sj.gt.3301862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2004.07.062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012837948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013904079", 
              "https://doi.org/10.1038/sj.gt.3302096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013904079", 
              "https://doi.org/10.1038/sj.gt.3302096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gng027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018469808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018526440", 
              "https://doi.org/10.1038/sj.gt.3302049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018526440", 
              "https://doi.org/10.1038/sj.gt.3302049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018713930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jgm.249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019288828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.01250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020672239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020749101", 
              "https://doi.org/10.1038/sj.gt.3302311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020749101", 
              "https://doi.org/10.1038/sj.gt.3302311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci19773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021959223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dnarep.2004.06.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022741508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022982316", 
              "https://doi.org/10.1038/sj.gt.3301610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022982316", 
              "https://doi.org/10.1038/sj.gt.3301610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jgm.613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024046719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m211837200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024152626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.02-0127hyp", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025604386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1533177100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028337603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dnarep.2004.03.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028624169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1232375100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028855775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddg133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029002698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.genet.36.061102.093104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030132240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1196/annals.1281.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030815492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031934701", 
              "https://doi.org/10.1038/nbt753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031934701", 
              "https://doi.org/10.1038/nbt753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2004.06.620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032238574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/mb:29:3:197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033060504", 
              "https://doi.org/10.1385/mb:29:3:197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkh822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033210606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.69.10.6216-6224.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033464454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddi020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033862209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkh703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037323895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2004.06.619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037584751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dnarep.2004.11.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038071575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/1-59259-761-0:195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039769214", 
              "https://doi.org/10.1385/1-59259-761-0:195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301857", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043050625", 
              "https://doi.org/10.1038/sj.gt.3301857"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301857", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043050625", 
              "https://doi.org/10.1038/sj.gt.3301857"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/1-59259-830-7:287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044615292", 
              "https://doi.org/10.1385/1-59259-830-7:287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046870045", 
              "https://doi.org/10.1038/sj.gt.3302228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046870045", 
              "https://doi.org/10.1038/sj.gt.3302228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205614", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049138603", 
              "https://doi.org/10.1038/sj.onc.1205614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205614", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049138603", 
              "https://doi.org/10.1038/sj.onc.1205614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg360", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050647642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050959603", 
              "https://doi.org/10.1038/nrg1156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050959603", 
              "https://doi.org/10.1038/nrg1156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051370883", 
              "https://doi.org/10.1038/sj.gt.3302454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051370883", 
              "https://doi.org/10.1038/sj.gt.3302454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/108729002320351557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059208027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/153623002753632066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059214898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/14712598.1.1.41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067588122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1566524043360465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069185612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/1121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070913429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijmm.12.1.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071505438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075064223", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075247023", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076955645", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2005-04", 
        "datePublishedReg": "2005-04-01", 
        "description": "The capacity to correct a mutant gene within the context of the chromosome holds great promise as a therapy for inherited disorders but fulfilling this promise has proven to be challenging. However, steady progress is being made and the development of gene repair as a viable and robust approach is underway. Here, we present some of the recent advances that are helping to shape our thinking about the feasibility and the limitations of this technique. For the most part, these advances center on understanding the regulation of the reaction and validating its application in animal models.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.gt.3302511", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1105638", 
            "issn": [
              "0969-7128", 
              "1476-5462"
            ], 
            "name": "Gene Therapy", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "name": "Gene therapy progress and prospects: targeted gene repair", 
        "pagination": "3302511", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d796e5ea1cf24f41a14f90421016836979f7aa387d503e7aa08b3492e959b66b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "15815682"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9421525"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.gt.3302511"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1045259912"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.gt.3302511", 
          "https://app.dimensions.ai/details/publication/pub.1045259912"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:06", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118342_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/3302511"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3302511'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3302511'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3302511'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3302511'


     

    This table displays all metadata directly associated to this object as RDF triples.

    310 TRIPLES      21 PREDICATES      92 URIs      29 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.gt.3302511 schema:about N182f7607cb5140d9ac8dedd6eb18379f
    2 N1d1e79415c154a04a9dbc8a898559423
    3 N26a25c4d5fb840a29ac2b17494b5cd9f
    4 N7cf69bc965474723a3f0a7fc4c82663b
    5 Na1283cec5450426eab6c20663769797b
    6 Nb17c3f9eb38d4cb49b768bc25ed55452
    7 Ndcf7ac3505c44617a4c513c18ab37463
    8 Ne5228edee21f44ee9e5f23c910877840
    9 anzsrc-for:06
    10 anzsrc-for:0604
    11 schema:author Na8685528c7034d4d80112726ad4686a1
    12 schema:citation sg:pub.10.1007/s00109-002-0393-8
    13 sg:pub.10.1038/nbt753
    14 sg:pub.10.1038/nrg1066
    15 sg:pub.10.1038/nrg1156
    16 sg:pub.10.1038/sj.gt.3301610
    17 sg:pub.10.1038/sj.gt.3301750
    18 sg:pub.10.1038/sj.gt.3301857
    19 sg:pub.10.1038/sj.gt.3301862
    20 sg:pub.10.1038/sj.gt.3302049
    21 sg:pub.10.1038/sj.gt.3302079
    22 sg:pub.10.1038/sj.gt.3302096
    23 sg:pub.10.1038/sj.gt.3302228
    24 sg:pub.10.1038/sj.gt.3302311
    25 sg:pub.10.1038/sj.gt.3302454
    26 sg:pub.10.1038/sj.onc.1205614
    27 sg:pub.10.1385/1-59259-761-0:195
    28 sg:pub.10.1385/1-59259-830-7:287
    29 sg:pub.10.1385/mb:29:3:197
    30 https://app.dimensions.ai/details/publication/pub.1075064223
    31 https://app.dimensions.ai/details/publication/pub.1075247023
    32 https://app.dimensions.ai/details/publication/pub.1076955645
    33 https://doi.org/10.1002/jgm.249
    34 https://doi.org/10.1002/jgm.613
    35 https://doi.org/10.1016/j.bbrc.2004.07.062
    36 https://doi.org/10.1016/j.dnarep.2004.03.020
    37 https://doi.org/10.1016/j.dnarep.2004.06.006
    38 https://doi.org/10.1016/j.dnarep.2004.11.007
    39 https://doi.org/10.1016/j.yexcr.2004.06.021
    40 https://doi.org/10.1016/j.ymthe.2004.06.619
    41 https://doi.org/10.1016/j.ymthe.2004.06.620
    42 https://doi.org/10.1016/s0006-291x(02)02749-3
    43 https://doi.org/10.1016/s0962-8924(02)02380-2
    44 https://doi.org/10.1073/pnas.1232375100
    45 https://doi.org/10.1073/pnas.1533177100
    46 https://doi.org/10.1074/jbc.m211837200
    47 https://doi.org/10.1089/108729002320351557
    48 https://doi.org/10.1089/153623002753632066
    49 https://doi.org/10.1093/hmg/ddg133
    50 https://doi.org/10.1093/hmg/ddi020
    51 https://doi.org/10.1093/nar/gkf397
    52 https://doi.org/10.1093/nar/gkg171
    53 https://doi.org/10.1093/nar/gkg360
    54 https://doi.org/10.1093/nar/gkh703
    55 https://doi.org/10.1093/nar/gkh822
    56 https://doi.org/10.1093/nar/gng027
    57 https://doi.org/10.1096/fj.02-0127hyp
    58 https://doi.org/10.1128/aem.69.10.6216-6224.2003
    59 https://doi.org/10.1146/annurev.genet.36.061102.093104
    60 https://doi.org/10.1172/jci19773
    61 https://doi.org/10.1196/annals.1281.006
    62 https://doi.org/10.1242/jcs.01250
    63 https://doi.org/10.1517/14712598.1.1.41
    64 https://doi.org/10.2174/1566524043360465
    65 https://doi.org/10.2741/1121
    66 https://doi.org/10.3892/ijmm.12.1.109
    67 schema:datePublished 2005-04
    68 schema:datePublishedReg 2005-04-01
    69 schema:description The capacity to correct a mutant gene within the context of the chromosome holds great promise as a therapy for inherited disorders but fulfilling this promise has proven to be challenging. However, steady progress is being made and the development of gene repair as a viable and robust approach is underway. Here, we present some of the recent advances that are helping to shape our thinking about the feasibility and the limitations of this technique. For the most part, these advances center on understanding the regulation of the reaction and validating its application in animal models.
    70 schema:genre research_article
    71 schema:inLanguage en
    72 schema:isAccessibleForFree true
    73 schema:isPartOf Ncab80a3c1f31409f999ff1bf2dc0ae90
    74 Ne71908b6248b4a4b9695beddb7d2e4ac
    75 sg:journal.1105638
    76 schema:name Gene therapy progress and prospects: targeted gene repair
    77 schema:pagination 3302511
    78 schema:productId N1d034b55e473462b8e5271f193a850dc
    79 N419cd2fa51a24a409eaca8ab72d0165d
    80 N58742a2a55e7497088f0830759b3cff4
    81 N86ce867abd97429e977ba5f96995df28
    82 Ncb0f28f85bca43139f2d716417a21e6f
    83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045259912
    84 https://doi.org/10.1038/sj.gt.3302511
    85 schema:sdDatePublished 2019-04-11T12:06
    86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    87 schema:sdPublisher Ne8010ccb2a554df9a56c6c251ff565a4
    88 schema:url http://www.nature.com/articles/3302511
    89 sgo:license sg:explorer/license/
    90 sgo:sdDataset articles
    91 rdf:type schema:ScholarlyArticle
    92 N182f7607cb5140d9ac8dedd6eb18379f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Gene Expression Regulation
    94 rdf:type schema:DefinedTerm
    95 N1d034b55e473462b8e5271f193a850dc schema:name readcube_id
    96 schema:value d796e5ea1cf24f41a14f90421016836979f7aa387d503e7aa08b3492e959b66b
    97 rdf:type schema:PropertyValue
    98 N1d1e79415c154a04a9dbc8a898559423 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Humans
    100 rdf:type schema:DefinedTerm
    101 N1eee002a0c534f2393ef9069261abccd rdf:first sg:person.0575472446.03
    102 rdf:rest N31021972770d4b07bac4532f6f7bbbe2
    103 N26a25c4d5fb840a29ac2b17494b5cd9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name DNA Repair
    105 rdf:type schema:DefinedTerm
    106 N31021972770d4b07bac4532f6f7bbbe2 rdf:first sg:person.0613343025.68
    107 rdf:rest rdf:nil
    108 N419cd2fa51a24a409eaca8ab72d0165d schema:name doi
    109 schema:value 10.1038/sj.gt.3302511
    110 rdf:type schema:PropertyValue
    111 N58742a2a55e7497088f0830759b3cff4 schema:name nlm_unique_id
    112 schema:value 9421525
    113 rdf:type schema:PropertyValue
    114 N7cf69bc965474723a3f0a7fc4c82663b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name DNA, Single-Stranded
    116 rdf:type schema:DefinedTerm
    117 N86ce867abd97429e977ba5f96995df28 schema:name dimensions_id
    118 schema:value pub.1045259912
    119 rdf:type schema:PropertyValue
    120 Na1283cec5450426eab6c20663769797b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Genetic Therapy
    122 rdf:type schema:DefinedTerm
    123 Na8685528c7034d4d80112726ad4686a1 rdf:first sg:person.0772201753.64
    124 rdf:rest Ncf7103a4b4144481adbf9e94a07ab4bd
    125 Nb17c3f9eb38d4cb49b768bc25ed55452 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Gene Targeting
    127 rdf:type schema:DefinedTerm
    128 Ncab80a3c1f31409f999ff1bf2dc0ae90 schema:issueNumber 8
    129 rdf:type schema:PublicationIssue
    130 Ncb0f28f85bca43139f2d716417a21e6f schema:name pubmed_id
    131 schema:value 15815682
    132 rdf:type schema:PropertyValue
    133 Ncf7103a4b4144481adbf9e94a07ab4bd rdf:first sg:person.0764560550.07
    134 rdf:rest N1eee002a0c534f2393ef9069261abccd
    135 Ndcf7ac3505c44617a4c513c18ab37463 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Point Mutation
    137 rdf:type schema:DefinedTerm
    138 Ne5228edee21f44ee9e5f23c910877840 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Genetic Diseases, Inborn
    140 rdf:type schema:DefinedTerm
    141 Ne71908b6248b4a4b9695beddb7d2e4ac schema:volumeNumber 12
    142 rdf:type schema:PublicationVolume
    143 Ne8010ccb2a554df9a56c6c251ff565a4 schema:name Springer Nature - SN SciGraph project
    144 rdf:type schema:Organization
    145 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    146 schema:name Biological Sciences
    147 rdf:type schema:DefinedTerm
    148 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    149 schema:name Genetics
    150 rdf:type schema:DefinedTerm
    151 sg:journal.1105638 schema:issn 0969-7128
    152 1476-5462
    153 schema:name Gene Therapy
    154 rdf:type schema:Periodical
    155 sg:person.0575472446.03 schema:affiliation https://www.grid.ac/institutes/grid.134907.8
    156 schema:familyName Brachman
    157 schema:givenName E
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575472446.03
    159 rdf:type schema:Person
    160 sg:person.0613343025.68 schema:affiliation https://www.grid.ac/institutes/grid.33489.35
    161 schema:familyName Kmiec
    162 schema:givenName E B
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613343025.68
    164 rdf:type schema:Person
    165 sg:person.0764560550.07 schema:affiliation https://www.grid.ac/institutes/grid.7605.4
    166 schema:familyName Ferrara
    167 schema:givenName L
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764560550.07
    169 rdf:type schema:Person
    170 sg:person.0772201753.64 schema:affiliation https://www.grid.ac/institutes/grid.33489.35
    171 schema:familyName Parekh-Olmedo
    172 schema:givenName H
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772201753.64
    174 rdf:type schema:Person
    175 sg:pub.10.1007/s00109-002-0393-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003522889
    176 https://doi.org/10.1007/s00109-002-0393-8
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1038/nbt753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031934701
    179 https://doi.org/10.1038/nbt753
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1038/nrg1066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003654890
    182 https://doi.org/10.1038/nrg1066
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1038/nrg1156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050959603
    185 https://doi.org/10.1038/nrg1156
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/sj.gt.3301610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022982316
    188 https://doi.org/10.1038/sj.gt.3301610
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/sj.gt.3301750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003776746
    191 https://doi.org/10.1038/sj.gt.3301750
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/sj.gt.3301857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043050625
    194 https://doi.org/10.1038/sj.gt.3301857
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/sj.gt.3301862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010215360
    197 https://doi.org/10.1038/sj.gt.3301862
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/sj.gt.3302049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018526440
    200 https://doi.org/10.1038/sj.gt.3302049
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/sj.gt.3302079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003086977
    203 https://doi.org/10.1038/sj.gt.3302079
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/sj.gt.3302096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013904079
    206 https://doi.org/10.1038/sj.gt.3302096
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/sj.gt.3302228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046870045
    209 https://doi.org/10.1038/sj.gt.3302228
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/sj.gt.3302311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020749101
    212 https://doi.org/10.1038/sj.gt.3302311
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/sj.gt.3302454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051370883
    215 https://doi.org/10.1038/sj.gt.3302454
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/sj.onc.1205614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049138603
    218 https://doi.org/10.1038/sj.onc.1205614
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1385/1-59259-761-0:195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039769214
    221 https://doi.org/10.1385/1-59259-761-0:195
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1385/1-59259-830-7:287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044615292
    224 https://doi.org/10.1385/1-59259-830-7:287
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1385/mb:29:3:197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033060504
    227 https://doi.org/10.1385/mb:29:3:197
    228 rdf:type schema:CreativeWork
    229 https://app.dimensions.ai/details/publication/pub.1075064223 schema:CreativeWork
    230 https://app.dimensions.ai/details/publication/pub.1075247023 schema:CreativeWork
    231 https://app.dimensions.ai/details/publication/pub.1076955645 schema:CreativeWork
    232 https://doi.org/10.1002/jgm.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019288828
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1002/jgm.613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024046719
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1016/j.bbrc.2004.07.062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012837948
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1016/j.dnarep.2004.03.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028624169
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/j.dnarep.2004.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022741508
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/j.dnarep.2004.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038071575
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/j.yexcr.2004.06.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005711068
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.ymthe.2004.06.619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037584751
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.ymthe.2004.06.620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032238574
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/s0006-291x(02)02749-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006862906
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/s0962-8924(02)02380-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003061007
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1073/pnas.1232375100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028855775
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1073/pnas.1533177100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028337603
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1074/jbc.m211837200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024152626
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1089/108729002320351557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059208027
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1089/153623002753632066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059214898
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1093/hmg/ddg133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029002698
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1093/hmg/ddi020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033862209
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1093/nar/gkf397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007316789
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1093/nar/gkg171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018713930
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1093/nar/gkg360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050647642
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1093/nar/gkh703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037323895
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1093/nar/gkh822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033210606
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1093/nar/gng027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018469808
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1096/fj.02-0127hyp schema:sameAs https://app.dimensions.ai/details/publication/pub.1025604386
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1128/aem.69.10.6216-6224.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033464454
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1146/annurev.genet.36.061102.093104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030132240
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1172/jci19773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021959223
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1196/annals.1281.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030815492
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1242/jcs.01250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020672239
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1517/14712598.1.1.41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067588122
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.2174/1566524043360465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069185612
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.2741/1121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070913429
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.3892/ijmm.12.1.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071505438
    299 rdf:type schema:CreativeWork
    300 https://www.grid.ac/institutes/grid.134907.8 schema:alternateName Rockefeller University
    301 schema:name Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE, USA
    302 The Rockefeller University, New York, NY 10021, USA
    303 rdf:type schema:Organization
    304 https://www.grid.ac/institutes/grid.33489.35 schema:alternateName University of Delaware
    305 schema:name Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE, USA
    306 rdf:type schema:Organization
    307 https://www.grid.ac/institutes/grid.7605.4 schema:alternateName University of Turin
    308 schema:name Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE, USA
    309 Department of Biology, Genetics, Biochemistry, University of Torino, Torino, Italy
    310 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...