HIV-1-derived lentiviral vectors and fetal route of administration on transgene biodistribution and expression in rhesus monkeys View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-05

AUTHORS

D F Jimenez, C I Lee, C E O'Shea, D B Kohn, A F Tarantal

ABSTRACT

The gene transfer efficiency of lentiviral vectors pseudotyped with vesicular stomatitis virus-glycoprotein (VSV-G) driven by the MND or CMV promoters and expressing the enhanced green fluorescent protein (EGFP) was investigated in fetal rhesus monkeys (Macaca mulatta) (N=21). Fetuses (50+/-10 days gestation; term 165+/-10 days) were injected under ultrasound guidance using an intraperitoneal (i.p.) or intrahepatic (i.h.) approach with a range of 1 x 10(7)-2 x 10(8) infectious particles/fetus. Analysis of transgene biodistribution and expression was performed in multiple tissues at 3-7 months postgene delivery using quantitative techniques. Overall, results indicated the following: (1) i.p. gene transfer at 40 days gestation resulted in a more diffuse distribution of the vector compared to administration at 60 days gestation; (2) vector biodistribution was similar after administration by the i.p. or i.h. routes; and (3) gene expression analysis in transduced tissues showed the presence of mRNA transcripts that correlated with the level of gene transfer. These studies suggest that fetal gene transfer using the i.p. and i.h. routes results in prolonged transduction and expression of the transgene in multiple tissues. More... »

PAGES

821

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.gt.3302464

DOI

http://dx.doi.org/10.1038/sj.gt.3302464

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001063639

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15815706


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HOW TO GET THIS DATA PROGRAMMATICALLY:

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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