Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-02

AUTHORS

M Golzio, L Mazzolini, P Moller, M P Rols, J Teissié

ABSTRACT

Owing to their capacity to induce strong, sequence-specific, gene silencing in cells, short interfering RNAs (siRNAs) represent new potential therapeutic tools. This development requires, however, new safe and efficient in vivo siRNA delivery methods. In the present technical report, we show that electrically mediated siRNA transfer can suppress transgene expression in adult mice muscles. Using electropulsation for siRNA delivery opens the way for a targeted gene silencing on a broad range of tissues. Clinical applications of electropulsation for delivery of other classes of molecules are under trials. We reported that gene silencing was efficiently obtained in vivo in an adult mammal (mouse) with chemically synthesized siRNA after its electrical delivery. The associated gene silencing was followed on the same animal and lasted at least 11 days. Gene silencing was obtained in muscles not only on young adult mice but also on much older animals. No tissue damages were detected under our electrical conditions. Therefore, this method should provide an efficient approach for a localized delivery of siRNAs in various tissues and organs. More... »

PAGES

3302405

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.gt.3302405

DOI

http://dx.doi.org/10.1038/sj.gt.3302405

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024492693

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15592423


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