Gene Therapy Progress and Prospects: Nonviral vectors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-12

AUTHORS

T Niidome, L Huang

ABSTRACT

The success of gene therapy is largely dependent on the development of the gene delivery vector. Recently, gene transfection into target cells using naked DNA, which is a simple and safe approach, has been improved by combining several physical techniques, for example, electroporation, gene gun, ultrasound and hydrodynamic pressure. Chemical approaches have been utilized to improve the efficiency and cell specificity of gene transfer. Novel gene carrier molecules, which facilitate DNA escape from the endosome into the cytosol, have been developed. Several functional polymers, which enable controlled release of DNA in response to an environmental change, have also been reported. Plasmids with reduced number of CpG motifs, the use of PCR fragments and the sequential injection method have been established for the reduction of immune response triggered by plasmid DNA. Construction of a long-lasting gene expression system is also an important theme for nonviral gene therapy. To date, tissue-specific expression, self-replicating and integrating plasmid systems have been reported. Improvement of delivery methods together with intelligent design of the DNA itself has brought about large degrees of enhancement in the efficiency, specificity and temporal control of nonviral vectors. More... »

PAGES

1647

References to SciGraph publications

  • 2001-03. Intramuscular electroporation delivery of IFN-α gene therapy for inhibition of tumor growth located at a distant site in GENE THERAPY
  • 2000-12. Direct intra-cardiomuscular transfer of β2-adrenergic receptor gene augments cardiac output in cardiomyopathic hamsters in GENE THERAPY
  • 2001-01. Efficient in vivo gene transfer by PCR amplified fragment with reduced inflammatory activity in GENE THERAPY
  • 2001-03. Intramuscular electroporation delivery of IL-12 gene for treatment of squamous cell carcinoma located at distant site in CANCER GENE THERAPY
  • 2002-02. Transfection of liver in vivo by biolistic particle delivery in MOLECULAR BIOTECHNOLOGY
  • 2000-05. Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system in NATURE GENETICS
  • 2000-07. Particle-mediated gene transfer into murine livers using a newly developed gene gun in GENE THERAPY
  • 2001-10. Highly efficient gene transfer into murine liver achieved by intravenous administration of naked Epstein–Barr virus (EBV)-based plasmid vectors in GENE THERAPY
  • 2002-03. Polyion complex micelles as vectors in gene therapy – pharmacokinetics and in vivo gene transfer in GENE THERAPY
  • 2000-12. Degradable polymeric carrier for the delivery of IL-10 plasmid DNA to prevent autoimmune insulitis of NOD mice in GENE THERAPY
  • 2000-05. Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo in GENE THERAPY
  • 2000-01. Effective suicide gene therapy in vivo by EBV-based plasmid vector coupled with polyamidoamine dendrimer in GENE THERAPY
  • 2002-02. Utilization of synthetic peptides containing nuclear localization signals for nonviral gene transfer systems in GENE THERAPY
  • 2000-12. Microbubble-enhanced ultrasound for vascular gene delivery in GENE THERAPY
  • 2000-07. Biodegradable Polyester, Poly[α-(4-Aminobutyl)-l-Glycolic Acid], as a Non-Toxic Gene Carrier in PHARMACEUTICAL RESEARCH
  • 2001-12. Skin-targeted gene transfer using in vivo electroporation in GENE THERAPY
  • 2001-01. Topical Gene Transfer into Rat Skin Using Electroporation in PHARMACEUTICAL RESEARCH
  • Journal

    TITLE

    Gene Therapy

    ISSUE

    24

    VOLUME

    9

    Author Affiliations

    Related Patents

  • Gene Expression Profile For Predicting Ovarian Cancer Patient Survival
  • Recombinant Polypeptide Useful For Neurotrophin Receptor Mediated Gene Delivery And As Neurotrophin Agonist
  • Nanocomplex Containing Amphipathic Peptide Useful For Efficient Transfection Of Biomolecules
  • Controlling Transgene Expression Across The Skin
  • Methods And Compositions For The Inhibition Of Stat5 In Prostate Cancer Cells
  • Nanocomplex Containing Amphipathic Peptide Useful For Efficient Transfection Of Biomolecules
  • Compositions, Kits, And Methods For The Diagnosis, Prognosis, Monitoring, Treatment And Modulation Of Post-Transplant Lymphoproliferative Disorders And Hypoxia Associated Angiogenesis Disorders Using Galectin-1
  • Compositions And Methods For Treating And Preventing Heart Tissue Degeneration And Uses Thereof
  • Compositions And Methods For Treating And Preventing Heart Tissue Degeneration, And Uses Thereof
  • Methods And Compositions For Inducing Brown Adipogenesis
  • Methods And Drugs Targeting Eva1 Or Ceacam1 Gene Expression For Treatment And Diagnosing Of Glioma
  • Vaccines For Protection From And Treatment Of Alzheimer's Disease
  • Supramolecular Approach For Preparation Of Size Controllable Nanoparticles
  • Fkbp-L And Uses Thereof
  • Treatment Of Infection Using Single Chain Antibody Gene Therapy
  • Composition Of Anti-Endo180 Antibodies And Methods Of Use For The Treatment Of Cancer And Fibrotic Diseases
  • Vaccines For Protection From And Treatment Of Alzheimer's Disease
  • Compositions And Methods For Generation Of Pluripotent Stem Cells
  • Multivalent Antibody Complexes Targeting Igf-1r Show Potent Toxicity Against Solid Tumors
  • Composition And Method For Inhibiting Tumor Cell Growth
  • Multivalent Antibody Complexes Targeting Igf-1r Show Potent Toxicity Against Solid Tumors
  • Method For Modulating Gene Expression By Modifying The Cpg Content
  • Methods Of Treating Cancer With Antibodies That Target The Insulin-Like Growth Factor Type I Receptor (Igf-1r)
  • Methods For Identifying Modulating Compounds Of Lymphangiogenesis, Means Therefore, Compounds And Uses Thereof
  • Composition Of Anti-Endo180 Antibodies And Methods Of Use For The Treatment Of Cancer And Fibrotic Diseases
  • Methods And Compositions For The Inhibition Of Stat5 In Prostate Cancer Cells
  • Mcpip Protection Against Cardiac Dysfunction
  • Compositions And Methods For Genetic Modification Of Cells Having Cosmetic Function To Enhance Cosmetic Appearance
  • Polycationic Polyrotaxanes Capable Of Forming Complexes With Nucleic Acids
  • Methods And Compositions For The Diagnosis And Treatment Of Cancer
  • Gene Signature For Predicting Prognosis Of Patients With Solid Tumors
  • Vaccines For Protection From And Treatment Of Alzheimer's Disease
  • Multivalent Antibody Complexes Targeting Igf-1r Show Potent Toxicity Against Solid Tumors
  • Regulated Expression Systems
  • Gene Signature For Predicting Prognosis Of Patients With Solid Tumors
  • Glioma Treatment Method, Glioma Testing Method, Method For Delivering Desired Substance To Glioma, And Drugs Used In These Methods
  • Asf1b As A Prognosis Marker And Therapeutic Target In Human Cancer
  • Class Of Monospecific And Bispecific Humanized Antibodies That Target The Insulin-Like Growth Factor Type I Receptor (Igf-1r)
  • Method For Sensitizing Tumor Cells To Chemotherapeutic Prodrug Cpt-11
  • Vaccines For Protection From And Treatment Of Alzheimer's Disease
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.gt.3301923

    DOI

    http://dx.doi.org/10.1038/sj.gt.3301923

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043735865

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12457277


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1004", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Biotechnology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Technology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Replication", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Carriers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Electroporation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liposomes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transfection", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh", 
              "id": "https://www.grid.ac/institutes/grid.21925.3d", 
              "name": [
                "Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Niidome", 
            "givenName": "T", 
            "id": "sg:person.0646211241.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646211241.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh", 
              "id": "https://www.grid.ac/institutes/grid.21925.3d", 
              "name": [
                "Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "L", 
            "id": "sg:person.01005331112.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005331112.69"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.gt.3301665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000051058", 
              "https://doi.org/10.1038/sj.gt.3301665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000051058", 
              "https://doi.org/10.1038/sj.gt.3301665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0735-1097(01)01793-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001127943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2001.0311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001495124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.2000.2558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003593488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0005-2736(01)00441-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004123223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.164.9.4635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004456242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004592524", 
              "https://doi.org/10.1038/sj.gt.3301173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004592524", 
              "https://doi.org/10.1038/sj.gt.3301173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(99)00194-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004669628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.275.14.9970", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005562796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(01)00426-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005872371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2002.0540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007521611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-409x(01)00211-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009105955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009117251", 
              "https://doi.org/10.1038/sj.gt.3301334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009117251", 
              "https://doi.org/10.1038/sj.gt.3301334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2002.0577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009994820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(01)00547-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011180215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.21.12.3926-3934.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012411175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2000.0124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013410039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m004461200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014908780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2001.0419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015381453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2002.0523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016004169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hc1002.105228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016955347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017095695", 
              "https://doi.org/10.1038/sj.gt.3301373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017095695", 
              "https://doi.org/10.1038/sj.gt.3301373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/jhep.2002.32534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017928517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1524-475x.2000.00452.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017935045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2001.0429", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021069768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jgm.222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021696586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021982075", 
              "https://doi.org/10.1038/sj.gt.3301339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021982075", 
              "https://doi.org/10.1038/sj.gt.3301339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.184.13.3657-3663.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022547177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cgt.7700287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022728043", 
              "https://doi.org/10.1038/sj.cgt.7700287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cgt.7700287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022728043", 
              "https://doi.org/10.1038/sj.cgt.7700287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(00)00297-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023541803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hc0902.104720", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024186117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2001.0278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024816804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80436-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025106858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025253184", 
              "https://doi.org/10.1038/sj.gt.3301604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025253184", 
              "https://doi.org/10.1038/sj.gt.3301604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2001.0511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026557281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1521-2254(200003/04)2:2<76::aid-jgm97>3.0.co;2-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028240357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jgm.187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029437488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1007552007765", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029853967", 
              "https://doi.org/10.1023/a:1007552007765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031286308", 
              "https://doi.org/10.1038/sj.gt.3301044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031286308", 
              "https://doi.org/10.1038/sj.gt.3301044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031600136", 
              "https://doi.org/10.1038/sj.gt.3301192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031600136", 
              "https://doi.org/10.1038/sj.gt.3301192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2000.0257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035046192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.101.22.2554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035779188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-409x(01)00242-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036199273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/jhep.2002.33467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036634765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/29.24.5044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036907733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1540-8175.2001.00355.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037007511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037062343", 
              "https://doi.org/10.1038/sj.gt.3301551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037062343", 
              "https://doi.org/10.1038/sj.gt.3301551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037237597", 
              "https://doi.org/10.1038/sj.gt.3301418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037237597", 
              "https://doi.org/10.1038/sj.gt.3301418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039686973", 
              "https://doi.org/10.1038/75568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039686973", 
              "https://doi.org/10.1038/75568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041211445", 
              "https://doi.org/10.1038/sj.gt.3301635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041211445", 
              "https://doi.org/10.1038/sj.gt.3301635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/mb:20:2:145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041648813", 
              "https://doi.org/10.1385/mb:20:2:145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1540-8175.2001.00339.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041961005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-1119(01)00711-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042120743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0735-1097(01)01253-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042948531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045917282", 
              "https://doi.org/10.1038/sj.gt.3301329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045917282", 
              "https://doi.org/10.1038/sj.gt.3301329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2000.0105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047057596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-4362.2000.00925.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048291472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2000.0036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048686845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1011026726938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051105451", 
              "https://doi.org/10.1023/a:1011026726938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2000.0075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051938287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc010070a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc010070a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja015867r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055809903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja015867r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055809903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja016062m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055811697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja016062m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055811697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/10430340050207984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059202074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/10430340150504046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059202167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/104303401750195836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059202243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/104303401750270922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059202271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1566523013348814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069184203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajplung.2000.278.3.l504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074602636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074809663", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2002-12", 
        "datePublishedReg": "2002-12-01", 
        "description": "The success of gene therapy is largely dependent on the development of the gene delivery vector. Recently, gene transfection into target cells using naked DNA, which is a simple and safe approach, has been improved by combining several physical techniques, for example, electroporation, gene gun, ultrasound and hydrodynamic pressure. Chemical approaches have been utilized to improve the efficiency and cell specificity of gene transfer. Novel gene carrier molecules, which facilitate DNA escape from the endosome into the cytosol, have been developed. Several functional polymers, which enable controlled release of DNA in response to an environmental change, have also been reported. Plasmids with reduced number of CpG motifs, the use of PCR fragments and the sequential injection method have been established for the reduction of immune response triggered by plasmid DNA. Construction of a long-lasting gene expression system is also an important theme for nonviral gene therapy. To date, tissue-specific expression, self-replicating and integrating plasmid systems have been reported. Improvement of delivery methods together with intelligent design of the DNA itself has brought about large degrees of enhancement in the efficiency, specificity and temporal control of nonviral vectors.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.gt.3301923", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1105638", 
            "issn": [
              "0969-7128", 
              "1476-5462"
            ], 
            "name": "Gene Therapy", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "24", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Gene Therapy Progress and Prospects: Nonviral vectors", 
        "pagination": "1647", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d054abad4a7a0d9ce39e2069d25bcc3708d40862faaf07a991330ea023aacf1f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "12457277"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9421525"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.gt.3301923"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1043735865"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.gt.3301923", 
          "https://app.dimensions.ai/details/publication/pub.1043735865"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:12", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53990_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/3301923"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3301923'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3301923'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3301923'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3301923'


     

    This table displays all metadata directly associated to this object as RDF triples.

    342 TRIPLES      21 PREDICATES      109 URIs      31 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.gt.3301923 schema:about N1d4e83337b9241aea6ee1894f7a55d0a
    2 N48a52fb4bace4c6c848152ab911f4b00
    3 N5473d6f9b1d74cdd8fac402b34800e22
    4 N564bcbe687f747a3b23083c23933a30d
    5 N744a130e6ef14590b3db6f61a9cec494
    6 N90360a26bb1244bbb633bd80006ab826
    7 N97b4ad52c4ae4c8c85528c6d18f6d214
    8 Nd5327fae74814c80a7a7595d835352a5
    9 Ne1a79e195f09410f89e12ae57c630e50
    10 Nefcea05fcc6945e3a3630f1d5b2acf60
    11 anzsrc-for:10
    12 anzsrc-for:1004
    13 schema:author N68b186894082428aac9137cb8f62cc77
    14 schema:citation sg:pub.10.1023/a:1007552007765
    15 sg:pub.10.1023/a:1011026726938
    16 sg:pub.10.1038/75568
    17 sg:pub.10.1038/sj.cgt.7700287
    18 sg:pub.10.1038/sj.gt.3301044
    19 sg:pub.10.1038/sj.gt.3301173
    20 sg:pub.10.1038/sj.gt.3301192
    21 sg:pub.10.1038/sj.gt.3301329
    22 sg:pub.10.1038/sj.gt.3301334
    23 sg:pub.10.1038/sj.gt.3301339
    24 sg:pub.10.1038/sj.gt.3301373
    25 sg:pub.10.1038/sj.gt.3301418
    26 sg:pub.10.1038/sj.gt.3301551
    27 sg:pub.10.1038/sj.gt.3301604
    28 sg:pub.10.1038/sj.gt.3301635
    29 sg:pub.10.1038/sj.gt.3301665
    30 sg:pub.10.1385/mb:20:2:145
    31 https://app.dimensions.ai/details/publication/pub.1074809663
    32 https://doi.org/10.1002/(sici)1521-2254(200003/04)2:2<76::aid-jgm97>3.0.co;2-4
    33 https://doi.org/10.1002/jgm.187
    34 https://doi.org/10.1002/jgm.222
    35 https://doi.org/10.1006/bbrc.2000.2558
    36 https://doi.org/10.1006/mthe.2000.0036
    37 https://doi.org/10.1006/mthe.2000.0075
    38 https://doi.org/10.1006/mthe.2000.0105
    39 https://doi.org/10.1006/mthe.2000.0124
    40 https://doi.org/10.1006/mthe.2000.0257
    41 https://doi.org/10.1006/mthe.2001.0278
    42 https://doi.org/10.1006/mthe.2001.0311
    43 https://doi.org/10.1006/mthe.2001.0419
    44 https://doi.org/10.1006/mthe.2001.0429
    45 https://doi.org/10.1006/mthe.2001.0511
    46 https://doi.org/10.1006/mthe.2002.0523
    47 https://doi.org/10.1006/mthe.2002.0540
    48 https://doi.org/10.1006/mthe.2002.0577
    49 https://doi.org/10.1016/s0005-2736(01)00441-2
    50 https://doi.org/10.1016/s0092-8674(00)80436-5
    51 https://doi.org/10.1016/s0168-3659(00)00297-2
    52 https://doi.org/10.1016/s0168-3659(01)00426-6
    53 https://doi.org/10.1016/s0168-3659(01)00547-8
    54 https://doi.org/10.1016/s0168-3659(99)00194-7
    55 https://doi.org/10.1016/s0169-409x(01)00211-3
    56 https://doi.org/10.1016/s0169-409x(01)00242-3
    57 https://doi.org/10.1016/s0378-1119(01)00711-9
    58 https://doi.org/10.1016/s0735-1097(01)01253-0
    59 https://doi.org/10.1016/s0735-1097(01)01793-4
    60 https://doi.org/10.1021/bc010070a
    61 https://doi.org/10.1021/ja015867r
    62 https://doi.org/10.1021/ja016062m
    63 https://doi.org/10.1046/j.1365-4362.2000.00925.x
    64 https://doi.org/10.1046/j.1524-475x.2000.00452.x
    65 https://doi.org/10.1046/j.1540-8175.2001.00339.x
    66 https://doi.org/10.1046/j.1540-8175.2001.00355.x
    67 https://doi.org/10.1053/jhep.2002.32534
    68 https://doi.org/10.1053/jhep.2002.33467
    69 https://doi.org/10.1074/jbc.275.14.9970
    70 https://doi.org/10.1074/jbc.m004461200
    71 https://doi.org/10.1089/10430340050207984
    72 https://doi.org/10.1089/10430340150504046
    73 https://doi.org/10.1089/104303401750195836
    74 https://doi.org/10.1089/104303401750270922
    75 https://doi.org/10.1093/nar/29.24.5044
    76 https://doi.org/10.1128/jb.184.13.3657-3663.2002
    77 https://doi.org/10.1128/mcb.21.12.3926-3934.2001
    78 https://doi.org/10.1152/ajplung.2000.278.3.l504
    79 https://doi.org/10.1161/01.cir.101.22.2554
    80 https://doi.org/10.1161/hc0902.104720
    81 https://doi.org/10.1161/hc1002.105228
    82 https://doi.org/10.2174/1566523013348814
    83 https://doi.org/10.4049/jimmunol.164.9.4635
    84 schema:datePublished 2002-12
    85 schema:datePublishedReg 2002-12-01
    86 schema:description The success of gene therapy is largely dependent on the development of the gene delivery vector. Recently, gene transfection into target cells using naked DNA, which is a simple and safe approach, has been improved by combining several physical techniques, for example, electroporation, gene gun, ultrasound and hydrodynamic pressure. Chemical approaches have been utilized to improve the efficiency and cell specificity of gene transfer. Novel gene carrier molecules, which facilitate DNA escape from the endosome into the cytosol, have been developed. Several functional polymers, which enable controlled release of DNA in response to an environmental change, have also been reported. Plasmids with reduced number of CpG motifs, the use of PCR fragments and the sequential injection method have been established for the reduction of immune response triggered by plasmid DNA. Construction of a long-lasting gene expression system is also an important theme for nonviral gene therapy. To date, tissue-specific expression, self-replicating and integrating plasmid systems have been reported. Improvement of delivery methods together with intelligent design of the DNA itself has brought about large degrees of enhancement in the efficiency, specificity and temporal control of nonviral vectors.
    87 schema:genre research_article
    88 schema:inLanguage en
    89 schema:isAccessibleForFree true
    90 schema:isPartOf N5c5f6f9602784f4a9de5f3a1fb972279
    91 N7f9f7ca64d4d40d9a967e261ce89c049
    92 sg:journal.1105638
    93 schema:name Gene Therapy Progress and Prospects: Nonviral vectors
    94 schema:pagination 1647
    95 schema:productId N180fc8d8f4084b3bb73a6ac0ef555d78
    96 N995c69b34ef2477cad793e55e653e69a
    97 Nb2710d7311d34995879042c2d802a644
    98 Nc82ebe0f29f640989d4cadb199ba840e
    99 Ned73705af6ee4d658e540e397fc438c0
    100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043735865
    101 https://doi.org/10.1038/sj.gt.3301923
    102 schema:sdDatePublished 2019-04-11T12:12
    103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    104 schema:sdPublisher N4c9c30a602f5410ba0673db5bf5f0432
    105 schema:url https://www.nature.com/articles/3301923
    106 sgo:license sg:explorer/license/
    107 sgo:sdDataset articles
    108 rdf:type schema:ScholarlyArticle
    109 N180fc8d8f4084b3bb73a6ac0ef555d78 schema:name nlm_unique_id
    110 schema:value 9421525
    111 rdf:type schema:PropertyValue
    112 N1d4e83337b9241aea6ee1894f7a55d0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Gene Expression
    114 rdf:type schema:DefinedTerm
    115 N48a52fb4bace4c6c848152ab911f4b00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Humans
    117 rdf:type schema:DefinedTerm
    118 N48ff5e2de4b9478983e2d4e28bea7f76 rdf:first sg:person.01005331112.69
    119 rdf:rest rdf:nil
    120 N4c9c30a602f5410ba0673db5bf5f0432 schema:name Springer Nature - SN SciGraph project
    121 rdf:type schema:Organization
    122 N5473d6f9b1d74cdd8fac402b34800e22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Drug Carriers
    124 rdf:type schema:DefinedTerm
    125 N564bcbe687f747a3b23083c23933a30d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name DNA
    127 rdf:type schema:DefinedTerm
    128 N5c5f6f9602784f4a9de5f3a1fb972279 schema:issueNumber 24
    129 rdf:type schema:PublicationIssue
    130 N68b186894082428aac9137cb8f62cc77 rdf:first sg:person.0646211241.31
    131 rdf:rest N48ff5e2de4b9478983e2d4e28bea7f76
    132 N744a130e6ef14590b3db6f61a9cec494 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Transfection
    134 rdf:type schema:DefinedTerm
    135 N7f9f7ca64d4d40d9a967e261ce89c049 schema:volumeNumber 9
    136 rdf:type schema:PublicationVolume
    137 N90360a26bb1244bbb633bd80006ab826 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Polymers
    139 rdf:type schema:DefinedTerm
    140 N97b4ad52c4ae4c8c85528c6d18f6d214 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Genetic Therapy
    142 rdf:type schema:DefinedTerm
    143 N995c69b34ef2477cad793e55e653e69a schema:name dimensions_id
    144 schema:value pub.1043735865
    145 rdf:type schema:PropertyValue
    146 Nb2710d7311d34995879042c2d802a644 schema:name doi
    147 schema:value 10.1038/sj.gt.3301923
    148 rdf:type schema:PropertyValue
    149 Nc82ebe0f29f640989d4cadb199ba840e schema:name readcube_id
    150 schema:value d054abad4a7a0d9ce39e2069d25bcc3708d40862faaf07a991330ea023aacf1f
    151 rdf:type schema:PropertyValue
    152 Nd5327fae74814c80a7a7595d835352a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Electroporation
    154 rdf:type schema:DefinedTerm
    155 Ne1a79e195f09410f89e12ae57c630e50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name DNA Replication
    157 rdf:type schema:DefinedTerm
    158 Ned73705af6ee4d658e540e397fc438c0 schema:name pubmed_id
    159 schema:value 12457277
    160 rdf:type schema:PropertyValue
    161 Nefcea05fcc6945e3a3630f1d5b2acf60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Liposomes
    163 rdf:type schema:DefinedTerm
    164 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
    165 schema:name Technology
    166 rdf:type schema:DefinedTerm
    167 anzsrc-for:1004 schema:inDefinedTermSet anzsrc-for:
    168 schema:name Medical Biotechnology
    169 rdf:type schema:DefinedTerm
    170 sg:journal.1105638 schema:issn 0969-7128
    171 1476-5462
    172 schema:name Gene Therapy
    173 rdf:type schema:Periodical
    174 sg:person.01005331112.69 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
    175 schema:familyName Huang
    176 schema:givenName L
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005331112.69
    178 rdf:type schema:Person
    179 sg:person.0646211241.31 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
    180 schema:familyName Niidome
    181 schema:givenName T
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646211241.31
    183 rdf:type schema:Person
    184 sg:pub.10.1023/a:1007552007765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029853967
    185 https://doi.org/10.1023/a:1007552007765
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1023/a:1011026726938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051105451
    188 https://doi.org/10.1023/a:1011026726938
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/75568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039686973
    191 https://doi.org/10.1038/75568
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/sj.cgt.7700287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022728043
    194 https://doi.org/10.1038/sj.cgt.7700287
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/sj.gt.3301044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031286308
    197 https://doi.org/10.1038/sj.gt.3301044
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/sj.gt.3301173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004592524
    200 https://doi.org/10.1038/sj.gt.3301173
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/sj.gt.3301192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031600136
    203 https://doi.org/10.1038/sj.gt.3301192
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/sj.gt.3301329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045917282
    206 https://doi.org/10.1038/sj.gt.3301329
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/sj.gt.3301334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009117251
    209 https://doi.org/10.1038/sj.gt.3301334
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/sj.gt.3301339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021982075
    212 https://doi.org/10.1038/sj.gt.3301339
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/sj.gt.3301373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017095695
    215 https://doi.org/10.1038/sj.gt.3301373
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/sj.gt.3301418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037237597
    218 https://doi.org/10.1038/sj.gt.3301418
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/sj.gt.3301551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037062343
    221 https://doi.org/10.1038/sj.gt.3301551
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/sj.gt.3301604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025253184
    224 https://doi.org/10.1038/sj.gt.3301604
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/sj.gt.3301635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041211445
    227 https://doi.org/10.1038/sj.gt.3301635
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/sj.gt.3301665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000051058
    230 https://doi.org/10.1038/sj.gt.3301665
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1385/mb:20:2:145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041648813
    233 https://doi.org/10.1385/mb:20:2:145
    234 rdf:type schema:CreativeWork
    235 https://app.dimensions.ai/details/publication/pub.1074809663 schema:CreativeWork
    236 https://doi.org/10.1002/(sici)1521-2254(200003/04)2:2<76::aid-jgm97>3.0.co;2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028240357
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1002/jgm.187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029437488
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1002/jgm.222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021696586
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1006/bbrc.2000.2558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003593488
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1006/mthe.2000.0036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048686845
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1006/mthe.2000.0075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051938287
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1006/mthe.2000.0105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047057596
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1006/mthe.2000.0124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013410039
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1006/mthe.2000.0257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035046192
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1006/mthe.2001.0278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024816804
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1006/mthe.2001.0311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001495124
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1006/mthe.2001.0419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015381453
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1006/mthe.2001.0429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021069768
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1006/mthe.2001.0511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026557281
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1006/mthe.2002.0523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016004169
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1006/mthe.2002.0540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007521611
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1006/mthe.2002.0577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009994820
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/s0005-2736(01)00441-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004123223
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/s0092-8674(00)80436-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025106858
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/s0168-3659(00)00297-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023541803
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/s0168-3659(01)00426-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005872371
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/s0168-3659(01)00547-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011180215
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/s0168-3659(99)00194-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004669628
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/s0169-409x(01)00211-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009105955
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/s0169-409x(01)00242-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036199273
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/s0378-1119(01)00711-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042120743
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/s0735-1097(01)01253-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042948531
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/s0735-1097(01)01793-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001127943
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1021/bc010070a schema:sameAs https://app.dimensions.ai/details/publication/pub.1055153215
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1021/ja015867r schema:sameAs https://app.dimensions.ai/details/publication/pub.1055809903
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1021/ja016062m schema:sameAs https://app.dimensions.ai/details/publication/pub.1055811697
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1046/j.1365-4362.2000.00925.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048291472
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1046/j.1524-475x.2000.00452.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017935045
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1046/j.1540-8175.2001.00339.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041961005
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1046/j.1540-8175.2001.00355.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037007511
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1053/jhep.2002.32534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017928517
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1053/jhep.2002.33467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036634765
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1074/jbc.275.14.9970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005562796
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1074/jbc.m004461200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014908780
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1089/10430340050207984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202074
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1089/10430340150504046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202167
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1089/104303401750195836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202243
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1089/104303401750270922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202271
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1093/nar/29.24.5044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036907733
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1128/jb.184.13.3657-3663.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022547177
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1128/mcb.21.12.3926-3934.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012411175
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1152/ajplung.2000.278.3.l504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074602636
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1161/01.cir.101.22.2554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035779188
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1161/hc0902.104720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024186117
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1161/hc1002.105228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016955347
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.2174/1566523013348814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069184203
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.4049/jimmunol.164.9.4635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004456242
    339 rdf:type schema:CreativeWork
    340 https://www.grid.ac/institutes/grid.21925.3d schema:alternateName University of Pittsburgh
    341 schema:name Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
    342 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...