Hepatic intra-arterial delivery of a retroviral vector expressing the cytosine deaminase gene, controlled by the CEA promoter and intraperitoneal treatment ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-08-01

AUTHORS

MJ Humphreys, P Ghaneh, W Greenhalf, F Campbell, TM Clayton, P Everett, BE Huber, CA Richards, MJ Ford, JP Neoptolemos

ABSTRACT

Targeting of colorectal liver metastases by regional gene therapy was tested in a clinically relevant syngeneic model. First, the CEA-CD-113 retroviral vector containing the cytosine deaminase gene controlled by the CEA specific tumour cell promoter, was shown in vitro to convert 5-fluorocytosine to 5-fluorouracil, resulting in cancer cell killing with a large bystander effect. Second, 10 days after the establishment of liver metastases, retroviral vectors were delivered to the liver by hepatic artery injection. After 5-fluorocytosine administration for 7 days, most surface metastases disappeared and tumour volumes were suppressed up to 8.2-fold. The results support the development of this approach for patient treatment. More... »

PAGES

1241-1247

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.gt.3301518

DOI

http://dx.doi.org/10.1038/sj.gt.3301518

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001388877

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11509957


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