Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-05

AUTHORS

L Heller, M J Jaroszeski, D Coppola, C Pottinger, R Gilbert, R Heller

ABSTRACT

Gene therapy by direct delivery of plasmid DNA has several advantages over viral gene transfer, but plasmid delivery is less efficient. In vivo electroporation has been used to enhance delivery of chemotherapeutic agents to tumors in both animal and human studies. Recently, this delivery technique has been extended to large molecules such as plasmid DNA. Here, the successful delivery of plasmids encoding reporter genes to rat hepatocellular carcinomas by in vivo electroporation is demonstrated. More... »

PAGES

826

References to SciGraph publications

Journal

TITLE

Gene Therapy

ISSUE

10

VOLUME

7

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.gt.3301173

    DOI

    http://dx.doi.org/10.1038/sj.gt.3301173

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004592524

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10845719


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