Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-05

AUTHORS

L Heller, M J Jaroszeski, D Coppola, C Pottinger, R Gilbert, R Heller

ABSTRACT

Gene therapy by direct delivery of plasmid DNA has several advantages over viral gene transfer, but plasmid delivery is less efficient. In vivo electroporation has been used to enhance delivery of chemotherapeutic agents to tumors in both animal and human studies. Recently, this delivery technique has been extended to large molecules such as plasmid DNA. Here, the successful delivery of plasmids encoding reporter genes to rat hepatocellular carcinomas by in vivo electroporation is demonstrated. More... »

PAGES

826

References to SciGraph publications

Journal

TITLE

Gene Therapy

ISSUE

10

VOLUME

7

Author Affiliations

Related Patents

  • Electrical Ablation Devices And Methods
  • Electrical Ablation Surgical Instruments
  • Needle Probe Guide
  • Endoscopic Suturing Tension Controlling And Indication Devices
  • Electrical Ablation Devices And Methods
  • Hand Held Surgical Device For Manipulating An Internal Magnet Assembly Within A Patient
  • Electrical Ablation Devices And Methods
  • User Interface Support Devices For Endoscopic Surgical Instruments
  • Overtube With Expandable Tip
  • Surgical Suturing Apparatus
  • Curved Needle Suturing Tool
  • Electroporation Ablation Apparatus, System, And Method
  • Specimen Retrieval Device
  • Surgical Instrument Comprising An Electrode
  • Electrosurgical System Energy Source
  • Actuating And Articulating Surgical Device
  • Suturing Device
  • Surgical Fastening Device
  • Electrical Ablation Devices
  • Endoscopic Drop Off Bag
  • Endoscopic Translumenal Articulatable Steerable Overtube
  • Anastomotic Device
  • Rotational Coupling Device For Surgical Instrument With Flexible Actuators
  • Electrical Ablation Devices
  • Hand Held Surgical Device For Manipulating An Internal Magnet Assembly Within A Patient
  • Endoscopic Cap Electrode And Method For Using The Same
  • Surgical Instrument Comprising An Electrode
  • Manually Articulating Devices
  • Apparatus For Forming An Anastomosis
  • Endoscopic Cap Electrode And Method For Using The Same
  • Apparatus And Methods For Cleaning The Lens Of An Endoscope
  • Surgical Instrument Comprising An Electrode
  • Surgical Access Device
  • Bipolar Forceps
  • Electrical Ablation Devices
  • Sterile Appliance Delivery Device For Endoscopic Procedures
  • Apparatus For Introducing A Steerable Camera Assembly Into A Patient
  • Electrosurgical Devices And Methods
  • Electrical Ablation Device
  • Surgical Suture Anchors And Deployment Device
  • Methods For Closing A Gastrotomy
  • Electrical Ablation Devices
  • Tissue Apposition Clip Application Devices And Methods
  • Articulating End Cap
  • Electroporation Ablation Apparatus, System, And Method
  • Bipolar Forceps
  • Surgical Grasping Device
  • Electroporation Ablation Apparatus, System, And Method
  • Electroporation Ablation Apparatus, System, And Method
  • Rotational Coupling Device For Surgical Instrument With Flexible Actuators
  • Vaginal Entry Surgical Devices, Kit, System, And Method
  • Surgical Scissors
  • Surgical Grasping Device
  • Reusable Electrode And Disposable Sheath
  • Detachable Distal Overtube Section And Methods For Forming A Sealable Opening In The Wall Of An Organ
  • Surgical Suture Arrangement
  • Selectively Positionable Camera For Surgical Guide Tube Assembly
  • Surgical Device
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.gt.3301173

    DOI

    http://dx.doi.org/10.1038/sj.gt.3301173

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004592524

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10845719


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1004", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Biotechnology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Technology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Electroporation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Transfer Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Reporter", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Neoplasms, Experimental", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Plasmids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats, Sprague-Dawley", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of South Florida", 
              "id": "https://www.grid.ac/institutes/grid.170693.a", 
              "name": [
                "Center for Molecular Delivery, University of South Florida, Tampa, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heller", 
            "givenName": "L", 
            "id": "sg:person.01143653473.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143653473.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of South Florida", 
              "id": "https://www.grid.ac/institutes/grid.170693.a", 
              "name": [
                "Department of Surgery, University of South Florida College of Medicine, Tampa, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jaroszeski", 
            "givenName": "M J", 
            "id": "sg:person.01144305106.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144305106.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of South Florida", 
              "id": "https://www.grid.ac/institutes/grid.170693.a", 
              "name": [
                "Department of Pathology, University of South Florida College of Medicine, Tampa, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Coppola", 
            "givenName": "D", 
            "id": "sg:person.01316543003.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316543003.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of South Florida", 
              "id": "https://www.grid.ac/institutes/grid.170693.a", 
              "name": [
                "Department of Surgery, University of South Florida College of Medicine, Tampa, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pottinger", 
            "givenName": "C", 
            "id": "sg:person.0604173262.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604173262.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of South Florida", 
              "id": "https://www.grid.ac/institutes/grid.170693.a", 
              "name": [
                "College of Engineering, University of South Florida, Tampa, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gilbert", 
            "givenName": "R", 
            "id": "sg:person.0716725263.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716725263.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of South Florida", 
              "id": "https://www.grid.ac/institutes/grid.170693.a", 
              "name": [
                "Department of Surgery, University of South Florida College of Medicine, Tampa, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heller", 
            "givenName": "R", 
            "id": "sg:person.01057200577.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057200577.35"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.80.4.1068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002315545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.1995.tb44729.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003553684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.24.12744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006840604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0264-410x(94)90077-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008383722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0264-410x(94)90077-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008383722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-409x(97)00034-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009784430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0298-168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021429953", 
              "https://doi.org/10.1038/nbt0298-168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1997.6361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022132452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(98)00284-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024087011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1996.5882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025330442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(96)00590-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027295683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-4781(91)90162-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027867599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-4781(91)90162-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027867599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(00)00407-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031400528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0304-4165(96)00119-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033277593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0998-867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034785216", 
              "https://doi.org/10.1038/nbt0998-867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0998-867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034785216", 
              "https://doi.org/10.1038/nbt0998-867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-409x(98)00067-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041781023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.8.4262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045236806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.87.24.9568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046686694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.11.6417", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047101772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/hum.1992.3.1-21", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059271096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1690918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062500820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074539432", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082889905", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2000-05", 
        "datePublishedReg": "2000-05-01", 
        "description": "Gene therapy by direct delivery of plasmid DNA has several advantages over viral gene transfer, but plasmid delivery is less efficient. In vivo electroporation has been used to enhance delivery of chemotherapeutic agents to tumors in both animal and human studies. Recently, this delivery technique has been extended to large molecules such as plasmid DNA. Here, the successful delivery of plasmids encoding reporter genes to rat hepatocellular carcinomas by in vivo electroporation is demonstrated.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.gt.3301173", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1105638", 
            "issn": [
              "0969-7128", 
              "1476-5462"
            ], 
            "name": "Gene Therapy", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "10", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo", 
        "pagination": "826", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "15e247f074f71dfdd772192e9d555c0b556892603da2782204167b7aee2312f7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "10845719"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9421525"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.gt.3301173"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1004592524"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.gt.3301173", 
          "https://app.dimensions.ai/details/publication/pub.1004592524"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118306_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/3301173"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3301173'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3301173'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3301173'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3301173'


     

    This table displays all metadata directly associated to this object as RDF triples.

    213 TRIPLES      21 PREDICATES      61 URIs      31 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.gt.3301173 schema:about N0d17891fbd5e450191b3643f52d17912
    2 N1693ca5da6504b9aa7db01118050c422
    3 N448573b104ed47288e7c7b7cc72b8981
    4 N5f2c422d1d5a41b6ad5a6f15b1c77a81
    5 N6c73d0d3446f44beb9e9054df903ada1
    6 N6cc435778b1347e5b823e6014a4ac419
    7 N730991fb9d334a2287872fb3ed192ed3
    8 Na563f9a8c5174e918754ef27f2836a62
    9 Ne11a48046c624c2187928b863b548c44
    10 Ne53278e45b174521926683e04d151e70
    11 anzsrc-for:10
    12 anzsrc-for:1004
    13 schema:author N049aaf453d44418dada134d94c7a0592
    14 schema:citation sg:pub.10.1038/nbt0298-168
    15 sg:pub.10.1038/nbt0998-867
    16 https://app.dimensions.ai/details/publication/pub.1074539432
    17 https://app.dimensions.ai/details/publication/pub.1082889905
    18 https://doi.org/10.1006/bbrc.1996.5882
    19 https://doi.org/10.1006/bbrc.1997.6361
    20 https://doi.org/10.1016/0014-5793(96)00590-x
    21 https://doi.org/10.1016/0167-4781(91)90162-f
    22 https://doi.org/10.1016/0264-410x(94)90077-9
    23 https://doi.org/10.1016/s0014-5793(98)00284-1
    24 https://doi.org/10.1016/s0169-409x(97)00034-3
    25 https://doi.org/10.1016/s0169-409x(98)00067-2
    26 https://doi.org/10.1016/s0304-4165(96)00119-5
    27 https://doi.org/10.1016/s0959-8049(00)00407-x
    28 https://doi.org/10.1073/pnas.80.4.1068
    29 https://doi.org/10.1073/pnas.87.24.9568
    30 https://doi.org/10.1073/pnas.94.24.12744
    31 https://doi.org/10.1073/pnas.96.11.6417
    32 https://doi.org/10.1073/pnas.96.8.4262
    33 https://doi.org/10.1089/hum.1992.3.1-21
    34 https://doi.org/10.1111/j.1749-6632.1995.tb44729.x
    35 https://doi.org/10.1126/science.1690918
    36 schema:datePublished 2000-05
    37 schema:datePublishedReg 2000-05-01
    38 schema:description Gene therapy by direct delivery of plasmid DNA has several advantages over viral gene transfer, but plasmid delivery is less efficient. In vivo electroporation has been used to enhance delivery of chemotherapeutic agents to tumors in both animal and human studies. Recently, this delivery technique has been extended to large molecules such as plasmid DNA. Here, the successful delivery of plasmids encoding reporter genes to rat hepatocellular carcinomas by in vivo electroporation is demonstrated.
    39 schema:genre research_article
    40 schema:inLanguage en
    41 schema:isAccessibleForFree true
    42 schema:isPartOf Na65ca35d351c41ebaddc997785254ddf
    43 Nbdc03ab5cb714f47bbd3a31bd5417fce
    44 sg:journal.1105638
    45 schema:name Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo
    46 schema:pagination 826
    47 schema:productId N1c417b9e625847ebaaa40f661945dc52
    48 N2ae0c00a3c0c42d5a242273f665582b2
    49 N467cdae424554ff0a4a22d8a621369d0
    50 N93932b88cd34487089f7ab8277de0c7b
    51 Ne168df457a704721bbcd1d66dda2890d
    52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004592524
    53 https://doi.org/10.1038/sj.gt.3301173
    54 schema:sdDatePublished 2019-04-11T12:03
    55 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    56 schema:sdPublisher Nb4eeb6db983840148e0cd47936ca7bf3
    57 schema:url https://www.nature.com/articles/3301173
    58 sgo:license sg:explorer/license/
    59 sgo:sdDataset articles
    60 rdf:type schema:ScholarlyArticle
    61 N049aaf453d44418dada134d94c7a0592 rdf:first sg:person.01143653473.34
    62 rdf:rest N5e706521b89b4482b323b5e3ac028320
    63 N0d17891fbd5e450191b3643f52d17912 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    64 schema:name Genetic Therapy
    65 rdf:type schema:DefinedTerm
    66 N1693ca5da6504b9aa7db01118050c422 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    67 schema:name Genes, Reporter
    68 rdf:type schema:DefinedTerm
    69 N1c417b9e625847ebaaa40f661945dc52 schema:name pubmed_id
    70 schema:value 10845719
    71 rdf:type schema:PropertyValue
    72 N2ae0c00a3c0c42d5a242273f665582b2 schema:name readcube_id
    73 schema:value 15e247f074f71dfdd772192e9d555c0b556892603da2782204167b7aee2312f7
    74 rdf:type schema:PropertyValue
    75 N448573b104ed47288e7c7b7cc72b8981 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    76 schema:name Electroporation
    77 rdf:type schema:DefinedTerm
    78 N467cdae424554ff0a4a22d8a621369d0 schema:name doi
    79 schema:value 10.1038/sj.gt.3301173
    80 rdf:type schema:PropertyValue
    81 N5e706521b89b4482b323b5e3ac028320 rdf:first sg:person.01144305106.75
    82 rdf:rest N71969ad9524f4bbdaaf12b2d7dfba098
    83 N5f2c422d1d5a41b6ad5a6f15b1c77a81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    84 schema:name Male
    85 rdf:type schema:DefinedTerm
    86 N6c73d0d3446f44beb9e9054df903ada1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Gene Transfer Techniques
    88 rdf:type schema:DefinedTerm
    89 N6cc435778b1347e5b823e6014a4ac419 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Liver Neoplasms, Experimental
    91 rdf:type schema:DefinedTerm
    92 N71969ad9524f4bbdaaf12b2d7dfba098 rdf:first sg:person.01316543003.47
    93 rdf:rest Ncfc93a96556b40d793a63396a69dcecb
    94 N730991fb9d334a2287872fb3ed192ed3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Plasmids
    96 rdf:type schema:DefinedTerm
    97 N85804e8993a446b6a5e90ebdaef41560 rdf:first sg:person.01057200577.35
    98 rdf:rest rdf:nil
    99 N93932b88cd34487089f7ab8277de0c7b schema:name nlm_unique_id
    100 schema:value 9421525
    101 rdf:type schema:PropertyValue
    102 Na563f9a8c5174e918754ef27f2836a62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Rats
    104 rdf:type schema:DefinedTerm
    105 Na65ca35d351c41ebaddc997785254ddf schema:issueNumber 10
    106 rdf:type schema:PublicationIssue
    107 Nb4eeb6db983840148e0cd47936ca7bf3 schema:name Springer Nature - SN SciGraph project
    108 rdf:type schema:Organization
    109 Nb73dd917a74f462ebde0b057b4f4e46b rdf:first sg:person.0716725263.03
    110 rdf:rest N85804e8993a446b6a5e90ebdaef41560
    111 Nbdc03ab5cb714f47bbd3a31bd5417fce schema:volumeNumber 7
    112 rdf:type schema:PublicationVolume
    113 Ncfc93a96556b40d793a63396a69dcecb rdf:first sg:person.0604173262.51
    114 rdf:rest Nb73dd917a74f462ebde0b057b4f4e46b
    115 Ne11a48046c624c2187928b863b548c44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Animals
    117 rdf:type schema:DefinedTerm
    118 Ne168df457a704721bbcd1d66dda2890d schema:name dimensions_id
    119 schema:value pub.1004592524
    120 rdf:type schema:PropertyValue
    121 Ne53278e45b174521926683e04d151e70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Rats, Sprague-Dawley
    123 rdf:type schema:DefinedTerm
    124 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
    125 schema:name Technology
    126 rdf:type schema:DefinedTerm
    127 anzsrc-for:1004 schema:inDefinedTermSet anzsrc-for:
    128 schema:name Medical Biotechnology
    129 rdf:type schema:DefinedTerm
    130 sg:journal.1105638 schema:issn 0969-7128
    131 1476-5462
    132 schema:name Gene Therapy
    133 rdf:type schema:Periodical
    134 sg:person.01057200577.35 schema:affiliation https://www.grid.ac/institutes/grid.170693.a
    135 schema:familyName Heller
    136 schema:givenName R
    137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057200577.35
    138 rdf:type schema:Person
    139 sg:person.01143653473.34 schema:affiliation https://www.grid.ac/institutes/grid.170693.a
    140 schema:familyName Heller
    141 schema:givenName L
    142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143653473.34
    143 rdf:type schema:Person
    144 sg:person.01144305106.75 schema:affiliation https://www.grid.ac/institutes/grid.170693.a
    145 schema:familyName Jaroszeski
    146 schema:givenName M J
    147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144305106.75
    148 rdf:type schema:Person
    149 sg:person.01316543003.47 schema:affiliation https://www.grid.ac/institutes/grid.170693.a
    150 schema:familyName Coppola
    151 schema:givenName D
    152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316543003.47
    153 rdf:type schema:Person
    154 sg:person.0604173262.51 schema:affiliation https://www.grid.ac/institutes/grid.170693.a
    155 schema:familyName Pottinger
    156 schema:givenName C
    157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604173262.51
    158 rdf:type schema:Person
    159 sg:person.0716725263.03 schema:affiliation https://www.grid.ac/institutes/grid.170693.a
    160 schema:familyName Gilbert
    161 schema:givenName R
    162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716725263.03
    163 rdf:type schema:Person
    164 sg:pub.10.1038/nbt0298-168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021429953
    165 https://doi.org/10.1038/nbt0298-168
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1038/nbt0998-867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034785216
    168 https://doi.org/10.1038/nbt0998-867
    169 rdf:type schema:CreativeWork
    170 https://app.dimensions.ai/details/publication/pub.1074539432 schema:CreativeWork
    171 https://app.dimensions.ai/details/publication/pub.1082889905 schema:CreativeWork
    172 https://doi.org/10.1006/bbrc.1996.5882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025330442
    173 rdf:type schema:CreativeWork
    174 https://doi.org/10.1006/bbrc.1997.6361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022132452
    175 rdf:type schema:CreativeWork
    176 https://doi.org/10.1016/0014-5793(96)00590-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027295683
    177 rdf:type schema:CreativeWork
    178 https://doi.org/10.1016/0167-4781(91)90162-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1027867599
    179 rdf:type schema:CreativeWork
    180 https://doi.org/10.1016/0264-410x(94)90077-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008383722
    181 rdf:type schema:CreativeWork
    182 https://doi.org/10.1016/s0014-5793(98)00284-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024087011
    183 rdf:type schema:CreativeWork
    184 https://doi.org/10.1016/s0169-409x(97)00034-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009784430
    185 rdf:type schema:CreativeWork
    186 https://doi.org/10.1016/s0169-409x(98)00067-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041781023
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1016/s0304-4165(96)00119-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033277593
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1016/s0959-8049(00)00407-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031400528
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1073/pnas.80.4.1068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002315545
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1073/pnas.87.24.9568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046686694
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1073/pnas.94.24.12744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006840604
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1073/pnas.96.11.6417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047101772
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1073/pnas.96.8.4262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045236806
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1089/hum.1992.3.1-21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059271096
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1111/j.1749-6632.1995.tb44729.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003553684
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1126/science.1690918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062500820
    207 rdf:type schema:CreativeWork
    208 https://www.grid.ac/institutes/grid.170693.a schema:alternateName University of South Florida
    209 schema:name Center for Molecular Delivery, University of South Florida, Tampa, FL, USA
    210 College of Engineering, University of South Florida, Tampa, FL, USA
    211 Department of Pathology, University of South Florida College of Medicine, Tampa, FL, USA
    212 Department of Surgery, University of South Florida College of Medicine, Tampa, FL, USA
    213 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...