The equine herpes virus 4 thymidine kinase is a better suicide gene than the human herpes virus 1 thymidine kinase View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-09

AUTHORS

L Loubière, M Tiraby, C Cazaux, E Brisson, M Grisoni, J C Zhao-Emonet, G Tiraby, D Klatzmann

ABSTRACT

The herpes simplex virus type 1 thymidine kinase suicide gene (HSV1tk) together with ganciclovir (GCV) have been successfully used for in vivo treatment of various experimental tumors, and many clinical trials using this system have been launched. With the aim to improve this therapeutic system, we compared the potential efficacy of different herpes virus derived thymidine kinases (HSV1, varicella-zoster virus, equine herpes virus type-4 and Epstein-Barr virus) as suicide genes in association with the nucleoside analogs acyclovir, ganciclovir and bromovinyldeoxyur- idine. Using various murine and human cell lines expressing these viral tk, we show that HSV1- and EHV4tk are the more efficient suicide genes for the different nucleoside analogs tested. Moreover, EHV4tk expressing murine and human cells were three- to 12-fold more sensitive to GCV than HSV1tk expressing cells. This was correlated with the presence of five-fold higher amounts of the toxic triphosphated-GCV in EHV4- versus HSV1tk expressing cells. Altogether, these experiments underline the potential advantages of the EHV4tk as a suicide gene. More... »

PAGES

3300993

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.gt.3300993

DOI

http://dx.doi.org/10.1038/sj.gt.3300993

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043293091

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10490775


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