Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: a pilot study in humans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-03

AUTHORS

G Palù, A Cavaggioni, P Calvi, E Franchin, M Pizzato, R Boschetto, C Parolin, M Chilosi, S Ferrini, A Zanusso, F Colombo

ABSTRACT

Retrovirus-mediated gene therapy is a particularly attractive approach for glioblastoma multiforme (GBM), given the poor prognosis of this tumour and its localized proliferation in post-mitotic tissue. In this study we assessed, for the first time in humans, the therapeutic potential of a newly designed bicistronic Moloney vector (pLIL-2-TK), combining the expression of a suicide gene (thymidine kinase, tk) with an immunomodulatory gene (human interleukin 2, IL-2). Evidence of transgene activity in the treated tumours is presented. More... »

PAGES

3300805

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.gt.3300805

DOI

http://dx.doi.org/10.1038/sj.gt.3300805

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040147664

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10435083


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