Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: a pilot study in humans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-03

AUTHORS

G Palù, A Cavaggioni, P Calvi, E Franchin, M Pizzato, R Boschetto, C Parolin, M Chilosi, S Ferrini, A Zanusso, F Colombo

ABSTRACT

Retrovirus-mediated gene therapy is a particularly attractive approach for glioblastoma multiforme (GBM), given the poor prognosis of this tumour and its localized proliferation in post-mitotic tissue. In this study we assessed, for the first time in humans, the therapeutic potential of a newly designed bicistronic Moloney vector (pLIL-2-TK), combining the expression of a suicide gene (thymidine kinase, tk) with an immunomodulatory gene (human interleukin 2, IL-2). Evidence of transgene activity in the treated tumours is presented. More... »

PAGES

3300805

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.gt.3300805

DOI

http://dx.doi.org/10.1038/sj.gt.3300805

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040147664

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10435083


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1004", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Biotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Vectors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pilot Projects", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retroviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymidine Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Institute of Microbiology, University of Padova, School of Medicine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pal\u00f9", 
        "givenName": "G", 
        "id": "sg:person.01107666354.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107666354.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Physiology, University of Padova, School of Medicine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cavaggioni", 
        "givenName": "A", 
        "id": "sg:person.01032137133.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032137133.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Institute of Microbiology, University of Padova, School of Medicine, Italy", 
            "Physiology, University of Padova, School of Medicine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calvi", 
        "givenName": "P", 
        "id": "sg:person.01354751457.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354751457.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Institute of Microbiology, University of Padova, School of Medicine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franchin", 
        "givenName": "E", 
        "id": "sg:person.01106345307.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106345307.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Institute of Microbiology, University of Padova, School of Medicine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pizzato", 
        "givenName": "M", 
        "id": "sg:person.01101333117.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101333117.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Institute of Microbiology, University of Padova, School of Medicine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boschetto", 
        "givenName": "R", 
        "id": "sg:person.01136161460.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136161460.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Institute of Microbiology, University of Padova, School of Medicine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parolin", 
        "givenName": "C", 
        "id": "sg:person.01341555365.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341555365.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Verona", 
          "id": "https://www.grid.ac/institutes/grid.5611.3", 
          "name": [
            "Department of Pathology, University of Verona, School of Medicine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chilosi", 
        "givenName": "M", 
        "id": "sg:person.0673161162.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673161162.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Martino", 
          "id": "https://www.grid.ac/institutes/grid.410345.7", 
          "name": [
            "National Institute for Cancer Research, Advanced Biotechnologies Center, Genova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrini", 
        "givenName": "S", 
        "id": "sg:person.0625261630.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625261630.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Neurosurgery, Vicenza Regional Hospital, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zanusso", 
        "givenName": "A", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Neurosurgery, Vicenza Regional Hospital, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Colombo", 
        "givenName": "F", 
        "id": "sg:person.01111013427.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111013427.92"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm0296-216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003774293", 
          "https://doi.org/10.1038/nm0296-216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6822(81)90642-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010025306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(87)90021-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013321498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81848-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014440427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19970410)71:2<267::aid-ijc23>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019604977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3835(95)03771-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022067843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031750491", 
          "https://doi.org/10.1038/bjc.1996.437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031750491", 
          "https://doi.org/10.1038/bjc.1996.437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/38.11.2212622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033183990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/38.11.2212622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033183990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042658283", 
          "https://doi.org/10.1038/sj.gt.3300670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042658283", 
          "https://doi.org/10.1038/sj.gt.3300670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00046345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048645972", 
          "https://doi.org/10.1007/bf00046345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00046345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048645972", 
          "https://doi.org/10.1007/bf00046345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1297-1354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051499070", 
          "https://doi.org/10.1038/nm1297-1354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00267823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052611363", 
          "https://doi.org/10.1007/bf00267823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00267823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052611363", 
          "https://doi.org/10.1007/bf00267823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abio.1987.9999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054484911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1993.4.1-39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059271193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1993.4.6-725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059271274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1998.9.8-1165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059272346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1989.70.2.0175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071095278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1989.70.2.0175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071095278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1989.70.2.0175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071095278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082385143", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082482610", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082708501", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082899614", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082929621", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082997656", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083003589", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083063746", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083216238", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-03", 
    "datePublishedReg": "1999-03-01", 
    "description": "Retrovirus-mediated gene therapy is a particularly attractive approach for glioblastoma multiforme (GBM), given the poor prognosis of this tumour and its localized proliferation in post-mitotic tissue. In this study we assessed, for the first time in humans, the therapeutic potential of a newly designed bicistronic Moloney vector (pLIL-2-TK), combining the expression of a suicide gene (thymidine kinase, tk) with an immunomodulatory gene (human interleukin 2, IL-2). Evidence of transgene activity in the treated tumours is presented.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.gt.3300805", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1105638", 
        "issn": [
          "0969-7128", 
          "1476-5462"
        ], 
        "name": "Gene Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: a pilot study in humans", 
    "pagination": "3300805", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bf3fe6c82444180dbe84f9e630bc86becf236f9d56779af978f806b8eadf8cee"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10435083"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9421525"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.gt.3300805"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040147664"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.gt.3300805", 
      "https://app.dimensions.ai/details/publication/pub.1040147664"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118324_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/3300805"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3300805'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3300805'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3300805'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.gt.3300805'


 

This table displays all metadata directly associated to this object as RDF triples.

292 TRIPLES      21 PREDICATES      72 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.gt.3300805 schema:about N140e4abed2f24e0a8a7a174da1ebe0a2
2 N1c8843c2b4c14b049eb67d76fd8ccbd1
3 N200a5f1d40d54defa0a6cc6a3ce0ef91
4 N263bb00167f04b1883e4a2548f6b55d2
5 N292e39a6d40241bea1c9977cc2580159
6 N2d9619fabc554105ac3cc34644f2cf83
7 N5452a8a6c14d4fe2a0598dd16858760a
8 N57d08ec25e72407f91e14d5f00174bf9
9 N7b60fa11e60342aeade83a9b92f696cb
10 N814a75539c9b46b3ae06376fff2549f9
11 Nacbbaea7fe694f4f8d216300bb8c1155
12 Nbef745c44bdb4423bd80a4a3c08d03b1
13 Nd1419234b62e40e4b3b47c48d2c1cb23
14 Nd543bab2ce464a6894810d618b88959d
15 Ndb34ba094f694ca6abd3607a9b3773a2
16 Ne11efd90682c4bb4b2cc560e00a77854
17 Neec9f84581654f3097e78585cbda1450
18 anzsrc-for:10
19 anzsrc-for:1004
20 schema:author N392d517f4430426abb4014584217b915
21 schema:citation sg:pub.10.1007/bf00046345
22 sg:pub.10.1007/bf00267823
23 sg:pub.10.1038/bjc.1996.437
24 sg:pub.10.1038/nm0296-216
25 sg:pub.10.1038/nm1297-1354
26 sg:pub.10.1038/sj.gt.3300670
27 https://app.dimensions.ai/details/publication/pub.1082385143
28 https://app.dimensions.ai/details/publication/pub.1082482610
29 https://app.dimensions.ai/details/publication/pub.1082708501
30 https://app.dimensions.ai/details/publication/pub.1082899614
31 https://app.dimensions.ai/details/publication/pub.1082929621
32 https://app.dimensions.ai/details/publication/pub.1082997656
33 https://app.dimensions.ai/details/publication/pub.1083003589
34 https://app.dimensions.ai/details/publication/pub.1083063746
35 https://app.dimensions.ai/details/publication/pub.1083216238
36 https://doi.org/10.1002/(sici)1097-0215(19970410)71:2<267::aid-ijc23>3.0.co;2-d
37 https://doi.org/10.1006/abio.1987.9999
38 https://doi.org/10.1016/0003-2697(87)90021-2
39 https://doi.org/10.1016/0042-6822(81)90642-5
40 https://doi.org/10.1016/0304-3835(95)03771-n
41 https://doi.org/10.1016/s0092-8674(00)81848-6
42 https://doi.org/10.1089/hum.1993.4.1-39
43 https://doi.org/10.1089/hum.1993.4.6-725
44 https://doi.org/10.1089/hum.1998.9.8-1165
45 https://doi.org/10.1177/38.11.2212622
46 https://doi.org/10.3171/jns.1989.70.2.0175
47 schema:datePublished 1999-03
48 schema:datePublishedReg 1999-03-01
49 schema:description Retrovirus-mediated gene therapy is a particularly attractive approach for glioblastoma multiforme (GBM), given the poor prognosis of this tumour and its localized proliferation in post-mitotic tissue. In this study we assessed, for the first time in humans, the therapeutic potential of a newly designed bicistronic Moloney vector (pLIL-2-TK), combining the expression of a suicide gene (thymidine kinase, tk) with an immunomodulatory gene (human interleukin 2, IL-2). Evidence of transgene activity in the treated tumours is presented.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree true
53 schema:isPartOf N3ee6d00f49134accad98fa79b8a25d96
54 N618c7822f403425ca09cd7b1c853b801
55 sg:journal.1105638
56 schema:name Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: a pilot study in humans
57 schema:pagination 3300805
58 schema:productId N17627bb9b26546118c86781ecb9a64a4
59 N53fbecc1254743ad9f1a960daaff6338
60 N6771f477d1344fd889eade318aac429d
61 N9955a02f9e9e40d881b7bca48b3be682
62 N9aabf2d458b9487383ca5c0d9c517a0e
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040147664
64 https://doi.org/10.1038/sj.gt.3300805
65 schema:sdDatePublished 2019-04-11T12:05
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N9872e4b86fa04883b1052eb782a448a5
68 schema:url http://www.nature.com/articles/3300805
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N052f751963c64168973c584eb9ab6b6f rdf:first sg:person.0673161162.96
73 rdf:rest Ncbbd9abea14740c3b48ceaf128a2f29b
74 N1245601f29c64a5c84cad1b989efb5f4 rdf:first sg:person.01106345307.48
75 rdf:rest Nbb0a2caa73684ac485963b8017f06a60
76 N140e4abed2f24e0a8a7a174da1ebe0a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Retroviridae
78 rdf:type schema:DefinedTerm
79 N1563194ab9c04f169d379b8560a90a42 rdf:first N8852bfd5529f4c4d903b958393ebc79c
80 rdf:rest N25b42e9b129f4247943a7f66acd06f9e
81 N17627bb9b26546118c86781ecb9a64a4 schema:name readcube_id
82 schema:value bf3fe6c82444180dbe84f9e630bc86becf236f9d56779af978f806b8eadf8cee
83 rdf:type schema:PropertyValue
84 N1c8843c2b4c14b049eb67d76fd8ccbd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Pilot Projects
86 rdf:type schema:DefinedTerm
87 N200a5f1d40d54defa0a6cc6a3ce0ef91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Interleukin-2
89 rdf:type schema:DefinedTerm
90 N25b42e9b129f4247943a7f66acd06f9e rdf:first sg:person.01111013427.92
91 rdf:rest rdf:nil
92 N263bb00167f04b1883e4a2548f6b55d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Gene Expression
94 rdf:type schema:DefinedTerm
95 N292e39a6d40241bea1c9977cc2580159 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Brain
97 rdf:type schema:DefinedTerm
98 N2d9619fabc554105ac3cc34644f2cf83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Genetic Therapy
100 rdf:type schema:DefinedTerm
101 N37b27798510a4b118348dfe9b9aac04b schema:name Division of Neurosurgery, Vicenza Regional Hospital, Italy
102 rdf:type schema:Organization
103 N392d517f4430426abb4014584217b915 rdf:first sg:person.01107666354.73
104 rdf:rest N66fe4fe5d2754ba8b820cdb1679a214a
105 N3ee6d00f49134accad98fa79b8a25d96 schema:volumeNumber 6
106 rdf:type schema:PublicationVolume
107 N4ed950fc17ca41248989ab47af0547a8 rdf:first sg:person.01136161460.16
108 rdf:rest Nfc91bae4ef9741eea8f2e73181662c9d
109 N53fbecc1254743ad9f1a960daaff6338 schema:name nlm_unique_id
110 schema:value 9421525
111 rdf:type schema:PropertyValue
112 N5452a8a6c14d4fe2a0598dd16858760a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Genetic Vectors
114 rdf:type schema:DefinedTerm
115 N57d08ec25e72407f91e14d5f00174bf9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Adult
117 rdf:type schema:DefinedTerm
118 N618c7822f403425ca09cd7b1c853b801 schema:issueNumber 3
119 rdf:type schema:PublicationIssue
120 N66fe4fe5d2754ba8b820cdb1679a214a rdf:first sg:person.01032137133.90
121 rdf:rest N9a590318a91c44acaefdd64755274542
122 N6771f477d1344fd889eade318aac429d schema:name doi
123 schema:value 10.1038/sj.gt.3300805
124 rdf:type schema:PropertyValue
125 N7b60fa11e60342aeade83a9b92f696cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Thymidine Kinase
127 rdf:type schema:DefinedTerm
128 N814a75539c9b46b3ae06376fff2549f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Brain Neoplasms
130 rdf:type schema:DefinedTerm
131 N8852bfd5529f4c4d903b958393ebc79c schema:affiliation N37b27798510a4b118348dfe9b9aac04b
132 schema:familyName Zanusso
133 schema:givenName A
134 rdf:type schema:Person
135 N9872e4b86fa04883b1052eb782a448a5 schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 N9955a02f9e9e40d881b7bca48b3be682 schema:name pubmed_id
138 schema:value 10435083
139 rdf:type schema:PropertyValue
140 N9a590318a91c44acaefdd64755274542 rdf:first sg:person.01354751457.96
141 rdf:rest N1245601f29c64a5c84cad1b989efb5f4
142 N9aabf2d458b9487383ca5c0d9c517a0e schema:name dimensions_id
143 schema:value pub.1040147664
144 rdf:type schema:PropertyValue
145 Nacbbaea7fe694f4f8d216300bb8c1155 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Middle Aged
147 rdf:type schema:DefinedTerm
148 Nbb0a2caa73684ac485963b8017f06a60 rdf:first sg:person.01101333117.58
149 rdf:rest N4ed950fc17ca41248989ab47af0547a8
150 Nbef745c44bdb4423bd80a4a3c08d03b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Magnetic Resonance Imaging
152 rdf:type schema:DefinedTerm
153 Ncbbd9abea14740c3b48ceaf128a2f29b rdf:first sg:person.0625261630.03
154 rdf:rest N1563194ab9c04f169d379b8560a90a42
155 Nd1419234b62e40e4b3b47c48d2c1cb23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Transfection
157 rdf:type schema:DefinedTerm
158 Nd543bab2ce464a6894810d618b88959d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Female
160 rdf:type schema:DefinedTerm
161 Ndb34ba094f694ca6abd3607a9b3773a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Glioblastoma
163 rdf:type schema:DefinedTerm
164 Ne11efd90682c4bb4b2cc560e00a77854 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 Neec9f84581654f3097e78585cbda1450 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Male
169 rdf:type schema:DefinedTerm
170 Nf823ee5980da4825b061a21e593c01fe schema:name Division of Neurosurgery, Vicenza Regional Hospital, Italy
171 rdf:type schema:Organization
172 Nfc91bae4ef9741eea8f2e73181662c9d rdf:first sg:person.01341555365.07
173 rdf:rest N052f751963c64168973c584eb9ab6b6f
174 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
175 schema:name Technology
176 rdf:type schema:DefinedTerm
177 anzsrc-for:1004 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical Biotechnology
179 rdf:type schema:DefinedTerm
180 sg:journal.1105638 schema:issn 0969-7128
181 1476-5462
182 schema:name Gene Therapy
183 rdf:type schema:Periodical
184 sg:person.01032137133.90 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
185 schema:familyName Cavaggioni
186 schema:givenName A
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032137133.90
188 rdf:type schema:Person
189 sg:person.01101333117.58 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
190 schema:familyName Pizzato
191 schema:givenName M
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101333117.58
193 rdf:type schema:Person
194 sg:person.01106345307.48 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
195 schema:familyName Franchin
196 schema:givenName E
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106345307.48
198 rdf:type schema:Person
199 sg:person.01107666354.73 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
200 schema:familyName Palù
201 schema:givenName G
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107666354.73
203 rdf:type schema:Person
204 sg:person.01111013427.92 schema:affiliation Nf823ee5980da4825b061a21e593c01fe
205 schema:familyName Colombo
206 schema:givenName F
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111013427.92
208 rdf:type schema:Person
209 sg:person.01136161460.16 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
210 schema:familyName Boschetto
211 schema:givenName R
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136161460.16
213 rdf:type schema:Person
214 sg:person.01341555365.07 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
215 schema:familyName Parolin
216 schema:givenName C
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341555365.07
218 rdf:type schema:Person
219 sg:person.01354751457.96 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
220 schema:familyName Calvi
221 schema:givenName P
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354751457.96
223 rdf:type schema:Person
224 sg:person.0625261630.03 schema:affiliation https://www.grid.ac/institutes/grid.410345.7
225 schema:familyName Ferrini
226 schema:givenName S
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625261630.03
228 rdf:type schema:Person
229 sg:person.0673161162.96 schema:affiliation https://www.grid.ac/institutes/grid.5611.3
230 schema:familyName Chilosi
231 schema:givenName M
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673161162.96
233 rdf:type schema:Person
234 sg:pub.10.1007/bf00046345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048645972
235 https://doi.org/10.1007/bf00046345
236 rdf:type schema:CreativeWork
237 sg:pub.10.1007/bf00267823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052611363
238 https://doi.org/10.1007/bf00267823
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/bjc.1996.437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031750491
241 https://doi.org/10.1038/bjc.1996.437
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/nm0296-216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003774293
244 https://doi.org/10.1038/nm0296-216
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/nm1297-1354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051499070
247 https://doi.org/10.1038/nm1297-1354
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/sj.gt.3300670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042658283
250 https://doi.org/10.1038/sj.gt.3300670
251 rdf:type schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1082385143 schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1082482610 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1082708501 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1082899614 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1082929621 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1082997656 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1083003589 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1083063746 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1083216238 schema:CreativeWork
261 https://doi.org/10.1002/(sici)1097-0215(19970410)71:2<267::aid-ijc23>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1019604977
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1006/abio.1987.9999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054484911
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/0003-2697(87)90021-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013321498
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/0042-6822(81)90642-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010025306
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/0304-3835(95)03771-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1022067843
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0092-8674(00)81848-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014440427
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1089/hum.1993.4.1-39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059271193
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1089/hum.1993.4.6-725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059271274
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1089/hum.1998.9.8-1165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272346
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1177/38.11.2212622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033183990
280 rdf:type schema:CreativeWork
281 https://doi.org/10.3171/jns.1989.70.2.0175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071095278
282 rdf:type schema:CreativeWork
283 https://www.grid.ac/institutes/grid.410345.7 schema:alternateName Ospedale San Martino
284 schema:name National Institute for Cancer Research, Advanced Biotechnologies Center, Genova, Italy
285 rdf:type schema:Organization
286 https://www.grid.ac/institutes/grid.5608.b schema:alternateName University of Padua
287 schema:name Institute of Microbiology, University of Padova, School of Medicine, Italy
288 Physiology, University of Padova, School of Medicine, Italy
289 rdf:type schema:Organization
290 https://www.grid.ac/institutes/grid.5611.3 schema:alternateName University of Verona
291 schema:name Department of Pathology, University of Verona, School of Medicine, Italy
292 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...