Gene therapy of mitochondrial diseases using human cytoplasts View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-01

AUTHORS

Y Kagawa, J-I Hayashi

ABSTRACT

Mitochondrial (mt) DNA is highly susceptible to mutation. A novel approach using cytoplasts is essential for gene therapy of the diseases caused by these mutations, because of their non-Mendelian genetics. In this method, mtDNA is transferred into the mutant cells by forming cybrids and can complement the defect correctly and safely. More... »

PAGES

6-10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.gt.3300347

DOI

http://dx.doi.org/10.1038/sj.gt.3300347

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9068789


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