The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-07

AUTHORS

P L De Jager, D Franchimont, A Waliszewska, A Bitton, A Cohen, D Langelier, J Belaiche, S Vermeire, L Farwell, A Goris, C Libioulle, N Jani, T Dassopoulos, G P Bromfield, B Dubois, J H Cho, S R Brant, R H Duerr, H Yang, J I Rotter, M S Silverberg, A H Steinhart, M J Daly, D K Podolsky, E Louis, D A Hafler, J D Rioux

ABSTRACT

The intestinal flora has long been thought to play a role either in initiating or in exacerbating the inflammatory bowel diseases (IBD). Host defenses, such as those mediated by the Toll-like receptors (TLR), are critical to the host/pathogen interaction and have been implicated in IBD pathophysiology. To explore the association of genetic variation in TLR pathways with susceptibility to IBD, we performed a replication study and pooled analyses of the putative IBD risk alleles in NFKB1 and TLR4, and we performed a haplotype-based screen for association to IBD in the TLR genes and a selection of their adaptor and signaling molecules. Our genotyping of 1539 cases of IBD and pooled analysis of 4805 cases of IBD validates the published association of a TLR4 allele with risk of IBD (odds ratio (OR): 1.30, 95% confidence interval (CI): 1.15-1.48; P=0.00017) and Crohn's disease (OR: 1.33, 95% CI: 1.16-1.54; P=0.000035) but not ulcerative colitis. We also describe novel suggestive evidence that TIRAP (OR: 1.16, 95% CI: 1.04-1.30; P=0.007) has a modest effect on risk of IBD. Our analysis, therefore, offers additional evidence that the TLR4 pathway - in this case, TLR4 and its signaling molecule TIRAP - plays a role in susceptibility to IBD. More... »

PAGES

6364398

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.gene.6364398

    DOI

    http://dx.doi.org/10.1038/sj.gene.6364398

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041412826

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17538633


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.gene.6364398'

    N-Triples is a line-based linked data format ideal for batch operations.

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