IL-10 polymorphism and cell-mediated immune response to Chlamydia trachomatis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-03-09

AUTHORS

H Öhman, A Tiitinen, M Halttunen, S Birkelund, G Christiansen, P Koskela, M Lehtinen, J Paavonen, H-M Surcel

ABSTRACT

Chlamydia trachomatis infection induces an inflammatory response that is crucial in resolving acute infection but may also play a key role in the pathogenesis of C trachomatis associated infertility. The immune response is linked to cytokine secretion pattern which is influenced by the host genetic background. To study a relationship between interleukin-10 (IL-10) promoter −1082 polymorphism and cell-mediated immune response during C trachomatis infection in vitro, lymphocyte proliferation and cytokine (IL-10, IFN-γ, TNF-α, IL-2, IL-4 and IL-5) secretion were analysed in subjects with different IL-10 genotypes. Enhanced IL-10 secretion and reduced antigen-specific lymphocyte proliferative and IFN-γ responses were found in subjects with IL-10 −1082 GG genotype when compared to those with −1082 AA genotype. CD14+ monocytes were main source of IL-10 indicating that these cells are important regulators of the antigen-specific cell-mediated responses during active C trachomatis infection. We conclude that impaired cell-mediated response to C trachomatis is associated with IL-10 genotype in subjects with high IL-10 producing capacity. A comparison of immune markers between subjects with a history of noncomplicated and complicated infection is needed to further understand the confounding factors associated with the development of C trachomatis associated sequelae. More... »

PAGES

243-249

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.gene.6364293

DOI

http://dx.doi.org/10.1038/sj.gene.6364293

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016224653

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16525502


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