Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-01

AUTHORS

W Zheng, P Rosenstiel, K Huse, C Sina, R Valentonyte, N Mah, L Zeitlmann, J Grosse, N Ruf, P Nürnberg, C M Costello, C Onnie, C Mathew, M Platzer, S Schreiber, J Hampe

ABSTRACT

Linkage analyses have implicated chromosome 7p21.3 as a susceptibility region for inflammatory bowel disease (IBD). Recently, the mouse phenotype with diarrhea and goblet cell dysfunction caused by anterior gradient protein 2 dysfunction was reported (European patent WO2004056858). The genes encoding for the human homologues AGR2 and AGR3 are localized on chromosome 7p21.3. The gene structures were verified and mutation detection was performed in 47 IBD patients. A total of 30 single nucleotide polymorphisms (SNPs) were tested for association to ulcerative colitis (UC, N = 317) and Crohn's disease (CD, N = 631) in a German cohort and verified in a UK cohort of 384 CD and 311 UC patients. An association signal was identified in the 5' region of the AGR2 gene (most significant SNP hcv1702494, nominal P(TDT) = 0.011, P(case/control) = 0.0007, OR = 1.34, combined cohort). The risk haplotype carried an odds ratio of 1.43 in the German population (P = 0.002). AGR2 was downregulated in UC patients as compared to normal controls (P < 0.001) and a trend toward lower expression was seen in carriers of the risk alleles. Luciferase assays of the AGR2 promoter showed regulation by the goblet cell-specific transcription factors FOXA1 and FOXA2. In summary, AGR2 represents an interesting new avenue into the etiopathophysiology of IBD and the maintenance of epithelial integrity. More... »

PAGES

11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.gene.6364263

DOI

http://dx.doi.org/10.1038/sj.gene.6364263

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027845167

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16222343


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colitis, Ulcerative", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crohn Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatocyte Nuclear Factor 3-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatocyte Nuclear Factor 3-beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammatory Bowel Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany", 
            "Kiel Center of the German National Genotyping Platform, Christian-Albrechts-University, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zheng", 
        "givenName": "W", 
        "id": "sg:person.0726237630.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726237630.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosenstiel", 
        "givenName": "P", 
        "id": "sg:person.01026521124.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026521124.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fritz Lipmann Institute", 
          "id": "https://www.grid.ac/institutes/grid.418245.e", 
          "name": [
            "Department of Genome Analysis, Institute of Molecular Biotechnology, Jena, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huse", 
        "givenName": "K", 
        "id": "sg:person.0747726071.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747726071.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sina", 
        "givenName": "C", 
        "id": "sg:person.0650270740.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650270740.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany", 
            "Kiel Center of the German National Genotyping Platform, Christian-Albrechts-University, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valentonyte", 
        "givenName": "R", 
        "id": "sg:person.01166436727.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166436727.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mah", 
        "givenName": "N", 
        "id": "sg:person.01157550014.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157550014.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Probiodrug (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.435222.0", 
          "name": [
            "Ingenium Pharmaceuticals AG, Martinsried, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zeitlmann", 
        "givenName": "L", 
        "id": "sg:person.01336247147.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336247147.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Probiodrug (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.435222.0", 
          "name": [
            "Ingenium Pharmaceuticals AG, Martinsried, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grosse", 
        "givenName": "J", 
        "id": "sg:person.01017102661.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017102661.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Gene Mapping Center, MDC Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ruf", 
        "givenName": "N", 
        "id": "sg:person.01123335063.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123335063.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Gene Mapping Center, MDC Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "N\u00fcrnberg", 
        "givenName": "P", 
        "id": "sg:person.01142432564.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142432564.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Costello", 
        "givenName": "C M", 
        "id": "sg:person.0732161347.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732161347.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Division of Genetics and Molecular Medicine, King's College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onnie", 
        "givenName": "C", 
        "id": "sg:person.0715260177.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715260177.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Division of Genetics and Molecular Medicine, King's College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mathew", 
        "givenName": "C", 
        "id": "sg:person.01313422073.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313422073.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fritz Lipmann Institute", 
          "id": "https://www.grid.ac/institutes/grid.418245.e", 
          "name": [
            "Department of Genome Analysis, Institute of Molecular Biotechnology, Jena, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Platzer", 
        "givenName": "M", 
        "id": "sg:person.01314631471.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314631471.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schreiber", 
        "givenName": "S", 
        "id": "sg:person.01223143620.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223143620.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany", 
            "Kiel Center of the German National Genotyping Platform, Christian-Albrechts-University, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hampe", 
        "givenName": "J", 
        "id": "sg:person.0770420375.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770420375.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.261567999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000136784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(98)70381-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000627345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(98)70381-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000627345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00451461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000796427", 
          "https://doi.org/10.1007/bf00451461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00451461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000796427", 
          "https://doi.org/10.1007/bf00451461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/17.7.654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001119823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra020831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004344000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005955498", 
          "https://doi.org/10.1038/ng1339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005955498", 
          "https://doi.org/10.1038/ng1339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.29.7.990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008537453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.38.5.738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011716264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1998.9440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014065497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1996.v111.pm8780563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018354321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.39.5.690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020074193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m414122200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020331352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(89)90413-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021133310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199109263251306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029031473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)05063-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030199334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030806509", 
          "https://doi.org/10.1038/35079114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030806509", 
          "https://doi.org/10.1038/35079114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031360950", 
          "https://doi.org/10.1038/35079107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031360950", 
          "https://doi.org/10.1038/35079107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/302677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031795557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0495-341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032967302", 
          "https://doi.org/10.1038/ng0495-341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00418851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033383475", 
          "https://doi.org/10.1007/bf00418851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00418851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033383475", 
          "https://doi.org/10.1007/bf00418851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199101103240203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037723482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/302294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037792018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20040309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038320777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20040309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038320777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039933647", 
          "https://doi.org/10.1038/ng1345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039933647", 
          "https://doi.org/10.1038/ng1345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01647703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042009311", 
          "https://doi.org/10.1007/bf01647703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01647703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042009311", 
          "https://doi.org/10.1007/bf01647703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365528909091339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045122809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(98)70075-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045808605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000015594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048439480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1096-199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050602394", 
          "https://doi.org/10.1038/ng1096-199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.00966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052622352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/302577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058610146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.312.7023.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062774525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.312.7023.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062774525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082810345", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082894760", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-01", 
    "datePublishedReg": "2006-01-01", 
    "description": "Linkage analyses have implicated chromosome 7p21.3 as a susceptibility region for inflammatory bowel disease (IBD). Recently, the mouse phenotype with diarrhea and goblet cell dysfunction caused by anterior gradient protein 2 dysfunction was reported (European patent WO2004056858). The genes encoding for the human homologues AGR2 and AGR3 are localized on chromosome 7p21.3. The gene structures were verified and mutation detection was performed in 47 IBD patients. A total of 30 single nucleotide polymorphisms (SNPs) were tested for association to ulcerative colitis (UC, N = 317) and Crohn's disease (CD, N = 631) in a German cohort and verified in a UK cohort of 384 CD and 311 UC patients. An association signal was identified in the 5' region of the AGR2 gene (most significant SNP hcv1702494, nominal P(TDT) = 0.011, P(case/control) = 0.0007, OR = 1.34, combined cohort). The risk haplotype carried an odds ratio of 1.43 in the German population (P = 0.002). AGR2 was downregulated in UC patients as compared to normal controls (P < 0.001) and a trend toward lower expression was seen in carriers of the risk alleles. Luciferase assays of the AGR2 promoter showed regulation by the goblet cell-specific transcription factors FOXA1 and FOXA2. In summary, AGR2 represents an interesting new avenue into the etiopathophysiology of IBD and the maintenance of epithelial integrity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.gene.6364263", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1022914", 
        "issn": [
          "1466-4879", 
          "1476-5470"
        ], 
        "name": "Genes & Immunity", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease", 
    "pagination": "11", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "84a501b4fde5983251462d5950f3156019eb70014daf6d6a822de9d352a7c77c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16222343"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100953417"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.gene.6364263"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027845167"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.gene.6364263", 
      "https://app.dimensions.ai/details/publication/pub.1027845167"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29191_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/6364263"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.gene.6364263'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.gene.6364263'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.gene.6364263'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.gene.6364263'


 

This table displays all metadata directly associated to this object as RDF triples.

341 TRIPLES      21 PREDICATES      74 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.gene.6364263 schema:about N0c9d8f6c6cfd4854bb2631a3e7358a29
2 N3aafcd3956af459cb964a8e08988e1e5
3 N57e6394df278444c9823684d195170ff
4 N5847248a74424c8b893db5e4786c6054
5 N65cdb0e9ed8b46d8a6f1d466da33a29b
6 N668bd88b72de47fe9727a98e6b96dc46
7 Na450ee15e47f4a8b9c8ae3a639e9af1d
8 Na58524faa79f4216ba3e5056b337183d
9 Nb5557c77803c4aeb929d8be8c38a076d
10 Nf4b86150a455428c8a8b501a1506aad7
11 Nf9e89e2c90554988a341aa639c1198ad
12 anzsrc-for:06
13 anzsrc-for:0604
14 schema:author Nc2c86d873bf54211aff82aa1636b86b2
15 schema:citation sg:pub.10.1007/bf00418851
16 sg:pub.10.1007/bf00451461
17 sg:pub.10.1007/bf01647703
18 sg:pub.10.1038/35079107
19 sg:pub.10.1038/35079114
20 sg:pub.10.1038/ng0495-341
21 sg:pub.10.1038/ng1096-199
22 sg:pub.10.1038/ng1339
23 sg:pub.10.1038/ng1345
24 https://app.dimensions.ai/details/publication/pub.1082810345
25 https://app.dimensions.ai/details/publication/pub.1082894760
26 https://doi.org/10.1006/bbrc.1998.9440
27 https://doi.org/10.1016/0092-8674(89)90413-3
28 https://doi.org/10.1016/s0016-5085(98)70075-7
29 https://doi.org/10.1016/s0016-5085(98)70381-6
30 https://doi.org/10.1016/s0140-6736(00)05063-7
31 https://doi.org/10.1042/cs20040309
32 https://doi.org/10.1053/gast.1996.v111.pm8780563
33 https://doi.org/10.1056/nejm199101103240203
34 https://doi.org/10.1056/nejm199109263251306
35 https://doi.org/10.1056/nejmra020831
36 https://doi.org/10.1073/pnas.261567999
37 https://doi.org/10.1074/jbc.m414122200
38 https://doi.org/10.1086/302294
39 https://doi.org/10.1086/302577
40 https://doi.org/10.1086/302677
41 https://doi.org/10.1093/bioinformatics/17.7.654
42 https://doi.org/10.1136/bmj.312.7023.95
43 https://doi.org/10.1136/gut.29.7.990
44 https://doi.org/10.1136/gut.38.5.738
45 https://doi.org/10.1136/gut.39.5.690
46 https://doi.org/10.1159/000015594
47 https://doi.org/10.1242/dev.00966
48 https://doi.org/10.3109/00365528909091339
49 schema:datePublished 2006-01
50 schema:datePublishedReg 2006-01-01
51 schema:description Linkage analyses have implicated chromosome 7p21.3 as a susceptibility region for inflammatory bowel disease (IBD). Recently, the mouse phenotype with diarrhea and goblet cell dysfunction caused by anterior gradient protein 2 dysfunction was reported (European patent WO2004056858). The genes encoding for the human homologues AGR2 and AGR3 are localized on chromosome 7p21.3. The gene structures were verified and mutation detection was performed in 47 IBD patients. A total of 30 single nucleotide polymorphisms (SNPs) were tested for association to ulcerative colitis (UC, N = 317) and Crohn's disease (CD, N = 631) in a German cohort and verified in a UK cohort of 384 CD and 311 UC patients. An association signal was identified in the 5' region of the AGR2 gene (most significant SNP hcv1702494, nominal P(TDT) = 0.011, P(case/control) = 0.0007, OR = 1.34, combined cohort). The risk haplotype carried an odds ratio of 1.43 in the German population (P = 0.002). AGR2 was downregulated in UC patients as compared to normal controls (P < 0.001) and a trend toward lower expression was seen in carriers of the risk alleles. Luciferase assays of the AGR2 promoter showed regulation by the goblet cell-specific transcription factors FOXA1 and FOXA2. In summary, AGR2 represents an interesting new avenue into the etiopathophysiology of IBD and the maintenance of epithelial integrity.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree true
55 schema:isPartOf Nb6f64f96bffa4046b2356b7b9bff9ce4
56 Ncf5b6a7347674e4dbae7011e5dacb379
57 sg:journal.1022914
58 schema:name Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease
59 schema:pagination 11
60 schema:productId N1d59f4eb8b774def8a70fece3670e00c
61 N327e26476d9c4ea5869f3d811c966fc5
62 N33ad12f9f14c424ca2bc197a933d7c39
63 N34a9631d3f0a46f397b1965e3ea7c402
64 Ne2703ad6fa3d408c93a6faccb27cfc17
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027845167
66 https://doi.org/10.1038/sj.gene.6364263
67 schema:sdDatePublished 2019-04-11T11:52
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher Ndecad592582542a188603814f1eb26af
70 schema:url https://www.nature.com/articles/6364263
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N0c9d8f6c6cfd4854bb2631a3e7358a29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Proteins
76 rdf:type schema:DefinedTerm
77 N0dd41444cfb64a0d85144781cc036398 rdf:first sg:person.01142432564.72
78 rdf:rest Ne685cd3dc5834e39a6d6223ef9d9d5cf
79 N0f13e5944ccc488a90862b2399261c34 schema:name Gene Mapping Center, MDC Berlin, Germany
80 rdf:type schema:Organization
81 N14f8e3b1655d42fbaa68635a90e73f23 rdf:first sg:person.01123335063.62
82 rdf:rest N0dd41444cfb64a0d85144781cc036398
83 N1cfa20b95f0f41e4a4542a1fedbbd33c schema:name Gene Mapping Center, MDC Berlin, Germany
84 rdf:type schema:Organization
85 N1d59f4eb8b774def8a70fece3670e00c schema:name nlm_unique_id
86 schema:value 100953417
87 rdf:type schema:PropertyValue
88 N206b49c57e17444091571844613a8306 rdf:first sg:person.01017102661.66
89 rdf:rest N14f8e3b1655d42fbaa68635a90e73f23
90 N27d26482921f4e9bb056179e70cadb19 rdf:first sg:person.01314631471.28
91 rdf:rest Nc85214aaf7b94c78952b0d7f0f478b10
92 N327e26476d9c4ea5869f3d811c966fc5 schema:name doi
93 schema:value 10.1038/sj.gene.6364263
94 rdf:type schema:PropertyValue
95 N33ad12f9f14c424ca2bc197a933d7c39 schema:name readcube_id
96 schema:value 84a501b4fde5983251462d5950f3156019eb70014daf6d6a822de9d352a7c77c
97 rdf:type schema:PropertyValue
98 N34a9631d3f0a46f397b1965e3ea7c402 schema:name pubmed_id
99 schema:value 16222343
100 rdf:type schema:PropertyValue
101 N3aafcd3956af459cb964a8e08988e1e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Humans
103 rdf:type schema:DefinedTerm
104 N57e6394df278444c9823684d195170ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Hepatocyte Nuclear Factor 3-alpha
106 rdf:type schema:DefinedTerm
107 N581bd05e150643b7a1ba537d777f33f7 rdf:first sg:person.01166436727.52
108 rdf:rest Nb2d06c2f288d401186bb035ef6537bcb
109 N5847248a74424c8b893db5e4786c6054 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Genetic Predisposition to Disease
111 rdf:type schema:DefinedTerm
112 N65cdb0e9ed8b46d8a6f1d466da33a29b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Carrier Proteins
114 rdf:type schema:DefinedTerm
115 N668bd88b72de47fe9727a98e6b96dc46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Neoplasm Proteins
117 rdf:type schema:DefinedTerm
118 N982499ca824e4a698cebd527b24397b3 rdf:first sg:person.0650270740.66
119 rdf:rest N581bd05e150643b7a1ba537d777f33f7
120 Na450ee15e47f4a8b9c8ae3a639e9af1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Inflammatory Bowel Diseases
122 rdf:type schema:DefinedTerm
123 Na58524faa79f4216ba3e5056b337183d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Colitis, Ulcerative
125 rdf:type schema:DefinedTerm
126 Nb2d06c2f288d401186bb035ef6537bcb rdf:first sg:person.01157550014.71
127 rdf:rest Nc8660a3103d8495398284b2704289c95
128 Nb2ed027009d34f28a964f65380e49345 rdf:first sg:person.0770420375.31
129 rdf:rest rdf:nil
130 Nb5557c77803c4aeb929d8be8c38a076d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Crohn Disease
132 rdf:type schema:DefinedTerm
133 Nb6f64f96bffa4046b2356b7b9bff9ce4 schema:volumeNumber 7
134 rdf:type schema:PublicationVolume
135 Nc2c86d873bf54211aff82aa1636b86b2 rdf:first sg:person.0726237630.37
136 rdf:rest Nf5d098e397a64b8ba515728828413f50
137 Nc85214aaf7b94c78952b0d7f0f478b10 rdf:first sg:person.01223143620.01
138 rdf:rest Nb2ed027009d34f28a964f65380e49345
139 Nc8660a3103d8495398284b2704289c95 rdf:first sg:person.01336247147.06
140 rdf:rest N206b49c57e17444091571844613a8306
141 Ncf5b6a7347674e4dbae7011e5dacb379 schema:issueNumber 1
142 rdf:type schema:PublicationIssue
143 Ndeac1ad9dc1345c49a0918b083afedef rdf:first sg:person.0747726071.53
144 rdf:rest N982499ca824e4a698cebd527b24397b3
145 Ndecad592582542a188603814f1eb26af schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 Ne2703ad6fa3d408c93a6faccb27cfc17 schema:name dimensions_id
148 schema:value pub.1027845167
149 rdf:type schema:PropertyValue
150 Ne685cd3dc5834e39a6d6223ef9d9d5cf rdf:first sg:person.0732161347.68
151 rdf:rest Nfbfb8ed2bff54c2daa90f60879ec28d0
152 Nf4b86150a455428c8a8b501a1506aad7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Cell Line
154 rdf:type schema:DefinedTerm
155 Nf5d098e397a64b8ba515728828413f50 rdf:first sg:person.01026521124.04
156 rdf:rest Ndeac1ad9dc1345c49a0918b083afedef
157 Nf9e89e2c90554988a341aa639c1198ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Hepatocyte Nuclear Factor 3-beta
159 rdf:type schema:DefinedTerm
160 Nfadac1f44a014598994d1c770d47c823 rdf:first sg:person.01313422073.62
161 rdf:rest N27d26482921f4e9bb056179e70cadb19
162 Nfbfb8ed2bff54c2daa90f60879ec28d0 rdf:first sg:person.0715260177.20
163 rdf:rest Nfadac1f44a014598994d1c770d47c823
164 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
165 schema:name Biological Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
168 schema:name Genetics
169 rdf:type schema:DefinedTerm
170 sg:journal.1022914 schema:issn 1466-4879
171 1476-5470
172 schema:name Genes & Immunity
173 rdf:type schema:Periodical
174 sg:person.01017102661.66 schema:affiliation https://www.grid.ac/institutes/grid.435222.0
175 schema:familyName Grosse
176 schema:givenName J
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017102661.66
178 rdf:type schema:Person
179 sg:person.01026521124.04 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
180 schema:familyName Rosenstiel
181 schema:givenName P
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026521124.04
183 rdf:type schema:Person
184 sg:person.01123335063.62 schema:affiliation N1cfa20b95f0f41e4a4542a1fedbbd33c
185 schema:familyName Ruf
186 schema:givenName N
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123335063.62
188 rdf:type schema:Person
189 sg:person.01142432564.72 schema:affiliation N0f13e5944ccc488a90862b2399261c34
190 schema:familyName Nürnberg
191 schema:givenName P
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142432564.72
193 rdf:type schema:Person
194 sg:person.01157550014.71 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
195 schema:familyName Mah
196 schema:givenName N
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157550014.71
198 rdf:type schema:Person
199 sg:person.01166436727.52 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
200 schema:familyName Valentonyte
201 schema:givenName R
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166436727.52
203 rdf:type schema:Person
204 sg:person.01223143620.01 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
205 schema:familyName Schreiber
206 schema:givenName S
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223143620.01
208 rdf:type schema:Person
209 sg:person.01313422073.62 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
210 schema:familyName Mathew
211 schema:givenName C
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313422073.62
213 rdf:type schema:Person
214 sg:person.01314631471.28 schema:affiliation https://www.grid.ac/institutes/grid.418245.e
215 schema:familyName Platzer
216 schema:givenName M
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314631471.28
218 rdf:type schema:Person
219 sg:person.01336247147.06 schema:affiliation https://www.grid.ac/institutes/grid.435222.0
220 schema:familyName Zeitlmann
221 schema:givenName L
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336247147.06
223 rdf:type schema:Person
224 sg:person.0650270740.66 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
225 schema:familyName Sina
226 schema:givenName C
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650270740.66
228 rdf:type schema:Person
229 sg:person.0715260177.20 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
230 schema:familyName Onnie
231 schema:givenName C
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715260177.20
233 rdf:type schema:Person
234 sg:person.0726237630.37 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
235 schema:familyName Zheng
236 schema:givenName W
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726237630.37
238 rdf:type schema:Person
239 sg:person.0732161347.68 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
240 schema:familyName Costello
241 schema:givenName C M
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732161347.68
243 rdf:type schema:Person
244 sg:person.0747726071.53 schema:affiliation https://www.grid.ac/institutes/grid.418245.e
245 schema:familyName Huse
246 schema:givenName K
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747726071.53
248 rdf:type schema:Person
249 sg:person.0770420375.31 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
250 schema:familyName Hampe
251 schema:givenName J
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770420375.31
253 rdf:type schema:Person
254 sg:pub.10.1007/bf00418851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033383475
255 https://doi.org/10.1007/bf00418851
256 rdf:type schema:CreativeWork
257 sg:pub.10.1007/bf00451461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000796427
258 https://doi.org/10.1007/bf00451461
259 rdf:type schema:CreativeWork
260 sg:pub.10.1007/bf01647703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042009311
261 https://doi.org/10.1007/bf01647703
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/35079107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031360950
264 https://doi.org/10.1038/35079107
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/35079114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030806509
267 https://doi.org/10.1038/35079114
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/ng0495-341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032967302
270 https://doi.org/10.1038/ng0495-341
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/ng1096-199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050602394
273 https://doi.org/10.1038/ng1096-199
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/ng1339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005955498
276 https://doi.org/10.1038/ng1339
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/ng1345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039933647
279 https://doi.org/10.1038/ng1345
280 rdf:type schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1082810345 schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1082894760 schema:CreativeWork
283 https://doi.org/10.1006/bbrc.1998.9440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014065497
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/0092-8674(89)90413-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021133310
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s0016-5085(98)70075-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045808605
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s0016-5085(98)70381-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000627345
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/s0140-6736(00)05063-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030199334
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1042/cs20040309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038320777
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1053/gast.1996.v111.pm8780563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018354321
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1056/nejm199101103240203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037723482
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1056/nejm199109263251306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029031473
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1056/nejmra020831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004344000
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1073/pnas.261567999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000136784
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1074/jbc.m414122200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020331352
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1086/302294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037792018
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1086/302577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058610146
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1086/302677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031795557
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/bioinformatics/17.7.654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001119823
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1136/bmj.312.7023.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062774525
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1136/gut.29.7.990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008537453
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1136/gut.38.5.738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011716264
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1136/gut.39.5.690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020074193
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1159/000015594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048439480
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1242/dev.00966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052622352
326 rdf:type schema:CreativeWork
327 https://doi.org/10.3109/00365528909091339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045122809
328 rdf:type schema:CreativeWork
329 https://www.grid.ac/institutes/grid.13097.3c schema:alternateName King's College London
330 schema:name Division of Genetics and Molecular Medicine, King's College London, London, UK
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.418245.e schema:alternateName Fritz Lipmann Institute
333 schema:name Department of Genome Analysis, Institute of Molecular Biotechnology, Jena, Germany
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.435222.0 schema:alternateName Probiodrug (Germany)
336 schema:name Ingenium Pharmaceuticals AG, Martinsried, Germany
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.9764.c schema:alternateName Kiel University
339 schema:name Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
340 Kiel Center of the German National Genotyping Platform, Christian-Albrechts-University, Kiel, Germany
341 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...