Cis-acting effect of the IL1B C−31T polymorphism on IL-1β mRNA expression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-09-09

AUTHORS

R Kimura, T Nishioka, A Soemantri, T Ishida

ABSTRACT

Since the effect of IL1B polymorphisms on IL-1β production is still controversial, we selected two polymorphisms to test their cis-acting effect on IL-1β mRNA expression by means of the allele-specific transcript quantification and the haplotype analysis. As for the C−31T polymorphism, we found that expression of the −31T allele was 2.2 times of the −31C allele. This higher transcription efficiency may correspond to the fact that C−31T is located in a TATA box. The other polymorphism, C+3954T, did not alter the levels of transcription. The use of the allele-specific transcript quantification enables us to exclude trans-acting effects of polymorphisms on the gene expression and contributes to understanding the roles of the IL1B polymorphisms in susceptibility to multifactorial diseases. More... »

PAGES

572-575

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.gene.6364128

DOI

http://dx.doi.org/10.1038/sj.gene.6364128

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043030254

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15356674


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Confidence Intervals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Complementation Test", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Statistics, Nonparametric", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Biological Sciences, Unit of Human Biology and Genetics, Graduate School of Science, The University of Tokyo, Tokyo, Bunkyo-ku, Japan", 
            "Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kimura", 
        "givenName": "R", 
        "id": "sg:person.0624243455.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624243455.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Sciences, Unit of Human Biology and Genetics, Graduate School of Science, The University of Tokyo, Tokyo, Bunkyo-ku, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Biological Sciences, Unit of Human Biology and Genetics, Graduate School of Science, The University of Tokyo, Tokyo, Bunkyo-ku, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishioka", 
        "givenName": "T", 
        "id": "sg:person.01310354746.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310354746.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Faculty of Medicine, Diponegoro University, Semarang, Indonesia", 
          "id": "http://www.grid.ac/institutes/grid.412032.6", 
          "name": [
            "Department of Pediatrics, Faculty of Medicine, Diponegoro University, Semarang, Indonesia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soemantri", 
        "givenName": "A", 
        "id": "sg:person.01226575435.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226575435.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Sciences, Unit of Human Biology and Genetics, Graduate School of Science, The University of Tokyo, Tokyo, Bunkyo-ku, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Biological Sciences, Unit of Human Biology and Genetics, Graduate School of Science, The University of Tokyo, Tokyo, Bunkyo-ku, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishida", 
        "givenName": "T", 
        "id": "sg:person.015576331772.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576331772.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.gene.6363978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013590092", 
          "https://doi.org/10.1038/sj.gene.6363978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6363881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046632828", 
          "https://doi.org/10.1038/sj.gene.6363881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6363645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035711663", 
          "https://doi.org/10.1038/sj.gene.6363645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6363733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004922879", 
          "https://doi.org/10.1038/sj.gene.6363733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6363747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015758306", 
          "https://doi.org/10.1038/sj.gene.6363747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35006081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030124366", 
          "https://doi.org/10.1038/35006081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6363812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052420043", 
          "https://doi.org/10.1038/sj.gene.6363812"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-09-09", 
    "datePublishedReg": "2004-09-09", 
    "description": "Since the effect of IL1B polymorphisms on IL-1\u03b2 production is still controversial, we selected two polymorphisms to test their cis-acting effect on IL-1\u03b2 mRNA expression by means of the allele-specific transcript quantification and the haplotype analysis. As for the C\u221231T polymorphism, we found that expression of the \u221231T allele was 2.2 times of the \u221231C allele. This higher transcription efficiency may correspond to the fact that C\u221231T is located in a TATA box. The other polymorphism, C+3954T, did not alter the levels of transcription. The use of the allele-specific transcript quantification enables us to exclude trans-acting effects of polymorphisms on the gene expression and contributes to understanding the roles of the IL1B polymorphisms in susceptibility to multifactorial diseases.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.gene.6364128", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1022914", 
        "issn": [
          "1466-4879", 
          "1476-5470"
        ], 
        "name": "Genes & Immunity", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "keywords": [
      "cis-acting effect", 
      "allele-specific transcript quantification", 
      "transcript quantification", 
      "level of transcription", 
      "high transcription efficiency", 
      "TATA box", 
      "gene expression", 
      "transcription efficiency", 
      "mRNA expression", 
      "expression", 
      "polymorphism", 
      "alleles", 
      "haplotype analysis", 
      "transcription", 
      "multifactorial disease", 
      "acting effect", 
      "IL1B", 
      "production", 
      "box", 
      "role", 
      "susceptibility", 
      "quantification", 
      "effect", 
      "levels", 
      "analysis", 
      "disease", 
      "fact", 
      "efficiency", 
      "use", 
      "time", 
      "means", 
      "IL1B polymorphisms"
    ], 
    "name": "Cis-acting effect of the IL1B C\u221231T polymorphism on IL-1\u03b2 mRNA expression", 
    "pagination": "572-575", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043030254"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.gene.6364128"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15356674"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.gene.6364128", 
      "https://app.dimensions.ai/details/publication/pub.1043030254"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_392.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.gene.6364128"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.gene.6364128'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.gene.6364128'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.gene.6364128'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.gene.6364128'


 

This table displays all metadata directly associated to this object as RDF triples.

184 TRIPLES      22 PREDICATES      74 URIs      59 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.gene.6364128 schema:about N0172a3c78b2042c4916786f757cdca11
2 N1639b3079824404ab85bea7b4897bdac
3 N18fced0799824cde93ea94305beb9466
4 N3262d8e2b8394667bbe8dfcc654eaf03
5 N5aff4731a3d54ea4aa91956ef1f8b631
6 N8128e13f693849f9ae056f0914b0bcb9
7 Na42721bb977b43c9a8c849a875690bad
8 Ncfa3f978b19740b2a7ef0c913ffe2b73
9 Ne1a97a9b47064b8abae1620480dc49bb
10 anzsrc-for:11
11 anzsrc-for:1107
12 schema:author N14c14bc2e79943949db4095c52a775bb
13 schema:citation sg:pub.10.1038/35006081
14 sg:pub.10.1038/sj.gene.6363645
15 sg:pub.10.1038/sj.gene.6363733
16 sg:pub.10.1038/sj.gene.6363747
17 sg:pub.10.1038/sj.gene.6363812
18 sg:pub.10.1038/sj.gene.6363881
19 sg:pub.10.1038/sj.gene.6363978
20 schema:datePublished 2004-09-09
21 schema:datePublishedReg 2004-09-09
22 schema:description Since the effect of IL1B polymorphisms on IL-1β production is still controversial, we selected two polymorphisms to test their cis-acting effect on IL-1β mRNA expression by means of the allele-specific transcript quantification and the haplotype analysis. As for the C−31T polymorphism, we found that expression of the −31T allele was 2.2 times of the −31C allele. This higher transcription efficiency may correspond to the fact that C−31T is located in a TATA box. The other polymorphism, C+3954T, did not alter the levels of transcription. The use of the allele-specific transcript quantification enables us to exclude trans-acting effects of polymorphisms on the gene expression and contributes to understanding the roles of the IL1B polymorphisms in susceptibility to multifactorial diseases.
23 schema:genre article
24 schema:inLanguage en
25 schema:isAccessibleForFree true
26 schema:isPartOf Naff22dc847074728b3e86f18f1eab6c7
27 Nb74ef792ce134c05a906163e6cad732a
28 sg:journal.1022914
29 schema:keywords IL1B
30 IL1B polymorphisms
31 TATA box
32 acting effect
33 allele-specific transcript quantification
34 alleles
35 analysis
36 box
37 cis-acting effect
38 disease
39 effect
40 efficiency
41 expression
42 fact
43 gene expression
44 haplotype analysis
45 high transcription efficiency
46 level of transcription
47 levels
48 mRNA expression
49 means
50 multifactorial disease
51 polymorphism
52 production
53 quantification
54 role
55 susceptibility
56 time
57 transcript quantification
58 transcription
59 transcription efficiency
60 use
61 schema:name Cis-acting effect of the IL1B C−31T polymorphism on IL-1β mRNA expression
62 schema:pagination 572-575
63 schema:productId N1d221839647e45fea05addfe178e7c81
64 Ndbee5b062b114d1cbe47deacc17b26ed
65 Nfa4f387c7ef948449f1f33736366ed44
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043030254
67 https://doi.org/10.1038/sj.gene.6364128
68 schema:sdDatePublished 2021-11-01T18:07
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher Nfb81a00dc02f4a00bba5bfe7106df982
71 schema:url https://doi.org/10.1038/sj.gene.6364128
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N0172a3c78b2042c4916786f757cdca11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name RNA, Messenger
77 rdf:type schema:DefinedTerm
78 N0192732053464dfe8e253fba00a68c16 rdf:first sg:person.015576331772.42
79 rdf:rest rdf:nil
80 N14c14bc2e79943949db4095c52a775bb rdf:first sg:person.0624243455.41
81 rdf:rest N43b9758175564cf694cbff525cceb1eb
82 N1639b3079824404ab85bea7b4897bdac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Cell Line
84 rdf:type schema:DefinedTerm
85 N18fced0799824cde93ea94305beb9466 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Gene Expression Regulation
87 rdf:type schema:DefinedTerm
88 N1d221839647e45fea05addfe178e7c81 schema:name doi
89 schema:value 10.1038/sj.gene.6364128
90 rdf:type schema:PropertyValue
91 N3262d8e2b8394667bbe8dfcc654eaf03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Statistics, Nonparametric
93 rdf:type schema:DefinedTerm
94 N358f66facf934cd5877eff780817bcc8 rdf:first sg:person.01226575435.13
95 rdf:rest N0192732053464dfe8e253fba00a68c16
96 N43b9758175564cf694cbff525cceb1eb rdf:first sg:person.01310354746.16
97 rdf:rest N358f66facf934cd5877eff780817bcc8
98 N5aff4731a3d54ea4aa91956ef1f8b631 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Genetic Complementation Test
100 rdf:type schema:DefinedTerm
101 N8128e13f693849f9ae056f0914b0bcb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Interleukin-1
103 rdf:type schema:DefinedTerm
104 Na42721bb977b43c9a8c849a875690bad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Polymorphism, Genetic
106 rdf:type schema:DefinedTerm
107 Naff22dc847074728b3e86f18f1eab6c7 schema:volumeNumber 5
108 rdf:type schema:PublicationVolume
109 Nb74ef792ce134c05a906163e6cad732a schema:issueNumber 7
110 rdf:type schema:PublicationIssue
111 Ncfa3f978b19740b2a7ef0c913ffe2b73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Humans
113 rdf:type schema:DefinedTerm
114 Ndbee5b062b114d1cbe47deacc17b26ed schema:name pubmed_id
115 schema:value 15356674
116 rdf:type schema:PropertyValue
117 Ne1a97a9b47064b8abae1620480dc49bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Confidence Intervals
119 rdf:type schema:DefinedTerm
120 Nfa4f387c7ef948449f1f33736366ed44 schema:name dimensions_id
121 schema:value pub.1043030254
122 rdf:type schema:PropertyValue
123 Nfb81a00dc02f4a00bba5bfe7106df982 schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
126 schema:name Medical and Health Sciences
127 rdf:type schema:DefinedTerm
128 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
129 schema:name Immunology
130 rdf:type schema:DefinedTerm
131 sg:journal.1022914 schema:issn 1466-4879
132 1476-5470
133 schema:name Genes & Immunity
134 schema:publisher Springer Nature
135 rdf:type schema:Periodical
136 sg:person.01226575435.13 schema:affiliation grid-institutes:grid.412032.6
137 schema:familyName Soemantri
138 schema:givenName A
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226575435.13
140 rdf:type schema:Person
141 sg:person.01310354746.16 schema:affiliation grid-institutes:grid.26999.3d
142 schema:familyName Nishioka
143 schema:givenName T
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310354746.16
145 rdf:type schema:Person
146 sg:person.015576331772.42 schema:affiliation grid-institutes:grid.26999.3d
147 schema:familyName Ishida
148 schema:givenName T
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576331772.42
150 rdf:type schema:Person
151 sg:person.0624243455.41 schema:affiliation grid-institutes:grid.26999.3d
152 schema:familyName Kimura
153 schema:givenName R
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624243455.41
155 rdf:type schema:Person
156 sg:pub.10.1038/35006081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030124366
157 https://doi.org/10.1038/35006081
158 rdf:type schema:CreativeWork
159 sg:pub.10.1038/sj.gene.6363645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035711663
160 https://doi.org/10.1038/sj.gene.6363645
161 rdf:type schema:CreativeWork
162 sg:pub.10.1038/sj.gene.6363733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004922879
163 https://doi.org/10.1038/sj.gene.6363733
164 rdf:type schema:CreativeWork
165 sg:pub.10.1038/sj.gene.6363747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015758306
166 https://doi.org/10.1038/sj.gene.6363747
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/sj.gene.6363812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052420043
169 https://doi.org/10.1038/sj.gene.6363812
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/sj.gene.6363881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046632828
172 https://doi.org/10.1038/sj.gene.6363881
173 rdf:type schema:CreativeWork
174 sg:pub.10.1038/sj.gene.6363978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013590092
175 https://doi.org/10.1038/sj.gene.6363978
176 rdf:type schema:CreativeWork
177 grid-institutes:grid.26999.3d schema:alternateName Department of Biological Sciences, Unit of Human Biology and Genetics, Graduate School of Science, The University of Tokyo, Tokyo, Bunkyo-ku, Japan
178 Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan
179 schema:name Department of Biological Sciences, Unit of Human Biology and Genetics, Graduate School of Science, The University of Tokyo, Tokyo, Bunkyo-ku, Japan
180 Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan
181 rdf:type schema:Organization
182 grid-institutes:grid.412032.6 schema:alternateName Department of Pediatrics, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
183 schema:name Department of Pediatrics, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
184 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...