Cost-effective analysis of candidate genes using htSNPs: a staged approach View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-03-18

AUTHORS

C E Lowe, J D Cooper, J M Chapman, B J Barratt, R C J Twells, E A Green, D A Savage, C Guja, C Ionescu-Tîrgovişte, E Tuomilehto-Wolf, J Tuomilehto, J A Todd, D G Clayton

ABSTRACT

We have previously shown that the selection of haplotype tag single nucleotide polymorphisms (htSNPs) and their statistical analysis in a multi-locus transmission/disequilibrium test (TDT) results in a more cost-effective genotyping strategy in disease association studies of genes by minimising redundancy due to linkage disequilibrium between SNPs. Further savings can be achieved by the use of a two-stage genotyping strategy. This approach is illustrated here in conjunction with the multi-locus TDT in determining whether common alleles of the immune regulatory genes RANK and its ligand TRANCE (RANKL) are associated with type 1 diabetes (T1D). A saving of approximately 75% of potential genotyping reactions could be made with minimal loss of power. There was little evidence from our analysis for association between the TRANCE and RANK genes and T1D in the populations tested. More... »

PAGES

301-305

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.gene.6364064

DOI

http://dx.doi.org/10.1038/sj.gene.6364064

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016383616

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15029236


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