Segregation of HLA/TNF region is linked to leprosy clinical spectrum in families displaying mixed leprosy subtypes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-01

AUTHORS

M T Mira, A Alcais, T di Pietrantonio, N V Thuc, M C Phuong, L Abel, E Schurr

ABSTRACT

Each year an estimated 600000 new leprosy cases are diagnosed worldwide. The spectrum of the disease varies widely from limited tuberculoid forms to extensive lepromatous forms. A measure of the risk to develop lepromatous forms of leprosy is provided by the extent of skin reactivity to lepromin (Mitsuda reaction). To address a postulated oligogenic control of leprosy pathogenesis, we investigated in the present study linkage of leprosy susceptibility, leprosy clinical subtypes, and extent of the Mitsuda reaction to six chromosomal regions carrying known or suspected leprosy susceptibility loci. The only significant result obtained was linkage of leprosy clinical subtype to the HLA/TNF region on human chromosome 6p21 (P(corrected)=0.00126). In addition, we established that within the same family different HLA/TNF haplotypes segregate into patients with different leprosy subtypes directly demonstrating the importance of this genome region for the control of clinical leprosy presentation. More... »

PAGES

67

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.gene.6363911

DOI

http://dx.doi.org/10.1038/sj.gene.6363911

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048708443

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12595904


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