An intronic variable number of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene modifies gene expression and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-12

AUTHORS

Toshinori Omi, Maki Kumada, Toyomi Kamesaki, Hiroshi Okuda, Lkhagvasuren Munkhtulga, Yoshiko Yanagisawa, Nanami Utsumi, Takaya Gotoh, Akira Hata, Masayoshi Soma, Satoshi Umemura, Toshio Ogihara, Norio Takahashi, Yasuharu Tabara, Kazuyuki Shimada, Hiroyuki Mano, Eiji Kajii, Tetsuro Miki, Sadahiko Iwamoto

ABSTRACT

Cold-induced autoinflammatory syndrome 1 (CIAS1) gene is a member of the NALP subfamily of the CATERPILLER protein family that is expressed predominantly in peripheral blood leukocytes, which is to regulate apoptosis or inflammation through the activation of NF-kappaB and caspase. Recent genetic analyses suggested an association between inflammation and oxidative stress-related genes in the development of hypertension. This is the first genetic study indicating an association between the CIAS1 gene and susceptibility to essential hypertension (EH). The frequency of subject with the homozygote of 12 repeat allele was significantly higher in patients with hypertension compared with control subjects (987 cases, 924 controls) (P=0.030; odds ratio=1.24) at a novel VNTR polymorphism of CIAS1 intron 4 loci. We also found that the mean of systolic blood pressure of homozygotes of 12 repeat allele was 6.4 mmHg higher than those of homozygotes of non-12 repeat allele in male random population (P=0.009). The frequency of six SNPs spanning of the CIAS1 gene was not significantly between patients and controls. The real-time PCR analysis showed that among healthy young adults, 12-12 subjects expressed CIAS1 mRNA in peripheral leukocytes significantly more abundantly than homozygote of non-12 repeat alleles subjects (P<0.05). Reporter gene assay of the CIAS1-VNTR in HL60 stimulated by lipopolysaccharides showed that the intronic sequence involving 12 repeat increased the expression of luciferase compared with 9, 7, and 6 repeats. Thus, we propose here the CIAS1 is associated with EH through the dominant expression of transcripts, which may depend on the CIAS1-VNTR genotype. More... »

PAGES

5201698

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.ejhg.5201698

DOI

http://dx.doi.org/10.1038/sj.ejhg.5201698

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047268398

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16868559


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Introns", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NLR Family, Pyrin Domain-Containing 3 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tandem Repeat Sequences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Human Genetics, Center for Community Medicine, Jichi Medical School, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Omi", 
        "givenName": "Toshinori", 
        "id": "sg:person.0670704345.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670704345.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Human Genetics, Center for Community Medicine, Jichi Medical School, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kumada", 
        "givenName": "Maki", 
        "id": "sg:person.01115520245.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115520245.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Human Genetics, Center for Community Medicine, Jichi Medical School, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamesaki", 
        "givenName": "Toyomi", 
        "id": "sg:person.01121361345.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121361345.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Human Genetics, Center for Community Medicine, Jichi Medical School, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okuda", 
        "givenName": "Hiroshi", 
        "id": "sg:person.0654661057.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654661057.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Human Genetics, Center for Community Medicine, Jichi Medical School, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Munkhtulga", 
        "givenName": "Lkhagvasuren", 
        "id": "sg:person.01273262620.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273262620.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Human Genetics, Center for Community Medicine, Jichi Medical School, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yanagisawa", 
        "givenName": "Yoshiko", 
        "id": "sg:person.01311426641.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311426641.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Human Genetics, Center for Community Medicine, Jichi Medical School, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Utsumi", 
        "givenName": "Nanami", 
        "id": "sg:person.01243313441.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243313441.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Human Genetics, Center for Community Medicine, Jichi Medical School, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gotoh", 
        "givenName": "Takaya", 
        "id": "sg:person.014076767001.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014076767001.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of Public Health, Graduate School of Medicine, Chiba University, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hata", 
        "givenName": "Akira", 
        "id": "sg:person.010315275275.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010315275275.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nihon University", 
          "id": "https://www.grid.ac/institutes/grid.260969.2", 
          "name": [
            "Department of Nephrology and Endocrinology, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soma", 
        "givenName": "Masayoshi", 
        "id": "sg:person.01172225644.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172225644.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Second Department of Internal Medicine, Yokohama City University Medical School, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Umemura", 
        "givenName": "Satoshi", 
        "id": "sg:person.0720711217.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720711217.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radiation Effects Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418889.4", 
          "name": [
            "Department of Genetics, Radiation Effects Research Foundation, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogihara", 
        "givenName": "Toshio", 
        "id": "sg:person.01174620432.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174620432.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "Norio", 
        "id": "sg:person.01275024343.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275024343.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ehime University", 
          "id": "https://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Department of Geriatric Medicine, Ehime University School of Medicine, Ehime, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tabara", 
        "givenName": "Yasuharu", 
        "id": "sg:person.01243043504.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243043504.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical School, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimada", 
        "givenName": "Kazuyuki", 
        "id": "sg:person.01204571246.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204571246.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Functional Genomics, Jichi Medical School, Kawachigun, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mano", 
        "givenName": "Hiroyuki", 
        "id": "sg:person.0776410617.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776410617.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Human Genetics, Center for Community Medicine, Jichi Medical School, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kajii", 
        "givenName": "Eiji", 
        "id": "sg:person.01352036345.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352036345.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ehime University", 
          "id": "https://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Department of Geriatric Medicine, Ehime University School of Medicine, Ehime, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miki", 
        "givenName": "Tetsuro", 
        "id": "sg:person.011202245512.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011202245512.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Human Genetics, Center for Community Medicine, Jichi Medical School, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwamoto", 
        "givenName": "Sadahiko", 
        "id": "sg:person.01264036557.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264036557.72"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.0402004101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001129575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199816090-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002390445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199816090-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002390445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(03)01222-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003167255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000144480.10207.34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004862069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000144480.10207.34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004862069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000018911.46067.6e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009048482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00041552-200103000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009480074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00041552-200103000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009480074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-07-2531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011102856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m102061200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012538473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hy09t1.096249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013664012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015613080", 
          "https://doi.org/10.1038/ng756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015613080", 
          "https://doi.org/10.1038/ng756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.34.4.943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018762325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jhh.1001785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020941289", 
          "https://doi.org/10.1038/sj.jhh.1001785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jhh.1001785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020941289", 
          "https://doi.org/10.1038/sj.jhh.1001785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000148994.89903.fa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021656164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000148994.89903.fa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021656164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.14.8175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021684038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00295.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022692886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(00)01577-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025754251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025852033", 
          "https://doi.org/10.1038/nature04515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025852033", 
          "https://doi.org/10.1038/nature04515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025852033", 
          "https://doi.org/10.1038/nature04515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(03)00331-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029033781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-200018110-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030588733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-200018110-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030588733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00269.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031748216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0895-7061(98)00099-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032605659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.102.16.1956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033867269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/30.1.158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035679619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112208200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037155248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.169.8.4088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038822839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11906-002-0041-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039193665", 
          "https://doi.org/10.1007/s11906-002-0041-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)13722-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039444153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040642205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042379672", 
          "https://doi.org/10.1038/nature04517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042379672", 
          "https://doi.org/10.1038/nature04517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042379672", 
          "https://doi.org/10.1038/nature04517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.36.4.477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043210286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000134790.02026.e4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044771354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000134790.02026.e4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044771354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00894-001-0064-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045557082", 
          "https://doi.org/10.1007/s00894-001-0064-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.20080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049540990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.101.24.2810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051101074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/342929", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058639601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03402000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075043534", 
          "https://doi.org/10.1007/bf03402000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.171.12.6329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076609526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.172.4.2522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076635547"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-12", 
    "datePublishedReg": "2006-12-01", 
    "description": "Cold-induced autoinflammatory syndrome 1 (CIAS1) gene is a member of the NALP subfamily of the CATERPILLER protein family that is expressed predominantly in peripheral blood leukocytes, which is to regulate apoptosis or inflammation through the activation of NF-kappaB and caspase. Recent genetic analyses suggested an association between inflammation and oxidative stress-related genes in the development of hypertension. This is the first genetic study indicating an association between the CIAS1 gene and susceptibility to essential hypertension (EH). The frequency of subject with the homozygote of 12 repeat allele was significantly higher in patients with hypertension compared with control subjects (987 cases, 924 controls) (P=0.030; odds ratio=1.24) at a novel VNTR polymorphism of CIAS1 intron 4 loci. We also found that the mean of systolic blood pressure of homozygotes of 12 repeat allele was 6.4 mmHg higher than those of homozygotes of non-12 repeat allele in male random population (P=0.009). The frequency of six SNPs spanning of the CIAS1 gene was not significantly between patients and controls. The real-time PCR analysis showed that among healthy young adults, 12-12 subjects expressed CIAS1 mRNA in peripheral leukocytes significantly more abundantly than homozygote of non-12 repeat alleles subjects (P<0.05). Reporter gene assay of the CIAS1-VNTR in HL60 stimulated by lipopolysaccharides showed that the intronic sequence involving 12 repeat increased the expression of luciferase compared with 9, 7, and 6 repeats. Thus, we propose here the CIAS1 is associated with EH through the dominant expression of transcripts, which may depend on the CIAS1-VNTR genotype.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.ejhg.5201698", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5794218", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103410", 
        "issn": [
          "1018-4813", 
          "1476-5438"
        ], 
        "name": "European Journal of Human Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "An intronic variable number of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene modifies gene expression and is associated with essential hypertension", 
    "pagination": "5201698", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e12c01756342c601a6d8960ef31ba533506961bc07107a11fb0d82cbe62690e4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16868559"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9302235"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.ejhg.5201698"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047268398"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.ejhg.5201698", 
      "https://app.dimensions.ai/details/publication/pub.1047268398"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53981_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/5201698"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.ejhg.5201698'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.ejhg.5201698'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.ejhg.5201698'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.ejhg.5201698'


 

This table displays all metadata directly associated to this object as RDF triples.

389 TRIPLES      21 PREDICATES      80 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.ejhg.5201698 schema:about N32f40088e1954182b54659c4cc366d81
2 N37e6107571c64ec296f6b13bfab161b8
3 N55c98a46b53b47669dc08ea0035bb9fd
4 N67ff63a9e59045368603ffd7775d1b38
5 N6a46363f9d4342da91cc690bf8900068
6 N7379cf96cb7f4972a87ccea84883b099
7 N991c26d9d04442358428c867423dfc5e
8 Na988d14e06b64fab8dbb13c4c1b71a9c
9 Nbe923361cdc14162ad14ed14a805a281
10 Nc93cc61f66534d63963c6903d0a4ed76
11 Ncb41a61492e54eddb515d7cc6d376735
12 Ndda1eccb768743eebc2a85fd6ed065f1
13 Nee96e46e12e743089581a789cd7ab3e4
14 anzsrc-for:06
15 anzsrc-for:0604
16 schema:author N72a2ddc9c2d54cc5bcc00222de102562
17 schema:citation sg:pub.10.1007/bf03402000
18 sg:pub.10.1007/s00894-001-0064-7
19 sg:pub.10.1007/s11906-002-0041-2
20 sg:pub.10.1038/nature04515
21 sg:pub.10.1038/nature04517
22 sg:pub.10.1038/ng756
23 sg:pub.10.1038/sj.jhh.1001785
24 https://doi.org/10.1002/gepi.7
25 https://doi.org/10.1002/humu.20080
26 https://doi.org/10.1016/s0014-5793(03)00331-4
27 https://doi.org/10.1016/s0014-5793(03)01222-5
28 https://doi.org/10.1016/s0140-6736(03)13722-1
29 https://doi.org/10.1016/s0895-7061(98)00099-5
30 https://doi.org/10.1016/s0968-0004(00)01577-2
31 https://doi.org/10.1073/pnas.0402004101
32 https://doi.org/10.1073/pnas.95.14.8175
33 https://doi.org/10.1074/jbc.m102061200
34 https://doi.org/10.1074/jbc.m112208200
35 https://doi.org/10.1086/342929
36 https://doi.org/10.1093/nar/30.1.158
37 https://doi.org/10.1097/00004872-199816090-00007
38 https://doi.org/10.1097/00004872-200018110-00008
39 https://doi.org/10.1097/00041552-200103000-00014
40 https://doi.org/10.1152/ajpcell.00295.2001
41 https://doi.org/10.1152/ajprenal.00269.2003
42 https://doi.org/10.1161/01.cir.101.24.2810
43 https://doi.org/10.1161/01.cir.102.16.1956
44 https://doi.org/10.1161/01.hyp.0000018911.46067.6e
45 https://doi.org/10.1161/01.hyp.0000134790.02026.e4
46 https://doi.org/10.1161/01.hyp.0000144480.10207.34
47 https://doi.org/10.1161/01.hyp.0000148994.89903.fa
48 https://doi.org/10.1161/01.hyp.34.4.943
49 https://doi.org/10.1161/01.hyp.36.4.477
50 https://doi.org/10.1161/hy09t1.096249
51 https://doi.org/10.1182/blood-2003-07-2531
52 https://doi.org/10.4049/jimmunol.169.8.4088
53 https://doi.org/10.4049/jimmunol.171.12.6329
54 https://doi.org/10.4049/jimmunol.172.4.2522
55 schema:datePublished 2006-12
56 schema:datePublishedReg 2006-12-01
57 schema:description Cold-induced autoinflammatory syndrome 1 (CIAS1) gene is a member of the NALP subfamily of the CATERPILLER protein family that is expressed predominantly in peripheral blood leukocytes, which is to regulate apoptosis or inflammation through the activation of NF-kappaB and caspase. Recent genetic analyses suggested an association between inflammation and oxidative stress-related genes in the development of hypertension. This is the first genetic study indicating an association between the CIAS1 gene and susceptibility to essential hypertension (EH). The frequency of subject with the homozygote of 12 repeat allele was significantly higher in patients with hypertension compared with control subjects (987 cases, 924 controls) (P=0.030; odds ratio=1.24) at a novel VNTR polymorphism of CIAS1 intron 4 loci. We also found that the mean of systolic blood pressure of homozygotes of 12 repeat allele was 6.4 mmHg higher than those of homozygotes of non-12 repeat allele in male random population (P=0.009). The frequency of six SNPs spanning of the CIAS1 gene was not significantly between patients and controls. The real-time PCR analysis showed that among healthy young adults, 12-12 subjects expressed CIAS1 mRNA in peripheral leukocytes significantly more abundantly than homozygote of non-12 repeat alleles subjects (P<0.05). Reporter gene assay of the CIAS1-VNTR in HL60 stimulated by lipopolysaccharides showed that the intronic sequence involving 12 repeat increased the expression of luciferase compared with 9, 7, and 6 repeats. Thus, we propose here the CIAS1 is associated with EH through the dominant expression of transcripts, which may depend on the CIAS1-VNTR genotype.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree true
61 schema:isPartOf Nbf90f4c3a9fb447fa976c1cdf8581217
62 Nd4b4f20d75594b2db7c200041b566c31
63 sg:journal.1103410
64 schema:name An intronic variable number of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene modifies gene expression and is associated with essential hypertension
65 schema:pagination 5201698
66 schema:productId N205fb97de74145b3afd7276df1b316ef
67 N3ae0e2f98d1e4579b1373813b874847a
68 N59be3c4ef03340fdb7a96b10fe9c7377
69 N9bed4f38590345d483eaddd6d49a0225
70 Na2cb0d8221334a36a24de7957f22713c
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047268398
72 https://doi.org/10.1038/sj.ejhg.5201698
73 schema:sdDatePublished 2019-04-11T12:11
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher Ned649e3647344a04881264b63bfda054
76 schema:url http://www.nature.com/articles/5201698
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N0226220f42334a22a0e626064124781d rdf:first sg:person.011202245512.26
81 rdf:rest N27aae625751a4997aa93a2b0f81f817d
82 N15b89572321c46109a64b2c926a79c61 rdf:first sg:person.0776410617.00
83 rdf:rest Ne10f4290572a4397b33d51bcefb7d55e
84 N205fb97de74145b3afd7276df1b316ef schema:name pubmed_id
85 schema:value 16868559
86 rdf:type schema:PropertyValue
87 N27aae625751a4997aa93a2b0f81f817d rdf:first sg:person.01264036557.72
88 rdf:rest rdf:nil
89 N28ea13c5efed425ebbf0e65d99594ddb rdf:first sg:person.01311426641.35
90 rdf:rest N83695c0d6f1b4832bd92ab089b2113c3
91 N32f40088e1954182b54659c4cc366d81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Tandem Repeat Sequences
93 rdf:type schema:DefinedTerm
94 N351cd0e3ea494ee88e66b5e0c247e586 schema:name Second Department of Internal Medicine, Yokohama City University Medical School, Kanagawa, Japan
95 rdf:type schema:Organization
96 N37e6107571c64ec296f6b13bfab161b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Middle Aged
98 rdf:type schema:DefinedTerm
99 N3ae0e2f98d1e4579b1373813b874847a schema:name doi
100 schema:value 10.1038/sj.ejhg.5201698
101 rdf:type schema:PropertyValue
102 N4cd927ba78174a319c55b42e2b53385c rdf:first sg:person.010315275275.17
103 rdf:rest Nd92c51f8ae1545e4a244150118431159
104 N55c98a46b53b47669dc08ea0035bb9fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Gene Expression
106 rdf:type schema:DefinedTerm
107 N59be3c4ef03340fdb7a96b10fe9c7377 schema:name dimensions_id
108 schema:value pub.1047268398
109 rdf:type schema:PropertyValue
110 N67ff63a9e59045368603ffd7775d1b38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name NLR Family, Pyrin Domain-Containing 3 Protein
112 rdf:type schema:DefinedTerm
113 N6a3e3aa3da2243f7959a9528041f622b rdf:first sg:person.01174620432.33
114 rdf:rest N87ba09ec3dda40c787dad2b30f947def
115 N6a46363f9d4342da91cc690bf8900068 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Genotype
117 rdf:type schema:DefinedTerm
118 N70b14cf2f9bb4420868883118642f1e7 rdf:first sg:person.01243043504.13
119 rdf:rest N7e97c67f5f8b4fb983c6d18ed044ca66
120 N72a2ddc9c2d54cc5bcc00222de102562 rdf:first sg:person.0670704345.68
121 rdf:rest Nf93bddec236046a9bd6f252ae7530f5e
122 N7379cf96cb7f4972a87ccea84883b099 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Male
124 rdf:type schema:DefinedTerm
125 N7e97c67f5f8b4fb983c6d18ed044ca66 rdf:first sg:person.01204571246.33
126 rdf:rest N15b89572321c46109a64b2c926a79c61
127 N83695c0d6f1b4832bd92ab089b2113c3 rdf:first sg:person.01243313441.34
128 rdf:rest Ne1ca34184097436fa420df055e1ea222
129 N87ba09ec3dda40c787dad2b30f947def rdf:first sg:person.01275024343.03
130 rdf:rest N70b14cf2f9bb4420868883118642f1e7
131 N991c26d9d04442358428c867423dfc5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Alleles
133 rdf:type schema:DefinedTerm
134 N9bed4f38590345d483eaddd6d49a0225 schema:name nlm_unique_id
135 schema:value 9302235
136 rdf:type schema:PropertyValue
137 Na2cb0d8221334a36a24de7957f22713c schema:name readcube_id
138 schema:value e12c01756342c601a6d8960ef31ba533506961bc07107a11fb0d82cbe62690e4
139 rdf:type schema:PropertyValue
140 Na988d14e06b64fab8dbb13c4c1b71a9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Hypertension
142 rdf:type schema:DefinedTerm
143 Naae75c193cbf4aa7be48ec7a40ba6ac0 rdf:first sg:person.0720711217.74
144 rdf:rest N6a3e3aa3da2243f7959a9528041f622b
145 Naea215532d304d7e981c4d5abdd4d851 rdf:first sg:person.01121361345.37
146 rdf:rest Ne19d3d0c97434acaaa0922e5174c36b1
147 Nbe923361cdc14162ad14ed14a805a281 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Female
149 rdf:type schema:DefinedTerm
150 Nbf90f4c3a9fb447fa976c1cdf8581217 schema:volumeNumber 14
151 rdf:type schema:PublicationVolume
152 Nc93cc61f66534d63963c6903d0a4ed76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Humans
154 rdf:type schema:DefinedTerm
155 Ncb41a61492e54eddb515d7cc6d376735 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Carrier Proteins
157 rdf:type schema:DefinedTerm
158 Nd4b4f20d75594b2db7c200041b566c31 schema:issueNumber 12
159 rdf:type schema:PublicationIssue
160 Nd92c51f8ae1545e4a244150118431159 rdf:first sg:person.01172225644.04
161 rdf:rest Naae75c193cbf4aa7be48ec7a40ba6ac0
162 Ndda1eccb768743eebc2a85fd6ed065f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Introns
164 rdf:type schema:DefinedTerm
165 Ne0f4fd3bf29c46f3bfc54db86f376326 rdf:first sg:person.01273262620.11
166 rdf:rest N28ea13c5efed425ebbf0e65d99594ddb
167 Ne10f4290572a4397b33d51bcefb7d55e rdf:first sg:person.01352036345.07
168 rdf:rest N0226220f42334a22a0e626064124781d
169 Ne19d3d0c97434acaaa0922e5174c36b1 rdf:first sg:person.0654661057.53
170 rdf:rest Ne0f4fd3bf29c46f3bfc54db86f376326
171 Ne1ca34184097436fa420df055e1ea222 rdf:first sg:person.014076767001.99
172 rdf:rest N4cd927ba78174a319c55b42e2b53385c
173 Ned649e3647344a04881264b63bfda054 schema:name Springer Nature - SN SciGraph project
174 rdf:type schema:Organization
175 Nee96e46e12e743089581a789cd7ab3e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Case-Control Studies
177 rdf:type schema:DefinedTerm
178 Nf93bddec236046a9bd6f252ae7530f5e rdf:first sg:person.01115520245.56
179 rdf:rest Naea215532d304d7e981c4d5abdd4d851
180 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
181 schema:name Biological Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
184 schema:name Genetics
185 rdf:type schema:DefinedTerm
186 sg:grant.5794218 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.ejhg.5201698
187 rdf:type schema:MonetaryGrant
188 sg:journal.1103410 schema:issn 1018-4813
189 1476-5438
190 schema:name European Journal of Human Genetics
191 rdf:type schema:Periodical
192 sg:person.010315275275.17 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
193 schema:familyName Hata
194 schema:givenName Akira
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010315275275.17
196 rdf:type schema:Person
197 sg:person.01115520245.56 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
198 schema:familyName Kumada
199 schema:givenName Maki
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115520245.56
201 rdf:type schema:Person
202 sg:person.011202245512.26 schema:affiliation https://www.grid.ac/institutes/grid.255464.4
203 schema:familyName Miki
204 schema:givenName Tetsuro
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011202245512.26
206 rdf:type schema:Person
207 sg:person.01121361345.37 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
208 schema:familyName Kamesaki
209 schema:givenName Toyomi
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121361345.37
211 rdf:type schema:Person
212 sg:person.01172225644.04 schema:affiliation https://www.grid.ac/institutes/grid.260969.2
213 schema:familyName Soma
214 schema:givenName Masayoshi
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172225644.04
216 rdf:type schema:Person
217 sg:person.01174620432.33 schema:affiliation https://www.grid.ac/institutes/grid.418889.4
218 schema:familyName Ogihara
219 schema:givenName Toshio
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174620432.33
221 rdf:type schema:Person
222 sg:person.01204571246.33 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
223 schema:familyName Shimada
224 schema:givenName Kazuyuki
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204571246.33
226 rdf:type schema:Person
227 sg:person.01243043504.13 schema:affiliation https://www.grid.ac/institutes/grid.255464.4
228 schema:familyName Tabara
229 schema:givenName Yasuharu
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243043504.13
231 rdf:type schema:Person
232 sg:person.01243313441.34 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
233 schema:familyName Utsumi
234 schema:givenName Nanami
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243313441.34
236 rdf:type schema:Person
237 sg:person.01264036557.72 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
238 schema:familyName Iwamoto
239 schema:givenName Sadahiko
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264036557.72
241 rdf:type schema:Person
242 sg:person.01273262620.11 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
243 schema:familyName Munkhtulga
244 schema:givenName Lkhagvasuren
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273262620.11
246 rdf:type schema:Person
247 sg:person.01275024343.03 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
248 schema:familyName Takahashi
249 schema:givenName Norio
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275024343.03
251 rdf:type schema:Person
252 sg:person.01311426641.35 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
253 schema:familyName Yanagisawa
254 schema:givenName Yoshiko
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311426641.35
256 rdf:type schema:Person
257 sg:person.01352036345.07 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
258 schema:familyName Kajii
259 schema:givenName Eiji
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352036345.07
261 rdf:type schema:Person
262 sg:person.014076767001.99 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
263 schema:familyName Gotoh
264 schema:givenName Takaya
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014076767001.99
266 rdf:type schema:Person
267 sg:person.0654661057.53 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
268 schema:familyName Okuda
269 schema:givenName Hiroshi
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654661057.53
271 rdf:type schema:Person
272 sg:person.0670704345.68 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
273 schema:familyName Omi
274 schema:givenName Toshinori
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670704345.68
276 rdf:type schema:Person
277 sg:person.0720711217.74 schema:affiliation N351cd0e3ea494ee88e66b5e0c247e586
278 schema:familyName Umemura
279 schema:givenName Satoshi
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720711217.74
281 rdf:type schema:Person
282 sg:person.0776410617.00 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
283 schema:familyName Mano
284 schema:givenName Hiroyuki
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776410617.00
286 rdf:type schema:Person
287 sg:pub.10.1007/bf03402000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075043534
288 https://doi.org/10.1007/bf03402000
289 rdf:type schema:CreativeWork
290 sg:pub.10.1007/s00894-001-0064-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045557082
291 https://doi.org/10.1007/s00894-001-0064-7
292 rdf:type schema:CreativeWork
293 sg:pub.10.1007/s11906-002-0041-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039193665
294 https://doi.org/10.1007/s11906-002-0041-2
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/nature04515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025852033
297 https://doi.org/10.1038/nature04515
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/nature04517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042379672
300 https://doi.org/10.1038/nature04517
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/ng756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015613080
303 https://doi.org/10.1038/ng756
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/sj.jhh.1001785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020941289
306 https://doi.org/10.1038/sj.jhh.1001785
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1002/gepi.7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040642205
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1002/humu.20080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049540990
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s0014-5793(03)00331-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029033781
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/s0014-5793(03)01222-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003167255
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/s0140-6736(03)13722-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039444153
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/s0895-7061(98)00099-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032605659
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/s0968-0004(00)01577-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025754251
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1073/pnas.0402004101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001129575
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1073/pnas.95.14.8175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021684038
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1074/jbc.m102061200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012538473
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1074/jbc.m112208200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037155248
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1086/342929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058639601
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1093/nar/30.1.158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035679619
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1097/00004872-199816090-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002390445
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1097/00004872-200018110-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030588733
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1097/00041552-200103000-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009480074
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1152/ajpcell.00295.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022692886
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1152/ajprenal.00269.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031748216
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1161/01.cir.101.24.2810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051101074
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1161/01.cir.102.16.1956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033867269
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1161/01.hyp.0000018911.46067.6e schema:sameAs https://app.dimensions.ai/details/publication/pub.1009048482
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1161/01.hyp.0000134790.02026.e4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044771354
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1161/01.hyp.0000144480.10207.34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004862069
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1161/01.hyp.0000148994.89903.fa schema:sameAs https://app.dimensions.ai/details/publication/pub.1021656164
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1161/01.hyp.34.4.943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018762325
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1161/01.hyp.36.4.477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043210286
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1161/hy09t1.096249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013664012
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1182/blood-2003-07-2531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011102856
363 rdf:type schema:CreativeWork
364 https://doi.org/10.4049/jimmunol.169.8.4088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038822839
365 rdf:type schema:CreativeWork
366 https://doi.org/10.4049/jimmunol.171.12.6329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076609526
367 rdf:type schema:CreativeWork
368 https://doi.org/10.4049/jimmunol.172.4.2522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076635547
369 rdf:type schema:CreativeWork
370 https://www.grid.ac/institutes/grid.136304.3 schema:alternateName Chiba University
371 schema:name Department of Public Health, Graduate School of Medicine, Chiba University, Chiba, Japan
372 rdf:type schema:Organization
373 https://www.grid.ac/institutes/grid.136593.b schema:alternateName Osaka University
374 schema:name Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
375 rdf:type schema:Organization
376 https://www.grid.ac/institutes/grid.255464.4 schema:alternateName Ehime University
377 schema:name Department of Geriatric Medicine, Ehime University School of Medicine, Ehime, Japan
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.260969.2 schema:alternateName Nihon University
380 schema:name Department of Nephrology and Endocrinology, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
381 rdf:type schema:Organization
382 https://www.grid.ac/institutes/grid.410804.9 schema:alternateName Jichi Medical University
383 schema:name Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical School, Tochigi, Japan
384 Division of Functional Genomics, Jichi Medical School, Kawachigun, Tochigi, Japan
385 Division of Human Genetics, Center for Community Medicine, Jichi Medical School, Tochigi, Japan
386 rdf:type schema:Organization
387 https://www.grid.ac/institutes/grid.418889.4 schema:alternateName Radiation Effects Research Foundation
388 schema:name Department of Genetics, Radiation Effects Research Foundation, Hiroshima, Japan
389 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...