A genome-wide scan for preeclampsia in the Netherlands View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-10

AUTHORS

Augusta MA Lachmeijer, Augustin Kong, Birgir Pálsson, Dan Nicolae, Esther J Bastiaans, Gerald Pals, Guustaaf A Dekker, Hreinn Stéfansson, Jan G Aarnoudse, Jeff R Gulcher, Kári Stéfansson, Leo P ten Kate, Michael L Frigge, Reynir Arngrímsson, Sigrun Sigurdardóttir

ABSTRACT

Preeclampsia, hallmarked by de novo hypertension and proteinuria in pregnancy, has a familial tendency. Recently, a large Icelandic genome-wide scan provided evidence for a maternal susceptibility locus for preeclampsia on chromosome 2p13 which was confirmed by a genome scan from Australia and New Zealand (NZ). The current study reports on a genome-wide scan of Dutch affected sib-pair families. In total 67 Dutch affected sib-pair families, comprising at least two siblings with proteinuric preeclampsia, eclampsia or HELLP-syndrome, were typed for 293 polymorphic markers throughout the genome and linkage analysis was performed. The highest allele sharing lod score of 1.99 was seen on chromosome 12q at 109.5 cM. Two peaks overlapped in the same regions between the Dutch and Icelandic genome-wide scan at chromosome 3p and chromosome 15q. No overlap was seen on 2p. Re-analysis in 38 families without HELLP-syndrome (preeclampsia families) and 34 families with at least one sibling with HELLP syndrome (HELLP families), revealed two peaks with suggestive evidence for linkage in the non-HELLP families on chromosome 10q (lod score 2.38, D10S1432, 93.9 cM) and 22q (lod score 2.41, D22S685, 32.4 cM). The peak on 12q appeared to be associated with HELLP syndrome; it increased to a lod score of 2.1 in the HELLP families and almost disappeared in the preeclampsia families. A nominal peak on chromosome 11 in the preeclampsia families showed overlap with the second highest peak in the Australian/NZ study. Results from our Dutch genome-wide scan indicate that HELLP syndrome might have a different genetic background than preeclampsia. More... »

PAGES

758

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.ejhg.5200706

DOI

http://dx.doi.org/10.1038/sj.ejhg.5200706

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037250157

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11781687


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