Short tandem repeat polymorphism evolution in humans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-01

AUTHORS

F Calafell, A Shuster, WC Speed, Kidd, KK Kidd

ABSTRACT

Forty-five dinucleotide short tandem repeat polymorphisms were typed in ten large samples of a globally distributed set of populations. Although these markers had been selected for high heterozygosity in European populations, we found them to be sufficiently informative for linkage analysis in non-Europeans. Heterozygosity, mean number of alleles, and mean number of private alleles followed a common trend: they were highest in the African samples, were somewhat lower in Europeans and East Asians, and were lowest in Amerindians. Genetic distances also reflected this pattern, and distances modelled after the stepwise mutation model yielded trees that were less in agreement with other genetic and archaeological evidence than distances based on differentiation by drift (FST). Genetic variation in non-Africans seems to be a subset of that in Africans, supporting the replacement hypothesis for the origin of modern humans. More... »

PAGES

5200151

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.ejhg.5200151

DOI

http://dx.doi.org/10.1038/sj.ejhg.5200151

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003038022

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9781013


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