A proposed method for assessing plasma hypertonicity in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-01

AUTHORS

A Arieff, C Gardner, D E Sellmeyer, J C King, J D Stookey, J E Greenleaf, L Van Hove, M Burg

ABSTRACT

Indices of plasma hypertonicity, elevated plasma concentrations of solutes that draw fluid out of cells by osmosis, are needed to pursue hypertonicity as a possible risk factor for obesity and chronic disease. This paper proposes a new index that may be more sensitive to mild hypertonicity in vivo at a point in time than traditional measures. The index compares mean corpuscular volume (MCV) estimates from diluted (in solution by automated cell counter) and nondiluted blood (calculated from manual hematocrit, MCV=Hct/RBC*10(6)). A larger Auto vs Manual MCV (>2 fl) in vitro indicates hypertonicity in vivo if the cell counter diluent is isotonic with the threshold for plasma vasopressin (PVP) release and PVP is detectable in plasma (>0.5 pg/ml). To evaluate this principle of concept, hypertonicity was induced by 24-h fluid restriction after a 20 ml/kg water load in four healthy men (20-46 years). Unlike serum and urine indices, the MCV difference-&-PVP index detected hypertonicity in all participants. More... »

PAGES

143

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.ejcn.1602481

DOI

http://dx.doi.org/10.1038/sj.ejcn.1602481

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001335037

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16855542


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