Safety and intestinal tolerance of high-dose enteral antioxidants and glutamine peptides after upper gastrointestinal surgery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-10-27

AUTHORS

J Schroeder, B Alteheld, P Stehle, M -C Cayeux, R L Chioléro, M M Berger

ABSTRACT

Objective: Safety and intestinal tolerance of an early high-dose enteral administration of antioxidative vitamins, trace elements, and glutamine dipeptides.Design: open intervention trial.Setting: Two university teaching hospitals.Patients: A total of 14 patients requiring jejunal feeding (64±14 y).Intervention: A measure of 500 ml/day Intestamin® (FreseniusKabi: 250 kcal/1.050 kJ, 300 μg selenium, 20 mg zinc, 400 μg chromium, 1500 mg vitamin C, 500 mg vitamin E, 10 mg β-carotene, 30 g glutamine) for 5 days beginning 6 h after surgery. Parenteral/enteral nutrition was provided to achieve energy target (25 kcal/kg/day).Assessments: Intestinal complaints, plasma nutrients, and glutathione.Results: Only minor signs of nausea, hiccups, flatulence (3/14). Plasma micronutrients (except β-carotene) postoperatively decreased and increased to normal on day 5. Extracellular glutamine remained low (preop: 520±94; d1: 357±67; d5: 389±79 μmol/l); total glutathione decreased (d1: 9.4±3.8; d5: 3.6±2.5 μmol/l).Conclusion: Study feed is well tolerated and metabolically safe representing a valuable tool for targeted pharmaconutrient supply.Sponsorship: The trials were carried out with the local University's human resources; Fresenius Kabi (Bad Homburg, Germany) partially supported the trial by financing the analytical determination and providing the supplementation solutions. More... »

PAGES

307-310

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URI

http://scigraph.springernature.com/pub.10.1038/sj.ejcn.1602073

DOI

http://dx.doi.org/10.1038/sj.ejcn.1602073

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035476557

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15508015


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