Nanog and transcriptional networks in embryonic stem cell pluripotency View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-01

AUTHORS

Guangjin Pan, James A Thomson

ABSTRACT

Several extrinsic signals such as LIF, BMP and Wnt can support the self-renewal and pluripotency of embryonic stem (ES) cells through regulating the "pluripotent genes." A unique homeobox transcription factor, Nanog, is one of the key downstream effectors of these signals. Elevated level of Nanog can maintain the mouse ES cell self-renewal independent of LIF and enable human ES cell growth without feeder cells. In addition to the external signal pathways, intrinsic transcription factors such as FoxD3, P53 and Oct4 are also involved in regulating the expression of Nanog. Functionally, Nanog works together with other key pluripotent factors such as Oct4 and Sox2 to control a set of target genes that have important functions in ES cell pluripotency. These key factors form a regulatory network to support or limit each other's expression level, which maintains the properties of ES cells. More... »

PAGES

7310125

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cr.7310125

DOI

http://dx.doi.org/10.1038/sj.cr.7310125

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028831849

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17211451


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HOW TO GET THIS DATA PROGRAMMATICALLY:

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.cr.7310125'


 

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