Cells in G2/M phase increased in human nasopharyngeal carcinoma cell line by EBV-LMP1 through activation of NF-κB and AP-1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-06

AUTHORS

DENG Lin, YANG Jing, Xiao Rong ZHAO, Xi Yun DENG, ZENG Liang, Huan Hua GU, TANG Min, CAO Ya

ABSTRACT

Although previous studies showed that the principal oncoprotein encoded by Epstein-Barr virus, latent membrane protein 1(LMP1), could induce the nasopharyngeal carcinoma cells in G2/M phase increased, little is known about the target molecules and mechanisms. The present study demonstrated that LMP1 could induce the accumulation of p53 protein and upregulate its transactivity in a dose dependent manner, which resulted in the decrease of the kinase activity of cdc2/cyclin B complex and inducing arrest at G2/M phase through the activation of NF-kappaB and AP-1 signaling pathways, and the effect of NF-kappaB was more obvious than that of AP-1. This study provided some significant evidence for further elucidating the molecular mechanisms that LMP1 had effects on the surveillance mechanism of cell cycle and promoting the survival of transformed cells and tumorigenesis. More... »

PAGES

7290163

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cr.7290163

DOI

http://dx.doi.org/10.1038/sj.cr.7290163

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021789297

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12862319


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HOW TO GET THIS DATA PROGRAMMATICALLY:

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RDF/XML is a standard XML format for linked data.

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