Inducible resistance to Fas-mediated apoptosis in B cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-12

AUTHORS

Thomas L ROTHSTEIN

ABSTRACT

Apoptosis produced in B cells through Fas (APO-1, CD95) triggering is regulated by signals derived from other surface receptors: CD40 engagement produces upregulation of Fas expression and marked susceptibility to Fas-induced cell death, whereas antigen receptor engagement, or IL-4R engagement, inhibits Fas killing and in so doing induces a state of Fas-resistance, even in otherwise sensitive, CD40-stimulated targets. Surface immunoglobulin and IL-4R utilize at least partially distinct pathways to produce Fas-resistance that differentially depend on PKC and STAT6, respectively. Further, surface immunoglobulin signaling for inducible Fas-resistance bypasses Btk, requires NF-kappaB, and entails new macromolecular synthesis. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic gene products, Bcl-xL and FLIP, and a novel anti-apoptotic gene that encodes FAIM (Fas Apoptosis Inhibitory Molecule). faim was identified by differential display and exists in two alternatively spliced forms; faim-S is broadly expressed, but faim-L expression is tissue-specific. The FAIM sequence is highly evolu- tionarily conserved, suggesting an important role for this molecule throughout phylogeny. Inducible resistance to Fas killing is hypothesized to protect foreign antigen-specific B cells during potentially hazardous interactions with FasL-bearing T cells, whereas autoreactive B cells fail to become Fas-resistant and are deleted via Fas-dependent cytotoxicity. Inadvertent or aberrant acquisition of Fas-resistance may permit autoreactive B cells to escape Fas deletion, and malignant lymphocytes to impede anti-tumor immunity. More... »

PAGES

7290053

References to SciGraph publications

  • 1995-07. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis in NATURE
  • 1995-02. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas in NATURE
  • 1992-05. Molecular and biological characterization of a murine ligand for CD40 in NATURE
  • 1995-03. Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells in NATURE
  • 1990-11. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death in NATURE
  • 1999-06. Regulation of inducible gene expression by the transcription factor NF-κB in IMMUNOLOGIC RESEARCH
  • 1987-08. The role of clonal selection and somatic mutation in autoimmunity in NATURE
  • 1997-05. Characteristic pattern of chromosomal gains and losses in marginal zone B cell lymphoma detected by comparative genomic hybridization in LEUKEMIA
  • 1995-02. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95) in NATURE
  • 1997-11. Malignant and reactive cells from human lymphomas frequently express Fas ligand but display a different sensitivity to Fas-mediated apoptosis in LEUKEMIA
  • 1997-08. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma in NATURE MEDICINE
  • 1992-03. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis in NATURE
  • 1997-07. Inhibition of death receptor signals by cellular FLIP in NATURE
  • 1995-02. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation in NATURE
  • 1995-07. CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.cr.7290053

    DOI

    http://dx.doi.org/10.1038/sj.cr.7290053

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1034520577

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11191348


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Agammaglobulinaemia Tyrosine Kinase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "B-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CASP8 and FADD-Like Apoptosis Regulating Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD40 Antigens", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD40 Ligand", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carrier Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intracellular Signaling Peptides and Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "NF-kappa B", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Kinase C", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein-Tyrosine Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins c-bcl-2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "bcl-X Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "fas Receptor", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Departments of Medicine and Microbiology, and the Evans Memorial Department of Clinical Research, Boston University Medical Center, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "ROTHSTEIN", 
            "givenName": "Thomas L", 
            "id": "sg:person.0777101466.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777101466.26"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90541-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000871975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/gyno.1999.5448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001488564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.13.4.382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001754338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7539157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001882800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/374163a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002142045", 
              "https://doi.org/10.1038/374163a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.iy.09.040191.001331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002919468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003401089", 
              "https://doi.org/10.1038/sj.leu.2400815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003401089", 
              "https://doi.org/10.1038/sj.leu.2400815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.191.10.1745", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005074846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80401-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005491233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/348334a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005542034", 
              "https://doi.org/10.1038/348334a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1521-4141(199903)29:03<878::aid-immu878>3.0.co;2-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005931414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0897-917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007081943", 
              "https://doi.org/10.1038/nm0897-917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02786486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007866059", 
              "https://doi.org/10.1007/bf02786486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02786486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007866059", 
              "https://doi.org/10.1007/bf02786486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1521-4141(200003)30:3<931::aid-immu931>3.0.co;2-h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007886648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/1074-7613(95)90114-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008014967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-5699(95)80069-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008063991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(05)80194-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008628727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(05)80194-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008628727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.3.1646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009276792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.14.6550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010875692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/376181a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011846067", 
              "https://doi.org/10.1038/376181a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.30.18542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012061996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830270523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012480317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.169.5.1747", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012816818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.171.1.265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013937956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015657269", 
              "https://doi.org/10.1038/sj.leu.2400635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015657269", 
              "https://doi.org/10.1038/sj.leu.2400635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830260222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017515772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.187.6.847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017617579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.190.7.1025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018218908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/357080a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018293308", 
              "https://doi.org/10.1038/357080a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830260709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018458325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(96)02293-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018557332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.510250428", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019208037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.81.22.7166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020111460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archsurg.1995.01430110017004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020453826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.182.5.1557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020739794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90149-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021350313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.147.3.814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022114228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.185.2.329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023920168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.11.5778", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024268267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.190.7.1033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025288591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.39.24154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025615777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.32.19641", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025746741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci118892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025899419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.10.4392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026148165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/cimm.1996.0260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026462248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/40657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027258655", 
              "https://doi.org/10.1038/40657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/40657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027258655", 
              "https://doi.org/10.1038/40657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.26.14871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027697469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.190.5.639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028403569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.13.4.400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028712706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0008-8749(86)90430-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029361069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.188.9.1717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029682080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80400-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030443302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0215(19990827)82:5<727::aid-ijc17>3.0.co;2-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032061443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.1999.01586.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032907280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.32.22532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033142503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.184.3.1149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034423878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830251034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034675216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830270922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035055295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/cimm.1995.9974", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035331149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.179.5.1539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035565097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0090-1229(88)90057-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035584918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.183.4.1377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035653655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80150-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035801876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830160118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036216525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81349-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036294823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830221016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036338922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81874-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036401594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(94)90422-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036449162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373444a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037666095", 
              "https://doi.org/10.1038/373444a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/geno.1996.0177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037693325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90013-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038358151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90375-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038464532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/376037a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038492988", 
              "https://doi.org/10.1038/376037a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.10.4185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038498937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.189.6.949", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038650779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80566-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038665630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.28.17255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039208819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0045(19980701)36:2<92::aid-pros4>3.0.co;2-g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040224607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.191.10.1735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040479653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80605-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041035560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90410-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041229717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.182.5.1265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041293582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.179.2.425", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041457267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.1995.tb00684.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041562692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/356314a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041635124", 
              "https://doi.org/10.1038/356314a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(79)90071-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041926864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.187.11.1825", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042260383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199611283352204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042753875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.5.2131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043330819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.175.5.1181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043801939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1521-4141(200001)30:1<155::aid-immu155>3.0.co;2-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044047140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.9.5923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044254009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bies.950150304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044554321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.3.1541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044581094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.188.4.651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044797678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80587-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045104611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373438a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045725490", 
              "https://doi.org/10.1038/373438a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.185.10.1837", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047593071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/328805a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048879260", 
              "https://doi.org/10.1038/328805a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373441a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049599122", 
              "https://doi.org/10.1038/373441a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830211214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051005778"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.16.9136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052269108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.182.2.367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052514484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.181.1.71", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053575031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0168-9525(91)90102-v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054554723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.181.3.1235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058438593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/intimm/5.6.625", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059711932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/intimm/7.12.1949", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059712277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00007890-199611270-00030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060276269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00007890-199611270-00030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060276269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00007890-199611270-00030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060276269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1354393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062477287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.274.5289.990", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062554762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2787530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062559099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.279.5358.1954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062560011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.281.5379.998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062562127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7732382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062649110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8332901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062654702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074357857", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074494532", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074509041", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.164.4.2200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074584661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076034671", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077844824", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077844936", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077987878", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079159250", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079440386", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079519058", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079663988", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082391245", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082392483", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082394568", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082405968", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082416199", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082449562", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082473597", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082767190", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082907313", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082912968", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082940494", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082963825", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082963846", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082972458", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083027625", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083105748", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083154941", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083171907", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083238822", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083249234", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083251676", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083254187", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083259840", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083274032", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2000-12", 
        "datePublishedReg": "2000-12-01", 
        "description": "Apoptosis produced in B cells through Fas (APO-1, CD95) triggering is regulated by signals derived from other surface receptors: CD40 engagement produces upregulation of Fas expression and marked susceptibility to Fas-induced cell death, whereas antigen receptor engagement, or IL-4R engagement, inhibits Fas killing and in so doing induces a state of Fas-resistance, even in otherwise sensitive, CD40-stimulated targets. Surface immunoglobulin and IL-4R utilize at least partially distinct pathways to produce Fas-resistance that differentially depend on PKC and STAT6, respectively. Further, surface immunoglobulin signaling for inducible Fas-resistance bypasses Btk, requires NF-kappaB, and entails new macromolecular synthesis. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic gene products, Bcl-xL and FLIP, and a novel anti-apoptotic gene that encodes FAIM (Fas Apoptosis Inhibitory Molecule). faim was identified by differential display and exists in two alternatively spliced forms; faim-S is broadly expressed, but faim-L expression is tissue-specific. The FAIM sequence is highly evolu- tionarily conserved, suggesting an important role for this molecule throughout phylogeny. Inducible resistance to Fas killing is hypothesized to protect foreign antigen-specific B cells during potentially hazardous interactions with FasL-bearing T cells, whereas autoreactive B cells fail to become Fas-resistant and are deleted via Fas-dependent cytotoxicity. Inadvertent or aberrant acquisition of Fas-resistance may permit autoreactive B cells to escape Fas deletion, and malignant lymphocytes to impede anti-tumor immunity.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.cr.7290053", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2597272", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2453548", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2454547", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1107753", 
            "issn": [
              "1001-0602", 
              "1748-7838"
            ], 
            "name": "Cell Research", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "Inducible resistance to Fas-mediated apoptosis in B cells", 
        "pagination": "7290053", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "a471a68007c50a1cddd4a60dccafcde20f4629367dd49ea469187bfa50af36c8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "11191348"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9425763"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.cr.7290053"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1034520577"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.cr.7290053", 
          "https://app.dimensions.ai/details/publication/pub.1034520577"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:11", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53978_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/7290053"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.cr.7290053'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.cr.7290053'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.cr.7290053'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.cr.7290053'


     

    This table displays all metadata directly associated to this object as RDF triples.

    578 TRIPLES      21 PREDICATES      198 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.cr.7290053 schema:about N0f4155656b444969a17f7b0e358e331a
    2 N0fe5cdfa69c2401e95ee56d8600af561
    3 N10c8811565e1400eacb1019a8dd6f2b6
    4 N3e7109b1916e4240acb10ed2fb1a32bf
    5 N469136773f9343a58b74f99e436f33ee
    6 N5001f313184a450bacd6ce4b153899c3
    7 N554f9e110e8849968ba17d9ce721922e
    8 N5c374f16521147d09b9171a3b466ea92
    9 N7fcd39f4e43f4144b9ee5d297991dba2
    10 N9daebd778b27460495abef2c78fbd814
    11 Naf9bcc2772124117b635f8e62849e004
    12 Nb50384c794aa4e96960e25de4b132426
    13 Ncca2000a89974c9199efbb782a6271bd
    14 Neacc89a1326d4419996c8b01fefe951b
    15 Nf3cef35a978249e8bd7559786e568991
    16 Nf7eceebab353497db2b60ab93f4a076d
    17 Nfb9ecafb2cfa40b996dcd51d1d4824ee
    18 anzsrc-for:06
    19 anzsrc-for:0601
    20 schema:author Nd14e09b24df8450d9985bd87ee161ab7
    21 schema:citation sg:pub.10.1007/bf02786486
    22 sg:pub.10.1038/328805a0
    23 sg:pub.10.1038/348334a0
    24 sg:pub.10.1038/356314a0
    25 sg:pub.10.1038/357080a0
    26 sg:pub.10.1038/373438a0
    27 sg:pub.10.1038/373441a0
    28 sg:pub.10.1038/373444a0
    29 sg:pub.10.1038/374163a0
    30 sg:pub.10.1038/376037a0
    31 sg:pub.10.1038/376181a0
    32 sg:pub.10.1038/40657
    33 sg:pub.10.1038/nm0897-917
    34 sg:pub.10.1038/sj.leu.2400635
    35 sg:pub.10.1038/sj.leu.2400815
    36 https://app.dimensions.ai/details/publication/pub.1074357857
    37 https://app.dimensions.ai/details/publication/pub.1074494532
    38 https://app.dimensions.ai/details/publication/pub.1074509041
    39 https://app.dimensions.ai/details/publication/pub.1076034671
    40 https://app.dimensions.ai/details/publication/pub.1077844824
    41 https://app.dimensions.ai/details/publication/pub.1077844936
    42 https://app.dimensions.ai/details/publication/pub.1077987878
    43 https://app.dimensions.ai/details/publication/pub.1079159250
    44 https://app.dimensions.ai/details/publication/pub.1079440386
    45 https://app.dimensions.ai/details/publication/pub.1079519058
    46 https://app.dimensions.ai/details/publication/pub.1079663988
    47 https://app.dimensions.ai/details/publication/pub.1082391245
    48 https://app.dimensions.ai/details/publication/pub.1082392483
    49 https://app.dimensions.ai/details/publication/pub.1082394568
    50 https://app.dimensions.ai/details/publication/pub.1082405968
    51 https://app.dimensions.ai/details/publication/pub.1082416199
    52 https://app.dimensions.ai/details/publication/pub.1082449562
    53 https://app.dimensions.ai/details/publication/pub.1082473597
    54 https://app.dimensions.ai/details/publication/pub.1082767190
    55 https://app.dimensions.ai/details/publication/pub.1082907313
    56 https://app.dimensions.ai/details/publication/pub.1082912968
    57 https://app.dimensions.ai/details/publication/pub.1082940494
    58 https://app.dimensions.ai/details/publication/pub.1082963825
    59 https://app.dimensions.ai/details/publication/pub.1082963846
    60 https://app.dimensions.ai/details/publication/pub.1082972458
    61 https://app.dimensions.ai/details/publication/pub.1083027625
    62 https://app.dimensions.ai/details/publication/pub.1083105748
    63 https://app.dimensions.ai/details/publication/pub.1083154941
    64 https://app.dimensions.ai/details/publication/pub.1083171907
    65 https://app.dimensions.ai/details/publication/pub.1083238822
    66 https://app.dimensions.ai/details/publication/pub.1083249234
    67 https://app.dimensions.ai/details/publication/pub.1083251676
    68 https://app.dimensions.ai/details/publication/pub.1083254187
    69 https://app.dimensions.ai/details/publication/pub.1083259840
    70 https://app.dimensions.ai/details/publication/pub.1083274032
    71 https://doi.org/10.1001/archsurg.1995.01430110017004
    72 https://doi.org/10.1002/(sici)1097-0045(19980701)36:2<92::aid-pros4>3.0.co;2-g
    73 https://doi.org/10.1002/(sici)1097-0215(19990827)82:5<727::aid-ijc17>3.0.co;2-e
    74 https://doi.org/10.1002/(sici)1521-4141(199903)29:03<878::aid-immu878>3.0.co;2-9
    75 https://doi.org/10.1002/1521-4141(200001)30:1<155::aid-immu155>3.0.co;2-x
    76 https://doi.org/10.1002/1521-4141(200003)30:3<931::aid-immu931>3.0.co;2-h
    77 https://doi.org/10.1002/bies.950150304
    78 https://doi.org/10.1002/eji.1830160118
    79 https://doi.org/10.1002/eji.1830211214
    80 https://doi.org/10.1002/eji.1830221016
    81 https://doi.org/10.1002/eji.1830251034
    82 https://doi.org/10.1002/eji.1830260222
    83 https://doi.org/10.1002/eji.1830260709
    84 https://doi.org/10.1002/eji.1830270523
    85 https://doi.org/10.1002/eji.1830270922
    86 https://doi.org/10.1002/hep.510250428
    87 https://doi.org/10.1006/cimm.1995.9974
    88 https://doi.org/10.1006/cimm.1996.0260
    89 https://doi.org/10.1006/geno.1996.0177
    90 https://doi.org/10.1006/gyno.1999.5448
    91 https://doi.org/10.1016/0008-8749(86)90430-2
    92 https://doi.org/10.1016/0090-1229(88)90057-8
    93 https://doi.org/10.1016/0092-8674(79)90071-0
    94 https://doi.org/10.1016/0092-8674(94)90375-1
    95 https://doi.org/10.1016/0092-8674(95)90013-6
    96 https://doi.org/10.1016/0092-8674(95)90149-3
    97 https://doi.org/10.1016/0092-8674(95)90410-7
    98 https://doi.org/10.1016/0092-8674(95)90541-3
    99 https://doi.org/10.1016/0167-5699(95)80069-7
    100 https://doi.org/10.1016/0168-9525(91)90102-v
    101 https://doi.org/10.1016/1074-7613(95)90114-0
    102 https://doi.org/10.1016/s0092-8674(00)80605-4
    103 https://doi.org/10.1016/s0092-8674(00)81349-5
    104 https://doi.org/10.1016/s0092-8674(00)81874-7
    105 https://doi.org/10.1016/s0092-8674(94)90422-7
    106 https://doi.org/10.1016/s0140-6736(96)02293-3
    107 https://doi.org/10.1016/s0959-437x(05)80194-7
    108 https://doi.org/10.1016/s1074-7613(00)80150-8
    109 https://doi.org/10.1016/s1074-7613(00)80400-8
    110 https://doi.org/10.1016/s1074-7613(00)80401-x
    111 https://doi.org/10.1016/s1074-7613(00)80566-x
    112 https://doi.org/10.1016/s1074-7613(00)80587-7
    113 https://doi.org/10.1046/j.1365-2141.1999.01586.x
    114 https://doi.org/10.1056/nejm199611283352204
    115 https://doi.org/10.1073/pnas.81.22.7166
    116 https://doi.org/10.1073/pnas.89.14.6550
    117 https://doi.org/10.1073/pnas.91.10.4185
    118 https://doi.org/10.1073/pnas.91.10.4392
    119 https://doi.org/10.1073/pnas.93.5.2131
    120 https://doi.org/10.1073/pnas.94.11.5778
    121 https://doi.org/10.1073/pnas.96.16.9136
    122 https://doi.org/10.1073/pnas.96.26.14871
    123 https://doi.org/10.1074/jbc.272.28.17255
    124 https://doi.org/10.1074/jbc.272.30.18542
    125 https://doi.org/10.1074/jbc.272.32.19641
    126 https://doi.org/10.1074/jbc.272.39.24154
    127 https://doi.org/10.1074/jbc.274.3.1541
    128 https://doi.org/10.1074/jbc.274.3.1646
    129 https://doi.org/10.1074/jbc.274.32.22532
    130 https://doi.org/10.1084/jem.147.3.814
    131 https://doi.org/10.1084/jem.169.5.1747
    132 https://doi.org/10.1084/jem.171.1.265
    133 https://doi.org/10.1084/jem.175.5.1181
    134 https://doi.org/10.1084/jem.179.2.425
    135 https://doi.org/10.1084/jem.179.5.1539
    136 https://doi.org/10.1084/jem.181.1.71
    137 https://doi.org/10.1084/jem.181.3.1235
    138 https://doi.org/10.1084/jem.182.2.367
    139 https://doi.org/10.1084/jem.182.5.1265
    140 https://doi.org/10.1084/jem.182.5.1557
    141 https://doi.org/10.1084/jem.183.4.1377
    142 https://doi.org/10.1084/jem.184.3.1149
    143 https://doi.org/10.1084/jem.185.10.1837
    144 https://doi.org/10.1084/jem.185.2.329
    145 https://doi.org/10.1084/jem.187.11.1825
    146 https://doi.org/10.1084/jem.187.6.847
    147 https://doi.org/10.1084/jem.188.4.651
    148 https://doi.org/10.1084/jem.188.9.1717
    149 https://doi.org/10.1084/jem.189.6.949
    150 https://doi.org/10.1084/jem.190.5.639
    151 https://doi.org/10.1084/jem.190.7.1025
    152 https://doi.org/10.1084/jem.190.7.1033
    153 https://doi.org/10.1084/jem.191.10.1735
    154 https://doi.org/10.1084/jem.191.10.1745
    155 https://doi.org/10.1093/intimm/5.6.625
    156 https://doi.org/10.1093/intimm/7.12.1949
    157 https://doi.org/10.1097/00007890-199611270-00030
    158 https://doi.org/10.1101/gad.13.4.382
    159 https://doi.org/10.1101/gad.13.4.400
    160 https://doi.org/10.1111/j.1600-065x.1995.tb00684.x
    161 https://doi.org/10.1126/science.1354393
    162 https://doi.org/10.1126/science.274.5289.990
    163 https://doi.org/10.1126/science.2787530
    164 https://doi.org/10.1126/science.279.5358.1954
    165 https://doi.org/10.1126/science.281.5379.998
    166 https://doi.org/10.1126/science.7539157
    167 https://doi.org/10.1126/science.7732382
    168 https://doi.org/10.1126/science.8332901
    169 https://doi.org/10.1128/mcb.19.9.5923
    170 https://doi.org/10.1146/annurev.iy.09.040191.001331
    171 https://doi.org/10.1172/jci118892
    172 https://doi.org/10.4049/jimmunol.164.4.2200
    173 schema:datePublished 2000-12
    174 schema:datePublishedReg 2000-12-01
    175 schema:description Apoptosis produced in B cells through Fas (APO-1, CD95) triggering is regulated by signals derived from other surface receptors: CD40 engagement produces upregulation of Fas expression and marked susceptibility to Fas-induced cell death, whereas antigen receptor engagement, or IL-4R engagement, inhibits Fas killing and in so doing induces a state of Fas-resistance, even in otherwise sensitive, CD40-stimulated targets. Surface immunoglobulin and IL-4R utilize at least partially distinct pathways to produce Fas-resistance that differentially depend on PKC and STAT6, respectively. Further, surface immunoglobulin signaling for inducible Fas-resistance bypasses Btk, requires NF-kappaB, and entails new macromolecular synthesis. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic gene products, Bcl-xL and FLIP, and a novel anti-apoptotic gene that encodes FAIM (Fas Apoptosis Inhibitory Molecule). faim was identified by differential display and exists in two alternatively spliced forms; faim-S is broadly expressed, but faim-L expression is tissue-specific. The FAIM sequence is highly evolu- tionarily conserved, suggesting an important role for this molecule throughout phylogeny. Inducible resistance to Fas killing is hypothesized to protect foreign antigen-specific B cells during potentially hazardous interactions with FasL-bearing T cells, whereas autoreactive B cells fail to become Fas-resistant and are deleted via Fas-dependent cytotoxicity. Inadvertent or aberrant acquisition of Fas-resistance may permit autoreactive B cells to escape Fas deletion, and malignant lymphocytes to impede anti-tumor immunity.
    176 schema:genre research_article
    177 schema:inLanguage en
    178 schema:isAccessibleForFree true
    179 schema:isPartOf N6095cb47d1ab4876905e9c892e214d0b
    180 N834e9b3c0cf4440392c2fc385cea05f7
    181 sg:journal.1107753
    182 schema:name Inducible resistance to Fas-mediated apoptosis in B cells
    183 schema:pagination 7290053
    184 schema:productId N4e4f8f4ab48441d38c004bc802f27e2c
    185 Na2f0dab7c8e04422a9ae85775be2a8ea
    186 Nbbf9859526f14f73ab85a9b801bb24d9
    187 Ncd04ced122bc4c9b8750a49539552fb5
    188 Nd774434a197247e0bd594d028a40c89a
    189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034520577
    190 https://doi.org/10.1038/sj.cr.7290053
    191 schema:sdDatePublished 2019-04-11T12:11
    192 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    193 schema:sdPublisher N846c8156b82f42d3a244e1c3c5c0bcc2
    194 schema:url http://www.nature.com/articles/7290053
    195 sgo:license sg:explorer/license/
    196 sgo:sdDataset articles
    197 rdf:type schema:ScholarlyArticle
    198 N0f4155656b444969a17f7b0e358e331a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Carrier Proteins
    200 rdf:type schema:DefinedTerm
    201 N0fe5cdfa69c2401e95ee56d8600af561 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name CD40 Antigens
    203 rdf:type schema:DefinedTerm
    204 N10c8811565e1400eacb1019a8dd6f2b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Agammaglobulinaemia Tyrosine Kinase
    206 rdf:type schema:DefinedTerm
    207 N2ebfa7122d344e5b81941c0ff3a0f4c7 schema:name Departments of Medicine and Microbiology, and the Evans Memorial Department of Clinical Research, Boston University Medical Center, Boston, MA, USA
    208 rdf:type schema:Organization
    209 N3e7109b1916e4240acb10ed2fb1a32bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name fas Receptor
    211 rdf:type schema:DefinedTerm
    212 N469136773f9343a58b74f99e436f33ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name B-Lymphocytes
    214 rdf:type schema:DefinedTerm
    215 N4e4f8f4ab48441d38c004bc802f27e2c schema:name nlm_unique_id
    216 schema:value 9425763
    217 rdf:type schema:PropertyValue
    218 N5001f313184a450bacd6ce4b153899c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name CD40 Ligand
    220 rdf:type schema:DefinedTerm
    221 N554f9e110e8849968ba17d9ce721922e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name CASP8 and FADD-Like Apoptosis Regulating Protein
    223 rdf:type schema:DefinedTerm
    224 N5c374f16521147d09b9171a3b466ea92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name bcl-X Protein
    226 rdf:type schema:DefinedTerm
    227 N6095cb47d1ab4876905e9c892e214d0b schema:issueNumber 4
    228 rdf:type schema:PublicationIssue
    229 N7fcd39f4e43f4144b9ee5d297991dba2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    230 schema:name Protein Kinase C
    231 rdf:type schema:DefinedTerm
    232 N834e9b3c0cf4440392c2fc385cea05f7 schema:volumeNumber 10
    233 rdf:type schema:PublicationVolume
    234 N846c8156b82f42d3a244e1c3c5c0bcc2 schema:name Springer Nature - SN SciGraph project
    235 rdf:type schema:Organization
    236 N9daebd778b27460495abef2c78fbd814 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    237 schema:name Humans
    238 rdf:type schema:DefinedTerm
    239 Na2f0dab7c8e04422a9ae85775be2a8ea schema:name pubmed_id
    240 schema:value 11191348
    241 rdf:type schema:PropertyValue
    242 Naf9bcc2772124117b635f8e62849e004 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    243 schema:name Proto-Oncogene Proteins c-bcl-2
    244 rdf:type schema:DefinedTerm
    245 Nb50384c794aa4e96960e25de4b132426 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    246 schema:name Signal Transduction
    247 rdf:type schema:DefinedTerm
    248 Nbbf9859526f14f73ab85a9b801bb24d9 schema:name readcube_id
    249 schema:value a471a68007c50a1cddd4a60dccafcde20f4629367dd49ea469187bfa50af36c8
    250 rdf:type schema:PropertyValue
    251 Ncca2000a89974c9199efbb782a6271bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    252 schema:name Protein-Tyrosine Kinases
    253 rdf:type schema:DefinedTerm
    254 Ncd04ced122bc4c9b8750a49539552fb5 schema:name dimensions_id
    255 schema:value pub.1034520577
    256 rdf:type schema:PropertyValue
    257 Nd14e09b24df8450d9985bd87ee161ab7 rdf:first sg:person.0777101466.26
    258 rdf:rest rdf:nil
    259 Nd774434a197247e0bd594d028a40c89a schema:name doi
    260 schema:value 10.1038/sj.cr.7290053
    261 rdf:type schema:PropertyValue
    262 Neacc89a1326d4419996c8b01fefe951b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    263 schema:name Animals
    264 rdf:type schema:DefinedTerm
    265 Nf3cef35a978249e8bd7559786e568991 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    266 schema:name Apoptosis
    267 rdf:type schema:DefinedTerm
    268 Nf7eceebab353497db2b60ab93f4a076d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    269 schema:name NF-kappa B
    270 rdf:type schema:DefinedTerm
    271 Nfb9ecafb2cfa40b996dcd51d1d4824ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    272 schema:name Intracellular Signaling Peptides and Proteins
    273 rdf:type schema:DefinedTerm
    274 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    275 schema:name Biological Sciences
    276 rdf:type schema:DefinedTerm
    277 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    278 schema:name Biochemistry and Cell Biology
    279 rdf:type schema:DefinedTerm
    280 sg:grant.2453548 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.cr.7290053
    281 rdf:type schema:MonetaryGrant
    282 sg:grant.2454547 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.cr.7290053
    283 rdf:type schema:MonetaryGrant
    284 sg:grant.2597272 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.cr.7290053
    285 rdf:type schema:MonetaryGrant
    286 sg:journal.1107753 schema:issn 1001-0602
    287 1748-7838
    288 schema:name Cell Research
    289 rdf:type schema:Periodical
    290 sg:person.0777101466.26 schema:affiliation N2ebfa7122d344e5b81941c0ff3a0f4c7
    291 schema:familyName ROTHSTEIN
    292 schema:givenName Thomas L
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777101466.26
    294 rdf:type schema:Person
    295 sg:pub.10.1007/bf02786486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007866059
    296 https://doi.org/10.1007/bf02786486
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/328805a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048879260
    299 https://doi.org/10.1038/328805a0
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/348334a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005542034
    302 https://doi.org/10.1038/348334a0
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/356314a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041635124
    305 https://doi.org/10.1038/356314a0
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/357080a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018293308
    308 https://doi.org/10.1038/357080a0
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/373438a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045725490
    311 https://doi.org/10.1038/373438a0
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/373441a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049599122
    314 https://doi.org/10.1038/373441a0
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/373444a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037666095
    317 https://doi.org/10.1038/373444a0
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/374163a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002142045
    320 https://doi.org/10.1038/374163a0
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/376037a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038492988
    323 https://doi.org/10.1038/376037a0
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/376181a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011846067
    326 https://doi.org/10.1038/376181a0
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/40657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027258655
    329 https://doi.org/10.1038/40657
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/nm0897-917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007081943
    332 https://doi.org/10.1038/nm0897-917
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/sj.leu.2400635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015657269
    335 https://doi.org/10.1038/sj.leu.2400635
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/sj.leu.2400815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003401089
    338 https://doi.org/10.1038/sj.leu.2400815
    339 rdf:type schema:CreativeWork
    340 https://app.dimensions.ai/details/publication/pub.1074357857 schema:CreativeWork
    341 https://app.dimensions.ai/details/publication/pub.1074494532 schema:CreativeWork
    342 https://app.dimensions.ai/details/publication/pub.1074509041 schema:CreativeWork
    343 https://app.dimensions.ai/details/publication/pub.1076034671 schema:CreativeWork
    344 https://app.dimensions.ai/details/publication/pub.1077844824 schema:CreativeWork
    345 https://app.dimensions.ai/details/publication/pub.1077844936 schema:CreativeWork
    346 https://app.dimensions.ai/details/publication/pub.1077987878 schema:CreativeWork
    347 https://app.dimensions.ai/details/publication/pub.1079159250 schema:CreativeWork
    348 https://app.dimensions.ai/details/publication/pub.1079440386 schema:CreativeWork
    349 https://app.dimensions.ai/details/publication/pub.1079519058 schema:CreativeWork
    350 https://app.dimensions.ai/details/publication/pub.1079663988 schema:CreativeWork
    351 https://app.dimensions.ai/details/publication/pub.1082391245 schema:CreativeWork
    352 https://app.dimensions.ai/details/publication/pub.1082392483 schema:CreativeWork
    353 https://app.dimensions.ai/details/publication/pub.1082394568 schema:CreativeWork
    354 https://app.dimensions.ai/details/publication/pub.1082405968 schema:CreativeWork
    355 https://app.dimensions.ai/details/publication/pub.1082416199 schema:CreativeWork
    356 https://app.dimensions.ai/details/publication/pub.1082449562 schema:CreativeWork
    357 https://app.dimensions.ai/details/publication/pub.1082473597 schema:CreativeWork
    358 https://app.dimensions.ai/details/publication/pub.1082767190 schema:CreativeWork
    359 https://app.dimensions.ai/details/publication/pub.1082907313 schema:CreativeWork
    360 https://app.dimensions.ai/details/publication/pub.1082912968 schema:CreativeWork
    361 https://app.dimensions.ai/details/publication/pub.1082940494 schema:CreativeWork
    362 https://app.dimensions.ai/details/publication/pub.1082963825 schema:CreativeWork
    363 https://app.dimensions.ai/details/publication/pub.1082963846 schema:CreativeWork
    364 https://app.dimensions.ai/details/publication/pub.1082972458 schema:CreativeWork
    365 https://app.dimensions.ai/details/publication/pub.1083027625 schema:CreativeWork
    366 https://app.dimensions.ai/details/publication/pub.1083105748 schema:CreativeWork
    367 https://app.dimensions.ai/details/publication/pub.1083154941 schema:CreativeWork
    368 https://app.dimensions.ai/details/publication/pub.1083171907 schema:CreativeWork
    369 https://app.dimensions.ai/details/publication/pub.1083238822 schema:CreativeWork
    370 https://app.dimensions.ai/details/publication/pub.1083249234 schema:CreativeWork
    371 https://app.dimensions.ai/details/publication/pub.1083251676 schema:CreativeWork
    372 https://app.dimensions.ai/details/publication/pub.1083254187 schema:CreativeWork
    373 https://app.dimensions.ai/details/publication/pub.1083259840 schema:CreativeWork
    374 https://app.dimensions.ai/details/publication/pub.1083274032 schema:CreativeWork
    375 https://doi.org/10.1001/archsurg.1995.01430110017004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020453826
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1002/(sici)1097-0045(19980701)36:2<92::aid-pros4>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1040224607
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1002/(sici)1097-0215(19990827)82:5<727::aid-ijc17>3.0.co;2-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1032061443
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1002/(sici)1521-4141(199903)29:03<878::aid-immu878>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005931414
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1002/1521-4141(200001)30:1<155::aid-immu155>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044047140
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1002/1521-4141(200003)30:3<931::aid-immu931>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1007886648
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1002/bies.950150304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044554321
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1002/eji.1830160118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036216525
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1002/eji.1830211214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051005778
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1002/eji.1830221016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036338922
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1002/eji.1830251034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034675216
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1002/eji.1830260222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017515772
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1002/eji.1830260709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018458325
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1002/eji.1830270523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012480317
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1002/eji.1830270922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035055295
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1002/hep.510250428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019208037
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1006/cimm.1995.9974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035331149
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1006/cimm.1996.0260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026462248
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1006/geno.1996.0177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037693325
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1006/gyno.1999.5448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001488564
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1016/0008-8749(86)90430-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029361069
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1016/0090-1229(88)90057-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035584918
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1016/0092-8674(79)90071-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041926864
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1016/0092-8674(94)90375-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038464532
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1016/0092-8674(95)90013-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038358151
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1016/0092-8674(95)90149-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021350313
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1016/0092-8674(95)90410-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041229717
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1016/0092-8674(95)90541-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000871975
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1016/0167-5699(95)80069-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008063991
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1016/0168-9525(91)90102-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1054554723
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1016/1074-7613(95)90114-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008014967
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1016/s0092-8674(00)80605-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041035560
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1016/s0092-8674(00)81349-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036294823
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1016/s0092-8674(00)81874-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036401594
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1016/s0092-8674(94)90422-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036449162
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1016/s0140-6736(96)02293-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018557332
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1016/s0959-437x(05)80194-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008628727
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1016/s1074-7613(00)80150-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035801876
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1016/s1074-7613(00)80400-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030443302
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1016/s1074-7613(00)80401-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005491233
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1016/s1074-7613(00)80566-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038665630
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1016/s1074-7613(00)80587-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045104611
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1046/j.1365-2141.1999.01586.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032907280
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1056/nejm199611283352204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042753875
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1073/pnas.81.22.7166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020111460
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1073/pnas.89.14.6550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010875692
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1073/pnas.91.10.4185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038498937
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1073/pnas.91.10.4392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026148165
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1073/pnas.93.5.2131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043330819
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1073/pnas.94.11.5778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024268267
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1073/pnas.96.16.9136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052269108
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1073/pnas.96.26.14871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027697469
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1074/jbc.272.28.17255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039208819
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1074/jbc.272.30.18542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012061996
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1074/jbc.272.32.19641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025746741
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1074/jbc.272.39.24154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025615777
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1074/jbc.274.3.1541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044581094
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1074/jbc.274.3.1646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009276792
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1074/jbc.274.32.22532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033142503
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1084/jem.147.3.814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022114228
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1084/jem.169.5.1747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012816818
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1084/jem.171.1.265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013937956
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1084/jem.175.5.1181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043801939
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1084/jem.179.2.425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041457267
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1084/jem.179.5.1539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035565097
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1084/jem.181.1.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053575031
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1084/jem.181.3.1235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058438593
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1084/jem.182.2.367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052514484
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1084/jem.182.5.1265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041293582
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1084/jem.182.5.1557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020739794
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1084/jem.183.4.1377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035653655
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1084/jem.184.3.1149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034423878
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1084/jem.185.10.1837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047593071
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1084/jem.185.2.329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023920168
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1084/jem.187.11.1825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042260383
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1084/jem.187.6.847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017617579
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1084/jem.188.4.651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044797678
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1084/jem.188.9.1717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029682080
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1084/jem.189.6.949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038650779
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1084/jem.190.5.639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028403569
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1084/jem.190.7.1025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018218908
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1084/jem.190.7.1033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025288591
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1084/jem.191.10.1735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040479653
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1084/jem.191.10.1745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005074846
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1093/intimm/5.6.625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059711932
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1093/intimm/7.12.1949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059712277
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1097/00007890-199611270-00030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060276269
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1101/gad.13.4.382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001754338
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1101/gad.13.4.400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028712706
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1111/j.1600-065x.1995.tb00684.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041562692
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1126/science.1354393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062477287
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1126/science.274.5289.990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062554762
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1126/science.2787530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062559099
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1126/science.279.5358.1954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062560011
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1126/science.281.5379.998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562127
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1126/science.7539157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001882800
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1126/science.7732382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649110
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1126/science.8332901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062654702
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1128/mcb.19.9.5923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044254009
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1146/annurev.iy.09.040191.001331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002919468
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1172/jci118892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025899419
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.4049/jimmunol.164.4.2200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074584661
    578 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...