ABCB1 Pharmacogenetics: Progress, Pitfalls, and Promise View Full Text


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Article Info

DATE

2007-02

AUTHORS

L W Chinn, D L Kroetz

ABSTRACT

In 1976, Juliano and Ling(1) reported expression of a 170 kDa protein in colchicine-resistant Chinese hamster ovary (CHO) cells that was absent in drug-sensitive cells. Because this protein altered cellular permeability to colchicine, the authors named it P-glycoprotein (P-gp).(1) P-gp overexpression was described in tumor samples and leukemic cells.(2) High homology with bacterial transporters suggested that P-gp was an efflux transporter, modulating intracellular xenobiotic concentrations.(3) In 1986, the gene encoding P-gp was discovered and designated MDR1 (HUGO name ABCB1).(4) Immunohistochemical studies demonstrated P-gp expression in tissues with secretory or excretory functions (liver, kidney, and gastrointestinal tract) and at blood-tissue barrier sites, such as the blood-brain barrier.(5) This pattern of expression indicated that P-gp may influence xenobiotic response and toxicity, either through pharmacokinetic or pharmacodynamic effects.(6) More... »

PAGES

265-269

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.clpt.6100052

DOI

http://dx.doi.org/10.1038/sj.clpt.6100052

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029250776

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17259950


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