Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-12

AUTHORS

C G Collins, M Tangney, J O Larkin, G Casey, M C Whelan, J Cashman, J Murphy, D Soden, S Vejda, S McKenna, B Kiely, J K Collins, J Barrett, S Aarons, G C O'Sullivan

ABSTRACT

Gene therapy-induced expression of immunostimulatory molecules at tumor cell level may evoke antitumor immune mechanisms by recruiting and enhancing viability of antigen-processing cells and specific tumoricidal lymphocytes. The antitumor efficacy of a plasmid, coding for granulocyte-macrophage colony-stimulating factor (GM-CSF) and the B7-1 costimulatory immune molecule, delivered into growing solid tumors by electroporation was investigated. Murine fibrosarcomas (JBS) growing in Balb/C mice ( More... »

PAGES

1061

Journal

TITLE

Cancer Gene Therapy

ISSUE

12

VOLUME

13

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.cgt.7700976

    DOI

    http://dx.doi.org/10.1038/sj.cgt.7700976

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047735548

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16874363


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