Mutant Bik expression mediated by the enhanced minimal topoisomerase IIα promoter selectively suppressed breast tumors in an animal model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-03-03

AUTHORS

C-P Day, K-M Rau, L Qiu, C-W Liu, H-P Kuo, X Xie, G Lopez-Berestein, G N Hortobagyi, M-C Hung

ABSTRACT

To ensure the success of systemic gene therapy, it is critical to enhance the tumor specificity and activity of the promoter. In the current study, we determined that topoisomerase IIα promoter is selectively activated in breast cancer cells. An element containing an inverted CCAAT box (ICB) was shown to be responsible for the breast cancer specificity. When the ICB-harboring topoisomerase IIα minimal promoter was linked with an enhancer sequence from the cytomegalovirus immediate early gene promoter (CMV promoter), this composite promoter, CT90, exhibited activity comparable to or higher than the CMV promoter in breast cancer cells in vitro and in vivo, yet expresses much lower activity in normal cell lines and normal organs than the CMV promoter. A CT90-driven construct expressing BikDD, a potent proapoptotic gene, was shown to selectively kill breast cancer cells in vitro, and to suppress mammary tumor development in an animal model of intravenously administrated, liposome-delivered gene therapy. Expression of BikDD was readily detectable in the tumors but not in the normal organs (such as heart) of CT90-BikDD-treated animals. The results indicate that liposomal CT90-BikDD is an effective systemic breast cancer-targeting gene therapy. More... »

PAGES

706-719

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cgt.7700945

DOI

http://dx.doi.org/10.1038/sj.cgt.7700945

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041704589

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16514421


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis Regulatory Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytomegalovirus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Topoisomerases, Type II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enhancer Elements, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Vectors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liposomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Response Elements", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, 833, Kaohsiung Hsien, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.413801.f", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
            "Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA", 
            "Division of Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, 833, Kaohsiung Hsien, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Day", 
        "givenName": "C-P", 
        "id": "sg:person.01272622475.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272622475.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, 833, Kaohsiung Hsien, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.413801.f", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
            "Division of Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, 833, Kaohsiung Hsien, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rau", 
        "givenName": "K-M", 
        "id": "sg:person.01102670672.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102670672.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qiu", 
        "givenName": "L", 
        "id": "sg:person.01052762346.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052762346.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "C-W", 
        "id": "sg:person.01002511440.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002511440.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuo", 
        "givenName": "H-P", 
        "id": "sg:person.01157734023.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157734023.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xie", 
        "givenName": "X", 
        "id": "sg:person.012712256607.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012712256607.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.267308.8", 
          "name": [
            "Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
            "Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopez-Berestein", 
        "givenName": "G", 
        "id": "sg:person.0650504273.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650504273.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hortobagyi", 
        "givenName": "G N", 
        "id": "sg:person.01365732165.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365732165.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.267308.8", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
            "Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hung", 
        "givenName": "M-C", 
        "id": "sg:person.01125127612.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125127612.53"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1205926", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023114159", 
          "https://doi.org/10.1038/sj.onc.1205926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0797-647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028041171", 
          "https://doi.org/10.1038/nbt0797-647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/0-306-46817-4_16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041547528", 
          "https://doi.org/10.1007/0-306-46817-4_16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040431949", 
          "https://doi.org/10.1038/sj.gt.3300728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/415530a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043001094", 
          "https://doi.org/10.1038/415530a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014965673", 
          "https://doi.org/10.1038/sj.cgt.7700214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1995.323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046765011", 
          "https://doi.org/10.1038/bjc.1995.323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017134921", 
          "https://doi.org/10.1038/sj.cgt.7700191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023825729", 
          "https://doi.org/10.1038/sj.gt.3300683"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-03-03", 
    "datePublishedReg": "2006-03-03", 
    "description": "To ensure the success of systemic gene therapy, it is critical to enhance the tumor specificity and activity of the promoter. In the current study, we determined that topoisomerase II\u03b1 promoter is selectively activated in breast cancer cells. An element containing an inverted CCAAT box (ICB) was shown to be responsible for the breast cancer specificity. When the ICB-harboring topoisomerase II\u03b1 minimal promoter was linked with an enhancer sequence from the cytomegalovirus immediate early gene promoter (CMV promoter), this composite promoter, CT90, exhibited activity comparable to or higher than the CMV promoter in breast cancer cells in vitro and in vivo, yet expresses much lower activity in normal cell lines and normal organs than the CMV promoter. A CT90-driven construct expressing BikDD, a potent proapoptotic gene, was shown to selectively kill breast cancer cells in vitro, and to suppress mammary tumor development in an animal model of intravenously administrated, liposome-delivered gene therapy. Expression of BikDD was readily detectable in the tumors but not in the normal organs (such as heart) of CT90-BikDD-treated animals. The results indicate that liposomal CT90-BikDD is an effective systemic breast cancer-targeting gene therapy.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.cgt.7700945", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7133856", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438826", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1112008", 
        "issn": [
          "0929-1903", 
          "1476-5500"
        ], 
        "name": "Cancer Gene Therapy", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "keywords": [
      "breast cancer cells", 
      "cancer cells", 
      "animal models", 
      "normal organs", 
      "mammary tumor development", 
      "gene therapy", 
      "topoisomerase II\u03b1 promoter", 
      "cancer-targeted gene therapy", 
      "CMV promoter", 
      "breast tumors", 
      "systemic gene therapy", 
      "tumor development", 
      "therapy", 
      "tumor specificity", 
      "cancer specificity", 
      "normal cell lines", 
      "cytomegalovirus immediate-early gene promoter", 
      "cell lines", 
      "BIK expression", 
      "CT90", 
      "tumors", 
      "proapoptotic genes", 
      "BikDD", 
      "immediate-early gene promoter", 
      "early gene promoter", 
      "current study", 
      "vitro", 
      "organs", 
      "cells", 
      "expression", 
      "gene promoter", 
      "specificity", 
      "activity", 
      "low activity", 
      "promoter", 
      "vivo", 
      "animals", 
      "enhancer sequences", 
      "composite promoter", 
      "liposomes", 
      "genes", 
      "study", 
      "minimal promoter", 
      "development", 
      "lines", 
      "success", 
      "model", 
      "results", 
      "constructs", 
      "CCAAT box", 
      "sequence", 
      "box", 
      "elements"
    ], 
    "name": "Mutant Bik expression mediated by the enhanced minimal topoisomerase II\u03b1 promoter selectively suppressed breast tumors in an animal model", 
    "pagination": "706-719", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041704589"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.cgt.7700945"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16514421"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.cgt.7700945", 
      "https://app.dimensions.ai/details/publication/pub.1041704589"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.cgt.7700945"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700945'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700945'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700945'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700945'


 

This table displays all metadata directly associated to this object as RDF triples.

310 TRIPLES      21 PREDICATES      109 URIs      92 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.cgt.7700945 schema:about N092180ca759e4a308d7d704e85ad4f38
2 N09f41c92966d499ea3ccaaee64ad1f00
3 N0d70ae0c1b1f45b0ba6c90efe54d359f
4 N24b78fe50cbf4f7e92b7f9388dd91c80
5 N278e82801dc041fd8643aa8b230e6fea
6 N4161edba495941f0976764c4e4f2746d
7 N42074feb028a41d4b0a6c859bd54620e
8 N51a3840d06564eeb9f05dc9db202f6ac
9 N54238e05615b46cdb08ed5881037a69f
10 N5bafd5182c3940668153ba59d6adc009
11 N799721ba67124030891e3c99df3cb402
12 N8befb09366df4b7994823d3c6269ea77
13 N8c9c19d8c0744bb789c474622ac6dc6b
14 N9da7d5da619946b9a0e3699483c62c03
15 N9f6dd221df4341eaba184acf2de7539f
16 Na4403a4142ed428bac28135e787a4f8c
17 Na7fc650545c8478a9867237f808441c1
18 Na9e0b6142b3d4ecdbeda57dfd93a52b9
19 Nc0e41e72122145389e93ca2686020dda
20 Nc75b358edf324411836c03caf510af9c
21 Nd453212cb52847538b0fd47b29e4137e
22 Nf9c16489d5804bc6942fd83b258a75d7
23 anzsrc-for:11
24 anzsrc-for:1112
25 schema:author Nc2cdf97bd44f4d918db0da6d5a6f57c0
26 schema:citation sg:pub.10.1007/0-306-46817-4_16
27 sg:pub.10.1038/415530a
28 sg:pub.10.1038/bjc.1995.323
29 sg:pub.10.1038/nbt0797-647
30 sg:pub.10.1038/sj.cgt.7700191
31 sg:pub.10.1038/sj.cgt.7700214
32 sg:pub.10.1038/sj.gt.3300683
33 sg:pub.10.1038/sj.gt.3300728
34 sg:pub.10.1038/sj.onc.1205926
35 schema:datePublished 2006-03-03
36 schema:datePublishedReg 2006-03-03
37 schema:description To ensure the success of systemic gene therapy, it is critical to enhance the tumor specificity and activity of the promoter. In the current study, we determined that topoisomerase IIα promoter is selectively activated in breast cancer cells. An element containing an inverted CCAAT box (ICB) was shown to be responsible for the breast cancer specificity. When the ICB-harboring topoisomerase IIα minimal promoter was linked with an enhancer sequence from the cytomegalovirus immediate early gene promoter (CMV promoter), this composite promoter, CT90, exhibited activity comparable to or higher than the CMV promoter in breast cancer cells in vitro and in vivo, yet expresses much lower activity in normal cell lines and normal organs than the CMV promoter. A CT90-driven construct expressing BikDD, a potent proapoptotic gene, was shown to selectively kill breast cancer cells in vitro, and to suppress mammary tumor development in an animal model of intravenously administrated, liposome-delivered gene therapy. Expression of BikDD was readily detectable in the tumors but not in the normal organs (such as heart) of CT90-BikDD-treated animals. The results indicate that liposomal CT90-BikDD is an effective systemic breast cancer-targeting gene therapy.
38 schema:genre article
39 schema:isAccessibleForFree false
40 schema:isPartOf N75cc8cf8190a4521af2adab087a09b62
41 N76ee386f8882465ea482dfbe64e79956
42 sg:journal.1112008
43 schema:keywords BIK expression
44 BikDD
45 CCAAT box
46 CMV promoter
47 CT90
48 activity
49 animal models
50 animals
51 box
52 breast cancer cells
53 breast tumors
54 cancer cells
55 cancer specificity
56 cancer-targeted gene therapy
57 cell lines
58 cells
59 composite promoter
60 constructs
61 current study
62 cytomegalovirus immediate-early gene promoter
63 development
64 early gene promoter
65 elements
66 enhancer sequences
67 expression
68 gene promoter
69 gene therapy
70 genes
71 immediate-early gene promoter
72 lines
73 liposomes
74 low activity
75 mammary tumor development
76 minimal promoter
77 model
78 normal cell lines
79 normal organs
80 organs
81 proapoptotic genes
82 promoter
83 results
84 sequence
85 specificity
86 study
87 success
88 systemic gene therapy
89 therapy
90 topoisomerase IIα promoter
91 tumor development
92 tumor specificity
93 tumors
94 vitro
95 vivo
96 schema:name Mutant Bik expression mediated by the enhanced minimal topoisomerase IIα promoter selectively suppressed breast tumors in an animal model
97 schema:pagination 706-719
98 schema:productId N034081b16c504643b3c6a936c369c323
99 N09a91849af954dc185b50e5a9cb95aa9
100 N9a53004a207c4133a8809e49b062ca80
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041704589
102 https://doi.org/10.1038/sj.cgt.7700945
103 schema:sdDatePublished 2022-09-02T15:51
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N18a743a5c9b7456c91b6f55c4f3cadb0
106 schema:url https://doi.org/10.1038/sj.cgt.7700945
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N034081b16c504643b3c6a936c369c323 schema:name dimensions_id
111 schema:value pub.1041704589
112 rdf:type schema:PropertyValue
113 N092180ca759e4a308d7d704e85ad4f38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Apoptosis Regulatory Proteins
115 rdf:type schema:DefinedTerm
116 N09a91849af954dc185b50e5a9cb95aa9 schema:name doi
117 schema:value 10.1038/sj.cgt.7700945
118 rdf:type schema:PropertyValue
119 N09f41c92966d499ea3ccaaee64ad1f00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Humans
121 rdf:type schema:DefinedTerm
122 N0d70ae0c1b1f45b0ba6c90efe54d359f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Breast Neoplasms
124 rdf:type schema:DefinedTerm
125 N14da26514e564c67ae3eb59e204fa7e6 rdf:first sg:person.01365732165.24
126 rdf:rest N756d5c32ab6c4792baae0a51297e8c5c
127 N18a743a5c9b7456c91b6f55c4f3cadb0 schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 N24b78fe50cbf4f7e92b7f9388dd91c80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Mice, Nude
131 rdf:type schema:DefinedTerm
132 N278e82801dc041fd8643aa8b230e6fea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Cell Line, Tumor
134 rdf:type schema:DefinedTerm
135 N318c53df4ee340c5b8baccc60ed11b80 rdf:first sg:person.012712256607.81
136 rdf:rest N9bb6bdd915dd43388938840125a3bb0b
137 N4161edba495941f0976764c4e4f2746d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Antigens, Neoplasm
139 rdf:type schema:DefinedTerm
140 N42074feb028a41d4b0a6c859bd54620e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name DNA-Binding Proteins
142 rdf:type schema:DefinedTerm
143 N4f84652dbade4d25b933d0f459349326 rdf:first sg:person.01157734023.32
144 rdf:rest N318c53df4ee340c5b8baccc60ed11b80
145 N51a3840d06564eeb9f05dc9db202f6ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Animals
147 rdf:type schema:DefinedTerm
148 N54238e05615b46cdb08ed5881037a69f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Cytomegalovirus
150 rdf:type schema:DefinedTerm
151 N5bafd5182c3940668153ba59d6adc009 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Enhancer Elements, Genetic
153 rdf:type schema:DefinedTerm
154 N756d5c32ab6c4792baae0a51297e8c5c rdf:first sg:person.01125127612.53
155 rdf:rest rdf:nil
156 N75cc8cf8190a4521af2adab087a09b62 schema:issueNumber 7
157 rdf:type schema:PublicationIssue
158 N76ee386f8882465ea482dfbe64e79956 schema:volumeNumber 13
159 rdf:type schema:PublicationVolume
160 N799721ba67124030891e3c99df3cb402 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Genetic Vectors
162 rdf:type schema:DefinedTerm
163 N869ce1b7158740d0afc18f7aa96dd9c0 rdf:first sg:person.01002511440.41
164 rdf:rest N4f84652dbade4d25b933d0f459349326
165 N88f247f850514a2eafee3367e0f06c00 rdf:first sg:person.01102670672.97
166 rdf:rest Nff4d4023a2be412b99b4c96e0fb6171b
167 N8befb09366df4b7994823d3c6269ea77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Mice
169 rdf:type schema:DefinedTerm
170 N8c9c19d8c0744bb789c474622ac6dc6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Gene Expression
172 rdf:type schema:DefinedTerm
173 N9a53004a207c4133a8809e49b062ca80 schema:name pubmed_id
174 schema:value 16514421
175 rdf:type schema:PropertyValue
176 N9bb6bdd915dd43388938840125a3bb0b rdf:first sg:person.0650504273.00
177 rdf:rest N14da26514e564c67ae3eb59e204fa7e6
178 N9da7d5da619946b9a0e3699483c62c03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Response Elements
180 rdf:type schema:DefinedTerm
181 N9f6dd221df4341eaba184acf2de7539f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Membrane Proteins
183 rdf:type schema:DefinedTerm
184 Na4403a4142ed428bac28135e787a4f8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Mitochondrial Proteins
186 rdf:type schema:DefinedTerm
187 Na7fc650545c8478a9867237f808441c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Liposomes
189 rdf:type schema:DefinedTerm
190 Na9e0b6142b3d4ecdbeda57dfd93a52b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Neoplasms, Experimental
192 rdf:type schema:DefinedTerm
193 Nc0e41e72122145389e93ca2686020dda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name DNA Topoisomerases, Type II
195 rdf:type schema:DefinedTerm
196 Nc2cdf97bd44f4d918db0da6d5a6f57c0 rdf:first sg:person.01272622475.04
197 rdf:rest N88f247f850514a2eafee3367e0f06c00
198 Nc75b358edf324411836c03caf510af9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Female
200 rdf:type schema:DefinedTerm
201 Nd453212cb52847538b0fd47b29e4137e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Genetic Therapy
203 rdf:type schema:DefinedTerm
204 Nf9c16489d5804bc6942fd83b258a75d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Mutation
206 rdf:type schema:DefinedTerm
207 Nff4d4023a2be412b99b4c96e0fb6171b rdf:first sg:person.01052762346.78
208 rdf:rest N869ce1b7158740d0afc18f7aa96dd9c0
209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
210 schema:name Medical and Health Sciences
211 rdf:type schema:DefinedTerm
212 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
213 schema:name Oncology and Carcinogenesis
214 rdf:type schema:DefinedTerm
215 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.cgt.7700945
216 rdf:type schema:MonetaryGrant
217 sg:grant.7133856 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.cgt.7700945
218 rdf:type schema:MonetaryGrant
219 sg:journal.1112008 schema:issn 0929-1903
220 1476-5500
221 schema:name Cancer Gene Therapy
222 schema:publisher Springer Nature
223 rdf:type schema:Periodical
224 sg:person.01002511440.41 schema:affiliation grid-institutes:grid.240145.6
225 schema:familyName Liu
226 schema:givenName C-W
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002511440.41
228 rdf:type schema:Person
229 sg:person.01052762346.78 schema:affiliation grid-institutes:grid.240145.6
230 schema:familyName Qiu
231 schema:givenName L
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052762346.78
233 rdf:type schema:Person
234 sg:person.01102670672.97 schema:affiliation grid-institutes:grid.413801.f
235 schema:familyName Rau
236 schema:givenName K-M
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102670672.97
238 rdf:type schema:Person
239 sg:person.01125127612.53 schema:affiliation grid-institutes:grid.267308.8
240 schema:familyName Hung
241 schema:givenName M-C
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125127612.53
243 rdf:type schema:Person
244 sg:person.01157734023.32 schema:affiliation grid-institutes:grid.240145.6
245 schema:familyName Kuo
246 schema:givenName H-P
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157734023.32
248 rdf:type schema:Person
249 sg:person.012712256607.81 schema:affiliation grid-institutes:grid.240145.6
250 schema:familyName Xie
251 schema:givenName X
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012712256607.81
253 rdf:type schema:Person
254 sg:person.01272622475.04 schema:affiliation grid-institutes:grid.413801.f
255 schema:familyName Day
256 schema:givenName C-P
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272622475.04
258 rdf:type schema:Person
259 sg:person.01365732165.24 schema:affiliation grid-institutes:grid.240145.6
260 schema:familyName Hortobagyi
261 schema:givenName G N
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365732165.24
263 rdf:type schema:Person
264 sg:person.0650504273.00 schema:affiliation grid-institutes:grid.267308.8
265 schema:familyName Lopez-Berestein
266 schema:givenName G
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650504273.00
268 rdf:type schema:Person
269 sg:pub.10.1007/0-306-46817-4_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041547528
270 https://doi.org/10.1007/0-306-46817-4_16
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/415530a schema:sameAs https://app.dimensions.ai/details/publication/pub.1043001094
273 https://doi.org/10.1038/415530a
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/bjc.1995.323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046765011
276 https://doi.org/10.1038/bjc.1995.323
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/nbt0797-647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028041171
279 https://doi.org/10.1038/nbt0797-647
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/sj.cgt.7700191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017134921
282 https://doi.org/10.1038/sj.cgt.7700191
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/sj.cgt.7700214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014965673
285 https://doi.org/10.1038/sj.cgt.7700214
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/sj.gt.3300683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023825729
288 https://doi.org/10.1038/sj.gt.3300683
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/sj.gt.3300728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040431949
291 https://doi.org/10.1038/sj.gt.3300728
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/sj.onc.1205926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023114159
294 https://doi.org/10.1038/sj.onc.1205926
295 rdf:type schema:CreativeWork
296 grid-institutes:grid.240145.6 schema:alternateName Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
297 Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
298 schema:name Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
299 Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
300 rdf:type schema:Organization
301 grid-institutes:grid.267308.8 schema:alternateName Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA
302 schema:name Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
303 Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
304 Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA
305 rdf:type schema:Organization
306 grid-institutes:grid.413801.f schema:alternateName Division of Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, 833, Kaohsiung Hsien, Taiwan
307 schema:name Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
308 Division of Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, 833, Kaohsiung Hsien, Taiwan
309 Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA
310 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...