Endostatin therapy reveals a U-shaped curve for antitumor activity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-06

AUTHORS

R M Tjin Tham Sjin, J Naspinski, A E Birsner, C Li, R Chan, K-M Lo, S Gillies, D Zurakowski, J Folkman, J Samulski, K Javaherian

ABSTRACT

Developing continuous systemic delivery of endostatin has been a goal of many laboratories. We have employed a method of gene therapy utilizing different viral constructs. Here, we report that a new serotype of adeno-associated viruses, which incorporates canine endostatin, provides dose-dependent transgene expression in the circulation after intramuscular injection in mice. Elevated levels of endostatin remained stable in the circulation for at least 4 months. In vitro assays determined that the protein expressed was biologically active. Antitumor activities of the above construct demonstrated a U-shape curve, where the maximum activity was observed within a certain critical concentration range. These data suggest that an optimum dose range may be required to achieve therapeutic efficacy in large animal models. More... »

PAGES

619

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cgt.7700938

DOI

http://dx.doi.org/10.1038/sj.cgt.7700938

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019691444

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16456550


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